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The map label for this gene is mrcA [H]

Identifier: 126451466

GI number: 126451466

Start: 3675493

End: 3677886

Strand: Direct

Name: mrcA [H]

Synonym: BURPS1106A_3763

Alternate gene names: 126451466

Gene position: 3675493-3677886 (Clockwise)

Preceding gene: 126453273

Following gene: 126453170

Centisome position: 92.15

GC content: 66.58

Gene sequence:

>2394_bases
ATGCAATCCACGAATCCTACGTCCCCGCCTCCTCCGCCCGAGCCGCGCCGCCGCCCGCTGTGGCTGAAGCTCGTGCTCGG
CGTGGCAGGCGTGTGCGTGGCGCTCGCGGTCAGCATCGGGCTCGTGCTCGGCTACGCGCTCGTCGTCGCGTCGCCGAACA
TGCCGTCGCTCGACGCGCTGACCGACTACCGCCCGAAGGTGCCGCTGCGCATCTATACGGCGGATCACGTGCTGATCGGC
GAATTCGGCGAGGAGCGCCGGGACATCGTCCGCCTGCAGGACATGCCCGATTCACTGAAGAAAGCGGTGCTCGCGATCGA
GGACGCGCGGTTCTACGAACACGGCGGCGTCGATCTGACGGGCATCATCCGCGCCGGCATCGTCGCGCTGACGAACGGCC
ACGCGACGCAGGGCGCGAGCACGATCACGATGCAGGTCGCGCGCAATTTCTTCCTGTCGAGCGAGAAAACGTACACGCGC
AAGATCTACGAGATGCTGCTCGCGTACCGAATCGAGCGCGCGCTCACGAAAGATCAGATTCTCGAGGTCTACATGAATCA
GATCTATCTGGGCCAGCGCGCCTACGGCTTCGCGGCCGCCGCGCACGCGTACTTCAACAAGGATCTGAAGGACATCACGC
TCGCCGAAGCCGCGATGCTCGCGGGCCTGCCGAAGGCGCCGTCCGCGTACAACCCGGTCGCCAATCCGAAGCGCGCGAAG
GTCCGGCAGCAATACATCCTGCAGCGGATGCTCGAGCTGAATTTCATCACGCGCGGGCAGTACGACGAGGCGCTCGCCGA
GCCGCTCGTCGTCAAGAGTCCGAGCCGGGAATACAGCGTGCACGCGGAGTACGTCGCCGAAATGGTGCGGCAGATGATGT
ATGCGCAGTACAAGGACGAGGCGTACACGCGCGGGCTGAATGTCGTCACGACGATCGATTCCGCCGACCAGACGCTCGCG
TACCGCGCGCTGCGCAAGGGCCTGATGACGTACGACAGGCGCCACGGCTATCGCGGCCCGGAAGGTTTCATCGAGCTGCC
CGCGAACGCGGACGACCGCGAGCAGGCGATCGACGACGCGCTCGTCGATCATCCGGACAACGGCGAATTGATCGCGGCCG
TCGTCACCGAGGCGAGCGCGCGCCAGATTCGCGTCGTATTCCCGAACGGTAGCGACGCCACGGTGAGCGGCGACGATCTG
CGGTTCGCCGCGAGTTCGCTGTCGTCGAACGCGCAGCCGAACAAGCGGATCCGCCCCGGCGCGATCGTGCGCGTGTTCAA
GAACGACGACGGCTCGTGGGCGATCGGGCAACTGCCGCAGATCGAGGGCGCATTCATTTCGATCGTCCCGCAGGACGGCG
CGATCCGCTCGCTGATCGGCGGCTTCGACTTCAACAAGAACAAGTTCAACCACGTGACGCAGGCGTGGCGGCAGCCCGGC
TCGTCGTTCAAGCCGTTCATCTATTCGGCGTCGCTCGACAAGGGGCTCGGCCCCGCGACGATCATCAACGACGGCCCGCT
CTACTTCAGCGCCGCCGAAACGGGCGGCCAGCCGTGGGAGCCGAAAAACTACGGCGGCGGCTTCGAGGGCCCGATGTCGA
TGCGCGTCGCGCTGCAGCGTTCGCGCAACCTGGTGTCGATCCGCATCCTGAACCACATCGGCCCGAAATACGCGCAGCAA
TACATCACACGCTTCGGCTTCGACGCGGATCGCCACCCGGCCTATCTGCCGATGGCGCTCGGCGCGGGCCTCGTCACGCC
GCTGCAGATGGCGGGCGCGTTCTCGGTGTTCGCGAACGGCGGCTATCGGATCAATCCGTATCTGATCGCCGAAGTGACCG
ACCCGAGCGGCAACGTCGTCGCGCGCGCGCAGCCGCTCGTCGCCGAGCAGAATGCGCCGCGCGCGATCGACCCGCGCAAC
GCATACGTGATGAACAGCCTGCTGCAGAGCGTCGCGCAGCGCGGCACGGGCGCGCGCTCGAACGTGCTCAAACGCACCGA
TCTCGCCGGCAAGACGGGCACGACGAACGATTCGCGCGACGCGTGGTTCGGCGGCTATCAGCACACGCTCGCGGCGATCG
CGTGGATCGGCTACGACAGCCCGCGCAGCCTCGGCGACCGCGAAACCGGCGGCGGCCTCGCGCTGCCCGTGTGGATCGAC
TACATGGGCCCCGCGCTCAAGAACGTGCCGGAATACAAGATGCCGATGCCCGACGGTGTCACGACGCTCGGCGGCGAACT
GTACTTCGACCAGTTCATGCCGGGCCGCGGTTTCGTCGCGACGGTCGGCGTGAATCTGGCGGCCGCGCCGCCCAACTCGG
CAAGCGACGTGCCCGGGCACGTCGACGAGCAGGAAAAGCAGGACATCATGAACCTGTTCCGCGGCGGCAACTGA

Upstream 100 bases:

>100_bases
CCGCACCGGCTGCGACGCGCCGATTTCCCGTCCGGCCCCCCTTCCGGAGTCCGGCAAAACCGGGCGGCTATAATCGCGGG
ACTGTTTTTCTGGTGTGTCT

Downstream 100 bases:

>100_bases
GTGCCCCGTACGCGGAAAGACAAAAGCGGCCGAAAGGCCGCTTTTGTCATAGGGAGCTCGGCTCGGCGGCGCCCGCGGCG
CGCTGCGCGCGAGCGCCGCC

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 797; Mature: 797

Protein sequence:

>797_residues
MQSTNPTSPPPPPEPRRRPLWLKLVLGVAGVCVALAVSIGLVLGYALVVASPNMPSLDALTDYRPKVPLRIYTADHVLIG
EFGEERRDIVRLQDMPDSLKKAVLAIEDARFYEHGGVDLTGIIRAGIVALTNGHATQGASTITMQVARNFFLSSEKTYTR
KIYEMLLAYRIERALTKDQILEVYMNQIYLGQRAYGFAAAAHAYFNKDLKDITLAEAAMLAGLPKAPSAYNPVANPKRAK
VRQQYILQRMLELNFITRGQYDEALAEPLVVKSPSREYSVHAEYVAEMVRQMMYAQYKDEAYTRGLNVVTTIDSADQTLA
YRALRKGLMTYDRRHGYRGPEGFIELPANADDREQAIDDALVDHPDNGELIAAVVTEASARQIRVVFPNGSDATVSGDDL
RFAASSLSSNAQPNKRIRPGAIVRVFKNDDGSWAIGQLPQIEGAFISIVPQDGAIRSLIGGFDFNKNKFNHVTQAWRQPG
SSFKPFIYSASLDKGLGPATIINDGPLYFSAAETGGQPWEPKNYGGGFEGPMSMRVALQRSRNLVSIRILNHIGPKYAQQ
YITRFGFDADRHPAYLPMALGAGLVTPLQMAGAFSVFANGGYRINPYLIAEVTDPSGNVVARAQPLVAEQNAPRAIDPRN
AYVMNSLLQSVAQRGTGARSNVLKRTDLAGKTGTTNDSRDAWFGGYQHTLAAIAWIGYDSPRSLGDRETGGGLALPVWID
YMGPALKNVPEYKMPMPDGVTTLGGELYFDQFMPGRGFVATVGVNLAAAPPNSASDVPGHVDEQEKQDIMNLFRGGN

Sequences:

>Translated_797_residues
MQSTNPTSPPPPPEPRRRPLWLKLVLGVAGVCVALAVSIGLVLGYALVVASPNMPSLDALTDYRPKVPLRIYTADHVLIG
EFGEERRDIVRLQDMPDSLKKAVLAIEDARFYEHGGVDLTGIIRAGIVALTNGHATQGASTITMQVARNFFLSSEKTYTR
KIYEMLLAYRIERALTKDQILEVYMNQIYLGQRAYGFAAAAHAYFNKDLKDITLAEAAMLAGLPKAPSAYNPVANPKRAK
VRQQYILQRMLELNFITRGQYDEALAEPLVVKSPSREYSVHAEYVAEMVRQMMYAQYKDEAYTRGLNVVTTIDSADQTLA
YRALRKGLMTYDRRHGYRGPEGFIELPANADDREQAIDDALVDHPDNGELIAAVVTEASARQIRVVFPNGSDATVSGDDL
RFAASSLSSNAQPNKRIRPGAIVRVFKNDDGSWAIGQLPQIEGAFISIVPQDGAIRSLIGGFDFNKNKFNHVTQAWRQPG
SSFKPFIYSASLDKGLGPATIINDGPLYFSAAETGGQPWEPKNYGGGFEGPMSMRVALQRSRNLVSIRILNHIGPKYAQQ
YITRFGFDADRHPAYLPMALGAGLVTPLQMAGAFSVFANGGYRINPYLIAEVTDPSGNVVARAQPLVAEQNAPRAIDPRN
AYVMNSLLQSVAQRGTGARSNVLKRTDLAGKTGTTNDSRDAWFGGYQHTLAAIAWIGYDSPRSLGDRETGGGLALPVWID
YMGPALKNVPEYKMPMPDGVTTLGGELYFDQFMPGRGFVATVGVNLAAAPPNSASDVPGHVDEQEKQDIMNLFRGGN
>Mature_797_residues
MQSTNPTSPPPPPEPRRRPLWLKLVLGVAGVCVALAVSIGLVLGYALVVASPNMPSLDALTDYRPKVPLRIYTADHVLIG
EFGEERRDIVRLQDMPDSLKKAVLAIEDARFYEHGGVDLTGIIRAGIVALTNGHATQGASTITMQVARNFFLSSEKTYTR
KIYEMLLAYRIERALTKDQILEVYMNQIYLGQRAYGFAAAAHAYFNKDLKDITLAEAAMLAGLPKAPSAYNPVANPKRAK
VRQQYILQRMLELNFITRGQYDEALAEPLVVKSPSREYSVHAEYVAEMVRQMMYAQYKDEAYTRGLNVVTTIDSADQTLA
YRALRKGLMTYDRRHGYRGPEGFIELPANADDREQAIDDALVDHPDNGELIAAVVTEASARQIRVVFPNGSDATVSGDDL
RFAASSLSSNAQPNKRIRPGAIVRVFKNDDGSWAIGQLPQIEGAFISIVPQDGAIRSLIGGFDFNKNKFNHVTQAWRQPG
SSFKPFIYSASLDKGLGPATIINDGPLYFSAAETGGQPWEPKNYGGGFEGPMSMRVALQRSRNLVSIRILNHIGPKYAQQ
YITRFGFDADRHPAYLPMALGAGLVTPLQMAGAFSVFANGGYRINPYLIAEVTDPSGNVVARAQPLVAEQNAPRAIDPRN
AYVMNSLLQSVAQRGTGARSNVLKRTDLAGKTGTTNDSRDAWFGGYQHTLAAIAWIGYDSPRSLGDRETGGGLALPVWID
YMGPALKNVPEYKMPMPDGVTTLGGELYFDQFMPGRGFVATVGVNLAAAPPNSASDVPGHVDEQEKQDIMNLFRGGN

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=805, Percent_Identity=38.1366459627329, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI1786343, Length=249, Percent_Identity=37.7510040160643, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI1788867, Length=228, Percent_Identity=32.0175438596491, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1789601, Length=178, Percent_Identity=34.2696629213483, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 87173; Mature: 87173

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTNPTSPPPPPEPRRRPLWLKLVLGVAGVCVALAVSIGLVLGYALVVASPNMPSLDAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TDYRPKVPLRIYTADHVLIGEFGEERRDIVRLQDMPDSLKKAVLAIEDARFYEHGGVDLT
HCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHH
GIIRAGIVALTNGHATQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYRIERALTKDQI
HHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEVYMNQIYLGQRAYGFAAAAHAYFNKDLKDITLAEAAMLAGLPKAPSAYNPVANPKRAK
HHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VRQQYILQRMLELNFITRGQYDEALAEPLVVKSPSREYSVHAEYVAEMVRQMMYAQYKDE
HHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEECCCCCCEECHHHHHHHHHHHHHHHHHHH
AYTRGLNVVTTIDSADQTLAYRALRKGLMTYDRRHGYRGPEGFIELPANADDREQAIDDA
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHH
LVDHPDNGELIAAVVTEASARQIRVVFPNGSDATVSGDDLRFAASSLSSNAQPNKRIRPG
HHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCC
AIVRVFKNDDGSWAIGQLPQIEGAFISIVPQDGAIRSLIGGFDFNKNKFNHVTQAWRQPG
EEEEEEECCCCCEEECCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHCCC
SSFKPFIYSASLDKGLGPATIINDGPLYFSAAETGGQPWEPKNYGGGFEGPMSMRVALQR
CCCCCEEEECCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SRNLVSIRILNHIGPKYAQQYITRFGFDADRHPAYLPMALGAGLVTPLQMAGAFSVFANG
CCCEEEEEEHHHCCHHHHHHHHHHHCCCCCCCCCEEHHHHCCCHHHHHHHHHHHEEEECC
GYRINPYLIAEVTDPSGNVVARAQPLVAEQNAPRAIDPRNAYVMNSLLQSVAQRGTGARS
CEEECCEEEEEEECCCCCEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
NVLKRTDLAGKTGTTNDSRDAWFGGYQHTLAAIAWIGYDSPRSLGDRETGGGLALPVWID
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHH
YMGPALKNVPEYKMPMPDGVTTLGGELYFDQFMPGRGFVATVGVNLAAAPPNSASDVPGH
HHCHHHHCCCCCCCCCCCCCHHCCCHHHHHHCCCCCCEEEEECCEEEECCCCCCCCCCCC
VDEQEKQDIMNLFRGGN
CCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQSTNPTSPPPPPEPRRRPLWLKLVLGVAGVCVALAVSIGLVLGYALVVASPNMPSLDAL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TDYRPKVPLRIYTADHVLIGEFGEERRDIVRLQDMPDSLKKAVLAIEDARFYEHGGVDLT
HCCCCCCCEEEEECCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHH
GIIRAGIVALTNGHATQGASTITMQVARNFFLSSEKTYTRKIYEMLLAYRIERALTKDQI
HHHHHCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LEVYMNQIYLGQRAYGFAAAAHAYFNKDLKDITLAEAAMLAGLPKAPSAYNPVANPKRAK
HHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VRQQYILQRMLELNFITRGQYDEALAEPLVVKSPSREYSVHAEYVAEMVRQMMYAQYKDE
HHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEECCCCCCEECHHHHHHHHHHHHHHHHHHH
AYTRGLNVVTTIDSADQTLAYRALRKGLMTYDRRHGYRGPEGFIELPANADDREQAIDDA
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHH
LVDHPDNGELIAAVVTEASARQIRVVFPNGSDATVSGDDLRFAASSLSSNAQPNKRIRPG
HHCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHHHHHHCCCCCCCCCCCCC
AIVRVFKNDDGSWAIGQLPQIEGAFISIVPQDGAIRSLIGGFDFNKNKFNHVTQAWRQPG
EEEEEEECCCCCEEECCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHCCC
SSFKPFIYSASLDKGLGPATIINDGPLYFSAAETGGQPWEPKNYGGGFEGPMSMRVALQR
CCCCCEEEECCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SRNLVSIRILNHIGPKYAQQYITRFGFDADRHPAYLPMALGAGLVTPLQMAGAFSVFANG
CCCEEEEEEHHHCCHHHHHHHHHHHCCCCCCCCCEEHHHHCCCHHHHHHHHHHHEEEECC
GYRINPYLIAEVTDPSGNVVARAQPLVAEQNAPRAIDPRNAYVMNSLLQSVAQRGTGARS
CEEECCEEEEEEECCCCCEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
NVLKRTDLAGKTGTTNDSRDAWFGGYQHTLAAIAWIGYDSPRSLGDRETGGGLALPVWID
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHH
YMGPALKNVPEYKMPMPDGVTTLGGELYFDQFMPGRGFVATVGVNLAAAPPNSASDVPGH
HHCHHHHCCCCCCCCCCCCCHHCCCHHHHHHCCCCCCEEEEECCEEEECCCCCCCCCCCC
VDEQEKQDIMNLFRGGN
CCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA