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The map label for this gene is murQ

Identifier: 126209000

GI number: 126209000

Start: 1750596

End: 1751510

Strand: Direct

Name: murQ

Synonym: APL_1536

Alternate gene names: 126209000

Gene position: 1750596-1751510 (Clockwise)

Preceding gene: 126208999

Following gene: 126209005

Centisome position: 76.97

GC content: 46.23

Gene sequence:

>915_bases
ATGTCAGAAAAAAATTTATTAACCGCGTTGTCAAAAATGATTACCGAACAACGCAATCCTAACTCAATGAATATCGATCA
ACTCTCTGCACTTGAGCTAGTGAAAGTGATCAATCAAGAGGATAAACAAGTCCCGCTTGCGGTGGAAAAATGTTTAGCGC
AAATCGCTCAAGCGGTCGAAAAAATCGTGCAAGCGTTCCAAAACGGCGGACGTTTAGTCTATATCGGTGCCGGTACGAGT
GGGCGCTTAGGCGTATTGGATGCTTCGGAATGTCCGCCGACTTACGGCGTTCCGCCGGAGATAGTGGTCGGCATTATTGC
CGGCGGTGAACGGGCGTTACGCCACCCGATTGAAGGAGCGGAAGATAATACGGAACGAGGCAAAGCCGATTTACAAGCGG
TCAATTTTTCACAAAAAGACGTATTGGTCGGCATTGCAGCAAGCGGACGTACCCCTTATGTCATCGGTGCGTTAGAATAT
GCTAAATCTTTAGGGGCAACCACCGTTTCAATTGCCAGCAACCCAAATTCGGCGATGGCACAAATTGCAGAGATTGCAAT
TGATACGGTTGTAGGGCCGGAAGTACTAACTGGCTCAAGCCGTATGAAATCCGGCACGGCACAAAAGCTGGTGTTGAATA
TGCTGACCACCGCTTCCATGGTGATGATCGGCAAATGTTATTCCAATTTAATGGTTGATGTACAAGCGAGCAACGAAAAA
CTTAAAGCTCGTGCGATAAAAATCGTGATGGAAGCCACCGAATGTGATCGAACGGTTGCCGAGAATACGCTAAAAATTGC
CGAAAACAACGCCAAATTAGCGATTATGATGATATTAAGCGATTCGGATAAAACCACTGCCGAACAGTTACTTTCCAAAC
ATCATGGAAAACTGCGTCAAGCTCTCGTAAACTAG

Upstream 100 bases:

>100_bases
CCGGAGCAAAAGAGCCGGTGAGTTTAGGGGTAATTTATCCTAAGTAATCACTTCCTCACTTGTATAAAACACCAAAAGTA
AAAGGTGGTTGGAGATAAAA

Downstream 100 bases:

>100_bases
GGCATAAAAAAGCGGTCGGATTTTGCAAATTTTCTACAAAATCCGACCGCTTTTTATTACGTTAAACTATTTCTTCACGC
CGGTAATACGACACCACTCT

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSEKNLLTALSKMITEQRNPNSMNIDQLSALELVKVINQEDKQVPLAVEKCLAQIAQAVEKIVQAFQNGGRLVYIGAGTS
GRLGVLDASECPPTYGVPPEIVVGIIAGGERALRHPIEGAEDNTERGKADLQAVNFSQKDVLVGIAASGRTPYVIGALEY
AKSLGATTVSIASNPNSAMAQIAEIAIDTVVGPEVLTGSSRMKSGTAQKLVLNMLTTASMVMIGKCYSNLMVDVQASNEK
LKARAIKIVMEATECDRTVAENTLKIAENNAKLAIMMILSDSDKTTAEQLLSKHHGKLRQALVN

Sequences:

>Translated_304_residues
MSEKNLLTALSKMITEQRNPNSMNIDQLSALELVKVINQEDKQVPLAVEKCLAQIAQAVEKIVQAFQNGGRLVYIGAGTS
GRLGVLDASECPPTYGVPPEIVVGIIAGGERALRHPIEGAEDNTERGKADLQAVNFSQKDVLVGIAASGRTPYVIGALEY
AKSLGATTVSIASNPNSAMAQIAEIAIDTVVGPEVLTGSSRMKSGTAQKLVLNMLTTASMVMIGKCYSNLMVDVQASNEK
LKARAIKIVMEATECDRTVAENTLKIAENNAKLAIMMILSDSDKTTAEQLLSKHHGKLRQALVN
>Mature_303_residues
SEKNLLTALSKMITEQRNPNSMNIDQLSALELVKVINQEDKQVPLAVEKCLAQIAQAVEKIVQAFQNGGRLVYIGAGTSG
RLGVLDASECPPTYGVPPEIVVGIIAGGERALRHPIEGAEDNTERGKADLQAVNFSQKDVLVGIAASGRTPYVIGALEYA
KSLGATTVSIASNPNSAMAQIAEIAIDTVVGPEVLTGSSRMKSGTAQKLVLNMLTTASMVMIGKCYSNLMVDVQASNEKL
KARAIKIVMEATECDRTVAENTLKIAENNAKLAIMMILSDSDKTTAEQLLSKHHGKLRQALVN

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Homo sapiens, GI221625433, Length=249, Percent_Identity=28.9156626506024, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788768, Length=293, Percent_Identity=57.3378839590444, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_ACTP2 (A3N2I4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054225.1
- ProteinModelPortal:   A3N2I4
- SMR:   A3N2I4
- STRING:   A3N2I4
- GeneID:   4849028
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1536
- eggNOG:   COG2103
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- PhylomeDB:   A3N2I4
- ProtClustDB:   PRK05441
- BioCyc:   APLE416269:APL_1536-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 32373; Mature: 32242

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 90-90 ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKNLLTALSKMITEQRNPNSMNIDQLSALELVKVINQEDKQVPLAVEKCLAQIAQAVE
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KIVQAFQNGGRLVYIGAGTSGRLGVLDASECPPTYGVPPEIVVGIIAGGERALRHPIEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEECCCHHHHHCCCCCC
EDNTERGKADLQAVNFSQKDVLVGIAASGRTPYVIGALEYAKSLGATTVSIASNPNSAMA
CCCCCCCCHHHHEECCCCCCEEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCHHHH
QIAEIAIDTVVGPEVLTGSSRMKSGTAQKLVLNMLTTASMVMIGKCYSNLMVDVQASNEK
HHHHHHHHHHCCCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCH
LKARAIKIVMEATECDRTVAENTLKIAENNAKLAIMMILSDSDKTTAEQLLSKHHGKLRQ
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHH
ALVN
HHCC
>Mature Secondary Structure 
SEKNLLTALSKMITEQRNPNSMNIDQLSALELVKVINQEDKQVPLAVEKCLAQIAQAVE
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KIVQAFQNGGRLVYIGAGTSGRLGVLDASECPPTYGVPPEIVVGIIAGGERALRHPIEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEECCCHHHHHCCCCCC
EDNTERGKADLQAVNFSQKDVLVGIAASGRTPYVIGALEYAKSLGATTVSIASNPNSAMA
CCCCCCCCHHHHEECCCCCCEEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCHHHH
QIAEIAIDTVVGPEVLTGSSRMKSGTAQKLVLNMLTTASMVMIGKCYSNLMVDVQASNEK
HHHHHHHHHHCCCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCH
LKARAIKIVMEATECDRTVAENTLKIAENNAKLAIMMILSDSDKTTAEQLLSKHHGKLRQ
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHH
ALVN
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA