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The map label for this gene is panF [H]

Identifier: 126209375

GI number: 126209375

Start: 2149362

End: 2150774

Strand: Reverse

Name: panF [H]

Synonym: APL_1915

Alternate gene names: 126209375

Gene position: 2150774-2149362 (Counterclockwise)

Preceding gene: 126209376

Following gene: 126209368

Centisome position: 94.56

GC content: 45.51

Gene sequence:

>1413_bases
ATGTTATTGCCGTTAATCGCTTATTTATGCTTTGTGTTCGGTGTCGCTTTTTATGCTTATCGTAAACGCCAAGGCGGTAG
CTTTTTATCCGAATATTACGTAGGCAGTCGCTCAATGTCCGGTTTTGTGTTGGCGATGACCACCGCCGCGACTTATGTCG
GGGCGAGTTCGTTTATCGGCGGCCCGGGTGCGGCTTATAAATACGGATTAGGCTGGGTATTACTCGCGATGATTCAAGTA
CCGGCGGTATTGCTGGCGTTAGGAGCGTTGGGTAAAAAATTCGCCTTACTCGCCCGCCAATATAATGCGGTAACTATCAA
CGATTTATTATTGGCTCGTTATCAAAATAAATTCGTGGTGTGGATTTCCGGCTTTGCCTTGTTGCTTTCATTCTTTGCGA
TGATGACGGTACAGTTTATCGGTGCCGGTCGCTTACTGGAAACCACCTTAGGCGTACCGTATCAAACTGCAGTAATTATT
TTTGCGATAACTGTCGGAATTTATACTTTTATCGGCGGTTTCCGTGCGGTAGTGCTAACCGATACGATTCAAGGGTTAGT
GATGTTAGTCGGTACATCGTTATTGTTGGGCGGCGTAATTTATGCCGCCGGCGGTGTAGAGAATGCGGTAAATACGTTGG
AAAGCATTAATCCGCAATTAATCGAGCCGTATGGCATTGACGAACGTCCGCTGGATTTTACCTTTATGACCTCGTTCTGG
GTATTGGTCTGCTTCGGTTTAATCGGTTTACCGCAACTTGCGGTACGCAGTATGGCGTATAAAGACAGCGCTTCTTTACA
TAAAGCGCTCGTTATCGGTACGTTAGTGGTATCGTTGCTGATGTTCGGTATGCACCTTGCCGGTGTGCTTGGACGTGCGG
TCATTCCCGATTTAAAAATTCCGGATCAGGTCATCCCGACCCTAATGATTCAGGTACTACCGCCACTGGTTGCCGGTATA
TTCTTGGCGGCACCGATGGCGGCGATTATGTCGTCGATTGACTCGTTATTAATTCAATCGTCTTCCACCCTAATCAAAGA
TTTATATTTAGCAGTGAAGCCGGAAGCAGTCAATAACGAAGCTAAGTTAAAACGCTTCTCAACCATGACCACGCTTACTT
TTGCGGTGTTATTAGTGTTTGCGGCGTTAAATCCGCCGGATATGTTAATTTGGCTTAACTTACTTTCGCTCGGCGGCTTA
GAAGCGACATTCTTATGGGTCATCGTATTAGGGCTTTACTGGAAAAATGCGAATGCAGCCGGTGCGATTAGCTCGATGTT
GGCAGGTTTAACAAGTTATGTGATTTTCACTAGCTTTAAAATCAGTATTTTGAGCTTCCATGCGATTGTACCGTCGTTAG
TGATCGGTTTAATCGCTTTCTTAATCGGCAATCGTTTCGGTAAAAAATCGTAA

Upstream 100 bases:

>100_bases
ATCGCTCTGCCGCTCGGTTTTACCGCCGTCGTGTATTGGACGGTCAAAAAAGTTTATCAAGACATTGATTTAAATAAGTA
ACATAGCAATGAATAAAGAG

Downstream 100 bases:

>100_bases
TCGGTAACAGCGGTTTTTAACCAACCGAATCGTAAAAAGGCATAGGTTCCCAACCTATGCCTTTCTTTTTAGTTAAGCAA
AGAAGCTACTACAATGACTA

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MLLPLIAYLCFVFGVAFYAYRKRQGGSFLSEYYVGSRSMSGFVLAMTTAATYVGASSFIGGPGAAYKYGLGWVLLAMIQV
PAVLLALGALGKKFALLARQYNAVTINDLLLARYQNKFVVWISGFALLLSFFAMMTVQFIGAGRLLETTLGVPYQTAVII
FAITVGIYTFIGGFRAVVLTDTIQGLVMLVGTSLLLGGVIYAAGGVENAVNTLESINPQLIEPYGIDERPLDFTFMTSFW
VLVCFGLIGLPQLAVRSMAYKDSASLHKALVIGTLVVSLLMFGMHLAGVLGRAVIPDLKIPDQVIPTLMIQVLPPLVAGI
FLAAPMAAIMSSIDSLLIQSSSTLIKDLYLAVKPEAVNNEAKLKRFSTMTTLTFAVLLVFAALNPPDMLIWLNLLSLGGL
EATFLWVIVLGLYWKNANAAGAISSMLAGLTSYVIFTSFKISILSFHAIVPSLVIGLIAFLIGNRFGKKS

Sequences:

>Translated_470_residues
MLLPLIAYLCFVFGVAFYAYRKRQGGSFLSEYYVGSRSMSGFVLAMTTAATYVGASSFIGGPGAAYKYGLGWVLLAMIQV
PAVLLALGALGKKFALLARQYNAVTINDLLLARYQNKFVVWISGFALLLSFFAMMTVQFIGAGRLLETTLGVPYQTAVII
FAITVGIYTFIGGFRAVVLTDTIQGLVMLVGTSLLLGGVIYAAGGVENAVNTLESINPQLIEPYGIDERPLDFTFMTSFW
VLVCFGLIGLPQLAVRSMAYKDSASLHKALVIGTLVVSLLMFGMHLAGVLGRAVIPDLKIPDQVIPTLMIQVLPPLVAGI
FLAAPMAAIMSSIDSLLIQSSSTLIKDLYLAVKPEAVNNEAKLKRFSTMTTLTFAVLLVFAALNPPDMLIWLNLLSLGGL
EATFLWVIVLGLYWKNANAAGAISSMLAGLTSYVIFTSFKISILSFHAIVPSLVIGLIAFLIGNRFGKKS
>Mature_470_residues
MLLPLIAYLCFVFGVAFYAYRKRQGGSFLSEYYVGSRSMSGFVLAMTTAATYVGASSFIGGPGAAYKYGLGWVLLAMIQV
PAVLLALGALGKKFALLARQYNAVTINDLLLARYQNKFVVWISGFALLLSFFAMMTVQFIGAGRLLETTLGVPYQTAVII
FAITVGIYTFIGGFRAVVLTDTIQGLVMLVGTSLLLGGVIYAAGGVENAVNTLESINPQLIEPYGIDERPLDFTFMTSFW
VLVCFGLIGLPQLAVRSMAYKDSASLHKALVIGTLVVSLLMFGMHLAGVLGRAVIPDLKIPDQVIPTLMIQVLPPLVAGI
FLAAPMAAIMSSIDSLLIQSSSTLIKDLYLAVKPEAVNNEAKLKRFSTMTTLTFAVLLVFAALNPPDMLIWLNLLSLGGL
EATFLWVIVLGLYWKNANAAGAISSMLAGLTSYVIFTSFKISILSFHAIVPSLVIGLIAFLIGNRFGKKS

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=447, Percent_Identity=29.3064876957494, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI14140236, Length=470, Percent_Identity=21.063829787234, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4507033, Length=402, Percent_Identity=23.8805970149254, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI17941285, Length=469, Percent_Identity=24.3070362473348, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI110835708, Length=477, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI87082237, Length=469, Percent_Identity=63.3262260127932, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1787251, Length=492, Percent_Identity=27.8455284552846, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1790503, Length=447, Percent_Identity=20.8053691275168, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790113, Length=458, Percent_Identity=23.1441048034935, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 50504; Mature: 50504

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPLIAYLCFVFGVAFYAYRKRQGGSFLSEYYVGSRSMSGFVLAMTTAATYVGASSFIG
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHCCC
GPGAAYKYGLGWVLLAMIQVPAVLLALGALGKKFALLARQYNAVTINDLLLARYQNKFVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCEEE
WISGFALLLSFFAMMTVQFIGAGRLLETTLGVPYQTAVIIFAITVGIYTFIGGFRAVVLT
EHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTIQGLVMLVGTSLLLGGVIYAAGGVENAVNTLESINPQLIEPYGIDERPLDFTFMTSFW
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHH
VLVCFGLIGLPQLAVRSMAYKDSASLHKALVIGTLVVSLLMFGMHLAGVLGRAVIPDLKI
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDQVIPTLMIQVLPPLVAGIFLAAPMAAIMSSIDSLLIQSSSTLIKDLYLAVKPEAVNNE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCH
AKLKRFSTMTTLTFAVLLVFAALNPPDMLIWLNLLSLGGLEATFLWVIVLGLYWKNANAA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHH
GAISSMLAGLTSYVIFTSFKISILSFHAIVPSLVIGLIAFLIGNRFGKKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLLPLIAYLCFVFGVAFYAYRKRQGGSFLSEYYVGSRSMSGFVLAMTTAATYVGASSFIG
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHCCC
GPGAAYKYGLGWVLLAMIQVPAVLLALGALGKKFALLARQYNAVTINDLLLARYQNKFVV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCEEE
WISGFALLLSFFAMMTVQFIGAGRLLETTLGVPYQTAVIIFAITVGIYTFIGGFRAVVLT
EHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTIQGLVMLVGTSLLLGGVIYAAGGVENAVNTLESINPQLIEPYGIDERPLDFTFMTSFW
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHH
VLVCFGLIGLPQLAVRSMAYKDSASLHKALVIGTLVVSLLMFGMHLAGVLGRAVIPDLKI
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDQVIPTLMIQVLPPLVAGIFLAAPMAAIMSSIDSLLIQSSSTLIKDLYLAVKPEAVNNE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCH
AKLKRFSTMTTLTFAVLLVFAALNPPDMLIWLNLLSLGGLEATFLWVIVLGLYWKNANAA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHH
GAISSMLAGLTSYVIFTSFKISILSFHAIVPSLVIGLIAFLIGNRFGKKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]