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The map label for this gene is dtd

Identifier: 126209407

GI number: 126209407

Start: 2179788

End: 2180222

Strand: Reverse

Name: dtd

Synonym: APL_1949

Alternate gene names: 126209407

Gene position: 2180222-2179788 (Counterclockwise)

Preceding gene: 126209408

Following gene: 126209404

Centisome position: 95.86

GC content: 44.83

Gene sequence:

>435_bases
ATGATCGGCTTAATCCAACGTGTAAAATGGGCAAAAGTGGAAGTGGAAGGCCAAACGGTCGGTGAAATCACACAAGGTTT
ATTGGTATTACTCGGTGTAGAACAGGGTGACGACCAAGCTAAAGCGGATAAATTACTTGAAAAGGTACTTAACTATCGAG
TGTTTTCCGACGAGCAAGGCAAAATGAACTTAAACGTACAACAAGCCGGCGGCAGTTTATTAGTGGTATCGCAATTTACT
TTAGCCGCCGATACCAACAAAGGTTTACGCCCAAGTTTTTCGCGTGGTGCAGCCCCACAGGAAGCGAATGCGTTATACGA
ATATTTTCATCAGCAAGCCGCTCGGAAAATCCATACTCAAACCGGACAATTCGCAGCGGATATGCAAGTCAGTTTGCAAA
ATGACGGACCGGTGACTTTTTGGCTACAGATCTAA

Upstream 100 bases:

>100_bases
TGTTATGGATTCATTTGAGCTGGCAAGTAGTACTGTTCGGCGGACTAATTACCTCTACTCTAAATGTATATAATGAAATG
AAAAAAGGAAAACTCAATTT

Downstream 100 bases:

>100_bases
AACGAAAAAAGGTGCAATGAATTGCACCTTTTTACTTAATAGAAAAATTGTTGTCCTCGGCTGCCGTCACATTGGTAAAT
CGCCAGTTTGTTACCTTGTT

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MIGLIQRVKWAKVEVEGQTVGEITQGLLVLLGVEQGDDQAKADKLLEKVLNYRVFSDEQGKMNLNVQQAGGSLLVVSQFT
LAADTNKGLRPSFSRGAAPQEANALYEYFHQQAARKIHTQTGQFAADMQVSLQNDGPVTFWLQI

Sequences:

>Translated_144_residues
MIGLIQRVKWAKVEVEGQTVGEITQGLLVLLGVEQGDDQAKADKLLEKVLNYRVFSDEQGKMNLNVQQAGGSLLVVSQFT
LAADTNKGLRPSFSRGAAPQEANALYEYFHQQAARKIHTQTGQFAADMQVSLQNDGPVTFWLQI
>Mature_144_residues
MIGLIQRVKWAKVEVEGQTVGEITQGLLVLLGVEQGDDQAKADKLLEKVLNYRVFSDEQGKMNLNVQQAGGSLLVVSQFT
LAADTNKGLRPSFSRGAAPQEANALYEYFHQQAARKIHTQTGQFAADMQVSLQNDGPVTFWLQI

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=147, Percent_Identity=38.0952380952381, Blast_Score=93, Evalue=9e-20,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=68.9655172413793, Blast_Score=209, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI115533292, Length=140, Percent_Identity=39.2857142857143, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319982, Length=143, Percent_Identity=37.7622377622378, Blast_Score=97, Evalue=7e-22,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=38.3561643835616, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_ACTP2 (A3N3P1)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054632.1
- ProteinModelPortal:   A3N3P1
- SMR:   A3N3P1
- STRING:   A3N3P1
- GeneID:   4848578
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1949
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   A3N3P1
- ProtClustDB:   PRK05273
- BioCyc:   APLE416269:APL_1949-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15862; Mature: 15862

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLIQRVKWAKVEVEGQTVGEITQGLLVLLGVEQGDDQAKADKLLEKVLNYRVFSDEQG
CCCHHHHCEEEEEEECCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCEEECCCCC
KMNLNVQQAGGSLLVVSQFTLAADTNKGLRPSFSRGAAPQEANALYEYFHQQAARKIHTQ
CEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
TGQFAADMQVSLQNDGPVTFWLQI
CCCEEEEEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MIGLIQRVKWAKVEVEGQTVGEITQGLLVLLGVEQGDDQAKADKLLEKVLNYRVFSDEQG
CCCHHHHCEEEEEEECCCCHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCEEECCCCC
KMNLNVQQAGGSLLVVSQFTLAADTNKGLRPSFSRGAAPQEANALYEYFHQQAARKIHTQ
CEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
TGQFAADMQVSLQNDGPVTFWLQI
CCCEEEEEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA