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The map label for this gene is cusS [H]

Identifier: 126442437

GI number: 126442437

Start: 1032268

End: 1033089

Strand: Reverse

Name: cusS [H]

Synonym: BURPS668_A1074

Alternate gene names: 126442437

Gene position: 1033089-1032268 (Counterclockwise)

Preceding gene: 126442923

Following gene: 126444581

Centisome position: 33.03

GC content: 71.17

Gene sequence:

>822_bases
ATGATGCCGACCGGTCGCGGCCACGCGCGGCCTGCGCTGTCGCCGCCGCCGTCCGCTCCGGCGCATCGAGCCGCCGCGCA
CACGGAGCCCGTGAGCATCCTGATCGGCCAGACGCAGGTCGCGCTCGCGCGCGAGCGCTCGGCCAAGCGGCTGCGCGAGA
CGCTCGAATCGAATCTCGAAGCGTTCGAGCGGCGGCGCATCATCGTCAACGACATGCTGTTCCTTGCTCGCCGCGATCGC
GGCGAGCGCGCGACCGATCTCGCCGACGTGTCGCTCGCGGCCGAGCTCACGCGCATGCTCGCGTTCCTCGAGATGTCGCT
CGACGACGCGCAACTGCGCGCCGAGCTCACGGGCGACGCACGCGCGAGCGTCGATCCGTCGCTGTTCGGCCGCGCGATGA
CGAACCTCTTGATCAACGCGATCCAGCACACGCGCGCGGAGAACACGATCCGCGCGACGAGCACGCCGCGCGGCGAGACG
GTGGAGATCGCGGTGTCCCATCCGGGCGAGCCGATCGACGCGGCCGCGCGCGCATCTGTTCGAGCGCGCCTACCGGATCG
AGCAGGCGCGCGCGAACAGCGACGAGAATCACGGGCCCGGCCTGTCGATCGTGAAGGCAGTCGCCGAGATGCACGGCGGC
GCCGTGTTCGTGTCGTGCGAGGACGGCTGGAACGCGATCGGCTTATCGGTCGCCGCGCAACCGGCCGGCACGGGCCCGCA
CGCGCACGACCCGCGGCCGGCGTTGAAGACGACTTGAGTGGTGGGGCGTCGTTGCATCGTTGTGCCGGTGCGTCGGCGCA
TCAGTGCATCGGCGGGTCGTGA

Upstream 100 bases:

>100_bases
CCAGATCGACGTGCTCGATCTGCCGAAGCTCGCGGCGTTCGGGATGGAGCAGATCTGACGGCCCGGTTGGCGGCCGCGGC
CGCCATCGCGTTCGCCGTCC

Downstream 100 bases:

>100_bases
CATCCGCACATATGCACATCGGCACATCGGCACATCGGCACATCGGCACATCGGCACATTGGCGCATCGGCGCATCGGCG
CAGCAAACGCATCAGGCAAC

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MMPTGRGHARPALSPPPSAPAHRAAAHTEPVSILIGQTQVALARERSAKRLRETLESNLEAFERRRIIVNDMLFLARRDR
GERATDLADVSLAAELTRMLAFLEMSLDDAQLRAELTGDARASVDPSLFGRAMTNLLINAIQHTRAENTIRATSTPRGET
VEIAVSHPGEPIDAAARASVRARLPDRAGAREQRRESRARPVDREGSRRDARRRRVRVVRGRLERDRLIGRRATGRHGPA
RARPAAGVEDDLSGGASLHRCAGASAHQCIGGS

Sequences:

>Translated_273_residues
MMPTGRGHARPALSPPPSAPAHRAAAHTEPVSILIGQTQVALARERSAKRLRETLESNLEAFERRRIIVNDMLFLARRDR
GERATDLADVSLAAELTRMLAFLEMSLDDAQLRAELTGDARASVDPSLFGRAMTNLLINAIQHTRAENTIRATSTPRGET
VEIAVSHPGEPIDAAARASVRARLPDRAGAREQRRESRARPVDREGSRRDARRRRVRVVRGRLERDRLIGRRATGRHGPA
RARPAAGVEDDLSGGASLHRCAGASAHQCIGGS
>Mature_273_residues
MMPTGRGHARPALSPPPSAPAHRAAAHTEPVSILIGQTQVALARERSAKRLRETLESNLEAFERRRIIVNDMLFLARRDR
GERATDLADVSLAAELTRMLAFLEMSLDDAQLRAELTGDARASVDPSLFGRAMTNLLINAIQHTRAENTIRATSTPRGET
VEIAVSHPGEPIDAAARASVRARLPDRAGAREQRRESRARPVDREGSRRDARRRRVRVVRGRLERDRLIGRRATGRHGPA
RARPAAGVEDDLSGGASLHRCAGASAHQCIGGS

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=144, Percent_Identity=35.4166666666667, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788279, Length=145, Percent_Identity=28.9655172413793, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 29799; Mature: 29799

Theoretical pI: Translated: 11.98; Mature: 11.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPTGRGHARPALSPPPSAPAHRAAAHTEPVSILIGQTQVALARERSAKRLRETLESNLE
CCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
AFERRRIIVNDMLFLARRDRGERATDLADVSLAAELTRMLAFLEMSLDDAQLRAELTGDA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
RASVDPSLFGRAMTNLLINAIQHTRAENTIRATSTPRGETVEIAVSHPGEPIDAAARASV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCHHHHHHH
RARLPDRAGAREQRRESRARPVDREGSRRDARRRRVRVVRGRLERDRLIGRRATGRHGPA
HHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RARPAAGVEDDLSGGASLHRCAGASAHQCIGGS
CCCCCCCCCHHHCCCCHHHHHCCCCHHHCCCCC
>Mature Secondary Structure
MMPTGRGHARPALSPPPSAPAHRAAAHTEPVSILIGQTQVALARERSAKRLRETLESNLE
CCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
AFERRRIIVNDMLFLARRDRGERATDLADVSLAAELTRMLAFLEMSLDDAQLRAELTGDA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
RASVDPSLFGRAMTNLLINAIQHTRAENTIRATSTPRGETVEIAVSHPGEPIDAAARASV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCHHHHHHH
RARLPDRAGAREQRRESRARPVDREGSRRDARRRRVRVVRGRLERDRLIGRRATGRHGPA
HHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RARPAAGVEDDLSGGASLHRCAGASAHQCIGGS
CCCCCCCCCHHHCCCCHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]