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The map label for this gene is lysR [H]

Identifier: 126445006

GI number: 126445006

Start: 271154

End: 272086

Strand: Reverse

Name: lysR [H]

Synonym: BURPS668_A0307

Alternate gene names: 126445006

Gene position: 272086-271154 (Counterclockwise)

Preceding gene: 126442610

Following gene: 126443564

Centisome position: 8.7

GC content: 70.85

Gene sequence:

>933_bases
ATGCGCCTCCGCCACATCGAAGTCTTCCACGCGATCATGCGCACCGGCTCGTTGTCGAAAGCCGCGCAGTTGCTATGCGT
ATCGCAGCCCGCCGTCAGCAAAGTGCTCGCGCACGCCGAGCAGAACCTCGGCATCCGCCTGTTCAGCCGCGCGCACGGCC
GCCTGCTGCCGACACGTGAAGCCGAGCTGCTGTTCGGCGAGACGCAGAAACTCCAGTCGAGCCTCGAGCGCATTCGCGCG
CTCGCACGCAATCTGGCGCTGCAGCCCGAAGGGCAGTTGCGCGTCGGCTGCCTGCCGAGTCTCGGCCTGAGCCTGATTCC
ACAGGCCGTGAAGGCGTTCCGCGACGATTACCCGCGCGTCGCGCTGAAAATCCAGACCTTGCATACCGACGCGCTGCTCA
ACGCGTTGCTCACGCGCGATCTCGACGTGGCCGTCGCGATCGATCCGCCGGCGCGTCCCGGCATCACGTCGGCGGAGCTC
GGTCGCACGGCCGTCGTCAGCGTCGGCCCGCCCGACGACGACGCGCCGGACGCGCCGCTTTCGCTGCACGCGTTCATGGA
AGGCGAATCGATCGGCATCGGCACCGAGGATCCGCTCGGCGACGCGATCGGCAACGCGCTCGAAGCGTTCGGCGAGGATC
GCGTGACGATGGTCGAGGCGCATACGTGGTACGTCGCGCGGGCGCTCGCCGCGCGCGGCGTCGGCCGCGTGCTGCTCGAC
GAGTTGACGGCGCGCGCGCCGGGCGAGCCGGTCACGATCCGGCCGATCGAGCCGGCGCTGTCGGTTGGCGTGTTCGCGCT
GTGGCGCGACGGCGGGCTCGACTCGCATGCGGGTGCGACGTTCGTCGACGCGCTGCGCGCGCCATTCGGCGAGCCGTCCG
GCAAGCCGCCCTCGATGCGCGCGCCGGGTGCGCCGAAGCGGCGGGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCCGCCTCCCAGCCGCCTTCCGGGCCGGACAGGATTGCGATCGGCCGCGACACGCGGTAGTGTCCGACGCACGAAGATC
CGTCTCGCTCTCGCCCCATC

Downstream 100 bases:

>100_bases
ACGACACGCGTCCGGCGCCCTTAACCCAGGGTTATGGGGCGGTACATCTGTTCACTTGCCGCGGTCGTTTCGGTCGGCAA
GACTAAAGGCCGTTCAAGCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRLRHIEVFHAIMRTGSLSKAAQLLCVSQPAVSKVLAHAEQNLGIRLFSRAHGRLLPTREAELLFGETQKLQSSLERIRA
LARNLALQPEGQLRVGCLPSLGLSLIPQAVKAFRDDYPRVALKIQTLHTDALLNALLTRDLDVAVAIDPPARPGITSAEL
GRTAVVSVGPPDDDAPDAPLSLHAFMEGESIGIGTEDPLGDAIGNALEAFGEDRVTMVEAHTWYVARALAARGVGRVLLD
ELTARAPGEPVTIRPIEPALSVGVFALWRDGGLDSHAGATFVDALRAPFGEPSGKPPSMRAPGAPKRRAR

Sequences:

>Translated_310_residues
MRLRHIEVFHAIMRTGSLSKAAQLLCVSQPAVSKVLAHAEQNLGIRLFSRAHGRLLPTREAELLFGETQKLQSSLERIRA
LARNLALQPEGQLRVGCLPSLGLSLIPQAVKAFRDDYPRVALKIQTLHTDALLNALLTRDLDVAVAIDPPARPGITSAEL
GRTAVVSVGPPDDDAPDAPLSLHAFMEGESIGIGTEDPLGDAIGNALEAFGEDRVTMVEAHTWYVARALAARGVGRVLLD
ELTARAPGEPVTIRPIEPALSVGVFALWRDGGLDSHAGATFVDALRAPFGEPSGKPPSMRAPGAPKRRAR
>Mature_310_residues
MRLRHIEVFHAIMRTGSLSKAAQLLCVSQPAVSKVLAHAEQNLGIRLFSRAHGRLLPTREAELLFGETQKLQSSLERIRA
LARNLALQPEGQLRVGCLPSLGLSLIPQAVKAFRDDYPRVALKIQTLHTDALLNALLTRDLDVAVAIDPPARPGITSAEL
GRTAVVSVGPPDDDAPDAPLSLHAFMEGESIGIGTEDPLGDAIGNALEAFGEDRVTMVEAHTWYVARALAARGVGRVLLD
ELTARAPGEPVTIRPIEPALSVGVFALWRDGGLDSHAGATFVDALRAPFGEPSGKPPSMRAPGAPKRRAR

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=248, Percent_Identity=34.6774193548387, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87082132, Length=172, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788481, Length=182, Percent_Identity=25.8241758241758, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081904, Length=159, Percent_Identity=31.4465408805031, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693105, Length=165, Percent_Identity=21.2121212121212, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=174, Percent_Identity=27.0114942528736, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI157672245, Length=160, Percent_Identity=31.25, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788887, Length=279, Percent_Identity=24.3727598566308, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789173, Length=170, Percent_Identity=30.5882352941176, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33121; Mature: 33121

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRHIEVFHAIMRTGSLSKAAQLLCVSQPAVSKVLAHAEQNLGIRLFSRAHGRLLPTRE
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
AELLFGETQKLQSSLERIRALARNLALQPEGQLRVGCLPSLGLSLIPQAVKAFRDDYPRV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEE
ALKIQTLHTDALLNALLTRDLDVAVAIDPPARPGITSAELGRTAVVSVGPPDDDAPDAPL
EEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCCEEEEECCCCCCCCCCCCE
SLHAFMEGESIGIGTEDPLGDAIGNALEAFGEDRVTMVEAHTWYVARALAARGVGRVLLD
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCHHHHHHH
ELTARAPGEPVTIRPIEPALSVGVFALWRDGGLDSHAGATFVDALRAPFGEPSGKPPSMR
HHHHCCCCCCEEEEECCHHHHHCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
APGAPKRRAR
CCCCCCCCCC
>Mature Secondary Structure
MRLRHIEVFHAIMRTGSLSKAAQLLCVSQPAVSKVLAHAEQNLGIRLFSRAHGRLLPTRE
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
AELLFGETQKLQSSLERIRALARNLALQPEGQLRVGCLPSLGLSLIPQAVKAFRDDYPRV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEE
ALKIQTLHTDALLNALLTRDLDVAVAIDPPARPGITSAELGRTAVVSVGPPDDDAPDAPL
EEEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHCCCEEEEECCCCCCCCCCCCE
SLHAFMEGESIGIGTEDPLGDAIGNALEAFGEDRVTMVEAHTWYVARALAARGVGRVLLD
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCHHHHHHH
ELTARAPGEPVTIRPIEPALSVGVFALWRDGGLDSHAGATFVDALRAPFGEPSGKPPSMR
HHHHCCCCCCEEEEECCHHHHHCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
APGAPKRRAR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]