Click here to switch to the map view.

The map label for this gene is hemK [H]

Identifier: 126209496

GI number: 126209496

Start: 2269371

End: 2270243

Strand: Reverse

Name: hemK [H]

Synonym: APL_2042

Alternate gene names: 126209496

Gene position: 2270243-2269371 (Counterclockwise)

Preceding gene: 126209497

Following gene: 126209495

Centisome position: 99.81

GC content: 43.87

Gene sequence:

>873_bases
ATGAACTATACCCAATGGCTTGATCAGGCAATAACGGCACTTAATGCCAATATTGCCCAGGATCCTTATCTGAATCCTAA
AACCGATGCCAATTTACTCTTGCAAGCAGTCACAAAACGCACAAAATCTGCTATTTTTGCGTTTGGCGAAACTGCGCTGC
ATCAGACGGAATTAGCGGAACTTGCGCAATTATTGGCTCGCCGTTTGCAGGGCGAGCCGATGGCGTATATTTTAGGCGAA
AAGGAATTTTGGTCGTTGCCGTTGAAAGTTTCGCCGCATACGTTAATTCCTCGTCCGGACACGGAACGTTTGGTTGAAGT
CGCGTTGGATTGGGTTTACAAGCGGTTGGAAAGCCAACAAACGTTGCAAATTTTGGATCTAGGCACCGGTACCGGAGCTA
TCGCCTTAGCACTTGCTTCGGAATTGGGCGATAAAGCGCAAATTATCGGTGTGGATTTTAAGCCGGAGGCGGTTACGCTT
GCCGAAACCAATCGTCAAAATTTAGGCTTTGAAAACGTTCGATTTTTACAAAGCGATTGGTTTTCCGCTCTTGAAAATCG
ACAATTTGATCTTATTGTCAGTAATCCGCCCTATATTGATAAACAAGATAAAAATCTGCAATACGGCGATGTACGATTCG
AGCCGCTCTCTGCATTGGTTGCCGAACAAAACGGTTTGAGCGATTTGCAAAAAATTATCGAAAACGCACCGCTTTACTTA
TTAGATAACGGTGCGTTAATGCTCGAACACGGCTGGCAACAAGCTCAAGCGGTTCAACAAATTTTCAAACAATATCAATG
GGATGAAATTGAGTCATTCCAAGATTACGGCGGTAATGACCGCTTAACTAAAGCAGTAAGAAAGGCAAAATAA

Upstream 100 bases:

>100_bases
AATATCGAAGTAAGCAATTTTGCGCCTAATGCGTTTAGCATTAAACAAAATATCGGCGGTACGGCTCGTACCGGACTTTG
TGTTCGTCCGAACAAATAAT

Downstream 100 bases:

>100_bases
ATGGACGATGTGATTGAAGAATTATTAAAAGAATTAGATCTGCCGAAAGTTGAAATCAGCCCGAAAGAATTACAAAAATA
TTTATATCGTGAAATGGTTC

Product: HemK-like protein

Products: NA

Alternate protein names: M.PmuHemKP [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNYTQWLDQAITALNANIAQDPYLNPKTDANLLLQAVTKRTKSAIFAFGETALHQTELAELAQLLARRLQGEPMAYILGE
KEFWSLPLKVSPHTLIPRPDTERLVEVALDWVYKRLESQQTLQILDLGTGTGAIALALASELGDKAQIIGVDFKPEAVTL
AETNRQNLGFENVRFLQSDWFSALENRQFDLIVSNPPYIDKQDKNLQYGDVRFEPLSALVAEQNGLSDLQKIIENAPLYL
LDNGALMLEHGWQQAQAVQQIFKQYQWDEIESFQDYGGNDRLTKAVRKAK

Sequences:

>Translated_290_residues
MNYTQWLDQAITALNANIAQDPYLNPKTDANLLLQAVTKRTKSAIFAFGETALHQTELAELAQLLARRLQGEPMAYILGE
KEFWSLPLKVSPHTLIPRPDTERLVEVALDWVYKRLESQQTLQILDLGTGTGAIALALASELGDKAQIIGVDFKPEAVTL
AETNRQNLGFENVRFLQSDWFSALENRQFDLIVSNPPYIDKQDKNLQYGDVRFEPLSALVAEQNGLSDLQKIIENAPLYL
LDNGALMLEHGWQQAQAVQQIFKQYQWDEIESFQDYGGNDRLTKAVRKAK
>Mature_290_residues
MNYTQWLDQAITALNANIAQDPYLNPKTDANLLLQAVTKRTKSAIFAFGETALHQTELAELAQLLARRLQGEPMAYILGE
KEFWSLPLKVSPHTLIPRPDTERLVEVALDWVYKRLESQQTLQILDLGTGTGAIALALASELGDKAQIIGVDFKPEAVTL
AETNRQNLGFENVRFLQSDWFSALENRQFDLIVSNPPYIDKQDKNLQYGDVRFEPLSALVAEQNGLSDLQKIIENAPLYL
LDNGALMLEHGWQQAQAVQQIFKQYQWDEIESFQDYGGNDRLTKAVRKAK

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=208, Percent_Identity=36.0576923076923, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787463, Length=283, Percent_Identity=54.416961130742, Blast_Score=290, Evalue=7e-80,
Organism=Escherichia coli, GI87082085, Length=210, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324266, Length=166, Percent_Identity=31.9277108433735, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24582226, Length=248, Percent_Identity=28.2258064516129, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32776; Mature: 32776

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYTQWLDQAITALNANIAQDPYLNPKTDANLLLQAVTKRTKSAIFAFGETALHQTELAE
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQLLARRLQGEPMAYILGEKEFWSLPLKVSPHTLIPRPDTERLVEVALDWVYKRLESQQ
HHHHHHHHHCCCCEEEEECCHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
TLQILDLGTGTGAIALALASELGDKAQIIGVDFKPEAVTLAETNRQNLGFENVRFLQSDW
EEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHH
FSALENRQFDLIVSNPPYIDKQDKNLQYGDVRFEPLSALVAEQNGLSDLQKIIENAPLYL
HHHHCCCCEEEEECCCCCCCCCCCCCEECCEEHHHHHHHHHCCCCHHHHHHHHHCCCEEE
LDNGALMLEHGWQQAQAVQQIFKQYQWDEIESFQDYGGNDRLTKAVRKAK
EECCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNYTQWLDQAITALNANIAQDPYLNPKTDANLLLQAVTKRTKSAIFAFGETALHQTELAE
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAQLLARRLQGEPMAYILGEKEFWSLPLKVSPHTLIPRPDTERLVEVALDWVYKRLESQQ
HHHHHHHHHCCCCEEEEECCHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
TLQILDLGTGTGAIALALASELGDKAQIIGVDFKPEAVTLAETNRQNLGFENVRFLQSDW
EEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHH
FSALENRQFDLIVSNPPYIDKQDKNLQYGDVRFEPLSALVAEQNGLSDLQKIIENAPLYL
HHHHCCCCEEEEECCCCCCCCCCCCCEECCEEHHHHHHHHHCCCCHHHHHHHHHCCCEEE
LDNGALMLEHGWQQAQAVQQIFKQYQWDEIESFQDYGGNDRLTKAVRKAK
EECCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]