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The map label for this gene is mtn

Identifier: 126209101

GI number: 126209101

Start: 1863055

End: 1863753

Strand: Reverse

Name: mtn

Synonym: APL_1637

Alternate gene names: 126209101

Gene position: 1863753-1863055 (Counterclockwise)

Preceding gene: 126209102

Following gene: 126209100

Centisome position: 81.94

GC content: 43.35

Gene sequence:

>699_bases
ATGAGATTAAAAATTGGTATTATCGGCGCAATGGCACAAGAAGTGGAAATTCTGCGTAATTTAATGGTTGAAGCTAAAGT
AATAGAAATTGCGGGTTGTAAAATTTATGACGGTAAAATTAATAATACGCAAGTAGCGTTATTACAATCAGGTATCGGCA
AAGTTGCGGCGGCGGTGGGTACCGCATTGTTATTGGAATTAACCAAACCGGATGTGATTATTAATACCGGTTCGGCCGGA
GGCTTGGATGCGAATTTAAATGTCGGCGATATAGTGATTTCTACGGAAGTACGCCACCACGATGCGGATGTAACGGCGTT
CGGTTATGAGAAAGGGCAATTACCGGCTAATCCCGCCGCCTTTCTGCCGAACGAACAGTTAGTTTCCGTTGCATTAAAAG
AAACGCAAACGGCGGGTTTTAATGCGGTTTCCGGTTTAATTTGTAGCGGAGACGTTTTTGTGAACGGAGCGGAAAAAATC
GCTCAAATTCGTCAAGATTTTCCTAATGTCGCCGCAGTAGAAATGGAAGCGGCAGCCATTGCACAGGTTTGTCATGCGTT
TAACGTACCTTTTGTGGTGGTCAGAGCCATCTCGGATGTAGCGGATAAAGAATCACATCTTTCTTTTGATGAATTTTTAC
CGTTAGCGGCAAAGAACTCTTCGGAGATCGTGGTCGCAATGTTAAATAACTTCGCTTAA

Upstream 100 bases:

>100_bases
TTTTATTACAAAATACTTTATACAATGACGACTATACTTACGGCGTATTAGATTTTTTAGTCAATAAACTACAACAAGAA
CAAAAAGAGGAAACAAAATA

Downstream 100 bases:

>100_bases
TTCTTACGGAGCAAGCGGTTCGATTTAGCTAAAAATTTGCAAAGAATCGCTAAAATATAACCGCTTGTTATCGCTATTTG
ATAGCAACTTCTGTACAATA

Product: MTA/SAH nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVGTALLLELTKPDVIINTGSAG
GLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAAFLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKI
AQIRQDFPNVAAVEMEAAAIAQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA

Sequences:

>Translated_232_residues
MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVGTALLLELTKPDVIINTGSAG
GLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAAFLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKI
AQIRQDFPNVAAVEMEAAAIAQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA
>Mature_232_residues
MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVGTALLLELTKPDVIINTGSAG
GLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAAFLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKI
AQIRQDFPNVAAVEMEAAAIAQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=230, Percent_Identity=61.7391304347826, Blast_Score=266, Evalue=8e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_ACTP2 (A3N2T5)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054326.1
- ProteinModelPortal:   A3N2T5
- SMR:   A3N2T5
- STRING:   A3N2T5
- GeneID:   4850348
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1637
- eggNOG:   COG0775
- HOGENOM:   HBG367723
- OMA:   HLDNAQE
- PhylomeDB:   A3N2T5
- ProtClustDB:   CLSK918996
- BioCyc:   APLE416269:APL_1637-MONOMER
- HAMAP:   MF_01684
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 24412; Mature: 24412

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: ACT_SITE 14-14 BINDING 80-80 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVG
CEEEEEEHHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCCCCEEEEEHHHHHHHHHHHH
TALLLELTKPDVIINTGSAGGLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAA
HHHEEEECCCCEEEECCCCCCEECCCCCCEEEEEEEEEECCCCEEEECCCCCCCCCCCCC
FLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKIAQIRQDFPNVAAVEMEAAAI
CCCCHHHHHHHHHHHCCCCCHHHHCEEECCCEEECCHHHHHHHHHCCCCEEEEHHHHHHH
AQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA
HHHHHHCCCHHHHHHHHHHHHCCHHCCCHHHHCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRLKIGIIGAMAQEVEILRNLMVEAKVIEIAGCKIYDGKINNTQVALLQSGIGKVAAAVG
CEEEEEEHHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCCCCEEEEEHHHHHHHHHHHH
TALLLELTKPDVIINTGSAGGLDANLNVGDIVISTEVRHHDADVTAFGYEKGQLPANPAA
HHHEEEECCCCEEEECCCCCCEECCCCCCEEEEEEEEEECCCCEEEECCCCCCCCCCCCC
FLPNEQLVSVALKETQTAGFNAVSGLICSGDVFVNGAEKIAQIRQDFPNVAAVEMEAAAI
CCCCHHHHHHHHHHHCCCCCHHHHCEEECCCEEECCHHHHHHHHHCCCCEEEEHHHHHHH
AQVCHAFNVPFVVVRAISDVADKESHLSFDEFLPLAAKNSSEIVVAMLNNFA
HHHHHHCCCHHHHHHHHHHHHCCHHCCCHHHHCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA