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The map label for this gene is uvrD [H]

Identifier: 126208790

GI number: 126208790

Start: 1519784

End: 1521982

Strand: Direct

Name: uvrD [H]

Synonym: APL_1326

Alternate gene names: 126208790

Gene position: 1519784-1521982 (Clockwise)

Preceding gene: 126208789

Following gene: 126208791

Centisome position: 66.82

GC content: 44.47

Gene sequence:

>2199_bases
ATGGATTTTTCTTTATTATTAGACGGTTTAAATGATAAGCAGCGAGAGGCTGTCGCTGCGCCGTTGGGCAATTATTTAGT
ATTGGCGGGAGCCGGTTCCGGTAAAACACGGGTGCTGACACATCGTATTGCATGGTTAATCGGTGTAGAAAACGTACCGG
AATCGAATATTCTAGCAGTCACCTTTACCAATAAAGCGGCAGCGGAAATGCGTCATCGTATCGAACATACCCTTTCTTCC
AGCAGCCATCACCGCCTGTTCGGTATGTGGGTCGGTACGTTCCACAGCATTGCCAACCGTTTGTTACGCTCACATTATCT
TGATGCCGATTTGCCGCAAGATTTCCAAATTATGGATAGCGAAGATCAGCAACGTTTACTTAAACGTTTGTTAAAGCTGC
ACAATATTGATGAAAAACATTTCCCACCGAAACACGTGGCGTGGTATATCAGTGTGCAAAAAGATAAAGGTAAACGCCCG
AAAGATATTGAACATCATAACGATCCGAACGAGAAGAAATTAGTCCAAATCTACCAAATTTATCAAGATGCCTGCGATCG
TGCCGGTCTGTTGGATTTTGCCGAATTATTGATTCGCGCTTATGAACTTTTCCGAGACAAACCGCCGATTTTACAGCGCT
ATCAGCAACGTTTTCAGCAGATTTTGATCGATGAGTTCCAAGATACCAACAATATTCAATATGACTTAATCCGTCTGCTT
GCCGGTGAAACCGGTAATGTGATGATTGTCGGCGATGACGACCAATCGATTTACGGCTGGCGTGGTGCGCAGGTTGAAAA
TATTCAGCGTTTCTTAAACGATTATCAAAAAGCGGAAACCATTCGTCTTGAGCAAAATTACCGCTCAACCGGTCATATTC
TCGCTACGGCAAACGAATTGATTTCCAATAACGAAGACCGTTTGGGTAAGAATTTATGGACGGATCAAGGCGACGGCGAT
CCGGTTGAAATTTATTGTGCTTTCAACGAATTGGACGAAGCCCGTTTTGTTGCCTCACAAATTAAACAATGGAAAGAGGA
CGAAGGCGATTTAAATGAATGTGCGGTGCTATATCGTAGTAACAGCCAATCTCGTGTGATTGAAGAAGCATTGATTCAAG
CGAATATTCCTTACCGTATTTACGGCGGTATGCGCTTCTTCGAACGCCAAGAAATCAAAGATGCGCTGGCGTATTTACGT
TTGATCGCTAATCGCCAAGACGATGCGGCATTTGAACGAGTGATTAACACACCGCCAAGAGGAATTGGCGAACGCACCTT
AGATACGATTCGTCAAATTACTCGTAATCGCCAAATAACCTTGTGGCAAGCGATTCAAGTGGCTGTGCAAGAAGAACAGC
TTTCCGGCAGAGCCGCTTCCGCCTTACTACGTTTTGTCGAATTGATTAATGCGCTCGAGCAAGAAACCGAGCAAATGCCA
CTGTTTGAACAAACCGATTTTGTGATTAAAAAATCCGGTTTGTACGAAATGTATAAACAAGAAAAAGGGGAAAAAGGCGA
AGTTCGTATCGAGAACTTAGAAGAGCTGGTTACCGCCACTAAACAATTCAGCAAGCCTGACGAAGCGGAAGAAATGTCGG
ATCTCACCGCATTTTTAACTCACGCTTCATTAGAAGCCGGCGAAGCGCAAGCCTCTCCGCATCAAGATTATGTCGAATTA
ATGACGTTACATTCGGCAAAAGGCTTAGAATTCCCCCGTGTATTTATAGTGGGTGTGGAAGAAGGCATTTTCCCGAGCGG
AATGAGCTTTGACGAAGGCAGACTGCAAGAAGAGCGCCGTTTGGCTTATGTCGGTATTACCCGTGCGAAGAAAAAATTGA
CGATCAGTTATGCCGAACTCAGACGTTTATACGGCAAAGAAGAGCGTCATATCGCTTCTCGTTTTATTGCCGAATTGCCC
GAGCAGCATATTCGCGAAGTACGTTTGAGAGGCTCTATCAATCGTGCGGCAAGTTTTGCCCAAAGCACGCCTTTTGCAAA
AAATTCGGCAAAAACGACCGCTTCTTGTTTAGAAGACAATAGCTGGAAAATGGGGCAAAAGGTGCAACACGCTAAATTCG
GACAAGGCACGATTGTTAATGTGGAAGGCAGCGGCGAAGCGACCCGTTTGCAAATCGCCTTTGCAGGTAACGGTATTAAG
TGGTTGATTGCTAAGATGGCAAATTTAGAGAAAATTTAA

Upstream 100 bases:

>100_bases
GAATATTTATATACTTTGCAAATCTTTTATAAAATTCAACCGCTTTGATCTATAATAGGATTAACTGTATAAACGAACAT
TAATTGAATACGAGGCGGTA

Downstream 100 bases:

>100_bases
ACCGCTTGATATAGGGTGAATATCGGCATATATGATTTATTCATATATGCTTTTTTTCTATTTAATAAAAATATCTCCGC
TATCTCTTATATACCTAATT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 732; Mature: 732

Protein sequence:

>732_residues
MDFSLLLDGLNDKQREAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEHTLSS
SSHHRLFGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDSEDQQRLLKRLLKLHNIDEKHFPPKHVAWYISVQKDKGKRP
KDIEHHNDPNEKKLVQIYQIYQDACDRAGLLDFAELLIRAYELFRDKPPILQRYQQRFQQILIDEFQDTNNIQYDLIRLL
AGETGNVMIVGDDDQSIYGWRGAQVENIQRFLNDYQKAETIRLEQNYRSTGHILATANELISNNEDRLGKNLWTDQGDGD
PVEIYCAFNELDEARFVASQIKQWKEDEGDLNECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLR
LIANRQDDAAFERVINTPPRGIGERTLDTIRQITRNRQITLWQAIQVAVQEEQLSGRAASALLRFVELINALEQETEQMP
LFEQTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFSKPDEAEEMSDLTAFLTHASLEAGEAQASPHQDYVEL
MTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERRLAYVGITRAKKKLTISYAELRRLYGKEERHIASRFIAELP
EQHIREVRLRGSINRAASFAQSTPFAKNSAKTTASCLEDNSWKMGQKVQHAKFGQGTIVNVEGSGEATRLQIAFAGNGIK
WLIAKMANLEKI

Sequences:

>Translated_732_residues
MDFSLLLDGLNDKQREAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEHTLSS
SSHHRLFGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDSEDQQRLLKRLLKLHNIDEKHFPPKHVAWYISVQKDKGKRP
KDIEHHNDPNEKKLVQIYQIYQDACDRAGLLDFAELLIRAYELFRDKPPILQRYQQRFQQILIDEFQDTNNIQYDLIRLL
AGETGNVMIVGDDDQSIYGWRGAQVENIQRFLNDYQKAETIRLEQNYRSTGHILATANELISNNEDRLGKNLWTDQGDGD
PVEIYCAFNELDEARFVASQIKQWKEDEGDLNECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLR
LIANRQDDAAFERVINTPPRGIGERTLDTIRQITRNRQITLWQAIQVAVQEEQLSGRAASALLRFVELINALEQETEQMP
LFEQTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFSKPDEAEEMSDLTAFLTHASLEAGEAQASPHQDYVEL
MTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERRLAYVGITRAKKKLTISYAELRRLYGKEERHIASRFIAELP
EQHIREVRLRGSINRAASFAQSTPFAKNSAKTTASCLEDNSWKMGQKVQHAKFGQGTIVNVEGSGEATRLQIAFAGNGIK
WLIAKMANLEKI
>Mature_732_residues
MDFSLLLDGLNDKQREAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEHTLSS
SSHHRLFGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDSEDQQRLLKRLLKLHNIDEKHFPPKHVAWYISVQKDKGKRP
KDIEHHNDPNEKKLVQIYQIYQDACDRAGLLDFAELLIRAYELFRDKPPILQRYQQRFQQILIDEFQDTNNIQYDLIRLL
AGETGNVMIVGDDDQSIYGWRGAQVENIQRFLNDYQKAETIRLEQNYRSTGHILATANELISNNEDRLGKNLWTDQGDGD
PVEIYCAFNELDEARFVASQIKQWKEDEGDLNECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLR
LIANRQDDAAFERVINTPPRGIGERTLDTIRQITRNRQITLWQAIQVAVQEEQLSGRAASALLRFVELINALEQETEQMP
LFEQTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFSKPDEAEEMSDLTAFLTHASLEAGEAQASPHQDYVEL
MTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERRLAYVGITRAKKKLTISYAELRRLYGKEERHIASRFIAELP
EQHIREVRLRGSINRAASFAQSTPFAKNSAKTTASCLEDNSWKMGQKVQHAKFGQGTIVNVEGSGEATRLQIAFAGNGIK
WLIAKMANLEKI

Specific function: May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=734, Percent_Identity=68.1198910081744, Blast_Score=1029, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=641, Percent_Identity=38.8455538221529, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1789183, Length=522, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322369, Length=759, Percent_Identity=29.9077733860343, Blast_Score=201, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324477, Length=686, Percent_Identity=23.9067055393586, Blast_Score=131, Evalue=4e-31,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83743; Mature: 83743

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSLLLDGLNDKQREAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAV
CCHHHEECCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
TFTNKAAAEMRHRIEHTLSSSSHHRLFGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDS
EECCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCC
EDQQRLLKRLLKLHNIDEKHFPPKHVAWYISVQKDKGKRPKDIEHHNDPNEKKLVQIYQI
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
YQDACDRAGLLDFAELLIRAYELFRDKPPILQRYQQRFQQILIDEFQDTNNIQYDLIRLL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AGETGNVMIVGDDDQSIYGWRGAQVENIQRFLNDYQKAETIRLEQNYRSTGHILATANEL
HCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHEEEHHCCCCCCCEEEEHHHH
ISNNEDRLGKNLWTDQGDGDPVEIYCAFNELDEARFVASQIKQWKEDEGDLNECAVLYRS
HCCCHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEC
NSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQDDAAFERVINTPPR
CCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
GIGERTLDTIRQITRNRQITLWQAIQVAVQEEQLSGRAASALLRFVELINALEQETEQMP
CCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
LFEQTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFSKPDEAEEMSDLTAFLT
CCCCCCHHEECCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
HASLEAGEAQASPHQDYVELMTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERR
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
LAYVGITRAKKKLTISYAELRRLYGKEERHIASRFIAELPEQHIREVRLRGSINRAASFA
EEEEEHHHHHHHHEEEHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHH
QSTPFAKNSAKTTASCLEDNSWKMGQKVQHAKFGQGTIVNVEGSGEATRLQIAFAGNGIK
HCCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEEEEEECCCHH
WLIAKMANLEKI
HHHHHHHHHCCC
>Mature Secondary Structure
MDFSLLLDGLNDKQREAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAV
CCHHHEECCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
TFTNKAAAEMRHRIEHTLSSSSHHRLFGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDS
EECCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCC
EDQQRLLKRLLKLHNIDEKHFPPKHVAWYISVQKDKGKRPKDIEHHNDPNEKKLVQIYQI
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
YQDACDRAGLLDFAELLIRAYELFRDKPPILQRYQQRFQQILIDEFQDTNNIQYDLIRLL
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AGETGNVMIVGDDDQSIYGWRGAQVENIQRFLNDYQKAETIRLEQNYRSTGHILATANEL
HCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHEEEHHCCCCCCCEEEEHHHH
ISNNEDRLGKNLWTDQGDGDPVEIYCAFNELDEARFVASQIKQWKEDEGDLNECAVLYRS
HCCCHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEC
NSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQDDAAFERVINTPPR
CCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
GIGERTLDTIRQITRNRQITLWQAIQVAVQEEQLSGRAASALLRFVELINALEQETEQMP
CCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
LFEQTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFSKPDEAEEMSDLTAFLT
CCCCCCHHEECCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
HASLEAGEAQASPHQDYVELMTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERR
HHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
LAYVGITRAKKKLTISYAELRRLYGKEERHIASRFIAELPEQHIREVRLRGSINRAASFA
EEEEEHHHHHHHHEEEHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHH
QSTPFAKNSAKTTASCLEDNSWKMGQKVQHAKFGQGTIVNVEGSGEATRLQIAFAGNGIK
HCCCCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEEECCCCEEEEEEEEECCCHH
WLIAKMANLEKI
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8294031; 7542800; 3259573 [H]