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The map label for this gene is clpA [H]

Identifier: 126452761

GI number: 126452761

Start: 944345

End: 946645

Strand: Direct

Name: clpA [H]

Synonym: BURPS1106A_0964

Alternate gene names: 126452761

Gene position: 944345-946645 (Clockwise)

Preceding gene: 126455350

Following gene: 126453093

Centisome position: 23.68

GC content: 64.93

Gene sequence:

>2301_bases
ATGATTGCCCAGGAATTGGAAGTCAGCCTGCACATGGCGTTCATGGAAGCGCGCCAGGCGCGGCATGAGTTCATTACGGT
CGAGCATCTTTTGTTGGCCCTGCTGGATAATCCGACGGCAGCCGAGGTGTTGCGCGCGTGCGCGGCGAACATCGAGGACC
TGCGTCAGAACCTGCGCAATTTCATCCACGACAACACGCCTACCGTTCCCGGCACCGACGATGTCGACACGCAGCCGACG
CTCGGCTTTCAGCGCGTGATCCAGCGGGCGATCATGCACGTGCAGTCGACGTCGAACGGCAAGAAGGAAGTCACGGGCGC
GAACGTGCTCGTCGCGATCTTCGGCGAGAAGGATTCGCACGCGGTCTACTACTTGCAGCAGCAGGGCGTGACGCGCCTCG
ACGTCGTCAACTTCATCTCGCACGGCATCGCGAAGACGAGCAGCGGCGAAGCCGCGAAGCCCGCCGACGCGAACGCGGAA
GGCGAGGACGCGGGCGCGCAGAAGGAAACGCCGCTCGCGCAGTTCACGCAGAACCTGAACCAGATGGCGAAGGACGGGCG
CATCGATCCGCTGATCGGGCGCGAGTCCGAGGTCGAGCGCGTCGTGCAGGTGCTCTGCCGCCGCCGCAAGAACAATCCGC
TCCTCGTCGGCGAGGCGGGCGTCGGCAAGACGGCGATCGCCGAAGGCCTCGCGTACCGGATCACGCGCGGCGAGGTGCCG
GACATCCTCGCGAACGCGCAGGTGTATTCGCTCGACATGGGCGCGCTCCTCGCGGGCACGAAGTACCGCGGCGATTTCGA
GCAGCGTCTGAAGACGGTGCTGAAGGAGCTGAAGGAGCGGCCGCACGCGATACTCTTCATCGACGAGATCCACACGCTGA
TCGGCGCGGGCGCCGCGTCGGGCGGCACGCTCGATGCGTCGAACCTGCTGAAGCCGGCGCTGTCGTCGGGCACGCTCAAG
TGCATTGGCGCGACGACGTTTACCGAATATCGCGGCATCTTCGAGAAGGATGCGGCGCTGTCGCGGCGCTTCCAGAAGAT
CGACGTGACCGAGCCGAGCGTCGAGCAGACGGTCGCGATCCTGCGCGGCCTGAAGTCGCGCTTCGAGGAGCATCACGGCG
TCAAGTATTCGTCGGGCGCGCTGTCGGCGGCCGCCGAACTGTCGGCGCGGTTCATCACCGACCGCCATCTGCCCGACAAG
GCGATCGACGTGATCGACGAAGCGGGCGCCGCGCAGCGCGTGCTGCCGAAATCCAAGCAGAAGAAGACGATCGGCAAGAG
CGAGATCGAGGAAATCATCTCGAAGATCGCGCGCGTGCCGCCGCAGAGCGTGTCGCAGGACGACCGCAGCAAGCTGCAGA
CGCTCGACCGCGATCTGAAGAGCGTCGTGTTCGGCCAGGACCCGGCGATCGACGCGCTCGCCGCCGCGATCAAGATGGCG
CGCGCGGGCCTCGGCAAGCTCGACAAGCCGATCGGCGCGTTCCTGTTCTCCGGCCCGACGGGCGTCGGCAAGACCGAAGT
GGCGCGCCAACTGGCGTTCACGCTCGGCATCGAGCTGATCCGCTTCGACATGTCGGAATACATGGAGCGTCACGCGGTGA
GCCGCCTGATCGGCGCGCCGCCCGGATACGTCGGGTTCGACCAGGGCGGCTTGCTGACCGAGGCCGTCACGAAGAAGCCG
CACTGCGTGCTGCTGCTCGACGAGATCGAGAAGGCGCATCCGGACATCTTCAACGTGCTGCTGCAGGTGATGGATCACGG
CACGCTGACGGACAACAACGGCCGCAAGGCGGATTTCCGCAACGTCATCATCATCATGACGACGAACGCGGGTGCGGAGT
CGATGCAGAAGGCGACGATCGGCTTCACGACGCGGCGCGAAACCGGCGACGAGATGGCAGACATCAAGCGCCTGTTCACG
CCCGAGTTCCGCAACCGGCTCGATGCGACGATCAGCTTCCGTTCGCTCGATGAGGAAATCATCATGCGGGTGGTCGACAA
GTTCCTGATCCAGCTCGAGGAGCAACTGCACGAGAAGAAGGTCGACGCGCTCTTTACCGATGCGCTGCGCAAGCATCTCG
CGAAGCACGGCTTCGATCCGCTGATGGGCGCGCGACCGATGCAGCGGTTGATCCAGGATACGATCCGGCGCGCGCTCGCC
GACGAGTTGCTGTTCGGCAAGCTCGTCAACGGCGGGCACGTGACGGTCGACGTCGACGAGAACGACAAGGTGCTGCTGTC
GTTCGACAAGACGGCGACGCCGCCCAGCAAGCCGAACGAAGAGGCGGTCGAAGTCGAATAG

Upstream 100 bases:

>100_bases
GTGGGGTCTATACGCGGGACATCGCGTCGACCAAAGTCGAGCAAGTCGTTACCCATGCGCGGCAGGCCGGGCATCCGCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
TTGTAGGTCCGAAACGTTTCGCATGAACGGCGCGGGAAGTCTTCCGCGCCGTTTCGTTTTATTTGCGGCAGATGAAAGGT
ACGGAAGCAGGAGTCTGGTT

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 766

Protein sequence:

>766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTSSGEAAKPADANAE
GEDAGAQKETPLAQFTQNLNQMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKIDVTEPSVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRVLPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAAAIKMA
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFT
PEFRNRLDATISFRSLDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE

Sequences:

>Translated_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTSSGEAAKPADANAE
GEDAGAQKETPLAQFTQNLNQMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKIDVTEPSVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRVLPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAAAIKMA
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFT
PEFRNRLDATISFRSLDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE
>Mature_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTSSGEAAKPADANAE
GEDAGAQKETPLAQFTQNLNQMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKIDVTEPSVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRVLPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAAAIKMA
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFT
PEFRNRLDATISFRSLDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=332, Percent_Identity=28.9156626506024, Blast_Score=155, Evalue=2e-37,
Organism=Escherichia coli, GI1787109, Length=741, Percent_Identity=62.2132253711201, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=402, Percent_Identity=45.5223880597015, Blast_Score=308, Evalue=9e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=259, Percent_Identity=56.3706563706564, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=304, Percent_Identity=47.6973684210526, Blast_Score=267, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84116; Mature: 84116

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTSSGEAAKPADANAEGEDAGAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
QMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGTLKCIGATTFTEYRGIFEKDAALSRRFQKIDVTEPSVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRVLPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAAAIKMA
HHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFTPEFRNRLDATISFRSLDEEI
CEEEEEECCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTSSGEAAKPADANAEGEDAGAQKETPLAQFTQNLN
EEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
QMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGTLKCIGATTFTEYRGIFEKDAALSRRFQKIDVTEPSVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRVLPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAAAIKMA
HHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKLDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRRETGDEMADIKRLFTPEFRNRLDATISFRSLDEEI
CEEEEEECCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]