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The map label for this gene is ubiE [H]

Identifier: 126209436

GI number: 126209436

Start: 2209901

End: 2210677

Strand: Direct

Name: ubiE [H]

Synonym: APL_1982

Alternate gene names: 126209436

Gene position: 2209901-2210677 (Clockwise)

Preceding gene: 126209433

Following gene: 126209437

Centisome position: 97.16

GC content: 43.63

Gene sequence:

>777_bases
ATGACTGATTTACAACACACGACGGAAACGGCTGAAAACGAAACGACCCATTTTGGTTTTAAAACTGTTGCCAAAGAAGA
AAAACAGCAATTGGTTGCCAATGTATTCCACAGCGTTGCCGGTAAATATGACTTAATGAACGATTTGCTTTCGTTTGGTA
TCCATCGTGTTTGGAAGCGTTTTACCATTGACTGCAGCGGCGTGCGTAAAGGGCAAAAAGTGTTGGATCTTGCCGGCGGA
ACCGGCGATTTTACCGCAAAATTTTCGCGCATTGTCGGCGAAAACGGCGAAGTGGTATTAGCCGATATTAATAGCTCGAT
GTTGGAAGTCGGTCGTGAGAAGCTGCGCAATTTGGGCGTAGTGGGAAATGTGAATTATGTGCAAGCGAATGCGGAATGTC
TGCCGTTTGCGGATAATACTTTCGATTGCGTGGTGATCAGTTTCGGTTTGCGTAATGTGACGGACAAAGACAAAGCGTTA
CGTTCGATGTTTCGTGTGTTGAAGCCGGGCGGTCGTTTATTGGTATTAGAATTTTCCAAACCGATTATTGACCCGATTAG
TCAGCTATATAATTTCTACTCTTTTAATATTTTGCCGAAAGTCGGCGAAGTGGTGGTAAACGATGCGGAGAGCTATCGCT
ATCTTGCCGAATCGATTCGTATGCACCCGAAACAAGACGAATTAAAAGCGATGATGGAAAATGCCGGCTTTGAAAGCGTA
AATTATTACAACTTAAGTGCCGGTATTGTAGCGTTACATCGAGGATATAAGTTTTAA

Upstream 100 bases:

>100_bases
CAAGCGGTCATTTACTTGCTTGATTTTGCAAAATTTTAAGGAAAAATGACCGCTTTTTTGCTATCGTTAGCACTCTGAAA
TAATCGATGAGAATTTGACA

Downstream 100 bases:

>100_bases
TTTATTGTCATCCGAGGAATACGCGATGTTATCTCAACTTAAACAGCAGCTTATGTTGCCGCAATTTGCTTTCGGTACGA
TAGAAACCGCTTTTAATGCA

Product: ubiquinone/menaquinone biosynthesis methyltransferase ubiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTDLQHTTETAENETTHFGFKTVAKEEKQQLVANVFHSVAGKYDLMNDLLSFGIHRVWKRFTIDCSGVRKGQKVLDLAGG
TGDFTAKFSRIVGENGEVVLADINSSMLEVGREKLRNLGVVGNVNYVQANAECLPFADNTFDCVVISFGLRNVTDKDKAL
RSMFRVLKPGGRLLVLEFSKPIIDPISQLYNFYSFNILPKVGEVVVNDAESYRYLAESIRMHPKQDELKAMMENAGFESV
NYYNLSAGIVALHRGYKF

Sequences:

>Translated_258_residues
MTDLQHTTETAENETTHFGFKTVAKEEKQQLVANVFHSVAGKYDLMNDLLSFGIHRVWKRFTIDCSGVRKGQKVLDLAGG
TGDFTAKFSRIVGENGEVVLADINSSMLEVGREKLRNLGVVGNVNYVQANAECLPFADNTFDCVVISFGLRNVTDKDKAL
RSMFRVLKPGGRLLVLEFSKPIIDPISQLYNFYSFNILPKVGEVVVNDAESYRYLAESIRMHPKQDELKAMMENAGFESV
NYYNLSAGIVALHRGYKF
>Mature_257_residues
TDLQHTTETAENETTHFGFKTVAKEEKQQLVANVFHSVAGKYDLMNDLLSFGIHRVWKRFTIDCSGVRKGQKVLDLAGGT
GDFTAKFSRIVGENGEVVLADINSSMLEVGREKLRNLGVVGNVNYVQANAECLPFADNTFDCVVISFGLRNVTDKDKALR
SMFRVLKPGGRLLVLEFSKPIIDPISQLYNFYSFNILPKVGEVVVNDAESYRYLAESIRMHPKQDELKAMMENAGFESVN
YYNLSAGIVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=44.5652173913043, Blast_Score=231, Evalue=6e-61,
Organism=Escherichia coli, GI48994983, Length=246, Percent_Identity=80.0813008130081, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17557039, Length=247, Percent_Identity=44.9392712550607, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323526, Length=274, Percent_Identity=39.7810218978102, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24641702, Length=262, Percent_Identity=43.1297709923664, Blast_Score=234, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28920; Mature: 28789

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLQHTTETAENETTHFGFKTVAKEEKQQLVANVFHSVAGKYDLMNDLLSFGIHRVWKR
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FTIDCSGVRKGQKVLDLAGGTGDFTAKFSRIVGENGEVVLADINSSMLEVGREKLRNLGV
HHCCCHHCCCCHHHHEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCC
VGNVNYVQANAECLPFADNTFDCVVISFGLRNVTDKDKALRSMFRVLKPGGRLLVLEFSK
CCCCEEEEECCCEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
PIIDPISQLYNFYSFNILPKVGEVVVNDAESYRYLAESIRMHPKQDELKAMMENAGFESV
CHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
NYYNLSAGIVALHRGYKF
EEEECHHHHHHHHCCCCC
>Mature Secondary Structure 
TDLQHTTETAENETTHFGFKTVAKEEKQQLVANVFHSVAGKYDLMNDLLSFGIHRVWKR
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FTIDCSGVRKGQKVLDLAGGTGDFTAKFSRIVGENGEVVLADINSSMLEVGREKLRNLGV
HHCCCHHCCCCHHHHEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCC
VGNVNYVQANAECLPFADNTFDCVVISFGLRNVTDKDKALRSMFRVLKPGGRLLVLEFSK
CCCCEEEEECCCEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
PIIDPISQLYNFYSFNILPKVGEVVVNDAESYRYLAESIRMHPKQDELKAMMENAGFESV
CHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
NYYNLSAGIVALHRGYKF
EEEECHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA