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The map label for this gene is mltC

Identifier: 126209205

GI number: 126209205

Start: 1975864

End: 1976961

Strand: Direct

Name: mltC

Synonym: APL_1741

Alternate gene names: 126209205

Gene position: 1975864-1976961 (Clockwise)

Preceding gene: 126209204

Following gene: 126209206

Centisome position: 86.87

GC content: 42.44

Gene sequence:

>1098_bases
ATGAAAAAATATACTAAATATTTACCGCTACTGTTGATTATTCCGTTTTTAGCCGCTTGCGGCAGTAGTTCTCCTAAAAA
GAGTAAAAGAACCAAAACTCGTGTGGACTACAACACTAAAGATACTAACGGTTTAGATATTTTAACGGGGCAGTTTTCGC
ATAATATTGACGATATTTGGGGAAGCAACGAGCTTTTAGTCGCAAGTAAAAAAGATTACGTAAAATATACGGATAAGTTT
TATACGCGTAGCCATATTTCTTTTGAAGACGGTCAAATCACGATTGAAACTTTAGGTGACCAAAATCATCTACGTAACAG
TATTATTCACACCTTATTGATGGGATCGGACCCGAAAGGGATCGACTTATTCGCTTCCGGTGATGCGCCGATTAGCAGTA
ATCCGTTCCTTGCCGGTCAGGTGAACGATCAATTCGGGCGCGATATCAATAATATTGCGATCGCCAACGATTTTGCGACC
TATTTAATCCAAAATAAATTGCAAACTCGTCGCTTGCAAAACGGCAGAACAGTAACTTATGTAGCGATTAAAATGGTGGC
GGGGCATATCGAAGTGCGCGCGCGCCAATATCTGCCGCTGGTACGTAAGATGGCAAAACGTTACGGCATTGAGCCTAGTT
TAATTTTGGGTATTATGGAAGTCGAATCGGCATTCAACCCGTATGCGGTCAGTTATGCGAACGCTATCGGCTTAATGCAG
GTTGTACCGCGTACCGCCGGACGCGATATTTTTGCCCGTAAAGGTTTTGACGGACAGCCGGATCGCGCTTATTTATATAA
CCCGTCGCAAAATATCGATTCGGGTACGTTATATTTAGCGATTTTACGTGATGAATATTTGGAAGGAATCACTAATCCGA
CCGCAAAACGTTATGCGATGATTTCCGCTTATAACAGTGGCGCCGGTGCGGTGCTTAAAGTCTTCGATTACGATAAGTAT
GATGCGATCGATCGTATTAACGAACTTTCGCCGGATGCGGTTTATCGCATTTTAACGACCGCACATCCGTCAAGCCAAGC
TCGAAATTATTTGAAGAAAGTATCAAAAGCGCGCGAGAAATATTTACACATTCGATAA

Upstream 100 bases:

>100_bases
TGCTTGAAACGGAAATGGTGAATTTTTTGTTTGAAGGTAAAGAGGTTCAGATTGAAGGTTATGTTCCTGTCGAACAGAAG
TAACAAGGTATTAATTTCTA

Downstream 100 bases:

>100_bases
TTTGTTGTTTTTTAAAGCAAAAAGTACAAAAAAAGCACGTTTGGACAGGCTTTTTTAAATTTTTTAAAAAAATGTTTGAC
GAAGTGGGGCTAAATCAGCA

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKKYTKYLPLLLIIPFLAACGSSSPKKSKRTKTRVDYNTKDTNGLDILTGQFSHNIDDIWGSNELLVASKKDYVKYTDKF
YTRSHISFEDGQITIETLGDQNHLRNSIIHTLLMGSDPKGIDLFASGDAPISSNPFLAGQVNDQFGRDINNIAIANDFAT
YLIQNKLQTRRLQNGRTVTYVAIKMVAGHIEVRARQYLPLVRKMAKRYGIEPSLILGIMEVESAFNPYAVSYANAIGLMQ
VVPRTAGRDIFARKGFDGQPDRAYLYNPSQNIDSGTLYLAILRDEYLEGITNPTAKRYAMISAYNSGAGAVLKVFDYDKY
DAIDRINELSPDAVYRILTTAHPSSQARNYLKKVSKAREKYLHIR

Sequences:

>Translated_365_residues
MKKYTKYLPLLLIIPFLAACGSSSPKKSKRTKTRVDYNTKDTNGLDILTGQFSHNIDDIWGSNELLVASKKDYVKYTDKF
YTRSHISFEDGQITIETLGDQNHLRNSIIHTLLMGSDPKGIDLFASGDAPISSNPFLAGQVNDQFGRDINNIAIANDFAT
YLIQNKLQTRRLQNGRTVTYVAIKMVAGHIEVRARQYLPLVRKMAKRYGIEPSLILGIMEVESAFNPYAVSYANAIGLMQ
VVPRTAGRDIFARKGFDGQPDRAYLYNPSQNIDSGTLYLAILRDEYLEGITNPTAKRYAMISAYNSGAGAVLKVFDYDKY
DAIDRINELSPDAVYRILTTAHPSSQARNYLKKVSKAREKYLHIR
>Mature_365_residues
MKKYTKYLPLLLIIPFLAACGSSSPKKSKRTKTRVDYNTKDTNGLDILTGQFSHNIDDIWGSNELLVASKKDYVKYTDKF
YTRSHISFEDGQITIETLGDQNHLRNSIIHTLLMGSDPKGIDLFASGDAPISSNPFLAGQVNDQFGRDINNIAIANDFAT
YLIQNKLQTRRLQNGRTVTYVAIKMVAGHIEVRARQYLPLVRKMAKRYGIEPSLILGIMEVESAFNPYAVSYANAIGLMQ
VVPRTAGRDIFARKGFDGQPDRAYLYNPSQNIDSGTLYLAILRDEYLEGITNPTAKRYAMISAYNSGAGAVLKVFDYDKY
DAIDRINELSPDAVYRILTTAHPSSQARNYLKKVSKAREKYLHIR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family

Homologues:

Organism=Escherichia coli, GI87082191, Length=343, Percent_Identity=51.6034985422741, Blast_Score=353, Evalue=8e-99,
Organism=Escherichia coli, GI87081855, Length=165, Percent_Identity=41.8181818181818, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MLTC_ACTP2 (A3N339)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054430.1
- ProteinModelPortal:   A3N339
- SMR:   A3N339
- STRING:   A3N339
- GeneID:   4848883
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1741
- eggNOG:   COG0741
- HOGENOM:   HBG563263
- OMA:   NEVLIAG
- PhylomeDB:   A3N339
- ProtClustDB:   PRK11671
- BioCyc:   APLE416269:APL_1741-MONOMER
- HAMAP:   MF_01616
- InterPro:   IPR008258
- InterPro:   IPR000189

Pfam domain/function: PF01464 SLT

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41061; Mature: 41061

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00922 TRANSGLYCOSYLASE; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYTKYLPLLLIIPFLAACGSSSPKKSKRTKTRVDYNTKDTNGLDILTGQFSHNIDDIW
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHC
GSNELLVASKKDYVKYTDKFYTRSHISFEDGQITIETLGDQNHLRNSIIHTLLMGSDPKG
CCCCEEEECCCCHHHHHHHHHHHCCCEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCC
IDLFASGDAPISSNPFLAGQVNDQFGRDINNIAIANDFATYLIQNKLQTRRLQNGRTVTY
EEEEECCCCCCCCCCEEEECCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEE
VAIKMVAGHIEVRARQYLPLVRKMAKRYGIEPSLILGIMEVESAFNPYAVSYANAIGLMQ
EEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VVPRTAGRDIFARKGFDGQPDRAYLYNPSQNIDSGTLYLAILRDEYLEGITNPTAKRYAM
HHCCCCCCCHHEECCCCCCCCCEEEECCCCCCCCCEEEEEEEHHHHHHHCCCCCHHHEEE
ISAYNSGAGAVLKVFDYDKYDAIDRINELSPDAVYRILTTAHPSSQARNYLKKVSKAREK
EEEECCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YLHIR
HCCCC
>Mature Secondary Structure
MKKYTKYLPLLLIIPFLAACGSSSPKKSKRTKTRVDYNTKDTNGLDILTGQFSHNIDDIW
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHC
GSNELLVASKKDYVKYTDKFYTRSHISFEDGQITIETLGDQNHLRNSIIHTLLMGSDPKG
CCCCEEEECCCCHHHHHHHHHHHCCCEECCCEEEEEECCCHHHHHHHHHHHHHCCCCCCC
IDLFASGDAPISSNPFLAGQVNDQFGRDINNIAIANDFATYLIQNKLQTRRLQNGRTVTY
EEEEECCCCCCCCCCEEEECCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEE
VAIKMVAGHIEVRARQYLPLVRKMAKRYGIEPSLILGIMEVESAFNPYAVSYANAIGLMQ
EEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VVPRTAGRDIFARKGFDGQPDRAYLYNPSQNIDSGTLYLAILRDEYLEGITNPTAKRYAM
HHCCCCCCCHHEECCCCCCCCCEEEECCCCCCCCCEEEEEEEHHHHHHHCCCCCHHHEEE
ISAYNSGAGAVLKVFDYDKYDAIDRINELSPDAVYRILTTAHPSSQARNYLKKVSKAREK
EEEECCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YLHIR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA