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The map label for this gene is hemE [H]

Identifier: 126451836

GI number: 126451836

Start: 3942705

End: 3943799

Strand: Reverse

Name: hemE [H]

Synonym: BURPS1106A_4036

Alternate gene names: 126451836

Gene position: 3943799-3942705 (Counterclockwise)

Preceding gene: 126453580

Following gene: 126455110

Centisome position: 98.88

GC content: 70.14

Gene sequence:

>1095_bases
GTGGCCCAGACTCTCCTCAACGACACCTTCCTGCGCGCGCTGCTGCGCGAGCCGACCGACTACACGCCGATCTGGCTGAT
GCGCCAGGCGGGCCGCTACCTGCCCGAGTACAACGCAACGCGCGCGCGCGCGGGCAGCTTCCTCGGGCTCGCGAAGCAGC
CCGATTACGCGACCGAAGTGACGCTGCAGCCGCTCGAGCGCTTTCCGCTCGACGCCGCGATCCTGTTCTCCGACATCCTG
ACGATTCCCGACGCGATGGGGCTGGGCCTCGATTTCGCCGCGGGCGAGGGGCCGAAGTTCGCGCATCCGGTGCGCACCGA
GGCCGACGTCGCGAAGCTCGCGGTGCCGGACATCGGCGCGACGCTCGGCTACGTGACCGACGCGGTGCGCGAGATTCGCC
GCGCGCTCACCGACGGCGAAGGCCGCCAGCGCGTGCCGCTGATCGGCTTCTCCGGCAGCCCGTGGACGCTCGCGTGCTAC
ATGGTCGAAGGCGGCGGCTCGGACGATTTCCGCACCGTGAAATCGATGGCGTACGCGCGGCCCGACCTGATGCACCGGAT
TCTCGACATCAATGCGCAGGCAGTGGCCGCGTATCTGAACGCGCAGATCGAAGCCGGCGCGCAGGCGGTGATGATCTTCG
ATACGTGGGGCGGCGCGCTCGCCGACGGCGCCTATCAGCGCTTCTCGCTCGACTACGTCCGACGCGTGCTCGCGCAGCTC
AAGCGCGAGCACGACGGCGCGCGCGTGCCGGCGATCGCGTTCACGAAGGGCGGCGGGCTCTGGCTCGAGGAGCTCGCGGC
GACGGGCGTCGATGCGGTCGGCCTCGACTGGACGGTCAACCTCGGCCGCGCGCGCGAGCGCGTCGCGGGGCGCGTCGCGC
TGCAGGGCAATCTCGATCCGACGATCCTGTTCGCGCCGCCCGAGGCGATCCGCGCCGAGGCGCGCGCGGTGCTCGACAGC
TACGGTAACCATCCGGGCCATGTGTTCAACCTCGGCCACGGCATCTCGCAGTTCACGCCGCCCGAGCATGTCGCTGAACT
CGTCGACGAAGTGCATCGTCATAGCCGCGCGATTCGTAGCGGCGCCGGATCGTGA

Upstream 100 bases:

>100_bases
TCATAACGGACGGCCGGCGAGCGTCATATGGCCGCGAGCGCCGGGCGGCGCGCCGCGTCCGGTAGAATGCTCCTTTGCGT
TTCGCTTCGTCGCACTCATC

Downstream 100 bases:

>100_bases
GCGCAAGCCCTTCGATGCTGCGGCGCGACGGGTCGAATTTGCGCAAACACGACTAAACAGGGCGTAAGCGCCCGTCCGAT
GGCACTCTTATGCTTGTCAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEVTLQPLERFPLDAAILFSDIL
TIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACY
MVEGGGSDDFRTVKSMAYARPDLMHRILDINAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYVRRVLAQL
KREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDS
YGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAGS

Sequences:

>Translated_364_residues
MAQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEVTLQPLERFPLDAAILFSDIL
TIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACY
MVEGGGSDDFRTVKSMAYARPDLMHRILDINAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYVRRVLAQL
KREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDS
YGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAGS
>Mature_363_residues
AQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEVTLQPLERFPLDAAILFSDILT
IPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYM
VEGGGSDDFRTVKSMAYARPDLMHRILDINAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYVRRVLAQLK
REHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDSY
GNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAGS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=48.7534626038781, Blast_Score=324, Evalue=7e-89,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=61.8233618233618, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6320252, Length=363, Percent_Identity=36.6391184573003, Blast_Score=243, Evalue=3e-65,
Organism=Drosophila melanogaster, GI19921920, Length=353, Percent_Identity=38.8101983002833, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=38.8101983002833, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39486; Mature: 39355

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEV
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCHHH
TLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGA
HHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCHH
TLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYAR
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCC
PDLMHRILDINAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYVRRVLAQL
HHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHH
KREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDP
HHHCCCCCCCEEEEECCCCHHHHHHHHCCCCEECCCEEEECHHHHHHHHCEEEEECCCCC
TILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRS
EEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GAGS
CCCC
>Mature Secondary Structure 
AQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEV
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCHHH
TLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGA
HHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCCHH
TLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYAR
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHCC
PDLMHRILDINAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGAYQRFSLDYVRRVLAQL
HHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHH
KREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDP
HHHCCCCCCCEEEEECCCCHHHHHHHHCCCCEECCCEEEECHHHHHHHHCEEEEECCCCC
TILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRS
EEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GAGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA