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The map label for this gene is clpP [H]

Identifier: 126451473

GI number: 126451473

Start: 2337479

End: 2338132

Strand: Reverse

Name: clpP [H]

Synonym: BURPS1106A_2365

Alternate gene names: 126451473

Gene position: 2338132-2337479 (Counterclockwise)

Preceding gene: 126454578

Following gene: 126452859

Centisome position: 58.62

GC content: 63.91

Gene sequence:

>654_bases
ATGATTAATCGCGCTCAATTGCTGGACACGTTGGCTTCGCAAGCCCCGCGGGATTTCGAGGCGCAAGCGCTCGGGCTCGT
GCCGATCGTCGTCGAGACGAGCGGCCGCGGCGAGCGTTCGTACGATATCTACTCGCGGCTCCTGAAAGAGCGCATCGTGT
TCATGGTCGGCGAGGTCAACGACCAGACGGCGAATCTCGTGGTCGCGCAGTTGCTGTTCCTCGAAAGCGAGAATCCCGAC
AAGGACATCAGCCTGTACATCAACAGCCCGGGCGGATCGGTATCGGCGGGGATGGCGATCTACGACACCATGCAGTTCGT
GAAGCCGGACGTGTCGACGCTCTGCATGGGCCTCGCGGCCAGCATGGGCGCGTTCCTGCTCGCGTCGGGCGCGAAGGGCA
AGCGCTACGCGCTGCCGAACGCGCGCGTGATGATCCACCAGCCGCTGGGCGGGGCACGCGGCCAGGCGTCGGATATCGAG
ATCCAGGCGCGCGAGATCCTCTACCTGAGGGATCGCCTGAATCACCTGCTCGCCCACCATACCGGCCAGGACGTCGAGCG
CATCGCGCGCGACACCGACCGTGATAATTTCATGTCCAGCGAAGATGCGAAGGCGTACGGCCTGATCGACCACGTGTCGA
CGAAGCGCCCGTAA

Upstream 100 bases:

>100_bases
ACGACGGCCCGCACGCCGTTTTTTCATCGGCGCCGCGCACGCGACGTTCTCCGGCTCGTTTCCTGCCGTTCAATACTCAT
TCTCGGACAAGGCTCATTGA

Downstream 100 bases:

>100_bases
GCTTTAGTGGGGTGCCGCCCCAATAGGGGCGGCGCCCGCCACGCGCCCCGAGCATCTGCGGCAAAAGAACATCGCCGCCG
TCTCCCGAGTATTTACCAGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAASMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIE
IQAREILYLRDRLNHLLAHHTGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP

Sequences:

>Translated_217_residues
MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAASMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIE
IQAREILYLRDRLNHLLAHHTGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP
>Mature_217_residues
MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAASMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIE
IQAREILYLRDRLNHLLAHHTGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=56.1224489795918, Blast_Score=237, Evalue=6e-63,
Organism=Escherichia coli, GI1786641, Length=200, Percent_Identity=67, Blast_Score=296, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=53.7234042553192, Blast_Score=219, Evalue=8e-58,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=56.701030927835, Blast_Score=242, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23836; Mature: 23836

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVN
CCCHHHHHHHHHHHCCCCCCHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEECCCC
DQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIEIQAREILYLRDRLNHLLAHH
HHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
TGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVN
CCCHHHHHHHHHHHCCCCCCHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEECCCC
DQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIEIQAREILYLRDRLNHLLAHH
HHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
TGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA