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The map label for this gene is mscS [H]

Identifier: 126451655

GI number: 126451655

Start: 3213069

End: 3213896

Strand: Direct

Name: mscS [H]

Synonym: BURPS1106A_3295

Alternate gene names: 126451655

Gene position: 3213069-3213896 (Clockwise)

Preceding gene: 126452454

Following gene: 126454824

Centisome position: 80.56

GC content: 65.22

Gene sequence:

>828_bases
GTGGATCTCGCTTCCGTGCAAACCTTCATCGTCACTCGCGGCCTCGACTTCGGCCTGCAGGTCATCGCGTCGATCGCGCT
CTGGATCTTCGGCCGCTGGGCGATCCGGATCGTCACGAATCTGATGGGCAAGCTCATCCGCAGGAGCGGAAAAGTCGATT
CGACGCTGTCGCACTATCTGGAATCGGTCGTGAGCGTCTTGCTCACGGTGCTCTTGATCCTCGCGATCCTGCAGGTGTTC
GGCGTGCAGACGACTTCGTTCGCCGCACTGCTCGCGGGCCTCGGCCTCGCGGTCGGCACCGCGTGGGGCGGCCTGCTCGC
GCACTTCGCGGCCGGCGTGTTCATGCAGGTGCTGCGGCCGTTCAAGGTCGGCGACGTGATCTCGGCGGGCGGCGTGACGG
GCACCGTCAAGGAACTGGGCCTCTTCGGCACGACGATCGTCACGGCAGACAACGTCGTCACGCTCGTCGGCAACAACAAG
ATCTTCTCCGACAACATCGCGAACTACAGCGCGACGCCCACGCGCCGCGTCGATCTGACGGCGAAGATCGCGAACGGCGT
CGACGCGGCCGATGCGATCAAGCGGCTGAAGGCCGCGCTCGAACTGATTCCGAACGTCGTCAAGCACCCGGCGCCCGATG
TCGGCGTGCTGTCGTTCACGCCGGAAGGCCCGCTGCTGTTCGTACGGCCATCGACGCAGCCCGCCAACTACTGGCAAGTG
TATTGCGACACCAATCGCGCGATTCTCGACACGTTCCGCGAGGCCGGCTATCCGACGCCGGAAACGCCGGTCGCGCATCG
CACGACCGCCGACGTCGCGAAATCCTGA

Upstream 100 bases:

>100_bases
GCATGGCGAAGGTTGCTCCATCGCCGCGAGTCGGTTATAAAAAACCCCCTTTCGCGTGGCTTCACGGCCGCCTCCGTTCA
ATTCATTTGGAGACCTCATC

Downstream 100 bases:

>100_bases
CGCGGCGGCGCCGCCCCGCCGCCGCGCGATGACGACGCGCGAGCGGCGGCCCGCTCGCCGCCTGAGAATGCGCCCGCCAC
GCCCAGGCAGGCGCATTTGC

Product: small conductance mechanosensitive ion channel (MscS) family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MDLASVQTFIVTRGLDFGLQVIASIALWIFGRWAIRIVTNLMGKLIRRSGKVDSTLSHYLESVVSVLLTVLLILAILQVF
GVQTTSFAALLAGLGLAVGTAWGGLLAHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIVTADNVVTLVGNNK
IFSDNIANYSATPTRRVDLTAKIANGVDAADAIKRLKAALELIPNVVKHPAPDVGVLSFTPEGPLLFVRPSTQPANYWQV
YCDTNRAILDTFREAGYPTPETPVAHRTTADVAKS

Sequences:

>Translated_275_residues
MDLASVQTFIVTRGLDFGLQVIASIALWIFGRWAIRIVTNLMGKLIRRSGKVDSTLSHYLESVVSVLLTVLLILAILQVF
GVQTTSFAALLAGLGLAVGTAWGGLLAHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIVTADNVVTLVGNNK
IFSDNIANYSATPTRRVDLTAKIANGVDAADAIKRLKAALELIPNVVKHPAPDVGVLSFTPEGPLLFVRPSTQPANYWQV
YCDTNRAILDTFREAGYPTPETPVAHRTTADVAKS
>Mature_275_residues
MDLASVQTFIVTRGLDFGLQVIASIALWIFGRWAIRIVTNLMGKLIRRSGKVDSTLSHYLESVVSVLLTVLLILAILQVF
GVQTTSFAALLAGLGLAVGTAWGGLLAHFAAGVFMQVLRPFKVGDVISAGGVTGTVKELGLFGTTIVTADNVVTLVGNNK
IFSDNIANYSATPTRRVDLTAKIANGVDAADAIKRLKAALELIPNVVKHPAPDVGVLSFTPEGPLLFVRPSTQPANYWQV
YCDTNRAILDTFREAGYPTPETPVAHRTTADVAKS

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=259, Percent_Identity=30.1158301158301, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786670, Length=201, Percent_Identity=24.8756218905473, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787591, Length=163, Percent_Identity=30.0613496932515, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29303; Mature: 29303

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLASVQTFIVTRGLDFGLQVIASIALWIFGRWAIRIVTNLMGKLIRRSGKVDSTLSHYL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ESVVSVLLTVLLILAILQVFGVQTTSFAALLAGLGLAVGTAWGGLLAHFAAGVFMQVLRP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKVGDVISAGGVTGTVKELGLFGTTIVTADNVVTLVGNNKIFSDNIANYSATPTRRVDLT
CCCCCHHHCCCCCHHHHHHHHHHHHEEECCCEEEEEECCEEECCCCCCCCCCCCEEEEEH
AKIANGVDAADAIKRLKAALELIPNVVKHPAPDVGVLSFTPEGPLLFVRPSTQPANYWQV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCEEEE
YCDTNRAILDTFREAGYPTPETPVAHRTTADVAKS
EECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MDLASVQTFIVTRGLDFGLQVIASIALWIFGRWAIRIVTNLMGKLIRRSGKVDSTLSHYL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ESVVSVLLTVLLILAILQVFGVQTTSFAALLAGLGLAVGTAWGGLLAHFAAGVFMQVLRP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKVGDVISAGGVTGTVKELGLFGTTIVTADNVVTLVGNNKIFSDNIANYSATPTRRVDLT
CCCCCHHHCCCCCHHHHHHHHHHHHEEECCCEEEEEECCEEECCCCCCCCCCCCEEEEEH
AKIANGVDAADAIKRLKAALELIPNVVKHPAPDVGVLSFTPEGPLLFVRPSTQPANYWQV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCEEEE
YCDTNRAILDTFREAGYPTPETPVAHRTTADVAKS
EECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]