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The map label for this gene is mutL [H]

Identifier: 126454824

GI number: 126454824

Start: 3215082

End: 3217136

Strand: Direct

Name: mutL [H]

Synonym: BURPS1106A_3297

Alternate gene names: 126454824

Gene position: 3215082-3217136 (Clockwise)

Preceding gene: 126451655

Following gene: 126453466

Centisome position: 80.61

GC content: 72.02

Gene sequence:

>2055_bases
ATGTCCGAATTCACCGATTCCGCCGCGGGCCGCTCGAGCACGCCGCCCGCCGACGCGCCGTCGCCCGCCTCGCGCCCGCT
GCGCGCGATCCAGCCGCTGCCCGACCAGTTGATCAGCCAGATCGCGGCGGGCGAAGTGGTCGAGCGGCCCGCCTCCGTCG
TCAAGGAGCTCGTCGAGAACGCGCTCGACGCCGGCGCGGGCACGCTGCGCATCCTGCTCGACGAAGGCGGCGTCAAGCGC
ATTTCGATCACCGACGACGGCTGCGGGATTCCCGCCGACGAGCTGCCGCTCGCGCTGATGCGCCACGCGACGAGCAAGAT
CCGCTCGCTCGCCGAGCTCGAGGCGGTCGCGACGCTCGGGTTCCGCGGCGAAGCGCTCGCATCGATCGCGTCGGTCGCCG
AGATGTTCATCACGAGCCGCACCGAGGATGCCGCGCACGCGACGCGCATCGACGCGCAGACGGGCGTCGTCGGGCCCGCG
GCCGGCACGCGCGGCACGACGATCGAAGTGCGCGAGCTGTACTTCAGCACGCCCGCGCGCCGCAAGTTCCTGAAGAGCGA
GCAGACCGAGTTCGGCCATTGCCTCGAGATGATTCGCCGCGCGGCGCTCGCGCGGCCGGACGTCGCGATCTCGGTGCTGC
ACAACGGCCGCGCGGTCGAGCACTGGAACGCGAGCGAGCCCGCCGCGCGCGTCGCGAAGATCCTCGGCGACGGTTTCGCC
ACCGCCCATCTGCCGCTCGACGAGCGCGCCGGCCCGCTCGCCGTCTACGGCTGCGCGGGGCTGCCGACCGCGAGCCGCGG
CCGCGCGGACCAGCAATACTTCTTCGTCAACGGCCGCTTCGTGCGCGACAAACTGCTCACGCACGCGGTGCGCGCCGCGT
ACGAGGACGTGCTGCACGGCGATCGCTATCCGTCGTACGTGCTGTTCCTCGACCTGCCGCCGGAAGCCGTCGACGTGAAC
GTCCATCCGTCAAAGATCGAGGTGCGCTTCCGCGATTCGCGCTCGATCCATCAGTTCGTGTTCCACGCGGTGCAGCGCGC
GCTCGCGCGGCACGCGGGCGCGTCGCCCGAGACGACGGCGGGCGGCCACGCCGCGCATCTTGCGCCCATCGTGCCGGCAT
CGGCCGACTCGGCGGCCGCGCCGGGCGCCTCGTTTGTCCGCTCGGGCCCGACGGCGGGCGCGGGCGTCGGTCAGCCCGCG
TCCGGCAATACATGGCTGCGCCAGTCGCGGATGACGCAGGGCACGCTGCCCGTCGCGCAGCCGCTCGCGCTGTACGACGC
GCTGTTCGGCCGCAAGGACACGGGCGCGGGCACCCCGCACGGCGCGACGCTCGCGCTCGAAGCGCATGACGCGCATGACG
CGCCGGACGGGGCGAATGCGCCGGGCGCGCCGCTCTACGCGACCATGCCGGGCGACGACGCGACGCCCGCGTTCTCCCCG
GCGGGTGCAGCCGGTCTTCCGATGCACGATGAGCAGCCGCTCGGCTTCGCGGTCGGCCAGATCCACGGCATTTACGTGCT
CGCGCAGAACGCGCGCGGGCTCGTGATCGTCGACATGCACGCCGCGCACGAGCGGATCCTGTACGAGCAGTTCAAGCGCG
CGCTCGCCGATCGCACGATCGCCGTGCAGACGCTGCTGATTCCGGTGTCGATGACGGCGACGCCCGTCGAGGTCGGCACC
GCGGAGGAGGAGCGCGAGACGCTCGACGCGCTCGGCTTCGATCTCGCGGTGCTGTCACCGACGACGCTCGCGATCCGCGC
GGTGCCCGCCTTGCTGAAGGACGCCGACCTGCAAGCGCTCGCGCGCGCGGTGCTCGCGGATCTGCATGCGTTCGGCGGCT
CGCGGGTGCTGACCGAGCGCCAGCACGAGCTGCTCGGCACGCTCGCGTGCCATCACGCGGTGCGCGCGAACCGGCGTCTC
ACGCTCGACGAGATGAACGCGCTGCTGCGGCAGATGGAGGCGACCGAGCGCGCGGATCAGTGCAACCATGGCCGGCCGAC
CTGGTATCAACTGACGCTCGGCGATCTCGACAAGCTTTTCATGCGCGGCCAATGA

Upstream 100 bases:

>100_bases
CCGAAAGTGCCTTAAGCGACCGTGAAATTCGGCCGACGAGCGACGTCGCGCACCGAACGCGGCACGCGCCGCGCCACGCG
GCCTCGTTATAATCCCCGTC

Downstream 100 bases:

>100_bases
GCGAACGCAACGCGGCGTCCGCGCGCACGGTCGCATGCCTGCTCGGCCCCACCGCCTCCGGCAAGACAGCCGCCGCGCTC
GCGCTCGCCGCGCGCCGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKR
ISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPA
AGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVN
VHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPA
SGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAHDAPDGANAPGAPLYATMPGDDATPAFSP
AGAAGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGT
AEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRL
TLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ

Sequences:

>Translated_684_residues
MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKR
ISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPA
AGTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVN
VHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPA
SGNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAHDAPDGANAPGAPLYATMPGDDATPAFSP
AGAAGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGT
AEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRL
TLDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ
>Mature_683_residues
SEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVENALDAGAGTLRILLDEGGVKRI
SITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLGFRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAA
GTRGTTIEVRELYFSTPARRKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFAT
AHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHGDRYPSYVLFLDLPPEAVDVNV
HPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTAGGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPAS
GNTWLRQSRMTQGTLPVAQPLALYDALFGRKDTGAGTPHGATLALEAHDAHDAPDGANAPGAPLYATMPGDDATPAFSPA
GAAGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTIAVQTLLIPVSMTATPVEVGTA
EEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQALARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLT
LDEMNALLRQMEATERADQCNHGRPTWYQLTLGDLDKLFMRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.2424242424242, Blast_Score=189, Evalue=9e-48,
Organism=Homo sapiens, GI189458898, Length=351, Percent_Identity=27.9202279202279, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI4505911, Length=351, Percent_Identity=27.9202279202279, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=26.8011527377522, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=26.8011527377522, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI189458896, Length=341, Percent_Identity=29.3255131964809, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=31.063829787234, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310128480, Length=293, Percent_Identity=23.8907849829352, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=24.7191011235955, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI91992160, Length=267, Percent_Identity=24.7191011235955, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=51.0574018126888, Blast_Score=313, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.375, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=25, Blast_Score=136, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=313, Percent_Identity=33.8658146964856, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324247, Length=345, Percent_Identity=26.3768115942029, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=713, Percent_Identity=20.0561009817672, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=373, Percent_Identity=23.8605898123324, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=34.185303514377, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI17136970, Length=368, Percent_Identity=25.8152173913043, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 72687; Mature: 72556

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVEN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDAGAGTLRILLDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLG
HHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAAGTRGTTIEVRELYFSTPAR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHH
RKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCE
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHG
EEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
DRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTA
CCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPASGNTWLRQSRMTQGTLPVAQ
CCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHH
PLALYDALFGRKDTGAGTPHGATLALEAHDAHDAPDGANAPGAPLYATMPGDDATPAFSP
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
AGAAGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTI
CCCCCCCCCCCCCCCEEHHCEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCHH
AVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQAL
EEEEEEEEEECCCCCEECCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCHHHH
ARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
CNHGRPTWYQLTLGDLDKLFMRGQ
CCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
SEFTDSAAGRSSTPPADAPSPASRPLRAIQPLPDQLISQIAAGEVVERPASVVKELVEN
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALDAGAGTLRILLDEGGVKRISITDDGCGIPADELPLALMRHATSKIRSLAELEAVATLG
HHHCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRGEALASIASVAEMFITSRTEDAAHATRIDAQTGVVGPAAGTRGTTIEVRELYFSTPAR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHCCHHH
RKFLKSEQTEFGHCLEMIRRAALARPDVAISVLHNGRAVEHWNASEPAARVAKILGDGFA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHCCCCE
TAHLPLDERAGPLAVYGCAGLPTASRGRADQQYFFVNGRFVRDKLLTHAVRAAYEDVLHG
EEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCC
DRYPSYVLFLDLPPEAVDVNVHPSKIEVRFRDSRSIHQFVFHAVQRALARHAGASPETTA
CCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GGHAAHLAPIVPASADSAAAPGASFVRSGPTAGAGVGQPASGNTWLRQSRMTQGTLPVAQ
CCCHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHH
PLALYDALFGRKDTGAGTPHGATLALEAHDAHDAPDGANAPGAPLYATMPGDDATPAFSP
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
AGAAGLPMHDEQPLGFAVGQIHGIYVLAQNARGLVIVDMHAAHERILYEQFKRALADRTI
CCCCCCCCCCCCCCCEEHHCEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCHH
AVQTLLIPVSMTATPVEVGTAEEERETLDALGFDLAVLSPTTLAIRAVPALLKDADLQAL
EEEEEEEEEECCCCCEECCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCHHHH
ARAVLADLHAFGGSRVLTERQHELLGTLACHHAVRANRRLTLDEMNALLRQMEATERADQ
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
CNHGRPTWYQLTLGDLDKLFMRGQ
CCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]