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The map label for this gene is serA [H]

Identifier: 126208916

GI number: 126208916

Start: 1664928

End: 1666157

Strand: Reverse

Name: serA [H]

Synonym: APL_1452

Alternate gene names: 126208916

Gene position: 1666157-1664928 (Counterclockwise)

Preceding gene: 126208917

Following gene: 126208915

Centisome position: 73.25

GC content: 43.74

Gene sequence:

>1230_bases
ATGACAGTTCAAATTGATAAATCAAAAATTAAATTTCTCTTACTTGAAGGTGTACACCAAAATGCGTTAGATGTGTTACA
AGCGGCAGGTTATACCAATATCGAATATCATAAAAAAGCGTTGGACGGCGAAGAATTAATTAATGCGATTAAAGATGCGC
ATTTTGTCGGCTTACGTTCTCGTACTTACCTAACCAAAGAAGTTCTCTCACACGCCAAAAATCTCGTGTCGATCGGTTGT
TTCTGTATCGGTACCAACCAAGTCGATTTAAAAGAAGCGAAACGTCTCGGTATTCCGGTATTTAATGCACCGTTTTCAAA
TACACGTTCGGTAGCGGAATTAGTGTTAGCGGAAATTATTCTTTTGATGCGTCAAGTGCCGAAAGCGAATGCCGAAGTAC
ATCGCGGTGTGTGGAACAAATCGGCTGCCGGCTCAAACGAAGTACGTGGTAAAAAATTAGGGATTGTCGGTTACGGTCAT
ATCGGCTCGCAATTAAGCGTAATGGCGGAATCTATCGGTATGCAGGTTTATTTTTACGATATTGAGAACAAACTGCCGTT
AGGTAACGCACAACAAATTGCAAGCTTAAACGAGCTACTTGCCGGCTGCGATGCGATTTCGCTACACGTACCGGAAAACG
CCTCAACCAAAAATTTAATGAATGCGGATCGTATTGCGCAATTAAAAGAAGATTCGGTATTAATTAATGCCGCTCGCGGT
ACGGTGGTGGATATTGACGCGTTAGCGGCACGCTTAGCGCAAGGTACGTTACGTGGTGCGGCGATTGACGTATTCCCGGA
AGAGCCGGCTTCAATCAATGATCCGTTTGAATCACCGCTACGCCAATTCGATAATGTGATTTTGACACCCCATATCGGCG
GTTCAACCGCAGAAGCGCAAGCGAATATCGGTACGGAAGTGGCAAACAAATTCGTGAAATATGCGGATAACGGTTCAACC
CTTTCAGCGGTTAATTTCCCGGAAGTATCGTTACCGATTCTGCATAGCGATGCGAAACGCTTGTTACATATTCACGAAAA
CCGTCCGGGTATTTTAAATAAGATCAACCAAGTATTCGTCGATGGCAACGTGAATATCGCCGGTCAGTATCTACAAACCG
ATCCGAATATCGGTTATGTGGTTATTGATGTGGAATTGGACGATGCAAGCGAAGCGTTAGAACGCTTACAACAAATTGAC
GGCACAATCAAAGCCCGTGTGATTTCATAA

Upstream 100 bases:

>100_bases
TTTGTTATGACGATAACTTCTATCAAATTCAAAAATTTTTCGTGTGTTTATCTTTATAAAATGGTAAAACAATAAAAGAC
AAGCACAACAGGAATCTAGT

Downstream 100 bases:

>100_bases
TATTTATACAAAATGACAAGCGGTGAAATTTGCAAAGTTTTATGCAAATTTCACCGCTTATTTTTTATCTGGCATAGTAG
ACAAAAAGGTTGGTAAAAAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTVQIDKSKIKFLLLEGVHQNALDVLQAAGYTNIEYHKKALDGEELINAIKDAHFVGLRSRTYLTKEVLSHAKNLVSIGC
FCIGTNQVDLKEAKRLGIPVFNAPFSNTRSVAELVLAEIILLMRQVPKANAEVHRGVWNKSAAGSNEVRGKKLGIVGYGH
IGSQLSVMAESIGMQVYFYDIENKLPLGNAQQIASLNELLAGCDAISLHVPENASTKNLMNADRIAQLKEDSVLINAARG
TVVDIDALAARLAQGTLRGAAIDVFPEEPASINDPFESPLRQFDNVILTPHIGGSTAEAQANIGTEVANKFVKYADNGST
LSAVNFPEVSLPILHSDAKRLLHIHENRPGILNKINQVFVDGNVNIAGQYLQTDPNIGYVVIDVELDDASEALERLQQID
GTIKARVIS

Sequences:

>Translated_409_residues
MTVQIDKSKIKFLLLEGVHQNALDVLQAAGYTNIEYHKKALDGEELINAIKDAHFVGLRSRTYLTKEVLSHAKNLVSIGC
FCIGTNQVDLKEAKRLGIPVFNAPFSNTRSVAELVLAEIILLMRQVPKANAEVHRGVWNKSAAGSNEVRGKKLGIVGYGH
IGSQLSVMAESIGMQVYFYDIENKLPLGNAQQIASLNELLAGCDAISLHVPENASTKNLMNADRIAQLKEDSVLINAARG
TVVDIDALAARLAQGTLRGAAIDVFPEEPASINDPFESPLRQFDNVILTPHIGGSTAEAQANIGTEVANKFVKYADNGST
LSAVNFPEVSLPILHSDAKRLLHIHENRPGILNKINQVFVDGNVNIAGQYLQTDPNIGYVVIDVELDDASEALERLQQID
GTIKARVIS
>Mature_408_residues
TVQIDKSKIKFLLLEGVHQNALDVLQAAGYTNIEYHKKALDGEELINAIKDAHFVGLRSRTYLTKEVLSHAKNLVSIGCF
CIGTNQVDLKEAKRLGIPVFNAPFSNTRSVAELVLAEIILLMRQVPKANAEVHRGVWNKSAAGSNEVRGKKLGIVGYGHI
GSQLSVMAESIGMQVYFYDIENKLPLGNAQQIASLNELLAGCDAISLHVPENASTKNLMNADRIAQLKEDSVLINAARGT
VVDIDALAARLAQGTLRGAAIDVFPEEPASINDPFESPLRQFDNVILTPHIGGSTAEAQANIGTEVANKFVKYADNGSTL
SAVNFPEVSLPILHSDAKRLLHIHENRPGILNKINQVFVDGNVNIAGQYLQTDPNIGYVVIDVELDDASEALERLQQIDG
TIKARVIS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=36.9085173501577, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=32.319391634981, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI61743967, Length=263, Percent_Identity=32.319391634981, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=34.5381526104418, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=34.5381526104418, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=34.5381526104418, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI6912396, Length=281, Percent_Identity=28.4697508896797, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=67.156862745098, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI87082289, Length=243, Percent_Identity=30.4526748971193, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=26.7241379310345, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788660, Length=310, Percent_Identity=26.1290322580645, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081824, Length=152, Percent_Identity=32.2368421052632, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=327, Percent_Identity=33.3333333333333, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=29.8507462686567, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=413, Percent_Identity=48.910411622276, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322116, Length=413, Percent_Identity=47.9418886198547, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=26.8115942028986, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=264, Percent_Identity=26.8939393939394, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=30.3225806451613, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=31.0344827586207, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646446, Length=266, Percent_Identity=33.8345864661654, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646448, Length=266, Percent_Identity=33.8345864661654, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646452, Length=266, Percent_Identity=33.8345864661654, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646450, Length=266, Percent_Identity=33.8345864661654, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI62472511, Length=266, Percent_Identity=33.8345864661654, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574286, Length=270, Percent_Identity=28.5185185185185, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28571528, Length=296, Percent_Identity=28.3783783783784, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=26.6903914590747, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=26.6903914590747, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574284, Length=281, Percent_Identity=26.6903914590747, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552429, Length=281, Percent_Identity=26.6903914590747, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551003, Length=308, Percent_Identity=25.6493506493506, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=23.5690235690236, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44368; Mature: 44237

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQIDKSKIKFLLLEGVHQNALDVLQAAGYTNIEYHKKALDGEELINAIKDAHFVGLRS
CEEEECHHHEEEEEECCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHEECCC
RTYLTKEVLSHAKNLVSIGCFCIGTNQVDLKEAKRLGIPVFNAPFSNTRSVAELVLAEII
HHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHH
LLMRQVPKANAEVHRGVWNKSAAGSNEVRGKKLGIVGYGHIGSQLSVMAESIGMQVYFYD
HHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEE
IENKLPLGNAQQIASLNELLAGCDAISLHVPENASTKNLMNADRIAQLKEDSVLINAARG
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHHCCCCEEEEECCC
TVVDIDALAARLAQGTLRGAAIDVFPEEPASINDPFESPLRQFDNVILTPHIGGSTAEAQ
CEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHH
ANIGTEVANKFVKYADNGSTLSAVNFPEVSLPILHSDAKRLLHIHENRPGILNKINQVFV
HHCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEHHCHHHHHEECCCCCHHHHHHHEEEE
DGNVNIAGQYLQTDPNIGYVVIDVELDDASEALERLQQIDGTIKARVIS
CCCCEEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure 
TVQIDKSKIKFLLLEGVHQNALDVLQAAGYTNIEYHKKALDGEELINAIKDAHFVGLRS
EEEECHHHEEEEEECCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHEECCC
RTYLTKEVLSHAKNLVSIGCFCIGTNQVDLKEAKRLGIPVFNAPFSNTRSVAELVLAEII
HHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHH
LLMRQVPKANAEVHRGVWNKSAAGSNEVRGKKLGIVGYGHIGSQLSVMAESIGMQVYFYD
HHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEE
IENKLPLGNAQQIASLNELLAGCDAISLHVPENASTKNLMNADRIAQLKEDSVLINAARG
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCHHHHHHHCCCCEEEEECCC
TVVDIDALAARLAQGTLRGAAIDVFPEEPASINDPFESPLRQFDNVILTPHIGGSTAEAQ
CEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHH
ANIGTEVANKFVKYADNGSTLSAVNFPEVSLPILHSDAKRLLHIHENRPGILNKINQVFV
HHCCHHHHHHHHHHCCCCCEEEEECCCCCCCEEEHHCHHHHHEECCCCCHHHHHHHEEEE
DGNVNIAGQYLQTDPNIGYVVIDVELDDASEALERLQQIDGTIKARVIS
CCCCEEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]