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The map label for this gene is iciA [H]

Identifier: 126443918

GI number: 126443918

Start: 394872

End: 395849

Strand: Reverse

Name: iciA [H]

Synonym: BURPS668_A0429

Alternate gene names: 126443918

Gene position: 395849-394872 (Counterclockwise)

Preceding gene: 126444547

Following gene: 126444426

Centisome position: 12.66

GC content: 73.01

Gene sequence:

>978_bases
ATGACGATCGATCCGAAACAGGCGGCGGCGCTCGTCGCCGTCGCCGATACCGGCAGCTTCGAGCAGGCGGCCGCGCGGCT
GCACGTGACCGCGTCGGCCGTCACGCAGCGCGTGCGGGCGCTGGAGACGAGCCTCGGCGCGCCGCTGCTGCTGCGCACGC
GGCCGTGCCGGCCGACGGCCGCCGGCCAGCGCGTGCTGCAGCACCTGCGCCGGATGGCGCTGCTGCAAGTCGATCTGCAA
GCGGAGCTCGAAGCCGAGCGCGGCTCGACGATCGCGGTCGCGATCGCGCTCAACTCGGACAGCCTCGGCTCGTGGTTCCT
GCCCGCGCTCACTTCGGTGCTCGCGGGCGAGCGGATGCTGTTCGAGCTGATCGTCGAGGATCAGGATCACACATTCGCGC
TGCTCGAAAGCGGCATGGCGATCGGCTGCGTGACGACGCAGAGCAAGCCGATGCGCGGCTGCTTCGCGACGCCGCTCGGC
ACGATGCGCTACCGGTTGATCGCCGCGGAGGAATTCGCCGCGCGCTGGTTCGCGCAGGGCCTCACCCGCGAGAGCGCGCG
CGAGGCGCCCGTCGTCGCGCACGGCCGGCGCGACACGCTGCAATCGTCGTTTCTGCGGGACAAGCTCGGCCTGCCGGACG
GCGCGTTTCCGTGCCATTACGTGCCGGGCACGCACGCGCACTTCGCGGCCGTGCGGCACGGGCTCGGCTATGCGATGGTG
CCCGAGCTGCTGCTCGGCACGACGCCGCTCGCCGAGCAGCGGCTCGTCGATCTCGCGCCCGCGCATTCGACCGACGTGTC
GCTGTACTGGCACGCGTGGACCGTGCAGTCGCCGAAGATGGAATCGCTGTCGTCGCGGGTCGTCGAGGCCGCGCAGCAAC
TGCTCGCGCCGCCGCCGCGCGGCGCCGCCGCGGCGGGCGGGCGCGCCGCGGCGGCGCCCGCTCCCGTCAAGCGCGCGAAC
GCGCGAAATACGCGCTGA

Upstream 100 bases:

>100_bases
GTCCGGGGAGGATCCCGATACCGATACAATATTTAGCTCAAGTTGATTACGCTAAATTTTATTTAGGCGGCCGGTGTGCC
CGGCGCCATGCGAGCGACAG

Downstream 100 bases:

>100_bases
TCGCGGCGACAGCCGTGTCGATGTCGTCGCGCGACACGTCGCAGTGCGTGACGAAGCGCGACGCATACAGCATCTGCGTG
AGAATCCCGCGCTCCTTGAG

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: OriC replication inhibitor [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTIDPKQAAALVAVADTGSFEQAAARLHVTASAVTQRVRALETSLGAPLLLRTRPCRPTAAGQRVLQHLRRMALLQVDLQ
AELEAERGSTIAVAIALNSDSLGSWFLPALTSVLAGERMLFELIVEDQDHTFALLESGMAIGCVTTQSKPMRGCFATPLG
TMRYRLIAAEEFAARWFAQGLTRESAREAPVVAHGRRDTLQSSFLRDKLGLPDGAFPCHYVPGTHAHFAAVRHGLGYAMV
PELLLGTTPLAEQRLVDLAPAHSTDVSLYWHAWTVQSPKMESLSSRVVEAAQQLLAPPPRGAAAAGGRAAAAPAPVKRAN
ARNTR

Sequences:

>Translated_325_residues
MTIDPKQAAALVAVADTGSFEQAAARLHVTASAVTQRVRALETSLGAPLLLRTRPCRPTAAGQRVLQHLRRMALLQVDLQ
AELEAERGSTIAVAIALNSDSLGSWFLPALTSVLAGERMLFELIVEDQDHTFALLESGMAIGCVTTQSKPMRGCFATPLG
TMRYRLIAAEEFAARWFAQGLTRESAREAPVVAHGRRDTLQSSFLRDKLGLPDGAFPCHYVPGTHAHFAAVRHGLGYAMV
PELLLGTTPLAEQRLVDLAPAHSTDVSLYWHAWTVQSPKMESLSSRVVEAAQQLLAPPPRGAAAAGGRAAAAPAPVKRAN
ARNTR
>Mature_324_residues
TIDPKQAAALVAVADTGSFEQAAARLHVTASAVTQRVRALETSLGAPLLLRTRPCRPTAAGQRVLQHLRRMALLQVDLQA
ELEAERGSTIAVAIALNSDSLGSWFLPALTSVLAGERMLFELIVEDQDHTFALLESGMAIGCVTTQSKPMRGCFATPLGT
MRYRLIAAEEFAARWFAQGLTRESAREAPVVAHGRRDTLQSSFLRDKLGLPDGAFPCHYVPGTHAHFAAVRHGLGYAMVP
ELLLGTTPLAEQRLVDLAPAHSTDVSLYWHAWTVQSPKMESLSSRVVEAAQQLLAPPPRGAAAAGGRAAAAPAPVKRANA
RNTR

Specific function: Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=293, Percent_Identity=35.8361774744027, Blast_Score=184, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34846; Mature: 34715

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDPKQAAALVAVADTGSFEQAAARLHVTASAVTQRVRALETSLGAPLLLRTRPCRPTA
CCCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCH
AGQRVLQHLRRMALLQVDLQAELEAERGSTIAVAIALNSDSLGSWFLPALTSVLAGERML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCHHHH
FELIVEDQDHTFALLESGMAIGCVTTQSKPMRGCFATPLGTMRYRLIAAEEFAARWFAQG
HHHHHCCCCCHHHHHHCCCEEEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHH
LTRESAREAPVVAHGRRDTLQSSFLRDKLGLPDGAFPCHYVPGTHAHFAAVRHGLGYAMV
HHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
PELLLGTTPLAEQRLVDLAPAHSTDVSLYWHAWTVQSPKMESLSSRVVEAAQQLLAPPPR
HHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
GAAAAGGRAAAAPAPVKRANARNTR
CCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
TIDPKQAAALVAVADTGSFEQAAARLHVTASAVTQRVRALETSLGAPLLLRTRPCRPTA
CCCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCH
AGQRVLQHLRRMALLQVDLQAELEAERGSTIAVAIALNSDSLGSWFLPALTSVLAGERML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCHHHH
FELIVEDQDHTFALLESGMAIGCVTTQSKPMRGCFATPLGTMRYRLIAAEEFAARWFAQG
HHHHHCCCCCHHHHHHCCCEEEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHH
LTRESAREAPVVAHGRRDTLQSSFLRDKLGLPDGAFPCHYVPGTHAHFAAVRHGLGYAMV
HHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHH
PELLLGTTPLAEQRLVDLAPAHSTDVSLYWHAWTVQSPKMESLSSRVVEAAQQLLAPPPR
HHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
GAAAAGGRAAAAPAPVKRANARNTR
CCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9286976 [H]