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The map label for this gene is mutY [H]

Identifier: 126209203

GI number: 126209203

Start: 1974422

End: 1975567

Strand: Direct

Name: mutY [H]

Synonym: APL_1739

Alternate gene names: 126209203

Gene position: 1974422-1975567 (Clockwise)

Preceding gene: 126209197

Following gene: 126209204

Centisome position: 86.81

GC content: 43.98

Gene sequence:

>1146_bases
GTGAAAACAAAATTACAGTTTCCTTTAGCACAATCTGATCCGGCTCAGCCGTTTGCCAAAGCAGTATTAGCTTGGTTCGC
ACAGTATGGGCGGAAACATTTACCTTGGCAACAAAATAAAACTTTATATGGGGTTTGGTTGTCGGAAGTGATGTTACAAC
AAACGCAGGTTGCGACCGTTATTCCGTATTTCGAGCGTTTTATCGAACGTTTCCCGACGGTAACGGATTTAGCCGATGCG
CACATTGATGAAGTGTTGCATTTGTGGACGGGCTTAGGTTATTACGCACGCGCCAGAAATTTGCATAAGGCGGCACAGCA
AATTCGTGATCAATTTAATGGTGAGTTCCCAACCGATTTTGATGATGTTTTGGCACTTTCCGGCGTAGGGCGCAGTACGG
CAGGGGCGATTTTATCGTCCGTGTTAAATGCACCGCATCCGATTTTAGACGGCAATGTAAAACGGGTGCTTTCCCGTGCG
TTTGCGGTGGAAGGCTGGAGCGGTGAAAAGAGTGTAGAAAATAAATTGTGGCAATTAACCGCAAGCGTTACGCCGAACAG
CCAAGTTGCCGATTTTAATCAGGCGATGATGGATCTCGGTGCAATGGTCTGTACCCGCAGCAAACCGAAATGCTCGTTAT
GTCCGTTAGCGAATTTATGCGAAGCGAATCGGCTTGAAGCATGGGATAAATTTCCGGCGAAAAAACCGAAGAAAGTATTG
CCGGAACGGCAGGCGTATTTTTTGATTATTAAGTCGGGTAGTAAGATTTTATTGGAACAGCGTGAAGCAAAAGGGCTTTG
GGGTGGATTATACGTATTTCCGCAATTTGAAAATACGGAGGAGCTTAAGCGGTCGCTTTCCGAACGGAATTTGCAAGTTT
CTCAGCAATTAATCGCATTTCGCCACACATTCAGCCATTTTCATTTGGATATTACCCCTATTTTGGTAGATCTGGATTTG
CAAAAAAATCCTCAAAATCAACCGCTTGTCGTACAAGAAAATTGCGGAAATTATCGCCTTTCAGTATCTTCAACCGCTAA
TTATTGGTATGATTTACAATTACCGAGCGAAATAGGTTTGGCAACGCCCGTAAAACGTATTTTGGACGAACTCAGTTTAA
CGCTAACTAGCACTAATAAGGAATAA

Upstream 100 bases:

>100_bases
CATAAATTTCCTTGTAAAAGTTTTGCAAAAAAACTGTTAAATATGACCGCTTAGGTTATGATGCACGGCTTGATATTATT
TTGATATTAAAAGGCTTCGA

Downstream 100 bases:

>100_bases
AAAATGGCTCGTACTGTATTTTGTGAATATTTAAAGCAAGAAGCCGAAGGCTTAGATTTTCAATTATATCCCGGCGAATT
GGGTAAGCGTATTTTTGATT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKTKLQFPLAQSDPAQPFAKAVLAWFAQYGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIERFPTVTDLADA
HIDEVLHLWTGLGYYARARNLHKAAQQIRDQFNGEFPTDFDDVLALSGVGRSTAGAILSSVLNAPHPILDGNVKRVLSRA
FAVEGWSGEKSVENKLWQLTASVTPNSQVADFNQAMMDLGAMVCTRSKPKCSLCPLANLCEANRLEAWDKFPAKKPKKVL
PERQAYFLIIKSGSKILLEQREAKGLWGGLYVFPQFENTEELKRSLSERNLQVSQQLIAFRHTFSHFHLDITPILVDLDL
QKNPQNQPLVVQENCGNYRLSVSSTANYWYDLQLPSEIGLATPVKRILDELSLTLTSTNKE

Sequences:

>Translated_381_residues
MKTKLQFPLAQSDPAQPFAKAVLAWFAQYGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIERFPTVTDLADA
HIDEVLHLWTGLGYYARARNLHKAAQQIRDQFNGEFPTDFDDVLALSGVGRSTAGAILSSVLNAPHPILDGNVKRVLSRA
FAVEGWSGEKSVENKLWQLTASVTPNSQVADFNQAMMDLGAMVCTRSKPKCSLCPLANLCEANRLEAWDKFPAKKPKKVL
PERQAYFLIIKSGSKILLEQREAKGLWGGLYVFPQFENTEELKRSLSERNLQVSQQLIAFRHTFSHFHLDITPILVDLDL
QKNPQNQPLVVQENCGNYRLSVSSTANYWYDLQLPSEIGLATPVKRILDELSLTLTSTNKE
>Mature_381_residues
MKTKLQFPLAQSDPAQPFAKAVLAWFAQYGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIERFPTVTDLADA
HIDEVLHLWTGLGYYARARNLHKAAQQIRDQFNGEFPTDFDDVLALSGVGRSTAGAILSSVLNAPHPILDGNVKRVLSRA
FAVEGWSGEKSVENKLWQLTASVTPNSQVADFNQAMMDLGAMVCTRSKPKCSLCPLANLCEANRLEAWDKFPAKKPKKVL
PERQAYFLIIKSGSKILLEQREAKGLWGGLYVFPQFENTEELKRSLSERNLQVSQQLIAFRHTFSHFHLDITPILVDLDL
QKNPQNQPLVVQENCGNYRLSVSSTANYWYDLQLPSEIGLATPVKRILDELSLTLTSTNKE

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=357, Percent_Identity=34.453781512605, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI115298648, Length=357, Percent_Identity=34.453781512605, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI190358497, Length=357, Percent_Identity=34.453781512605, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI115298654, Length=357, Percent_Identity=34.453781512605, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI115298652, Length=357, Percent_Identity=34.453781512605, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI115298650, Length=357, Percent_Identity=34.453781512605, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1789331, Length=359, Percent_Identity=58.4958217270195, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1787920, Length=128, Percent_Identity=32.8125, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43091; Mature: 43091

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKLQFPLAQSDPAQPFAKAVLAWFAQYGRKHLPWQQNKTLYGVWLSEVMLQQTQVATV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
IPYFERFIERFPTVTDLADAHIDEVLHLWTGLGYYARARNLHKAAQQIRDQFNGEFPTDF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
DDVLALSGVGRSTAGAILSSVLNAPHPILDGNVKRVLSRAFAVEGWSGEKSVENKLWQLT
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHEEE
ASVTPNSQVADFNQAMMDLGAMVCTRSKPKCSLCPLANLCEANRLEAWDKFPAKKPKKVL
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHC
PERQAYFLIIKSGSKILLEQREAKGLWGGLYVFPQFENTEELKRSLSERNLQVSQQLIAF
CCCCEEEEEEECCCCEEHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHH
RHTFSHFHLDITPILVDLDLQKNPQNQPLVVQENCGNYRLSVSSTANYWYDLQLPSEIGL
HHHHHHHEEEEEEEEEEEECCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEECCHHCCC
ATPVKRILDELSLTLTSTNKE
HHHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure
MKTKLQFPLAQSDPAQPFAKAVLAWFAQYGRKHLPWQQNKTLYGVWLSEVMLQQTQVATV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHH
IPYFERFIERFPTVTDLADAHIDEVLHLWTGLGYYARARNLHKAAQQIRDQFNGEFPTDF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
DDVLALSGVGRSTAGAILSSVLNAPHPILDGNVKRVLSRAFAVEGWSGEKSVENKLWQLT
HHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHEEE
ASVTPNSQVADFNQAMMDLGAMVCTRSKPKCSLCPLANLCEANRLEAWDKFPAKKPKKVL
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCHHHC
PERQAYFLIIKSGSKILLEQREAKGLWGGLYVFPQFENTEELKRSLSERNLQVSQQLIAF
CCCCEEEEEEECCCCEEHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHH
RHTFSHFHLDITPILVDLDLQKNPQNQPLVVQENCGNYRLSVSSTANYWYDLQLPSEIGL
HHHHHHHEEEEEEEEEEEECCCCCCCCCEEEEECCCCEEEEEECCCCEEEEEECCHHCCC
ATPVKRILDELSLTLTSTNKE
HHHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]