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The map label for this gene is fumC [H]

Identifier: 126209221

GI number: 126209221

Start: 1994160

End: 1995554

Strand: Reverse

Name: fumC [H]

Synonym: APL_1757

Alternate gene names: 126209221

Gene position: 1995554-1994160 (Counterclockwise)

Preceding gene: 126209222

Following gene: 126209214

Centisome position: 87.74

GC content: 42.65

Gene sequence:

>1395_bases
ATGGAATTTCGTATTGAAAAAGATACCATGGGCGAAGTTCAAGTACCTGCCAATCGTTATTGGGCGGCACAAACAGAGCG
TTCACGCAATAATTTTAAAATCGGTCCCGAAGCGTCAATGCCTAAAGAAATTATTGAAGCGTTCGGTTACTTGAAAAAAG
CAGCGGCATTTGCCAACACAGATTTAGGCGTATTACCTGCGGAAAAACGTGATTTAATCGCTCAAGCCTGTGATGAGATC
CTTGCCGGTAAATTAAACGAAGAATTCCCGCTTGTAATCTGGCAAACCGGTTCCGGTACGCAATCCAATATGAACTTAAA
CGAAGTTATTGCAAACCGTGCGCATGTTATTCACGGCGGTAAATTAGGTGAAAAATCGGTAATTCACCCGAATGATGACG
TAAACAAATCACAATCGTCAAACGACACTTATCCGACAGCAATGCACATCGCCGCTTACAAAAAAGTGGTTGAACAAACT
ATCCCTGCGGTAGAACGTTTACAAAAAACCTTTGCGGCAAAATCGGAAGCATTTAAAGACGTAGTAAAAATCGGTCGCAC
GCACTTAATGGATGCGACGCCATTAACATTAGGTCAAGAATTTTCCGCTTATGCGGCACAATTACATTTCGGTTTAATCG
CACTGAAAAACACCTTACCGCATTTACGTCAAATGGCATTGGGCGGTACGGCGGTAGGTACCGGCTTAAATACACCGAAA
GGTTATGATGTAAAAGTTGCCGAATATATTGCAAAATTTACCGGTTTACCGTTTATCACGGCGGAAAATAAATTCGAAGC
ACTAGCAACCCACGATGCAATCGTTGAAACACACGGTGCGTTAAAACAAATTGCGATGTCTTTATTCAAAATTGCGAATG
ACATTCGTTTACTAGCGTCCGGTCCTCGTTCCGGTATCGGCGAAATCTTAATTCCTGAAAACGAACCGGGTTCATCAATT
ATGCCGGGTAAAGTAAATCCGACTCAATGCGAAGCGATGACGATGGTTGCGGCGCAAGTATTAGGTAACGATACCACCAT
TTCATTTGCCGGTAGCCAAGGTCACTTCCAATTAAACGTATTTAAACCGGTAATGGCGGCAAACTTCTTACAATCCGCGC
AACTTTTAGCGGATGTTTGTATTTCGTTTGACGAACATTGTGCGACAGGTATCGAACCGAATTACCAACGCATTAAGCGG
CAGCTTGACCAATCATTAATGTTGGTAACCGCATTAAATACGCATATCGGCTATGAAAATGCGGCGAAAATTGCTAAAAC
CGCACATAAAAACGGTACAACTTTAAAAGAAGAAGCGATTAACTTAGGCTTAGTGACCGCAGAACAATTCGACGAGTGGG
TTCGTCCGGAAGATATGGTGGGTAGCTTAAAATAA

Upstream 100 bases:

>100_bases
CTGTAAGCCGGTTCCTTTCTGATTATCTCAATGCTACCATCCTACCTATAACTTGTTAGTTTATTTAAGTGAAATCTACT
TTTATCCATAGGAGAACACA

Downstream 100 bases:

>100_bases
GCTAACACTTATTCTTATATGAAAAGGCTATCAAACGATAGCCTTTTTTACTATGTCAAAGTTGTAGAACAAGCGGTTAA
ATTTCAGTGTTTTTTTGCAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MEFRIEKDTMGEVQVPANRYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAFANTDLGVLPAEKRDLIAQACDEI
LAGKLNEEFPLVIWQTGSGTQSNMNLNEVIANRAHVIHGGKLGEKSVIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEQT
IPAVERLQKTFAAKSEAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLHFGLIALKNTLPHLRQMALGGTAVGTGLNTPK
GYDVKVAEYIAKFTGLPFITAENKFEALATHDAIVETHGALKQIAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVAAQVLGNDTTISFAGSQGHFQLNVFKPVMAANFLQSAQLLADVCISFDEHCATGIEPNYQRIKR
QLDQSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK

Sequences:

>Translated_464_residues
MEFRIEKDTMGEVQVPANRYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAFANTDLGVLPAEKRDLIAQACDEI
LAGKLNEEFPLVIWQTGSGTQSNMNLNEVIANRAHVIHGGKLGEKSVIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEQT
IPAVERLQKTFAAKSEAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLHFGLIALKNTLPHLRQMALGGTAVGTGLNTPK
GYDVKVAEYIAKFTGLPFITAENKFEALATHDAIVETHGALKQIAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVAAQVLGNDTTISFAGSQGHFQLNVFKPVMAANFLQSAQLLADVCISFDEHCATGIEPNYQRIKR
QLDQSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK
>Mature_464_residues
MEFRIEKDTMGEVQVPANRYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAFANTDLGVLPAEKRDLIAQACDEI
LAGKLNEEFPLVIWQTGSGTQSNMNLNEVIANRAHVIHGGKLGEKSVIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEQT
IPAVERLQKTFAAKSEAFKDVVKIGRTHLMDATPLTLGQEFSAYAAQLHFGLIALKNTLPHLRQMALGGTAVGTGLNTPK
GYDVKVAEYIAKFTGLPFITAENKFEALATHDAIVETHGALKQIAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVAAQVLGNDTTISFAGSQGHFQLNVFKPVMAANFLQSAQLLADVCISFDEHCATGIEPNYQRIKR
QLDQSLMLVTALNTHIGYENAAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=61.7391304347826, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI266458395, Length=87, Percent_Identity=48.2758620689655, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=61.3882863340564, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.9132321041215, Blast_Score=341, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=62.6898047722343, Blast_Score=604, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=63.3846153846154, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=60, Blast_Score=550, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=60.1731601731602, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=60.1731601731602, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=59.5238095238095, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=58.1896551724138, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=51.1930585683297, Blast_Score=465, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50560; Mature: 50560

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRIEKDTMGEVQVPANRYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAFANT
CCEEECCCCCCCEECCCCHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCC
DLGVLPAEKRDLIAQACDEILAGKLNEEFPLVIWQTGSGTQSNMNLNEVIANRAHVIHGG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEECC
KLGEKSVIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEQTIPAVERLQKTFAAKSEAFKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVKIGRTHLMDATPLTLGQEFSAYAAQLHFGLIALKNTLPHLRQMALGGTAVGTGLNTPK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GYDVKVAEYIAKFTGLPFITAENKFEALATHDAIVETHGALKQIAMSLFKIANDIRLLAS
CCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVAAQVLGNDTTISFAGSQGHFQLNV
CCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
FKPVMAANFLQSAQLLADVCISFDEHCATGIEPNYQRIKRQLDQSLMLVTALNTHIGYEN
HHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK
HHHHHHHHCCCCCCHHHHHHHCCEEEHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MEFRIEKDTMGEVQVPANRYWAAQTERSRNNFKIGPEASMPKEIIEAFGYLKKAAAFANT
CCEEECCCCCCCEECCCCHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCC
DLGVLPAEKRDLIAQACDEILAGKLNEEFPLVIWQTGSGTQSNMNLNEVIANRAHVIHGG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEECC
KLGEKSVIHPNDDVNKSQSSNDTYPTAMHIAAYKKVVEQTIPAVERLQKTFAAKSEAFKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVKIGRTHLMDATPLTLGQEFSAYAAQLHFGLIALKNTLPHLRQMALGGTAVGTGLNTPK
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GYDVKVAEYIAKFTGLPFITAENKFEALATHDAIVETHGALKQIAMSLFKIANDIRLLAS
CCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVAAQVLGNDTTISFAGSQGHFQLNV
CCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
FKPVMAANFLQSAQLLADVCISFDEHCATGIEPNYQRIKRQLDQSLMLVTALNTHIGYEN
HHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
AAKIAKTAHKNGTTLKEEAINLGLVTAEQFDEWVRPEDMVGSLK
HHHHHHHHCCCCCCHHHHHHHCCEEEHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA