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The map label for this gene is 126452596

Identifier: 126452596

GI number: 126452596

Start: 330695

End: 331588

Strand: Direct

Name: 126452596

Synonym: BURPS1106A_0359

Alternate gene names: NA

Gene position: 330695-331588 (Clockwise)

Preceding gene: 126451505

Following gene: 126454784

Centisome position: 8.29

GC content: 69.57

Gene sequence:

>894_bases
ATGTCGTTTGAGGAGTTCGCGCCGTTTCGCGTCACGGCGCAAGACGTCGACATCTTCGGCGTCAAAGGAGGTGCGGGGCC
GCCGATCCTGTTGCTGCACGGGCACCCGCAAACACACATGATCTGGCATCGCGTCGCGGCGACGCTTGCCCGGCATTTCA
CGGTGATCGCCACCGATCTGCGCGGCTACGGGGCGTCGGGCAAGCCGCCGAGCGATGCGCGGCACGCGCCGTATTCGAAG
CGCGCGATGGCGGCCGACCAGGTCGCCGTGATGCGTCACTTCGGCTTTCCGCGCTTCTACGTATGCGCGCACGATCGCGG
CGCGCGCGTCGCGCACCGGATGGCGCTCGATCATCCGGACGCGGTGGAGCGGATGCTGCTGCTCGACATCGCGCCGACCC
TCGCGATGTACGAGCGCACCGATCGCGCGTTCGCGACCGCGTACTTCCACTGGTTCTTCCTGATCCAGCCCGAGCCGCTG
CCCGAGACGCTGATCGGCGGGCAGTCGGACGCGTACGTCGAGGCGGTGATGGGCAACCGCTCGGCGGGGCTCGCGCCGTT
TTCGCCGGAGGCGTTGCACGCGTACCGCGAAGCGCTGCGCCAGCCGGGCGCGGTGCATGCGATGTGCGAGGACTATCGCG
CGTCGGCGACGATCGATCTCGATCACGATCGCGCGGATCTCGAGCGCGGGCACAAGCTCGCATGCCCGCTGCGCGTGCTG
TGGGGCGAGCAGGGCGTCGTCGCGCGCTGCTTCGAGCCGCTCGACGAATGGCGGCGCGTCGCGCGCGACGTGAGCGGCCG
CGCGCTCGCGTGCGGGCATTACATTCCGGAGGAAGCGCCCGTCGCGCTGATCGACGAGATCGTGTCGTTCTTCGAGGCGC
GCGAGGCGGCGTGA

Upstream 100 bases:

>100_bases
GAATGAGTGCTCTGTTTCTACGCTTTGCGCGGGTAGGGCGGCGATGACGCGACGATCGCGCTCCTACAATAACGAGACAA
CAATTCGAGAGAACAAGACC

Downstream 100 bases:

>100_bases
CACCCCGCCGCGCACGCGGCGGCTATCGCGGCGCCGCGCCCCGGCCGCGCGGCGCGCGTGCGGCGAGGCGCGCCGCGCGC
GTCAATCCTCTTCGCGTGCG

Product: putative epoxide hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSFEEFAPFRVTAQDVDIFGVKGGAGPPILLLHGHPQTHMIWHRVAATLARHFTVIATDLRGYGASGKPPSDARHAPYSK
RAMAADQVAVMRHFGFPRFYVCAHDRGARVAHRMALDHPDAVERMLLLDIAPTLAMYERTDRAFATAYFHWFFLIQPEPL
PETLIGGQSDAYVEAVMGNRSAGLAPFSPEALHAYREALRQPGAVHAMCEDYRASATIDLDHDRADLERGHKLACPLRVL
WGEQGVVARCFEPLDEWRRVARDVSGRALACGHYIPEEAPVALIDEIVSFFEAREAA

Sequences:

>Translated_297_residues
MSFEEFAPFRVTAQDVDIFGVKGGAGPPILLLHGHPQTHMIWHRVAATLARHFTVIATDLRGYGASGKPPSDARHAPYSK
RAMAADQVAVMRHFGFPRFYVCAHDRGARVAHRMALDHPDAVERMLLLDIAPTLAMYERTDRAFATAYFHWFFLIQPEPL
PETLIGGQSDAYVEAVMGNRSAGLAPFSPEALHAYREALRQPGAVHAMCEDYRASATIDLDHDRADLERGHKLACPLRVL
WGEQGVVARCFEPLDEWRRVARDVSGRALACGHYIPEEAPVALIDEIVSFFEAREAA
>Mature_296_residues
SFEEFAPFRVTAQDVDIFGVKGGAGPPILLLHGHPQTHMIWHRVAATLARHFTVIATDLRGYGASGKPPSDARHAPYSKR
AMAADQVAVMRHFGFPRFYVCAHDRGARVAHRMALDHPDAVERMLLLDIAPTLAMYERTDRAFATAYFHWFFLIQPEPLP
ETLIGGQSDAYVEAVMGNRSAGLAPFSPEALHAYREALRQPGAVHAMCEDYRASATIDLDHDRADLERGHKLACPLRVLW
GEQGVVARCFEPLDEWRRVARDVSGRALACGHYIPEEAPVALIDEIVSFFEAREAA

Specific function: Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has low activity towards chloroacetate [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=280, Percent_Identity=27.8571428571429, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI13376164, Length=280, Percent_Identity=27.8571428571429, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI218777837, Length=227, Percent_Identity=23.7885462555066, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554012, Length=292, Percent_Identity=21.9178082191781, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562298, Length=223, Percent_Identity=22.8699551569507, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.3 [H]

Molecular weight: Translated: 33036; Mature: 32905

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFEEFAPFRVTAQDVDIFGVKGGAGPPILLLHGHPQTHMIWHRVAATLARHFTVIATDL
CCCCCCCCEEEEECCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEEHH
RGYGASGKPPSDARHAPYSKRAMAADQVAVMRHFGFPRFYVCAHDRGARVAHRMALDHPD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHH
AVERMLLLDIAPTLAMYERTDRAFATAYFHWFFLIQPEPLPETLIGGQSDAYVEAVMGNR
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHCCCCCHHHHHHHCCC
SAGLAPFSPEALHAYREALRQPGAVHAMCEDYRASATIDLDHDRADLERGHKLACPLRVL
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCHHHHHCCCEECCCEEEE
WGEQGVVARCFEPLDEWRRVARDVSGRALACGHYIPEEAPVALIDEIVSFFEAREAA
ECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFEEFAPFRVTAQDVDIFGVKGGAGPPILLLHGHPQTHMIWHRVAATLARHFTVIATDL
CCCCCCCEEEEECCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHEEEEHH
RGYGASGKPPSDARHAPYSKRAMAADQVAVMRHFGFPRFYVCAHDRGARVAHRMALDHPD
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHH
AVERMLLLDIAPTLAMYERTDRAFATAYFHWFFLIQPEPLPETLIGGQSDAYVEAVMGNR
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHCCCCCHHHHHHHCCC
SAGLAPFSPEALHAYREALRQPGAVHAMCEDYRASATIDLDHDRADLERGHKLACPLRVL
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCHHHHHCCCEECCCEEEE
WGEQGVVARCFEPLDEWRRVARDVSGRALACGHYIPEEAPVALIDEIVSFFEAREAA
ECCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA