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The map label for this gene is adhI [H]

Identifier: 126209413

GI number: 126209413

Start: 2189591

End: 2190640

Strand: Direct

Name: adhI [H]

Synonym: APL_1959

Alternate gene names: 126209413

Gene position: 2189591-2190640 (Clockwise)

Preceding gene: 126209412

Following gene: 126209414

Centisome position: 96.27

GC content: 49.43

Gene sequence:

>1050_bases
ATGATGAAAATGCGTGCTGCTGTGGTTGCCCCACAATGTGATGGAACAGTTGAAATTGTTGAACGTGACATTCCTGAAAT
CAAAAATGGCGAAGCCCTTGTAGAAGTTGAATATTGCGGTGTATGTCATACCGATTTACACGTCGCTGCCGGTGATTACG
GTAAAAAACCGGGGCGTATATTAGGTCATGAAGGGATCGGTATCGTTAAATCGATCGCACCGGATGTGACTAATTTAAAA
GTCGGTGATCGTGTCAGTATTGCATGGATGTTCGAGAGCTGCGGCTCGTGCGAATATTGCACTACCGGACGTGAAACGCT
TTGCCGTAGCGTGAAAAATGCCGGCTATACGGTGGACGGCGGTATGGCGACGCACTGTGTCGTAACGGCAGATTATGCGG
TAAAAGTACCGGACGGTTTGGATCCGGCACAAGCAAGTAGTATCACTTGCGCCGGTGTAACCACTTATAAAGGGATTAAA
GTCTCGGGCGTACGTGCGGGACAATGGATTGCGATTTACGGTGCCGGCGGTTTAGGCAACTTGGCGGTGCAATATGCGAA
GAAAGTATTCGGCGCACGTGTGATTGCAATCGATATTAATGATGACAAACTGGCGTTTGCCAAAGAAGTCGGTGCGGATT
TAACCATTAACCCGTTGAAAGAAGACAGCGTACAAGTGATTCAAGAAAAAGTCGGCGGTGCGCATGCGGCGGTTGTGACG
GCGGTATCTAAAGTGGCGTTTAACGCTGCGGTGAACTGCGTTCGAGCAGGCGGTCGCGTGGTGGCTATCGGTCTGCCGCC
GGAAACCATGGATCTCTCTATCCCTCGTATCGTATTGGACGGTATCGAAATTGTCGGCTCGTTGGTCGGTACTCGTCAAG
ATCTTGCCGAGGCGTTCCAATTCGGTGCGGAAGGTTTAGTAGTACCGTTAGTGCAATTACGTCGCTTGGACGAAGCGAAT
GACATTTTCCAAGAAATGCGTGACGGTAAAATTCAAGGTCGAATGGTGATCGATATGAAAAAAGGCTGCGGTTGCGGTTG
TAGTCACTAA

Upstream 100 bases:

>100_bases
ACAAAAAAAGTACATGGGCATACTAAAGGCAGTTCTAATGTTTAAATACTAAACATTGTACGAAAGCGTTTACCGTTGTT
TTTACTTCATAGGAGAAATC

Downstream 100 bases:

>100_bases
GCCTTAATCGGCAAGCGGTCGTAAGTCGGAAGATTTACGACCGTTTTTGTTTTTATGTTTAATTATGCCGATTTGGGCTT
TTGGCAAATTTCCGTTAAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MMKMRAAVVAPQCDGTVEIVERDIPEIKNGEALVEVEYCGVCHTDLHVAAGDYGKKPGRILGHEGIGIVKSIAPDVTNLK
VGDRVSIAWMFESCGSCEYCTTGRETLCRSVKNAGYTVDGGMATHCVVTADYAVKVPDGLDPAQASSITCAGVTTYKGIK
VSGVRAGQWIAIYGAGGLGNLAVQYAKKVFGARVIAIDINDDKLAFAKEVGADLTINPLKEDSVQVIQEKVGGAHAAVVT
AVSKVAFNAAVNCVRAGGRVVAIGLPPETMDLSIPRIVLDGIEIVGSLVGTRQDLAEAFQFGAEGLVVPLVQLRRLDEAN
DIFQEMRDGKIQGRMVIDMKKGCGCGCSH

Sequences:

>Translated_349_residues
MMKMRAAVVAPQCDGTVEIVERDIPEIKNGEALVEVEYCGVCHTDLHVAAGDYGKKPGRILGHEGIGIVKSIAPDVTNLK
VGDRVSIAWMFESCGSCEYCTTGRETLCRSVKNAGYTVDGGMATHCVVTADYAVKVPDGLDPAQASSITCAGVTTYKGIK
VSGVRAGQWIAIYGAGGLGNLAVQYAKKVFGARVIAIDINDDKLAFAKEVGADLTINPLKEDSVQVIQEKVGGAHAAVVT
AVSKVAFNAAVNCVRAGGRVVAIGLPPETMDLSIPRIVLDGIEIVGSLVGTRQDLAEAFQFGAEGLVVPLVQLRRLDEAN
DIFQEMRDGKIQGRMVIDMKKGCGCGCSH
>Mature_349_residues
MMKMRAAVVAPQCDGTVEIVERDIPEIKNGEALVEVEYCGVCHTDLHVAAGDYGKKPGRILGHEGIGIVKSIAPDVTNLK
VGDRVSIAWMFESCGSCEYCTTGRETLCRSVKNAGYTVDGGMATHCVVTADYAVKVPDGLDPAQASSITCAGVTTYKGIK
VSGVRAGQWIAIYGAGGLGNLAVQYAKKVFGARVIAIDINDDKLAFAKEVGADLTINPLKEDSVQVIQEKVGGAHAAVVT
AVSKVAFNAAVNCVRAGGRVVAIGLPPETMDLSIPRIVLDGIEIVGSLVGTRQDLAEAFQFGAEGLVVPLVQLRRLDEAN
DIFQEMRDGKIQGRMVIDMKKGCGCGCSH

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=28.6885245901639, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=28.2548476454294, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=27.7008310249307, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=26.8698060941828, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=26.8698060941828, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565154, Length=248, Percent_Identity=34.2741935483871, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=26.8817204301075, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156523966, Length=365, Percent_Identity=27.6712328767123, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=27.6712328767123, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI156627571, Length=327, Percent_Identity=26.2996941896024, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI28557745, Length=271, Percent_Identity=26.9372693726937, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI194239674, Length=315, Percent_Identity=23.4920634920635, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI13236495, Length=315, Percent_Identity=23.4920634920635, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=68.2492581602374, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1790045, Length=325, Percent_Identity=27.0769230769231, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=27.9883381924198, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788073, Length=275, Percent_Identity=30.5454545454545, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787863, Length=317, Percent_Identity=29.0220820189274, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=32.3287671232877, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786518, Length=358, Percent_Identity=26.8156424581006, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI226510992, Length=301, Percent_Identity=27.2425249169435, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=26.865671641791, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788075, Length=328, Percent_Identity=26.8292682926829, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082125, Length=354, Percent_Identity=26.271186440678, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788407, Length=214, Percent_Identity=30.3738317757009, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786825, Length=244, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=36.8421052631579, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=34.0175953079179, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=34.8973607038123, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562876, Length=262, Percent_Identity=30.9160305343511, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=207, Percent_Identity=34.2995169082126, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=236, Percent_Identity=28.3898305084746, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=227, Percent_Identity=27.3127753303965, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=211, Percent_Identity=28.9099526066351, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=346, Percent_Identity=38.728323699422, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=38.8405797101449, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=37.6093294460641, Blast_Score=219, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=38.728323699422, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320033, Length=354, Percent_Identity=31.0734463276836, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=28.0597014925373, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=307, Percent_Identity=29.9674267100977, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=307, Percent_Identity=29.6416938110749, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323980, Length=318, Percent_Identity=27.6729559748428, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=299, Percent_Identity=26.0869565217391, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=349, Percent_Identity=23.7822349570201, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=315, Percent_Identity=25.3968253968254, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17737897, Length=225, Percent_Identity=29.7777777777778, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17137530, Length=226, Percent_Identity=29.646017699115, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737895, Length=237, Percent_Identity=31.2236286919831, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36768; Mature: 36768

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKMRAAVVAPQCDGTVEIVERDIPEIKNGEALVEVEYCGVCHTDLHVAAGDYGKKPGRI
CCCCCEEEECCCCCCHHHHHHCCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCCE
LGHEGIGIVKSIAPDVTNLKVGDRVSIAWMFESCGSCEYCTTGRETLCRSVKNAGYTVDG
ECCCCCCHHHHHCCCCCCEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCEEECC
GMATHCVVTADYAVKVPDGLDPAQASSITCAGVTTYKGIKVSGVRAGQWIAIYGAGGLGN
CCEEEEEEEECEEEECCCCCCCCCCCCEEEECEEEECCEEEECEECCCEEEEEECCCCHH
LAVQYAKKVFGARVIAIDINDDKLAFAKEVGADLTINPLKEDSVQVIQEKVGGAHAAVVT
HHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHCCHHHHHHH
AVSKVAFNAAVNCVRAGGRVVAIGLPPETMDLSIPRIVLDGIEIVGSLVGTRQDLAEAFQ
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
FGAEGLVVPLVQLRRLDEANDIFQEMRDGKIQGRMVIDMKKGCGCGCSH
CCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MMKMRAAVVAPQCDGTVEIVERDIPEIKNGEALVEVEYCGVCHTDLHVAAGDYGKKPGRI
CCCCCEEEECCCCCCHHHHHHCCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCCE
LGHEGIGIVKSIAPDVTNLKVGDRVSIAWMFESCGSCEYCTTGRETLCRSVKNAGYTVDG
ECCCCCCHHHHHCCCCCCEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCEEECC
GMATHCVVTADYAVKVPDGLDPAQASSITCAGVTTYKGIKVSGVRAGQWIAIYGAGGLGN
CCEEEEEEEECEEEECCCCCCCCCCCCEEEECEEEECCEEEECEECCCEEEEEECCCCHH
LAVQYAKKVFGARVIAIDINDDKLAFAKEVGADLTINPLKEDSVQVIQEKVGGAHAAVVT
HHHHHHHHHHCCEEEEEEECCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHCCHHHHHHH
AVSKVAFNAAVNCVRAGGRVVAIGLPPETMDLSIPRIVLDGIEIVGSLVGTRQDLAEAFQ
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
FGAEGLVVPLVQLRRLDEANDIFQEMRDGKIQGRMVIDMKKGCGCGCSH
CCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]