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The map label for this gene is fabG2 [H]

Identifier: 126451637

GI number: 126451637

Start: 910196

End: 911155

Strand: Reverse

Name: fabG2 [H]

Synonym: BURPS1106A_0926

Alternate gene names: 126451637

Gene position: 911155-910196 (Counterclockwise)

Preceding gene: 126452690

Following gene: 126453217

Centisome position: 22.84

GC content: 68.54

Gene sequence:

>960_bases
GTGAATCGCGGCGCGCAGGCCGCGCGCAGGACGATGACGAAGGAACCGCCCGCTCCGGGCGGTTTTTTTTCGTTTTTTTC
GTCCGGTCGTTCGCTTCGCGCCGGGCCTCGGCGCCCGCTCGTACAATCGTCGGCAAGCGCGCGTCGCTTCACGGCATTCG
TTCGACATTCATACCAATCAATCCAAGGACAAGGAGCAAACATGGAGATTCGCGACAACGTCTTCCTGATCACGGGCGGC
GCATCGGGGCTCGGCGCGGGCACCGCGCGGCTGCTGACCGAAGCGGGCGGCAAGGTCGTGCTCGCCGACCTGAATCAGCA
AGCGGGCGAAGCGCTCGCGCGCGAACTGGGCGGCGTGTTCGTCAAGTGCGACGTCGCGCGCGAGGAGGACGCGCAGGCGG
CCGTCGCCGCCGCGGCGAAGCTCGGCACGCTGCGCGGGCTCGTCAACTGCGCGGGCATCGCGCCGGCGGCGAAGACGGTC
GGCAAGGACGGCCCGCATCCGCTCGAGCTGTTCGCGAAGACGATCACCGTGAACCTGATCGGCACGTTCAACATGATTCG
CGTCGCGGCCGCGGCGATGGCCGCGAACGAGCCGGCGCAGACCGGCGAGCGCGGCGTGATCGTCAGCACCGCGTCGGTCG
CCGCGTTCGACGGCCAGATCGGCCAGGCCGCCTATGCGGCGTCGAAGGCGGGCGTCGCCGGCATGACGCTGCCGATCGCG
CGCGACCTGTCGCGCAATGCGATTCGCGTGATGACGATCGCACCCGGCATCTTCGAGACGCCGATGCTGCTCGGCATGCC
GCAGGACGTGCAGGACGCGCTCGGCGCGATGGTGCCGTTTCCCCCGCGCCTCGGCAAGCCGGCCGAATACGCGATGCTCG
TCAAGCAGATCTTCGAGAACCCGATGCTCAACGGCGAGGTGATTCGCCTCGACGGCGCGATCCGGATGCAGCCGAAGTGA

Upstream 100 bases:

>100_bases
GGCGCGGGGCGGAAAACGGCCTGAAGGCGCCCGCTTACCGGAAGATCTCCGGCCTCGGCGCCGTCGAGGAAATCCGCGCG
CGCGTGTTCGACGCGCTCAA

Downstream 100 bases:

>100_bases
CGAAATGACGAGGCGGCGCACGCGGCCGCAACGACGGCAGCCGCGTCGCCCGTCGCGTGTCGTCGAATGGGGAAGGCATG
CCCGCGGATGCGACGGCATC

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNRGAQAARRTMTKEPPAPGGFFSFFSSGRSLRAGPRRPLVQSSASARRFTAFVRHSYQSIQGQGANMEIRDNVFLITGG
ASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGVFVKCDVAREEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTV
GKDGPHPLELFAKTITVNLIGTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIA
RDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEVIRLDGAIRMQPK

Sequences:

>Translated_319_residues
MNRGAQAARRTMTKEPPAPGGFFSFFSSGRSLRAGPRRPLVQSSASARRFTAFVRHSYQSIQGQGANMEIRDNVFLITGG
ASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGVFVKCDVAREEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTV
GKDGPHPLELFAKTITVNLIGTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIA
RDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEVIRLDGAIRMQPK
>Mature_319_residues
MNRGAQAARRTMTKEPPAPGGFFSFFSSGRSLRAGPRRPLVQSSASARRFTAFVRHSYQSIQGQGANMEIRDNVFLITGG
ASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGVFVKCDVAREEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTV
GKDGPHPLELFAKTITVNLIGTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIA
RDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFENPMLNGEVIRLDGAIRMQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=58.6614173228346, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=56.078431372549, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=34.5833333333333, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=30, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI59889578, Length=219, Percent_Identity=29.2237442922374, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=26.8199233716475, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI32483357, Length=270, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI33667109, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI5031737, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=29.9610894941634, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082100, Length=233, Percent_Identity=30.4721030042918, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=28.6259541984733, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787905, Length=236, Percent_Identity=30.0847457627119, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=51.219512195122, Blast_Score=240, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17555706, Length=239, Percent_Identity=32.6359832635983, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=231, Percent_Identity=30.7359307359307, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=211, Percent_Identity=28.9099526066351, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=205, Percent_Identity=30.2439024390244, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=58.6614173228346, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=33.4645669291339, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357041, Length=230, Percent_Identity=30, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571526, Length=228, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33230; Mature: 33230

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRGAQAARRTMTKEPPAPGGFFSFFSSGRSLRAGPRRPLVQSSASARRFTAFVRHSYQS
CCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHH
IQGQGANMEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGVF
HCCCCCCEEEECCEEEEECCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCEE
VKCDVAREEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTVGKDGPHPLELFAKTITVNLI
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHEEEEH
GTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIA
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEECCCCCCHHHHHHHHCCCCCEEHHHH
RDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFEN
HHCCCCCEEEEEECCCHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
PMLNGEVIRLDGAIRMQPK
CCCCCEEEEECCEEEECCC
>Mature Secondary Structure
MNRGAQAARRTMTKEPPAPGGFFSFFSSGRSLRAGPRRPLVQSSASARRFTAFVRHSYQS
CCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHH
IQGQGANMEIRDNVFLITGGASGLGAGTARLLTEAGGKVVLADLNQQAGEALARELGGVF
HCCCCCCEEEECCEEEEECCCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCEE
VKCDVAREEDAQAAVAAAAKLGTLRGLVNCAGIAPAAKTVGKDGPHPLELFAKTITVNLI
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHEEEEH
GTFNMIRVAAAAMAANEPAQTGERGVIVSTASVAAFDGQIGQAAYAASKAGVAGMTLPIA
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEECCCCCCHHHHHHHHCCCCCEEHHHH
RDLSRNAIRVMTIAPGIFETPMLLGMPQDVQDALGAMVPFPPRLGKPAEYAMLVKQIFEN
HHCCCCCEEEEEECCCHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
PMLNGEVIRLDGAIRMQPK
CCCCCEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]