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The map label for this gene is hcr [H]

Identifier: 126209011

GI number: 126209011

Start: 1769175

End: 1770194

Strand: Direct

Name: hcr [H]

Synonym: APL_1547

Alternate gene names: 126209011

Gene position: 1769175-1770194 (Clockwise)

Preceding gene: 126209010

Following gene: 126209019

Centisome position: 77.78

GC content: 45.1

Gene sequence:

>1020_bases
ATGGCAAATACCAATAAAAACCCTTTATGTATTAACGAATTACAGGTTTATTCAATCGTACAAGAAGCACCTCATGTAAA
AACGATTAACTTTATCGCACAGGATTTCTACCCATATCAAGCGGGGCAATATGCGTTAGTTAGCATTAAAAACACGCCGC
ATATTACTCGTGCTTACTCACTGTCTTCTACCCCGGGCGAAAGCCGTTTCGTATCGATTACCGTGCGTGAAATTGAAGGC
GGCGTCGGTTCGACTTGGCTCAATAATGAGGTAAAAGTCGGTGACCAAGTATGGTTCTCGAATCCAATGGGCGAGTTCTC
TTGCCAACACGTATTGGCGGATAATTACTTATTAGTCGGTGCGGGAAGCGGCGTTACCCCGATTATGTCAATGGCTCGTT
GGTTATTAGCAAACCGCCCTAAAGTGAACTTAACCGTTATCCATTCGGTGCATTCGCCGGAAGATGTGATTTTCAAATCG
GAATGGCAAGAATTAAAAGCCAAATATCCGCAACTCAACTTAGTAATGAACGCTTCGGTCGGGGCAACCGAAGGCTTTGC
AAGCGGTCGAATTTCAGCGGAAATTATCAAAAATGCCGTGCCGAATGTGAGCGATTACACCGTGATGACCTGCGGCCCTG
AAGCCTATATGGCGGCATTAAAAAATATCGTGCTTGAATTAGGTGTTAGCGAAGATCGTTTCTTTACCGAAGCCTTCTTT
AATACCTCCTTAGCCGGAGAAATCAGTTCGGATAAGAAAACCACCCTAACTATTAACGCTGCAAAACAAATTAAAGCGGA
AGTGCCGGTCGGTATGACCTTATTAGCCGCTTTAGAAGCGCAAGAACAACCGGTGGTTTCCGGCTGCCGCACCGGTTTAT
GCGGTTTATGCAAAACCAAAGTAACGGGTGGGGAATATGAAGTAGTCGGTACCGGCGATTTAACCGAAGAGGAAATCGCA
CAAGGCTATGTACTGGCGTGTAGCTGCCGTGTAAAAGAAAACGTATCGGTTTCTTTATAA

Upstream 100 bases:

>100_bases
TCAAATTTCGCAAAATTTTTGCAAATTTCTCAGCAATTTTGACCGCTTGTTGAATGTAGGGACACATTGCATCCCTACAC
ATATCGAAAGGAACAACAAA

Downstream 100 bases:

>100_bases
ATTTTATAAACAAAAAAACCTCAAAGGAAATCTTTGAGGTTTTAATTTTTTAGGTAGCGACGAAACGCAAATAAGCAGAT
AAAGAAATAACAAAAATAAG

Product: HCP oxidoreductase, NADH-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MANTNKNPLCINELQVYSIVQEAPHVKTINFIAQDFYPYQAGQYALVSIKNTPHITRAYSLSSTPGESRFVSITVREIEG
GVGSTWLNNEVKVGDQVWFSNPMGEFSCQHVLADNYLLVGAGSGVTPIMSMARWLLANRPKVNLTVIHSVHSPEDVIFKS
EWQELKAKYPQLNLVMNASVGATEGFASGRISAEIIKNAVPNVSDYTVMTCGPEAYMAALKNIVLELGVSEDRFFTEAFF
NTSLAGEISSDKKTTLTINAAKQIKAEVPVGMTLLAALEAQEQPVVSGCRTGLCGLCKTKVTGGEYEVVGTGDLTEEEIA
QGYVLACSCRVKENVSVSL

Sequences:

>Translated_339_residues
MANTNKNPLCINELQVYSIVQEAPHVKTINFIAQDFYPYQAGQYALVSIKNTPHITRAYSLSSTPGESRFVSITVREIEG
GVGSTWLNNEVKVGDQVWFSNPMGEFSCQHVLADNYLLVGAGSGVTPIMSMARWLLANRPKVNLTVIHSVHSPEDVIFKS
EWQELKAKYPQLNLVMNASVGATEGFASGRISAEIIKNAVPNVSDYTVMTCGPEAYMAALKNIVLELGVSEDRFFTEAFF
NTSLAGEISSDKKTTLTINAAKQIKAEVPVGMTLLAALEAQEQPVVSGCRTGLCGLCKTKVTGGEYEVVGTGDLTEEEIA
QGYVLACSCRVKENVSVSL
>Mature_338_residues
ANTNKNPLCINELQVYSIVQEAPHVKTINFIAQDFYPYQAGQYALVSIKNTPHITRAYSLSSTPGESRFVSITVREIEGG
VGSTWLNNEVKVGDQVWFSNPMGEFSCQHVLADNYLLVGAGSGVTPIMSMARWLLANRPKVNLTVIHSVHSPEDVIFKSE
WQELKAKYPQLNLVMNASVGATEGFASGRISAEIIKNAVPNVSDYTVMTCGPEAYMAALKNIVLELGVSEDRFFTEAFFN
TSLAGEISSDKKTTLTINAAKQIKAEVPVGMTLLAALEAQEQPVVSGCRTGLCGLCKTKVTGGEYEVVGTGDLTEEEIAQ
GYVLACSCRVKENVSVSL

Specific function: NADH oxidoreductase acting in concert with HCP [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1787098, Length=320, Percent_Identity=50.625, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1787658, Length=338, Percent_Identity=26.6272189349112, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788104, Length=328, Percent_Identity=28.3536585365854, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788903, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322699, Length=202, Percent_Identity=26.7326732673267, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323552, Length=184, Percent_Identity=22.8260869565217, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36746; Mature: 36615

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTNKNPLCINELQVYSIVQEAPHVKTINFIAQDFYPYQAGQYALVSIKNTPHITRAYS
CCCCCCCCEEEHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEE
LSSTPGESRFVSITVREIEGGVGSTWLNNEVKVGDQVWFSNPMGEFSCQHVLADNYLLVG
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEECCEEEECCCCCCHHHHEEECCCEEEEE
AGSGVTPIMSMARWLLANRPKVNLTVIHSVHSPEDVIFKSEWQELKAKYPQLNLVMNASV
CCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHEEHHHHHHHHHCCCEEEEEEECCC
GATEGFASGRISAEIIKNAVPNVSDYTVMTCGPEAYMAALKNIVLELGVSEDRFFTEAFF
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NTSLAGEISSDKKTTLTINAAKQIKAEVPVGMTLLAALEAQEQPVVSGCRTGLCGLCKTK
CCCCCCCCCCCCEEEEEEECHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHCC
VTGGEYEVVGTGDLTEEEIAQGYVLACSCRVKENVSVSL
CCCCEEEEEECCCCCHHHHHCCEEEEEEEEECCCCEECC
>Mature Secondary Structure 
ANTNKNPLCINELQVYSIVQEAPHVKTINFIAQDFYPYQAGQYALVSIKNTPHITRAYS
CCCCCCCEEEHHHHHHHHHHHCCCEEEHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEE
LSSTPGESRFVSITVREIEGGVGSTWLNNEVKVGDQVWFSNPMGEFSCQHVLADNYLLVG
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEECCEEEECCCCCCHHHHEEECCCEEEEE
AGSGVTPIMSMARWLLANRPKVNLTVIHSVHSPEDVIFKSEWQELKAKYPQLNLVMNASV
CCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHEEHHHHHHHHHCCCEEEEEEECCC
GATEGFASGRISAEIIKNAVPNVSDYTVMTCGPEAYMAALKNIVLELGVSEDRFFTEAFF
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NTSLAGEISSDKKTTLTINAAKQIKAEVPVGMTLLAALEAQEQPVVSGCRTGLCGLCKTK
CCCCCCCCCCCCEEEEEEECHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHCC
VTGGEYEVVGTGDLTEEEIAQGYVLACSCRVKENVSVSL
CCCCEEEEEECCCCCHHHHHCCEEEEEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10651802 [H]