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The map label for this gene is dfp [H]

Identifier: 126209423

GI number: 126209423

Start: 2196656

End: 2197861

Strand: Reverse

Name: dfp [H]

Synonym: APL_1969

Alternate gene names: 126209423

Gene position: 2197861-2196656 (Counterclockwise)

Preceding gene: 126209430

Following gene: 126209422

Centisome position: 96.63

GC content: 47.68

Gene sequence:

>1206_bases
ATGCTCGATAACAAGCGCATTTTAGTGGGTATTACCGGTGGAATCGCCGCTTATAAAACGATTGAATTAATTCGTCATTT
CAAAAAAGCCAATGCCGATGTGCGAGTGGTTTTAACGCCTGCAGCAGAAGCCTTCGTTACTCCGCTTACCCTGCAAGCGA
TTTCGGCGAATGCGGTATCAACTTCTCTGTTAGATCCGCAAGCGGAATTAGCGATGGGTCATATCGAACTGGCAAAATGG
GCGGATTTAGTCGTTATTGCGCCGGCATCCGCCGATTTTATCGCGCGTTTACGTGCCGGTATGGCAAATGATTTGCTCTC
CACCCTCTGCTTGGCAACCGCCAGCCCGATTTTACTCGCACCGGCAATGAACCAACAAATGTTCAAACAAGCAATCACGC
AAGAAAATTTAGCGGTGTTGGCAAATCGCGGCGTGCAAATGATCGGCCCGAATAGCGGTTTCCAAGCCTGTGGTGATGTC
GGTGCCGGCAGAATGTCCGAGCCGAGCGAGCTCTTCCAAGCGGTATGTGATCACTTTAACCATATACAAGATCTGAAAGA
TATTAGTGTGACAATTACCGCCGGTCCGACCCGTGAAGCGATCGATCCGGTACGTTATATCAGTAATCACAGCTCCGGCA
AAATGGGCTTTGCAATTGCCGAAGCCTTCGCCAAACGTGGCGCAACTGTAAATCTGATTGCCGGCCCGGTCAATCTTGCC
ACACCGGCAAATGTCACTCGAATCGATGTAGAATCTGCGGTAGAAATGGAGCAACAAGCGGTCAAATTTGCGCAAAAATC
TGCAATCTTTATCGGTTGTGCCGCGGTTGCCGACTATCGTATGGCGGAGGTATCGACCCAAAAAATCAAGAAAACCGCTG
ATAATAACGAGCTGATGCTTAAATTGGTTAAAAATCCGGACATTATCGCCAATGTGGCGAATTTAACCGAAAATCGTCCG
TTTACCGTCGGCTTTGCGGCAGAGACGCAAGATGTCGCAAGCTATGCCAAAGATAAACTTAAACGCAAAAACTTAGATTT
AATCTGTGCTAATGATGTGTCCGGCGGACAGGTATTCGGGCAAGATCAAAATGCTCTGCAACTCTTTTGGCAAGACGGTG
AGAAAATGCTACCGCTTGCCGATAAAAGCAAACTGGCGGAAGCCTTAGTTCACGAGATTATTGAGCAATTTAAACACGAC
AAATAG

Upstream 100 bases:

>100_bases
TTGTGAGTGAGTGCTTATTAAGGTAGAATTACATTATTGTTAATGACTTTGCTCAAACAAAGATGTTAGTGATCAAATAC
ATTTCAAAATAGGAATTACT

Downstream 100 bases:

>100_bases
GAACATAAATGAAACAAATCGACTTAAAAATTTTAGACGGCCGTATCGGCAACGAATTTCCATTACCGGCTTATGCAACC
GAAGGTTCGGCAGGCTTGGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLDNKRILVGITGGIAAYKTIELIRHFKKANADVRVVLTPAAEAFVTPLTLQAISANAVSTSLLDPQAELAMGHIELAKW
ADLVVIAPASADFIARLRAGMANDLLSTLCLATASPILLAPAMNQQMFKQAITQENLAVLANRGVQMIGPNSGFQACGDV
GAGRMSEPSELFQAVCDHFNHIQDLKDISVTITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGATVNLIAGPVNLA
TPANVTRIDVESAVEMEQQAVKFAQKSAIFIGCAAVADYRMAEVSTQKIKKTADNNELMLKLVKNPDIIANVANLTENRP
FTVGFAAETQDVASYAKDKLKRKNLDLICANDVSGGQVFGQDQNALQLFWQDGEKMLPLADKSKLAEALVHEIIEQFKHD
K

Sequences:

>Translated_401_residues
MLDNKRILVGITGGIAAYKTIELIRHFKKANADVRVVLTPAAEAFVTPLTLQAISANAVSTSLLDPQAELAMGHIELAKW
ADLVVIAPASADFIARLRAGMANDLLSTLCLATASPILLAPAMNQQMFKQAITQENLAVLANRGVQMIGPNSGFQACGDV
GAGRMSEPSELFQAVCDHFNHIQDLKDISVTITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGATVNLIAGPVNLA
TPANVTRIDVESAVEMEQQAVKFAQKSAIFIGCAAVADYRMAEVSTQKIKKTADNNELMLKLVKNPDIIANVANLTENRP
FTVGFAAETQDVASYAKDKLKRKNLDLICANDVSGGQVFGQDQNALQLFWQDGEKMLPLADKSKLAEALVHEIIEQFKHD
K
>Mature_401_residues
MLDNKRILVGITGGIAAYKTIELIRHFKKANADVRVVLTPAAEAFVTPLTLQAISANAVSTSLLDPQAELAMGHIELAKW
ADLVVIAPASADFIARLRAGMANDLLSTLCLATASPILLAPAMNQQMFKQAITQENLAVLANRGVQMIGPNSGFQACGDV
GAGRMSEPSELFQAVCDHFNHIQDLKDISVTITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGATVNLIAGPVNLA
TPANVTRIDVESAVEMEQQAVKFAQKSAIFIGCAAVADYRMAEVSTQKIKKTADNNELMLKLVKNPDIIANVANLTENRP
FTVGFAAETQDVASYAKDKLKRKNLDLICANDVSGGQVFGQDQNALQLFWQDGEKMLPLADKSKLAEALVHEIIEQFKHD
K

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=166, Percent_Identity=30.1204819277108, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=60.3015075376884, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17560194, Length=172, Percent_Identity=29.0697674418605, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322762, Length=210, Percent_Identity=30, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24657262, Length=196, Percent_Identity=30.6122448979592, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43153; Mature: 43153

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNKRILVGITGGIAAYKTIELIRHFKKANADVRVVLTPAAEAFVTPLTLQAISANAVS
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHHHCCCHHH
TSLLDPQAELAMGHIELAKWADLVVIAPASADFIARLRAGMANDLLSTLCLATASPILLA
HHHCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAMNQQMFKQAITQENLAVLANRGVQMIGPNSGFQACGDVGAGRMSEPSELFQAVCDHFN
CCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
HIQDLKDISVTITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGATVNLIAGPVNLA
HHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
TPANVTRIDVESAVEMEQQAVKFAQKSAIFIGCAAVADYRMAEVSTQKIKKTADNNELML
CCCCEEEEEHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEE
KLVKNPDIIANVANLTENRPFTVGFAAETQDVASYAKDKLKRKNLDLICANDVSGGQVFG
EEECCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEC
QDQNALQLFWQDGEKMLPLADKSKLAEALVHEIIEQFKHDK
CCCCHHHHEEECCCEECCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDNKRILVGITGGIAAYKTIELIRHFKKANADVRVVLTPAAEAFVTPLTLQAISANAVS
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHHHCCCHHH
TSLLDPQAELAMGHIELAKWADLVVIAPASADFIARLRAGMANDLLSTLCLATASPILLA
HHHCCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
PAMNQQMFKQAITQENLAVLANRGVQMIGPNSGFQACGDVGAGRMSEPSELFQAVCDHFN
CCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
HIQDLKDISVTITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGATVNLIAGPVNLA
HHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
TPANVTRIDVESAVEMEQQAVKFAQKSAIFIGCAAVADYRMAEVSTQKIKKTADNNELML
CCCCEEEEEHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEE
KLVKNPDIIANVANLTENRPFTVGFAAETQDVASYAKDKLKRKNLDLICANDVSGGQVFG
EEECCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEC
QDQNALQLFWQDGEKMLPLADKSKLAEALVHEIIEQFKHDK
CCCCHHHHEEECCCEECCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]