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The map label for this gene is czcB [H]

Identifier: 126443033

GI number: 126443033

Start: 1467446

End: 1468915

Strand: Reverse

Name: czcB [H]

Synonym: BURPS668_A1526

Alternate gene names: 126443033

Gene position: 1468915-1467446 (Counterclockwise)

Preceding gene: 126445487

Following gene: 126442386

Centisome position: 46.97

GC content: 72.52

Gene sequence:

>1470_bases
ATGCAACGCAAGCCCCTGATTCTCGCCGGCGCGGCCGCGGCCGGCGCTCTCGCCATCGTGCTGGCGCTCGCGCGCGCGCC
GTCCACGTCGTCCGCGCCGGCGGCCTCCGGGGCCGCCGCGGTCGCGCCCGCATCCGGCGCGACCGGCCCGCACGGCGGCG
CGATGTTCGCGCAAGGCGCGCTGTCCGCCGAAATCGTGCTGTCCGAGAAGCCGGACGACGCGCGCCTCGTCGTCTATCCG
TTCGTCGACGGCAAGCCCGTCGAGCAAGGCGCGGCCGTCTCCGCGACGCTGACCCGCCACGACGGCGAACGCGTCGCGCT
GCAGTTCGCGCAAGCGGGCGCGAAGTACACGTCGGCGCAGCCGATCGCGAGGCCGCACGTGTTCGACGCGTCGATCGACG
TGAGGATCGGCGCGCGCAGCGCATCGTTTCCGTTCTCGCGTGCGGACGGCGCGATCGCGCTGGACGACGCTCAGCTCGGC
GCGGCGAGGATCGGCATCGCGCGCGCGGGCCCCGCGCAGATCATCACGAGCTTCCAGTTGCCGGGCGAAATCAGGTTCAA
CGAGGATCGCACCGCGCACGTCGTGCCGCGCGTCGCGGGGATCGTCGAGCGGGTCGCCGTGTCGATCGGCGAGAACGTCA
AGCCAGGGCAAGTGCTCGCGGTGATCGCGAGCACGGATCTCGCCGATCGCCGCAGCGAGCTGATGACGGCCGAGCGCCGG
CTGCAGGCGGCCCGCACGTCGTACGCGCGCGAGAAGACCTTGTGGGAGGAGCGGATCTCCGCCGAGCAGGACTATCTGCA
GGCGCAGGTGCAACTGCGCGAGGCGGAGATCGCCGCGGCGAACGCGCGGCAGAAACTCGCCGCGCTGAACGCGAGCGCCG
CATCCGGCGCGCTCAACCGCTACGAGCTGCGCGCGCCGTTCGCGGGCACCATCGTCGAGAAGCACATCGCGCCGGGCGAG
GCGATCGCGGCCGACGCGAACGTGTTCGTCGTGTCCGATCTGTCGTCGGTGTGGGCCGAAATGGCCGTGCCCGCGCAGCG
CCTGAACGAGGTGCGCGTCGGCCGCCACGCGACGGTCAGCGCGGCCGCGTTCGAATCGAAGTCGAGCGGGCCGATCGCGT
ACGTCGGCGCGCTGCTCGGCGAGCAGACCCGCACCGCGCCCGCGCGTGTCGTGCTGCCGAATCCCGACGGCGCGTGGCGG
CCGGGCATGTTCGTCAACGTGACCGTCGACGCCGGCGCGCAAAACGTGCCCGTCGCGATCGAGAGCGACGCGCTGCAGGA
CGTCGATGGCGCGCCCGCCGTGTTCGTTCGAACGCCGAAGGGTTTCGTCGCGCAGGCGATCGAGACGGGCCGGCGCGACG
AGCGGCGCGTCGAGATCGTCAAGGGCCTCGCGCCCGGTCAGACCTACGCCGCGGCGAACAGCTTCGTGCTGAAGGCGGAG
CTCGGCAAGGGCGTCGCCGACGAGCACTGA

Upstream 100 bases:

>100_bases
GCCGACGCGCATCAGTCGTATGCGGACATCGAGCGCGTCGTCGGCGCGCCGTCGCGCGACGTTTCCCGCCCCCTCGCCCA
ACTTCGCTGAAGAACTCGCC

Downstream 100 bases:

>100_bases
CGCGCGGGCCGCTTCGTTTTCCACGCATTCCAGAGGACCGTCACCATGTTTGAGCGCCTGATCCGCTTCGCGATCGCGCA
CCGCTGGCTCGTGATGCTCG

Product: cobalt-zinc-cadmium resistance protein CzcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MQRKPLILAGAAAAGALAIVLALARAPSTSSAPAASGAAAVAPASGATGPHGGAMFAQGALSAEIVLSEKPDDARLVVYP
FVDGKPVEQGAAVSATLTRHDGERVALQFAQAGAKYTSAQPIARPHVFDASIDVRIGARSASFPFSRADGAIALDDAQLG
AARIGIARAGPAQIITSFQLPGEIRFNEDRTAHVVPRVAGIVERVAVSIGENVKPGQVLAVIASTDLADRRSELMTAERR
LQAARTSYAREKTLWEERISAEQDYLQAQVQLREAEIAAANARQKLAALNASAASGALNRYELRAPFAGTIVEKHIAPGE
AIAADANVFVVSDLSSVWAEMAVPAQRLNEVRVGRHATVSAAAFESKSSGPIAYVGALLGEQTRTAPARVVLPNPDGAWR
PGMFVNVTVDAGAQNVPVAIESDALQDVDGAPAVFVRTPKGFVAQAIETGRRDERRVEIVKGLAPGQTYAAANSFVLKAE
LGKGVADEH

Sequences:

>Translated_489_residues
MQRKPLILAGAAAAGALAIVLALARAPSTSSAPAASGAAAVAPASGATGPHGGAMFAQGALSAEIVLSEKPDDARLVVYP
FVDGKPVEQGAAVSATLTRHDGERVALQFAQAGAKYTSAQPIARPHVFDASIDVRIGARSASFPFSRADGAIALDDAQLG
AARIGIARAGPAQIITSFQLPGEIRFNEDRTAHVVPRVAGIVERVAVSIGENVKPGQVLAVIASTDLADRRSELMTAERR
LQAARTSYAREKTLWEERISAEQDYLQAQVQLREAEIAAANARQKLAALNASAASGALNRYELRAPFAGTIVEKHIAPGE
AIAADANVFVVSDLSSVWAEMAVPAQRLNEVRVGRHATVSAAAFESKSSGPIAYVGALLGEQTRTAPARVVLPNPDGAWR
PGMFVNVTVDAGAQNVPVAIESDALQDVDGAPAVFVRTPKGFVAQAIETGRRDERRVEIVKGLAPGQTYAAANSFVLKAE
LGKGVADEH
>Mature_489_residues
MQRKPLILAGAAAAGALAIVLALARAPSTSSAPAASGAAAVAPASGATGPHGGAMFAQGALSAEIVLSEKPDDARLVVYP
FVDGKPVEQGAAVSATLTRHDGERVALQFAQAGAKYTSAQPIARPHVFDASIDVRIGARSASFPFSRADGAIALDDAQLG
AARIGIARAGPAQIITSFQLPGEIRFNEDRTAHVVPRVAGIVERVAVSIGENVKPGQVLAVIASTDLADRRSELMTAERR
LQAARTSYAREKTLWEERISAEQDYLQAQVQLREAEIAAANARQKLAALNASAASGALNRYELRAPFAGTIVEKHIAPGE
AIAADANVFVVSDLSSVWAEMAVPAQRLNEVRVGRHATVSAAAFESKSSGPIAYVGALLGEQTRTAPARVVLPNPDGAWR
PGMFVNVTVDAGAQNVPVAIESDALQDVDGAPAVFVRTPKGFVAQAIETGRRDERRVEIVKGLAPGQTYAAANSFVLKAE
LGKGVADEH

Specific function: CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Attached To The Inner Membrane By A Lipid Anchor [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=278, Percent_Identity=25.1798561151079, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081796, Length=300, Percent_Identity=25.3333333333333, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005695
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50851; Mature: 50851

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRKPLILAGAAAAGALAIVLALARAPSTSSAPAASGAAAVAPASGATGPHGGAMFAQGA
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHCCC
LSAEIVLSEKPDDARLVVYPFVDGKPVEQGAAVSATLTRHDGERVALQFAQAGAKYTSAQ
CEEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCC
PIARPHVFDASIDVRIGARSASFPFSRADGAIALDDAQLGAARIGIARAGPAQIITSFQL
CCCCCEEECCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHEEECCCCHHHHHEEECC
PGEIRFNEDRTAHVVPRVAGIVERVAVSIGENVKPGQVLAVIASTDLADRRSELMTAERR
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
LQAARTSYAREKTLWEERISAEQDYLQAQVQLREAEIAAANARQKLAALNASAASGALNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCE
YELRAPFAGTIVEKHIAPGEAIAADANVFVVSDLSSVWAEMAVPAQRLNEVRVGRHATVS
EEECCCCHHHHHHHHCCCCCCEECCCCEEEEECHHHHHHHHCCCHHHHHHHHCCCCCEEE
AAAFESKSSGPIAYVGALLGEQTRTAPARVVLPNPDGAWRPGMFVNVTVDAGAQNVPVAI
HHHHCCCCCCCCEEHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCEEE
ESDALQDVDGAPAVFVRTPKGFVAQAIETGRRDERRVEIVKGLAPGQTYAAANSFVLKAE
ECCCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEE
LGKGVADEH
CCCCCCCCC
>Mature Secondary Structure
MQRKPLILAGAAAAGALAIVLALARAPSTSSAPAASGAAAVAPASGATGPHGGAMFAQGA
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHCCC
LSAEIVLSEKPDDARLVVYPFVDGKPVEQGAAVSATLTRHDGERVALQFAQAGAKYTSAQ
CEEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCC
PIARPHVFDASIDVRIGARSASFPFSRADGAIALDDAQLGAARIGIARAGPAQIITSFQL
CCCCCEEECCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHEEECCCCHHHHHEEECC
PGEIRFNEDRTAHVVPRVAGIVERVAVSIGENVKPGQVLAVIASTDLADRRSELMTAERR
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
LQAARTSYAREKTLWEERISAEQDYLQAQVQLREAEIAAANARQKLAALNASAASGALNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCE
YELRAPFAGTIVEKHIAPGEAIAADANVFVVSDLSSVWAEMAVPAQRLNEVRVGRHATVS
EEECCCCHHHHHHHHCCCCCCEECCCCEEEEECHHHHHHHHCCCHHHHHHHHCCCCCEEE
AAAFESKSSGPIAYVGALLGEQTRTAPARVVLPNPDGAWRPGMFVNVTVDAGAQNVPVAI
HHHHCCCCCCCCEEHHHHHCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCCCEEE
ESDALQDVDGAPAVFVRTPKGFVAQAIETGRRDERRVEIVKGLAPGQTYAAANSFVLKAE
ECCCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEE
LGKGVADEH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]