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The map label for this gene is pdxY

Identifier: 126208949

GI number: 126208949

Start: 1699929

End: 1700789

Strand: Reverse

Name: pdxY

Synonym: APL_1485

Alternate gene names: 126208949

Gene position: 1700789-1699929 (Counterclockwise)

Preceding gene: 126208950

Following gene: 126208948

Centisome position: 74.78

GC content: 41.23

Gene sequence:

>861_bases
ATGAAAAACATTCTGTCTATTCAATCTCATGTGGTTTACGGTTATGCGGGCAATAAATCCGCTACCTTTCCCATGCAATT
GTTAGGTGTCGATGTTTGGGCGTTGAATACGGTACAATTTTCGAATCATACCCAATACGGTAAATGGAAAGGAATAGTAA
TGCCGAAAGAACAAATCGGTGAAATTATCCAAGGTATTGATGAGATTGGCGAATTGGCAAAATGCGATGCGGTACTTTCC
GGTTATATCGGTTCGGCCGAACAAGTCACGGAAATCGTAAACGCATTTCATACGGTGAAAAGTCGTAATCCGAATGCGAT
TTATCTGTGTGATCCGGTCATGGGGCATCCGGATAAAGGCCGTATCGTCGCCGACGGCGTAAAAGAAGGCTTAATAAAAC
AGGCAATGGCGCATGCCGATATTATTACGCCGAACTTAGTCGAATTAAGAGAATTAAGCGGTTTAAGAGTAGAAAATTTT
GAACAAGCGATTGAAGCGGTAAAAGTCATTCTCACCAAAGGACCGAAAAAAGTTTTAGTGAAGCATTTAAGTAAAGTCGG
TAAACAAGCGGATAAATTTGAAATGTTTTTTGCAACCGAGGAAGGTATTTGGCATATCAGTCGTCCGCTCTATCAATTTG
ACAAAGAGCCGGTAGGTGTAGGCGATTTAACCGCAGGTTTATTCTTAGCCAATTTACTGAACGGTAAATCGGATATCGAA
GCCTTTGAACATACCGCAAATGCCGTAAATGATGTGATGGAAGTTACCGCAAATTCCGGCGTTTACGAACTGCAAATTAT
TGCCGCTCGAGAATTTATCCTTACACCTCGCAGCCAATATAAAGCGATAAAGATTGTTTAA

Upstream 100 bases:

>100_bases
GTATCTTGAAAAGAGGCGTTATTATAGTTTTTTCGTTTAAAGTTACAAGTCTATTTTGTTAGATTTTTATACATTCAAAA
ATAAAAAGGGAGTTAATTGA

Downstream 100 bases:

>100_bases
TCGAAATAGCCTAAAAATCATGCCGCTTGTTGTGAAATAAGCGGTTTTTGGGATAGTGGACAAAATTGAGTCTACAAAGT
GGGTTAAAACCTTGTACTAT

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKNILSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWKGIVMPKEQIGEIIQGIDEIGELAKCDAVLS
GYIGSAEQVTEIVNAFHTVKSRNPNAIYLCDPVMGHPDKGRIVADGVKEGLIKQAMAHADIITPNLVELRELSGLRVENF
EQAIEAVKVILTKGPKKVLVKHLSKVGKQADKFEMFFATEEGIWHISRPLYQFDKEPVGVGDLTAGLFLANLLNGKSDIE
AFEHTANAVNDVMEVTANSGVYELQIIAAREFILTPRSQYKAIKIV

Sequences:

>Translated_286_residues
MKNILSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWKGIVMPKEQIGEIIQGIDEIGELAKCDAVLS
GYIGSAEQVTEIVNAFHTVKSRNPNAIYLCDPVMGHPDKGRIVADGVKEGLIKQAMAHADIITPNLVELRELSGLRVENF
EQAIEAVKVILTKGPKKVLVKHLSKVGKQADKFEMFFATEEGIWHISRPLYQFDKEPVGVGDLTAGLFLANLLNGKSDIE
AFEHTANAVNDVMEVTANSGVYELQIIAAREFILTPRSQYKAIKIV
>Mature_286_residues
MKNILSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWKGIVMPKEQIGEIIQGIDEIGELAKCDAVLS
GYIGSAEQVTEIVNAFHTVKSRNPNAIYLCDPVMGHPDKGRIVADGVKEGLIKQAMAHADIITPNLVELRELSGLRVENF
EQAIEAVKVILTKGPKKVLVKHLSKVGKQADKFEMFFATEEGIWHISRPLYQFDKEPVGVGDLTAGLFLANLLNGKSDIE
AFEHTANAVNDVMEVTANSGVYELQIIAAREFILTPRSQYKAIKIV

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family

Homologues:

Organism=Homo sapiens, GI4505701, Length=265, Percent_Identity=31.6981132075472, Blast_Score=144, Evalue=8e-35,
Organism=Escherichia coli, GI1787924, Length=286, Percent_Identity=53.8461538461538, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI1788758, Length=254, Percent_Identity=29.1338582677165, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17507759, Length=293, Percent_Identity=32.4232081911263, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17507757, Length=303, Percent_Identity=31.6831683168317, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320806, Length=264, Percent_Identity=35.2272727272727, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324354, Length=179, Percent_Identity=37.4301675977654, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45553007, Length=299, Percent_Identity=34.1137123745819, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXY_ACTP2 (A3N2D3)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054174.1
- ProteinModelPortal:   A3N2D3
- SMR:   A3N2D3
- STRING:   A3N2D3
- GeneID:   4848730
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1485
- eggNOG:   COG2240
- HOGENOM:   HBG661459
- OMA:   CPNQLEL
- PhylomeDB:   A3N2D3
- ProtClustDB:   PRK05756
- BioCyc:   APLE416269:APL_1485-MONOMER
- HAMAP:   MF_01639
- InterPro:   IPR013749
- InterPro:   IPR004625
- TIGRFAMs:   TIGR00687

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.35

Molecular weight: Translated: 31506; Mature: 31506

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 9-9 BINDING 44-44 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWKGIVMPKEQIG
CCCHHEEHHEEEEEEECCCCCCCHHHHHHCEEEEEEEEEECCCCCCCCEEEEECCHHHHH
EIIQGIDEIGELAKCDAVLSGYIGSAEQVTEIVNAFHTVKSRNPNAIYLCDPVMGHPDKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
RIVADGVKEGLIKQAMAHADIITPNLVELRELSGLRVENFEQAIEAVKVILTKGPKKVLV
CEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHH
KHLSKVGKQADKFEMFFATEEGIWHISRPLYQFDKEPVGVGDLTAGLFLANLLNGKSDIE
HHHHHHCCCCHHEEEEEECCCCCCHHHCHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHH
AFEHTANAVNDVMEVTANSGVYELQIIAAREFILTPRSQYKAIKIV
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHCCCHHHCCEEEEC
>Mature Secondary Structure
MKNILSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWKGIVMPKEQIG
CCCHHEEHHEEEEEEECCCCCCCHHHHHHCEEEEEEEEEECCCCCCCCEEEEECCHHHHH
EIIQGIDEIGELAKCDAVLSGYIGSAEQVTEIVNAFHTVKSRNPNAIYLCDPVMGHPDKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
RIVADGVKEGLIKQAMAHADIITPNLVELRELSGLRVENFEQAIEAVKVILTKGPKKVLV
CEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHH
KHLSKVGKQADKFEMFFATEEGIWHISRPLYQFDKEPVGVGDLTAGLFLANLLNGKSDIE
HHHHHHCCCCHHEEEEEECCCCCCHHHCHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHH
AFEHTANAVNDVMEVTANSGVYELQIIAAREFILTPRSQYKAIKIV
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHCCCHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA