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The map label for this gene is pncB [H]

Identifier: 126451694

GI number: 126451694

Start: 755317

End: 756672

Strand: Direct

Name: pncB [H]

Synonym: BURPS1106A_0775

Alternate gene names: 126451694

Gene position: 755317-756672 (Clockwise)

Preceding gene: 126455330

Following gene: 126452451

Centisome position: 18.94

GC content: 70.87

Gene sequence:

>1356_bases
ATGAGGGCGAAGCCTGCCTGCACGCGGGCGCTGCTCGCCGACCTGTACGAATTCACGATGCTGCAGTCGTACTTCGACTG
CGGGATGAACGATACGGCGACGTTCGAGCTGTTCGTGCGCAGGCTGCCCGCGCATCGGAATTTCATGATGGCGGCGGGGC
TCGAGCAGGCGCTCGACTATCTGGCGAACCTCGCATTCGACGCCGACGAGATCGAAGCGCTCGCGGGCATGGGGCTCTTC
GGCGACGGCTTTCTCGCGTCGCTCGCATCGCTGCGCTTCACGGGCACGGTTCGCGCGATGCGCGAGGGCACCGTGTTCTT
CGCGGACGAGCCGATCCTGCAAGTCACCGCGCCGCTGCGCGAGGCGCAACTGATCGAGAGCCGCGTGATGAACCTGCTGC
ACTACGAAACGATCGTCGCGAGCAAGGCCGCGCGCGCGGTGCTCGCGGCGCCGGGCAAGGCGCTCGTCGATTTCGGGCTG
CGCCGCGCGCATGGCGCCGAGGCCGCGCTGCTGTCGGCGCGCGCGAGCTACGTGGCGGGCTTCGCCGGCACGGCGACGCT
GCTTGCCGGCCTGCGCTACGGGATTCCGACGTACGGCACGATGGCGCATTCGTACGTGCAGGCGCACGACGACGAAGCAC
TCGCGTTCGAGCATTTCGCGCGCTCGTTCCCGCGCAACGCGATGCTGCTCGTCGACACGTACGACACCGAGGCGGCCGCG
GGCAAGGTCATCGAAGTCGCGAGGAGGCTCGCGCGCGACGGCGTCGAGGTGAAGGGCGTGCGGCTCGACAGCGGCGATCT
CGCGCAGCACGCGATGCGCGTGCGCGCGCAGCTCGATCGCGCGGGGCTCGGCCGGTTGACGCTCTTCGCGAGCGGCAATC
TCGACGAATACCGGCTCGCCGAGCTGATCGGGCAGGGCGCGCCGATCGACGGCTTCGGCGTGGGCACGCGGATGAACACG
TCGGCGGACGCGCCGTACGCGGATTGCGCGTACAAGCTGACCGAATACGCGGGCGTGCCGCGGCGCAAGCGCTCGGAGGG
CAAGGCGACGTGGCCGGGGCGCAAGCAGGTGTTTCGCCGCTATCGCGACGATGGCCTGCTCGACGGCGATTGCCTCGCGC
TGCACGACGATGCGCAGGCGGGCGTCGCGCTGCTCGAACCGGTGATGATCGGCGGCGAGCGCGTCGCGCCTTCGCCGAGC
CTTGCCGACGTTCGCGCGCATGCGCGCGCGCAGCTCGACACGCTGCCCGCGGCGCTGCGCGATCTCGCGCGCGCGGCCGA
GTATCCGGTCGCGGTGGCCGGCACGTTGGCGGCGCTCGCGCAACGGCTCGATGCGCGGGCGGCGAGCGGCGCGTAG

Upstream 100 bases:

>100_bases
TCGAGGAGCCGGGCACGCTCGACGAAGTCGCGCGCGTCGCGGCCGACTGGTTCGTCGCGCATCTCGGCGAGGGCCGGCCA
TCGCCCGAAGGGGCGCGAAG

Downstream 100 bases:

>100_bases
CGCGACGCGCGGTGCATGCGAGCCGTATGGCCCGTTGCGCGGACCGCGCGCGCCGGCGCGCATCGCCGCCGCCCGACACG
CGCCGGCCATGCGAGCCAAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRAKPACTRALLADLYEFTMLQSYFDCGMNDTATFELFVRRLPAHRNFMMAAGLEQALDYLANLAFDADEIEALAGMGLF
GDGFLASLASLRFTGTVRAMREGTVFFADEPILQVTAPLREAQLIESRVMNLLHYETIVASKAARAVLAAPGKALVDFGL
RRAHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDEALAFEHFARSFPRNAMLLVDTYDTEAAA
GKVIEVARRLARDGVEVKGVRLDSGDLAQHAMRVRAQLDRAGLGRLTLFASGNLDEYRLAELIGQGAPIDGFGVGTRMNT
SADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVFRRYRDDGLLDGDCLALHDDAQAGVALLEPVMIGGERVAPSPS
LADVRAHARAQLDTLPAALRDLARAAEYPVAVAGTLAALAQRLDARAASGA

Sequences:

>Translated_451_residues
MRAKPACTRALLADLYEFTMLQSYFDCGMNDTATFELFVRRLPAHRNFMMAAGLEQALDYLANLAFDADEIEALAGMGLF
GDGFLASLASLRFTGTVRAMREGTVFFADEPILQVTAPLREAQLIESRVMNLLHYETIVASKAARAVLAAPGKALVDFGL
RRAHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDEALAFEHFARSFPRNAMLLVDTYDTEAAA
GKVIEVARRLARDGVEVKGVRLDSGDLAQHAMRVRAQLDRAGLGRLTLFASGNLDEYRLAELIGQGAPIDGFGVGTRMNT
SADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVFRRYRDDGLLDGDCLALHDDAQAGVALLEPVMIGGERVAPSPS
LADVRAHARAQLDTLPAALRDLARAAEYPVAVAGTLAALAQRLDARAASGA
>Mature_451_residues
MRAKPACTRALLADLYEFTMLQSYFDCGMNDTATFELFVRRLPAHRNFMMAAGLEQALDYLANLAFDADEIEALAGMGLF
GDGFLASLASLRFTGTVRAMREGTVFFADEPILQVTAPLREAQLIESRVMNLLHYETIVASKAARAVLAAPGKALVDFGL
RRAHGAEAALLSARASYVAGFAGTATLLAGLRYGIPTYGTMAHSYVQAHDDEALAFEHFARSFPRNAMLLVDTYDTEAAA
GKVIEVARRLARDGVEVKGVRLDSGDLAQHAMRVRAQLDRAGLGRLTLFASGNLDEYRLAELIGQGAPIDGFGVGTRMNT
SADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVFRRYRDDGLLDGDCLALHDDAQAGVALLEPVMIGGERVAPSPS
LADVRAHARAQLDTLPAALRDLARAAEYPVAVAGTLAALAQRLDARAASGA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=525, Percent_Identity=33.1428571428571, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71997952, Length=533, Percent_Identity=27.9549718574109, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71997947, Length=533, Percent_Identity=27.9549718574109, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71997955, Length=225, Percent_Identity=35.5555555555556, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24581587, Length=521, Percent_Identity=30.5182341650672, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=38.3495145631068, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=38.3495145631068, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=38.3495145631068, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=38.3495145631068, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=38.3495145631068, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 48475; Mature: 48475

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKPACTRALLADLYEFTMLQSYFDCGMNDTATFELFVRRLPAHRNFMMAAGLEQALDY
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LANLAFDADEIEALAGMGLFGDGFLASLASLRFTGTVRAMREGTVFFADEPILQVTAPLR
HHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCHH
EAQLIESRVMNLLHYETIVASKAARAVLAAPGKALVDFGLRRAHGAEAALLSARASYVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FAGTATLLAGLRYGIPTYGTMAHSYVQAHDDEALAFEHFARSFPRNAMLLVDTYDTEAAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHH
GKVIEVARRLARDGVEVKGVRLDSGDLAQHAMRVRAQLDRAGLGRLTLFASGNLDEYRLA
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
ELIGQGAPIDGFGVGTRMNTSADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVFRR
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
YRDDGLLDGDCLALHDDAQAGVALLEPVMIGGERVAPSPSLADVRAHARAQLDTLPAALR
HHCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DLARAAEYPVAVAGTLAALAQRLDARAASGA
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRAKPACTRALLADLYEFTMLQSYFDCGMNDTATFELFVRRLPAHRNFMMAAGLEQALDY
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LANLAFDADEIEALAGMGLFGDGFLASLASLRFTGTVRAMREGTVFFADEPILQVTAPLR
HHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCHH
EAQLIESRVMNLLHYETIVASKAARAVLAAPGKALVDFGLRRAHGAEAALLSARASYVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
FAGTATLLAGLRYGIPTYGTMAHSYVQAHDDEALAFEHFARSFPRNAMLLVDTYDTEAAA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHH
GKVIEVARRLARDGVEVKGVRLDSGDLAQHAMRVRAQLDRAGLGRLTLFASGNLDEYRLA
HHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
ELIGQGAPIDGFGVGTRMNTSADAPYADCAYKLTEYAGVPRRKRSEGKATWPGRKQVFRR
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
YRDDGLLDGDCLALHDDAQAGVALLEPVMIGGERVAPSPSLADVRAHARAQLDTLPAALR
HHCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DLARAAEYPVAVAGTLAALAQRLDARAASGA
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]