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The map label for this gene is fkpA [C]

Identifier: 126209104

GI number: 126209104

Start: 1864839

End: 1865570

Strand: Direct

Name: fkpA [C]

Synonym: APL_1640

Alternate gene names: 126209104

Gene position: 1864839-1865570 (Clockwise)

Preceding gene: 126209089

Following gene: 126209105

Centisome position: 81.99

GC content: 40.3

Gene sequence:

>732_bases
ATGTTAAAAAATAAACTTTCTGTTCTTGCAATCGTAGCCGGTACGTTCGTTTCAGCTCAAACTGCATTTGCAGCGGAACA
AAAAGCGGATCAAAAATTCATTGACGATTCATCATATGCAGTCGGCGTATTGATGGGTAAAAATATCGAAGGCGTCGTTG
AATCACAAAAAGAAATTTTTTCTTATAACCAAGATAAAATCTTGGCGGGTGTCCAAGATACCATCAAAAAAACCGGTAAA
TTAACCGATGAAGATCTACAAAAACAATTAAAATCGCTTGATACTTATCTTGCAAGCCAAGAAAGCAAAATTGCGGCGGA
GAAAAGCAAAGCAACCGTAGAAGCCGGTAATAAATTTCGTGCCGACTACGAAAAACAAAGCGGCGTGAAAAAAACCGCTT
CCGGTTTACTTTATAAAATTGAAAAAGCCGGCACGGGCGAATCGCCTAAAGCGGAAGATACCGTTAAAGTTCACTATAAA
GGGACATTAACCGATGGTACGGTATTCGATAGCTCATACGATCGCGGTGAGCCGATTGAATTCCAATTAAACCAATTAAT
TCCGGGTTGGATTGAAGCGATTCCAATGTTGAAAAAAGGCGGAAAAATGGAAATCGTCGTTCCGCCTGAACTTGGTTACG
GCGAACGCCAAGCAGGTAAGATTCCGGCAAGTTCAACCTTAAAATTCGAGATTGAATTGTTAGATTTCAAAGCGGCCGAA
GCGAAAAAATAA

Upstream 100 bases:

>100_bases
CTGTAGTCATTTGAAATAAAAAGGTTGTATAAAATAGAAATACACTTTACCCTATCCACCATTCTTTTAACAAATTATTT
TATTTATATAAGGAAAATCT

Downstream 100 bases:

>100_bases
CCCTTGAATCCAAGCGGTCTAATTTGTAAAATTTTTTGCAAATTAGACCGCTTTCTTTTTTGAAGGCTTATTAAGCTATA
ACTAGAATTAACGGCGTAAG

Product: putative FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLKNKLSVLAIVAGTFVSAQTAFAAEQKADQKFIDDSSYAVGVLMGKNIEGVVESQKEIFSYNQDKILAGVQDTIKKTGK
LTDEDLQKQLKSLDTYLASQESKIAAEKSKATVEAGNKFRADYEKQSGVKKTASGLLYKIEKAGTGESPKAEDTVKVHYK
GTLTDGTVFDSSYDRGEPIEFQLNQLIPGWIEAIPMLKKGGKMEIVVPPELGYGERQAGKIPASSTLKFEIELLDFKAAE
AKK

Sequences:

>Translated_243_residues
MLKNKLSVLAIVAGTFVSAQTAFAAEQKADQKFIDDSSYAVGVLMGKNIEGVVESQKEIFSYNQDKILAGVQDTIKKTGK
LTDEDLQKQLKSLDTYLASQESKIAAEKSKATVEAGNKFRADYEKQSGVKKTASGLLYKIEKAGTGESPKAEDTVKVHYK
GTLTDGTVFDSSYDRGEPIEFQLNQLIPGWIEAIPMLKKGGKMEIVVPPELGYGERQAGKIPASSTLKFEIELLDFKAAE
AKK
>Mature_243_residues
MLKNKLSVLAIVAGTFVSAQTAFAAEQKADQKFIDDSSYAVGVLMGKNIEGVVESQKEIFSYNQDKILAGVQDTIKKTGK
LTDEDLQKQLKSLDTYLASQESKIAAEKSKATVEAGNKFRADYEKQSGVKKTASGLLYKIEKAGTGESPKAEDTVKVHYK
GTLTDGTVFDSSYDRGEPIEFQLNQLIPGWIEAIPMLKKGGKMEIVVPPELGYGERQAGKIPASSTLKFEIELLDFKAAE
AKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=114, Percent_Identity=45.6140350877193, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224809327, Length=114, Percent_Identity=45.6140350877193, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4758384, Length=114, Percent_Identity=45.6140350877193, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224809331, Length=114, Percent_Identity=45.6140350877193, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=45.5555555555556, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503729, Length=113, Percent_Identity=45.1327433628319, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=48.2352941176471, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=48.2352941176471, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=48.2352941176471, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI192448443, Length=101, Percent_Identity=37.6237623762376, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI8923659, Length=93, Percent_Identity=40.8602150537634, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI17149836, Length=89, Percent_Identity=40.4494382022472, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4503725, Length=89, Percent_Identity=40.4494382022472, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=37.3737373737374, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=42.6605504587156, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI87082390, Length=202, Percent_Identity=36.6336633663366, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540882, Length=112, Percent_Identity=42.8571428571429, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=110, Percent_Identity=43.6363636363636, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=89, Percent_Identity=41.5730337078652, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=48.3516483516484, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=104, Percent_Identity=45.1923076923077, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=43.6170212765958, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=43.6170212765958, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24655568, Length=89, Percent_Identity=44.9438202247191, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583150, Length=109, Percent_Identity=41.2844036697248, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356629, Length=89, Percent_Identity=44.9438202247191, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26495; Mature: 26495

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKLSVLAIVAGTFVSAQTAFAAEQKADQKFIDDSSYAVGVLMGKNIEGVVESQKEIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
SYNQDKILAGVQDTIKKTGKLTDEDLQKQLKSLDTYLASQESKIAAEKSKATVEAGNKFR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ADYEKQSGVKKTASGLLYKIEKAGTGESPKAEDTVKVHYKGTLTDGTVFDSSYDRGEPIE
CCHHHHCCHHHHHHHHEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCCCCE
FQLNQLIPGWIEAIPMLKKGGKMEIVVPPELGYGERQAGKIPASSTLKFEIELLDFKAAE
EEHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCC
AKK
CCC
>Mature Secondary Structure
MLKNKLSVLAIVAGTFVSAQTAFAAEQKADQKFIDDSSYAVGVLMGKNIEGVVESQKEIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
SYNQDKILAGVQDTIKKTGKLTDEDLQKQLKSLDTYLASQESKIAAEKSKATVEAGNKFR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ADYEKQSGVKKTASGLLYKIEKAGTGESPKAEDTVKVHYKGTLTDGTVFDSSYDRGEPIE
CCHHHHCCHHHHHHHHEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCCCCE
FQLNQLIPGWIEAIPMLKKGGKMEIVVPPELGYGERQAGKIPASSTLKFEIELLDFKAAE
EEHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCC
AKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]