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The map label for this gene is hdaH [H]

Identifier: 126452138

GI number: 126452138

Start: 135959

End: 137071

Strand: Direct

Name: hdaH [H]

Synonym: BURPS1106A_0141

Alternate gene names: 126452138

Gene position: 135959-137071 (Clockwise)

Preceding gene: 126455252

Following gene: 126453061

Centisome position: 3.41

GC content: 70.17

Gene sequence:

>1113_bases
TTGATTCCCACCGGACTGCTGTTCGATCCCGCATTCCTGTCGCATCGGCAGGGTGATCTCGTGTATGTCGTGCCGCACGG
CACGCTGAACCTCGGCGAGCATTTCGACAGCTCGCTGAGGCTCGCGTATACGAAGCAGTTGCTCGACGCGGTCGGCATGA
CCGAGCGCCTGACGCGCGTCGCTTTCGCGCGTGCGACCGATGAGCAATTGCTGCGCGTGCATCGGCCCGAATATCTGCGG
CAGCTCGCCGAGGCTTGCGCGGTGGCGGGCGAGCAGGTGGTGCGGCTCGGCGACGACGCGGCGGGCAGCGCGTCGACCGA
AGACGTCGCGCGGCTCGCGGCGGGCGCCGCGTGCGCGGCTGTCGATGCGGTGATGACGGGGCCGCTTCGGCAGGCGTATG
CGCTGATCCGGCCGTCTGGCCACCATGCGGGCGCCGATTTCGCGATGGGCTACTGCTACTACAACAACGTCGCGATCGCG
GCGCGCCATGCGCAGGCCGCGCACGGCGTCGAGCGGGTGGCGATCGTCGACTGGGACGTGCATCACGGCAACGGCACGCA
GCAGACGTTCTACGACGATCCTTCGGTATTGTTCGTGTCGCTGCACGAGGCGGCGAATTTCCCGGTCGACGGCGGCGAGG
CGCGTGAGACGGGCGGCGGCGCGGGCGCGGGCTACAACGCGAACGTGCCGTTGCCGTCCGGCACGGGCGACGCCGGCTAT
CGGCACGCGTTCGACGAGCTGGTGCTGCCGCTCGTCGAGGCGTTCGCGCCGCAGCTCATTCTCGTGTCGGCGGGGCAGGA
TGCGAACGCGTTCGATCCGCTCGGCCGCATGCGCGTGCAGCGCGACGGGTTCCGGCACATGGCGCGCGCATTGCGGCAAG
CGGCGGGCGGCGCATGCGGGGGGCGCATCGTGATGCTGCAGGAGGGCGGCTACAGCCTGCCGTATCTGCCGATCGCGACG
CTCGGCGTGCTCGAGGGGCTCGTCGGCTGGAACGCGCCGTTCGACGATCCGCACCAGTTCGTCCAGTATCCGCTCGGCGA
AGGCGAGCGCGCCGCGGTGAAGGCCGCCCGCGCCGCGCTGGCGCCGTATTGGCCCACGCTGCATCGATCCTGA

Upstream 100 bases:

>100_bases
AAGCGCCCGATGCCGCCGCAGGCAATACGCATGCAGACGCGCTACTGGACCCGGTTCAAGACCGGTTACTGAGCGGCTTC
ATTCTGACGAGGAGACCGAA

Downstream 100 bases:

>100_bases
GGCGCGCACAATGAGAAAGACGACCGTTGCCGTTACGCAGATGGCTTGCGACTGGAACGTCGACGCGAACCTGTCGCGCG
CCGAGCGACTCGTGCGCGAC

Product: histone deacetylase family protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIPTGLLFDPAFLSHRQGDLVYVVPHGTLNLGEHFDSSLRLAYTKQLLDAVGMTERLTRVAFARATDEQLLRVHRPEYLR
QLAEACAVAGEQVVRLGDDAAGSASTEDVARLAAGAACAAVDAVMTGPLRQAYALIRPSGHHAGADFAMGYCYYNNVAIA
ARHAQAAHGVERVAIVDWDVHHGNGTQQTFYDDPSVLFVSLHEAANFPVDGGEARETGGGAGAGYNANVPLPSGTGDAGY
RHAFDELVLPLVEAFAPQLILVSAGQDANAFDPLGRMRVQRDGFRHMARALRQAAGGACGGRIVMLQEGGYSLPYLPIAT
LGVLEGLVGWNAPFDDPHQFVQYPLGEGERAAVKAARAALAPYWPTLHRS

Sequences:

>Translated_370_residues
MIPTGLLFDPAFLSHRQGDLVYVVPHGTLNLGEHFDSSLRLAYTKQLLDAVGMTERLTRVAFARATDEQLLRVHRPEYLR
QLAEACAVAGEQVVRLGDDAAGSASTEDVARLAAGAACAAVDAVMTGPLRQAYALIRPSGHHAGADFAMGYCYYNNVAIA
ARHAQAAHGVERVAIVDWDVHHGNGTQQTFYDDPSVLFVSLHEAANFPVDGGEARETGGGAGAGYNANVPLPSGTGDAGY
RHAFDELVLPLVEAFAPQLILVSAGQDANAFDPLGRMRVQRDGFRHMARALRQAAGGACGGRIVMLQEGGYSLPYLPIAT
LGVLEGLVGWNAPFDDPHQFVQYPLGEGERAAVKAARAALAPYWPTLHRS
>Mature_370_residues
MIPTGLLFDPAFLSHRQGDLVYVVPHGTLNLGEHFDSSLRLAYTKQLLDAVGMTERLTRVAFARATDEQLLRVHRPEYLR
QLAEACAVAGEQVVRLGDDAAGSASTEDVARLAAGAACAAVDAVMTGPLRQAYALIRPSGHHAGADFAMGYCYYNNVAIA
ARHAQAAHGVERVAIVDWDVHHGNGTQQTFYDDPSVLFVSLHEAANFPVDGGEARETGGGAGAGYNANVPLPSGTGDAGY
RHAFDELVLPLVEAFAPQLILVSAGQDANAFDPLGRMRVQRDGFRHMARALRQAAGGACGGRIVMLQEGGYSLPYLPIAT
LGVLEGLVGWNAPFDDPHQFVQYPLGEGERAAVKAARAALAPYWPTLHRS

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=340, Percent_Identity=38.8235294117647, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI13128864, Length=319, Percent_Identity=39.4984326018809, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226529806, Length=340, Percent_Identity=36.1764705882353, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI153085395, Length=269, Percent_Identity=39.0334572490706, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI17158039, Length=356, Percent_Identity=32.5842696629214, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI30795202, Length=356, Percent_Identity=32.5842696629214, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI30795204, Length=356, Percent_Identity=32.5842696629214, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI148539870, Length=232, Percent_Identity=42.2413793103448, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI169234807, Length=232, Percent_Identity=42.2413793103448, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI62750349, Length=249, Percent_Identity=40.5622489959839, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI62750347, Length=249, Percent_Identity=40.5622489959839, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI13128860, Length=281, Percent_Identity=25.6227758007117, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI293336691, Length=243, Percent_Identity=27.1604938271605, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI13128862, Length=245, Percent_Identity=27.7551020408163, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI8923769, Length=282, Percent_Identity=26.241134751773, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI262073088, Length=192, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262073092, Length=209, Percent_Identity=28.2296650717703, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI217272877, Length=280, Percent_Identity=25.3571428571429, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=361, Percent_Identity=34.6260387811634, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17540332, Length=361, Percent_Identity=34.6260387811634, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI193206283, Length=361, Percent_Identity=34.6260387811634, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI193209491, Length=393, Percent_Identity=31.8066157760814, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25154020, Length=262, Percent_Identity=33.969465648855, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17537347, Length=303, Percent_Identity=34.983498349835, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25154022, Length=299, Percent_Identity=31.7725752508361, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17561978, Length=311, Percent_Identity=26.3665594855305, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17508561, Length=253, Percent_Identity=28.0632411067194, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17534739, Length=282, Percent_Identity=26.5957446808511, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=326, Percent_Identity=32.5153374233129, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321244, Length=247, Percent_Identity=28.7449392712551, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323999, Length=293, Percent_Identity=27.3037542662116, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6325141, Length=310, Percent_Identity=24.8387096774194, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325325, Length=176, Percent_Identity=25.5681818181818, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281360899, Length=319, Percent_Identity=37.3040752351097, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24642146, Length=319, Percent_Identity=37.3040752351097, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24642144, Length=319, Percent_Identity=37.3040752351097, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24642142, Length=319, Percent_Identity=37.3040752351097, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24641720, Length=341, Percent_Identity=35.7771260997067, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI281360801, Length=341, Percent_Identity=35.7771260997067, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI281360799, Length=341, Percent_Identity=35.7771260997067, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24644244, Length=272, Percent_Identity=29.0441176470588, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24657891, Length=245, Percent_Identity=28.9795918367347, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24649807, Length=251, Percent_Identity=27.4900398406374, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39447; Mature: 39447

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTGLLFDPAFLSHRQGDLVYVVPHGTLNLGEHFDSSLRLAYTKQLLDAVGMTERLTRV
CCCCCCEECHHHHCCCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHCHHHHHHHH
AFARATDEQLLRVHRPEYLRQLAEACAVAGEQVVRLGDDAAGSASTEDVARLAAGAACAA
HHHHCCHHHHHHHCCHHHHHHHHHHHHHCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHH
VDAVMTGPLRQAYALIRPSGHHAGADFAMGYCYYNNVAIAARHAQAAHGVERVAIVDWDV
HHHHHHCHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEEHHHHHHCCCCEEEEEEEEE
HHGNGTQQTFYDDPSVLFVSLHEAANFPVDGGEARETGGGAGAGYNANVPLPSGTGDAGY
ECCCCCCCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
RHAFDELVLPLVEAFAPQLILVSAGQDANAFDPLGRMRVQRDGFRHMARALRQAAGGACG
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GRIVMLQEGGYSLPYLPIATLGVLEGLVGWNAPFDDPHQFVQYPLGEGERAAVKAARAAL
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHH
APYWPTLHRS
CCCCCHHCCC
>Mature Secondary Structure
MIPTGLLFDPAFLSHRQGDLVYVVPHGTLNLGEHFDSSLRLAYTKQLLDAVGMTERLTRV
CCCCCCEECHHHHCCCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHCHHHHHHHH
AFARATDEQLLRVHRPEYLRQLAEACAVAGEQVVRLGDDAAGSASTEDVARLAAGAACAA
HHHHCCHHHHHHHCCHHHHHHHHHHHHHCCHHHEECCCCCCCCCCHHHHHHHHHHHHHHH
VDAVMTGPLRQAYALIRPSGHHAGADFAMGYCYYNNVAIAARHAQAAHGVERVAIVDWDV
HHHHHHCHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEEHHHHHHCCCCEEEEEEEEE
HHGNGTQQTFYDDPSVLFVSLHEAANFPVDGGEARETGGGAGAGYNANVPLPSGTGDAGY
ECCCCCCCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
RHAFDELVLPLVEAFAPQLILVSAGQDANAFDPLGRMRVQRDGFRHMARALRQAAGGACG
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GRIVMLQEGGYSLPYLPIATLGVLEGLVGWNAPFDDPHQFVQYPLGEGERAAVKAARAAL
CEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHH
APYWPTLHRS
CCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA