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The map label for this gene is lldD

Identifier: 126209311

GI number: 126209311

Start: 2079893

End: 2081038

Strand: Reverse

Name: lldD

Synonym: APL_1849

Alternate gene names: 126209311

Gene position: 2081038-2079893 (Counterclockwise)

Preceding gene: 126209312

Following gene: 126209306

Centisome position: 91.5

GC content: 49.65

Gene sequence:

>1146_bases
ATGATTATTTCATCAGCCAATGACTATCGTGAAGCGGCGCGTCGCCGCGTTCCCCCGTTTATGTTTCATTATGCGGACGG
CGGATCATTCTCTGAACGCACGTTAGAACGTAACGTAACTGATCTTGCCGATCTGGCATTACGTCAGCGCGTATTAAAAG
ATATGTCACAGCTTGATACCGAAATCGAATTATTCGGGGAAAAACTGGCGATGCCGGCGGTATTAGCACCGGTGGGCGCT
TGCGGTATGTATGCTCGCCGTGGCGAAGTGCAGGCGGCGCAGGCGGCGGAAAATAAAGGCATTCCGTTCACGCTTTCCAC
GGTATCAATTTGCCCGATTGAAGAAGTGACCGCTGCAATTAAACGCCCGATGTGGTTCCAGCTTTATGTGCTAAAAGACC
GCGGTTTTATGAAACACGTGTTAGAACGTGCCAAAGCGGCAGGTTGTTCAACCTTAGTGTTTACCGTGGATATGCCGACA
CCGGGCGCACGTTATCGTGATCGCCATTCGGGTATGAGCGGTGATTACAAAGAAATTCGCCGTGCATTACAAGCGGTAAC
TCACCCGTTCTGGGCGTGGGATGTCGGTATTAAAGGTAAACCGCATACGCTTGGTAACGTTTCGGCTTATACCGGTAAAG
CGGTGGGTTTAGATGATTACGTGGTGTGGTTAGGCGAAAACTTCGACCCGTCAATTTCGTGGAAAGATTTGGAATGGATT
CGTGATTTCTGGGACGGTCCGATGGTAATCAAGGGCATTTTAGATCCTGAAGATGCGAAAGATGCGGTACGTTTCGGCGC
AGACGGTATTGTGGTTTCAAATCACGGCGGTCGCCAACTAGACGGTGCATTATCCAGCGCAAGAGCTTTACCTTCGATTG
CCGATGCGGTAAAAGGCGATATTAAGATTCTTGCCGACTCGGGCATTCGTAACGGTTTAGATATTGTACGTATGCTCGCA
TTAGGCGCGGACGCTACTATGCTCGGACGTGCGTTTGTGTACGCTCTCGGCGCAGCGGGCAAAGCCGGCGTGGAAAATAT
GTTAGATATTTTCAAGAAAGAAATGCACGTTGCAATGACCCTTACCAGCAACCAAAAAATCAGCGACATCACCCGTGATG
CACTGGTTGATTTAAGCAAGCTGTAA

Upstream 100 bases:

>100_bases
CAAAAAATTTACATCTAATTATATCCTTATTAACAATTTTGATTTAAAATCTAAATGCTAATTATTTCTATTTTAATTAA
AACAGTATAAGGAAGTATCT

Downstream 100 bases:

>100_bases
TATCATTTCTCAATATAAGAAAGCGGTTAAATTTGCAAACTTTTAGGCAAAATTAACCGCTTATCTCTATATCTAACCTT
CATACAACCTAGATCATAAA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIISSANDYREAARRRVPPFMFHYADGGSFSERTLERNVTDLADLALRQRVLKDMSQLDTEIELFGEKLAMPAVLAPVGA
CGMYARRGEVQAAQAAENKGIPFTLSTVSICPIEEVTAAIKRPMWFQLYVLKDRGFMKHVLERAKAAGCSTLVFTVDMPT
PGARYRDRHSGMSGDYKEIRRALQAVTHPFWAWDVGIKGKPHTLGNVSAYTGKAVGLDDYVVWLGENFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGALSSARALPSIADAVKGDIKILADSGIRNGLDIVRMLA
LGADATMLGRAFVYALGAAGKAGVENMLDIFKKEMHVAMTLTSNQKISDITRDALVDLSKL

Sequences:

>Translated_381_residues
MIISSANDYREAARRRVPPFMFHYADGGSFSERTLERNVTDLADLALRQRVLKDMSQLDTEIELFGEKLAMPAVLAPVGA
CGMYARRGEVQAAQAAENKGIPFTLSTVSICPIEEVTAAIKRPMWFQLYVLKDRGFMKHVLERAKAAGCSTLVFTVDMPT
PGARYRDRHSGMSGDYKEIRRALQAVTHPFWAWDVGIKGKPHTLGNVSAYTGKAVGLDDYVVWLGENFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGALSSARALPSIADAVKGDIKILADSGIRNGLDIVRMLA
LGADATMLGRAFVYALGAAGKAGVENMLDIFKKEMHVAMTLTSNQKISDITRDALVDLSKL
>Mature_381_residues
MIISSANDYREAARRRVPPFMFHYADGGSFSERTLERNVTDLADLALRQRVLKDMSQLDTEIELFGEKLAMPAVLAPVGA
CGMYARRGEVQAAQAAENKGIPFTLSTVSICPIEEVTAAIKRPMWFQLYVLKDRGFMKHVLERAKAAGCSTLVFTVDMPT
PGARYRDRHSGMSGDYKEIRRALQAVTHPFWAWDVGIKGKPHTLGNVSAYTGKAVGLDDYVVWLGENFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGALSSARALPSIADAVKGDIKILADSGIRNGLDIVRMLA
LGADATMLGRAFVYALGAAGKAGVENMLDIFKKEMHVAMTLTSNQKISDITRDALVDLSKL

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI54234014, Length=382, Percent_Identity=32.9842931937173, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI7705393, Length=382, Percent_Identity=32.9842931937173, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI11068137, Length=370, Percent_Identity=32.1621621621622, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=77.1276595744681, Blast_Score=617, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI193208036, Length=382, Percent_Identity=32.4607329842932, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI32566217, Length=287, Percent_Identity=31.3588850174216, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=385, Percent_Identity=28.051948051948, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI78707188, Length=381, Percent_Identity=34.9081364829396, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281363140, Length=381, Percent_Identity=34.9081364829396, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI78707190, Length=381, Percent_Identity=34.9081364829396, Blast_Score=202, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_ACTP2 (A3N3E5)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054536.1
- ProteinModelPortal:   A3N3E5
- SMR:   A3N3E5
- STRING:   A3N3E5
- GeneID:   4849717
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1849
- eggNOG:   COG1304
- HOGENOM:   HBG517781
- OMA:   WIREFWE
- PhylomeDB:   A3N3E5
- ProtClustDB:   PRK11197
- BioCyc:   APLE416269:APL_1849-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 41753; Mature: 41753

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSANDYREAARRRVPPFMFHYADGGSFSERTLERNVTDLADLALRQRVLKDMSQLDT
CCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIELFGEKLAMPAVLAPVGACGMYARRGEVQAAQAAENKGIPFTLSTVSICPIEEVTAAI
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLKDRGFMKHVLERAKAAGCSTLVFTVDMPTPGARYRDRHSGMSGDYKEIR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCCCCCHHHHH
RALQAVTHPFWAWDVGIKGKPHTLGNVSAYTGKAVGLDDYVVWLGENFDPSISWKDLEWI
HHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGALSSARALPSIADAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCHHHHHHHCCC
IKILADSGIRNGLDIVRMLALGADATMLGRAFVYALGAAGKAGVENMLDIFKKEMHVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEE
LTSNQKISDITRDALVDLSKL
EECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIISSANDYREAARRRVPPFMFHYADGGSFSERTLERNVTDLADLALRQRVLKDMSQLDT
CCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIELFGEKLAMPAVLAPVGACGMYARRGEVQAAQAAENKGIPFTLSTVSICPIEEVTAAI
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLKDRGFMKHVLERAKAAGCSTLVFTVDMPTPGARYRDRHSGMSGDYKEIR
CCCCEEEEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCCCCCHHHHH
RALQAVTHPFWAWDVGIKGKPHTLGNVSAYTGKAVGLDDYVVWLGENFDPSISWKDLEWI
HHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGALSSARALPSIADAVKGD
HHHCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCHHHHHHHCCC
IKILADSGIRNGLDIVRMLALGADATMLGRAFVYALGAAGKAGVENMLDIFKKEMHVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEE
LTSNQKISDITRDALVDLSKL
EECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA