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The map label for this gene is mutL [H]

Identifier: 126209412

GI number: 126209412

Start: 2187521

End: 2189389

Strand: Direct

Name: mutL [H]

Synonym: APL_1958

Alternate gene names: 126209412

Gene position: 2187521-2189389 (Clockwise)

Preceding gene: 126209406

Following gene: 126209413

Centisome position: 96.18

GC content: 45.32

Gene sequence:

>1869_bases
ATGAATAAGCCGTTAATCCATATTCTCCCGCCGCAACTTGCCAACCAAATCGCCGCAGGCGAGGTGGTGGAACGCCCCGC
ATCCGTTGTGAAGGAGTTGGTTGAAAACAGTTTGGATGCCGGTGCAAATCAGATTCAAATTGATATTGAGAAAGGCGGTG
CGCAGCTTATTCGTATCCGAGATAACGGTTGTGGTATCGGTAAGCAGGATTTAGCGTTGGCGTTAGCTCGTCACGCGACT
AGCAAAATTTCCAGCCTCGAAGATTTGGAGATGATTTTAAGTTTGGGCTTTCGTGGTGAAGCATTAGCAAGTATCAGCTC
GGTTTCTCGCTTAACGCTGACTTCCCGTCCGGCAGGGCAAGCGGAAGCGTGGCAAGCCTATGCGCAAGGGCGTGAAATGG
AGGTTGAAATTCAACCGGCTTCACATCCGGTCGGTACGACGATTGAAGTGGCGAATCTATTCTTTAATACGCCGGCACGC
CGTAAGTTTTTACGTACCGATAAAACCGAATTTACGCATATTGATGAAGTCGTACGCCGTATTGCATTAGCAAAACCGAA
TATCGGTTTTACCTTAACGCATAACGGCAAAACGGTGCGTCAATATCGTAAAGTGCAAGATAATTCGGTCGAGCAACAGC
AACGCCGAGTAGCGGCAATTTGCGGCGATGATTTTATTCAAAATGCAATTCATATCGACTGGCAGCACGGCGATTTACAC
CTGCACGGTTGGATTGGCCTACCGAATATTTCCAGACCGCAAAATGATTTATGTTACAGCTACGTAAACGGGCGAATGAT
GCGAGATAAAACGATTAATCACGCCATTCGTCAAGCTTATGAAGCCACTGATATGCCAGAGGGTAATTATCCGGCGTTTG
TGGTTTTTCTCGATATCGACCCGAGTCAAGTGGATGTCAATGTACATCCGGCAAAACACGAAGTGCGTTTCCATCAAGGA
CGATTAGTACATGACTTTATTTTGCAAGGTGTGCAAACCGCCTTACAAGGGCAATCGGAAATCGGTTTAACCGATCAAGT
GAATGAGCCGTTGCCGAGTTATCAGCGAGATACCAATCGCATGGCGGCGGGTGGTAATAGCTTTTTAGCGCCGCAACAAG
CGGTCGAATTTTCCGAAAATTTTGTAAAACCGACCGCTTCTCGTATGCCGAGCTATTCTCCTCGTACAACAAGTGTCTCT
AAATCGGCACAAAAATGGTATGGGGAATTAATCAGCCAGCCGCAACCCCAATCGGATAACAGACAAGATTTCGTTGAACC
GAAAACCAATGCGGCACCGGTGATTTTTGCTCAAGAGAGAGTGGAAGCCGAACATAAGCCGATACAATCCGTACCGATGA
AATCAGACCATTGGCAGCCGTTAGCTATCGTGCAAAATCAGGCTTTGTTATTAAAAGCGGATCAACAATTCTATTTAATC
TCACTAGAAAAATTGGCGCGTTTGCGATTTCAAACACAACTTGCGAAAGGAGAAAGTCAAGCGTTATTGATTCCGCTCAA
TTTAAGTTTGGATGAAGTGCAGGCGCAACATTGGCAAATACTTAAAGCCCCATTGGCGGAGTTAGGCTTTGTGATTAGCG
AAAAAGCATGGCAAGGACAAATTCGGCTTTCGCTTTCACAGGTACCGAGATTGTTAAGAGAACAAAATTTACAACAAATT
TTATTAGGGTTATTAACTGCACAAGCGGTCGATTTAGTCGAATTTTTTGCAAAATTTGCGCCGATTCCGACATCTTATAG
TTTGGCGGAAGCGGTTAATTGGTTGGCGGAAACCGAACAGTCGGCTAAATCGGAACTGGAAAAACTAAAAGTAGCGGTGG
ATTTTTCAGCATTTTTAGCAATTTGTTAG

Upstream 100 bases:

>100_bases
TTATTTACGTATTAAGCGTGTGGAAACGCCTTTTTCTATAAAAACGCGGATATTTTCGCTAGAATGGGCGTTATATTTTT
ATTGTTATTCGAGAAATAGT

Downstream 100 bases:

>100_bases
ACTGTTCAATTTGCAATAATCCCATAATTTAATTATGGTTAAGTTATTGATTTTGTTAAATTTTTGTGAAATATGTCATA
AAATTGATAAAAGATTGTTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MNKPLIHILPPQLANQIAAGEVVERPASVVKELVENSLDAGANQIQIDIEKGGAQLIRIRDNGCGIGKQDLALALARHAT
SKISSLEDLEMILSLGFRGEALASISSVSRLTLTSRPAGQAEAWQAYAQGREMEVEIQPASHPVGTTIEVANLFFNTPAR
RKFLRTDKTEFTHIDEVVRRIALAKPNIGFTLTHNGKTVRQYRKVQDNSVEQQQRRVAAICGDDFIQNAIHIDWQHGDLH
LHGWIGLPNISRPQNDLCYSYVNGRMMRDKTINHAIRQAYEATDMPEGNYPAFVVFLDIDPSQVDVNVHPAKHEVRFHQG
RLVHDFILQGVQTALQGQSEIGLTDQVNEPLPSYQRDTNRMAAGGNSFLAPQQAVEFSENFVKPTASRMPSYSPRTTSVS
KSAQKWYGELISQPQPQSDNRQDFVEPKTNAAPVIFAQERVEAEHKPIQSVPMKSDHWQPLAIVQNQALLLKADQQFYLI
SLEKLARLRFQTQLAKGESQALLIPLNLSLDEVQAQHWQILKAPLAELGFVISEKAWQGQIRLSLSQVPRLLREQNLQQI
LLGLLTAQAVDLVEFFAKFAPIPTSYSLAEAVNWLAETEQSAKSELEKLKVAVDFSAFLAIC

Sequences:

>Translated_622_residues
MNKPLIHILPPQLANQIAAGEVVERPASVVKELVENSLDAGANQIQIDIEKGGAQLIRIRDNGCGIGKQDLALALARHAT
SKISSLEDLEMILSLGFRGEALASISSVSRLTLTSRPAGQAEAWQAYAQGREMEVEIQPASHPVGTTIEVANLFFNTPAR
RKFLRTDKTEFTHIDEVVRRIALAKPNIGFTLTHNGKTVRQYRKVQDNSVEQQQRRVAAICGDDFIQNAIHIDWQHGDLH
LHGWIGLPNISRPQNDLCYSYVNGRMMRDKTINHAIRQAYEATDMPEGNYPAFVVFLDIDPSQVDVNVHPAKHEVRFHQG
RLVHDFILQGVQTALQGQSEIGLTDQVNEPLPSYQRDTNRMAAGGNSFLAPQQAVEFSENFVKPTASRMPSYSPRTTSVS
KSAQKWYGELISQPQPQSDNRQDFVEPKTNAAPVIFAQERVEAEHKPIQSVPMKSDHWQPLAIVQNQALLLKADQQFYLI
SLEKLARLRFQTQLAKGESQALLIPLNLSLDEVQAQHWQILKAPLAELGFVISEKAWQGQIRLSLSQVPRLLREQNLQQI
LLGLLTAQAVDLVEFFAKFAPIPTSYSLAEAVNWLAETEQSAKSELEKLKVAVDFSAFLAIC
>Mature_622_residues
MNKPLIHILPPQLANQIAAGEVVERPASVVKELVENSLDAGANQIQIDIEKGGAQLIRIRDNGCGIGKQDLALALARHAT
SKISSLEDLEMILSLGFRGEALASISSVSRLTLTSRPAGQAEAWQAYAQGREMEVEIQPASHPVGTTIEVANLFFNTPAR
RKFLRTDKTEFTHIDEVVRRIALAKPNIGFTLTHNGKTVRQYRKVQDNSVEQQQRRVAAICGDDFIQNAIHIDWQHGDLH
LHGWIGLPNISRPQNDLCYSYVNGRMMRDKTINHAIRQAYEATDMPEGNYPAFVVFLDIDPSQVDVNVHPAKHEVRFHQG
RLVHDFILQGVQTALQGQSEIGLTDQVNEPLPSYQRDTNRMAAGGNSFLAPQQAVEFSENFVKPTASRMPSYSPRTTSVS
KSAQKWYGELISQPQPQSDNRQDFVEPKTNAAPVIFAQERVEAEHKPIQSVPMKSDHWQPLAIVQNQALLLKADQQFYLI
SLEKLARLRFQTQLAKGESQALLIPLNLSLDEVQAQHWQILKAPLAELGFVISEKAWQGQIRLSLSQVPRLLREQNLQQI
LLGLLTAQAVDLVEFFAKFAPIPTSYSLAEAVNWLAETEQSAKSELEKLKVAVDFSAFLAIC

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=338, Percent_Identity=36.3905325443787, Blast_Score=209, Evalue=8e-54,
Organism=Homo sapiens, GI4505911, Length=373, Percent_Identity=28.1501340482574, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI189458898, Length=373, Percent_Identity=28.1501340482574, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI189458896, Length=364, Percent_Identity=27.7472527472527, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=374, Percent_Identity=26.4705882352941, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=373, Percent_Identity=26.5415549597855, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=243, Percent_Identity=31.2757201646091, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI91992160, Length=361, Percent_Identity=25.207756232687, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI91992162, Length=361, Percent_Identity=25.207756232687, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310128480, Length=335, Percent_Identity=23.8805970149254, Blast_Score=94, Evalue=6e-19,
Organism=Escherichia coli, GI1790612, Length=609, Percent_Identity=51.888341543514, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71991825, Length=325, Percent_Identity=33.8461538461538, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=354, Percent_Identity=26.8361581920904, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=345, Percent_Identity=36.5217391304348, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=370, Percent_Identity=27.027027027027, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323063, Length=360, Percent_Identity=25.2777777777778, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325093, Length=357, Percent_Identity=24.9299719887955, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136968, Length=426, Percent_Identity=32.8638497652582, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17136970, Length=351, Percent_Identity=25.3561253561254, Blast_Score=109, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 69429; Mature: 69429

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1 ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPLIHILPPQLANQIAAGEVVERPASVVKELVENSLDAGANQIQIDIEKGGAQLIRIR
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEE
DNGCGIGKQDLALALARHATSKISSLEDLEMILSLGFRGEALASISSVSRLTLTSRPAGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCC
AEAWQAYAQGREMEVEIQPASHPVGTTIEVANLFFNTPARRKFLRTDKTEFTHIDEVVRR
HHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHH
IALAKPNIGFTLTHNGKTVRQYRKVQDNSVEQQQRRVAAICGDDFIQNAIHIDWQHGDLH
HHHCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHCCCEEEEEECCCEE
LHGWIGLPNISRPQNDLCYSYVNGRMMRDKTINHAIRQAYEATDMPEGNYPAFVVFLDID
EEEEEECCCCCCCCHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
PSQVDVNVHPAKHEVRFHQGRLVHDFILQGVQTALQGQSEIGLTDQVNEPLPSYQRDTNR
CCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCH
MAAGGNSFLAPQQAVEFSENFVKPTASRMPSYSPRTTSVSKSAQKWYGELISQPQPQSDN
HCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
RQDFVEPKTNAAPVIFAQERVEAEHKPIQSVPMKSDHWQPLAIVQNQALLLKADQQFYLI
CCCCCCCCCCCCCEEEEHHHHHHHCCCHHCCCCCCCCCCCEEEECCCEEEEECCCCEEEE
SLEKLARLRFQTQLAKGESQALLIPLNLSLDEVQAQHWQILKAPLAELGFVISEKAWQGQ
EHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IRLSLSQVPRLLREQNLQQILLGLLTAQAVDLVEFFAKFAPIPTSYSLAEAVNWLAETEQ
EEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SAKSELEKLKVAVDFSAFLAIC
HHHHHHHHHHHHEEHHHHHHCC
>Mature Secondary Structure
MNKPLIHILPPQLANQIAAGEVVERPASVVKELVENSLDAGANQIQIDIEKGGAQLIRIR
CCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEE
DNGCGIGKQDLALALARHATSKISSLEDLEMILSLGFRGEALASISSVSRLTLTSRPAGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEECCCCCC
AEAWQAYAQGREMEVEIQPASHPVGTTIEVANLFFNTPARRKFLRTDKTEFTHIDEVVRR
HHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHH
IALAKPNIGFTLTHNGKTVRQYRKVQDNSVEQQQRRVAAICGDDFIQNAIHIDWQHGDLH
HHHCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHCCCEEEEEECCCEE
LHGWIGLPNISRPQNDLCYSYVNGRMMRDKTINHAIRQAYEATDMPEGNYPAFVVFLDID
EEEEEECCCCCCCCHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
PSQVDVNVHPAKHEVRFHQGRLVHDFILQGVQTALQGQSEIGLTDQVNEPLPSYQRDTNR
CCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCH
MAAGGNSFLAPQQAVEFSENFVKPTASRMPSYSPRTTSVSKSAQKWYGELISQPQPQSDN
HCCCCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
RQDFVEPKTNAAPVIFAQERVEAEHKPIQSVPMKSDHWQPLAIVQNQALLLKADQQFYLI
CCCCCCCCCCCCCEEEEHHHHHHHCCCHHCCCCCCCCCCCEEEECCCEEEEECCCCEEEE
SLEKLARLRFQTQLAKGESQALLIPLNLSLDEVQAQHWQILKAPLAELGFVISEKAWQGQ
EHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IRLSLSQVPRLLREQNLQQILLGLLTAQAVDLVEFFAKFAPIPTSYSLAEAVNWLAETEQ
EEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SAKSELEKLKVAVDFSAFLAIC
HHHHHHHHHHHHEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA