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The map label for this gene is adk [H]

Identifier: 126452690

GI number: 126452690

Start: 911152

End: 911814

Strand: Reverse

Name: adk [H]

Synonym: BURPS1106A_0927

Alternate gene names: 126452690

Gene position: 911814-911152 (Counterclockwise)

Preceding gene: 126453920

Following gene: 126451637

Centisome position: 22.86

GC content: 65.31

Gene sequence:

>663_bases
ATGCGTTTGATCCTGTTGGGCGCGCCCGGCGCGGGAAAGGGCACCCAGGCAAACTTCATCAAGGAGAAGTTCGGCATCCC
GCAAATCTCGACGGGCGACATGCTGCGCGCCGCCGTGAAGGCCGGCACGCCGCTCGGCGTCGAGGCGAAGACGTACATGG
ACGAAGGCAAGCTCGTGCCGGATTCGCTGATCATCGGCCTCGTCAAGGAACGTCTGAAGGAAGCGGACTGCGCGAACGGC
TATCTGTTCGACGGCTTCCCGCGCACGATCGCGCAGGCCGACGCGATGAAGGAAGCGGGCGTCGCGATCGACTACGTGCT
GGAGATCGACGTGCCGTTCTCGGAAATCATCGAACGCATGAGCGGCCGCCGCACGCATCCGGCGTCGGGCCGCACGTATC
ACGTGAAGTTCAACCCGCCGAAGGTCGAGGGCAAGGACGACGTCACAGGCGAGCCGCTGGTCCAGCGCGACGACGACAAG
GAAGAGACGGTGAAGAAACGCCTCGACGTGTACGAGGCGCAGACGAAGCCGCTCATCACGTACTACGGCGACTGGGCGCG
GCGCGGGGCGGAAAACGGCCTGAAGGCGCCCGCTTACCGGAAGATCTCCGGCCTCGGCGCCGTCGAGGAAATCCGCGCGC
GCGTGTTCGACGCGCTCAAGTGA

Upstream 100 bases:

>100_bases
CAGTCAGCCCGGCCGATCGCGCTTGCGGCAGAACCGCCGAGCCGCGCAGCGGATCCCGTAGCGTCTCGCGCCAAGGCATT
CACATACCGGAGATATCACC

Downstream 100 bases:

>100_bases
ATCGCGGCGCGCAGGCCGCGCGCAGGACGATGACGAAGGAACCGCCCGCTCCGGGCGGTTTTTTTTCGTTTTTTTCGTCC
GGTCGTTCGCTTCGCGCCGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDK
EETVKKRLDVYEAQTKPLITYYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK

Sequences:

>Translated_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDK
EETVKKRLDVYEAQTKPLITYYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK
>Mature_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVPDSLIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDK
EETVKKRLDVYEAQTKPLITYYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=200, Percent_Identity=48.5, Blast_Score=197, Evalue=6e-51,
Organism=Homo sapiens, GI4502013, Length=200, Percent_Identity=48.5, Blast_Score=197, Evalue=7e-51,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=49.4505494505495, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=45.0549450549451, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=45.0549450549451, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=45.0549450549451, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=45.0549450549451, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=31.1827956989247, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI4502011, Length=222, Percent_Identity=28.8288288288288, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI7706497, Length=193, Percent_Identity=30.0518134715026, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=27.807486631016, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=27.807486631016, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI237858799, Length=150, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=65.2582159624413, Blast_Score=275, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=45.1612903225806, Blast_Score=176, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=38.9189189189189, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=197, Percent_Identity=31.9796954314721, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.3478260869565, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=29.3478260869565, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=48.4536082474227, Blast_Score=194, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=46.7391304347826, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=50.5434782608696, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=48.3516483516484, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=48.3516483516484, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=27.9329608938547, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=27.9329608938547, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24170; Mature: 24170

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDKEETVKKRLDVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK
ECCHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCH
DSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDKEETVKKRLDVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK
ECCHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA