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The map label for this gene is arcB [H]

Identifier: 126208781

GI number: 126208781

Start: 1508919

End: 1509923

Strand: Direct

Name: arcB [H]

Synonym: APL_1317

Alternate gene names: 126208781

Gene position: 1508919-1509923 (Clockwise)

Preceding gene: 126208779

Following gene: 126208782

Centisome position: 66.34

GC content: 44.78

Gene sequence:

>1005_bases
ATGGCATTTAACCTTAAAAATAGACATTTACTCAGCCTTGTAAACCACACTGAACGTGAAATCAAATTCTTATTAGACTT
ATCCCGCGATCTAAAACGAGCGAAATATGCAGGAACCGAACAACAACGATTAAAAGGTAAAAACATTGCGTTAATTTTTG
AGAAAACTTCAACCCGTACCCGTTGTGCTTTTGAAGTGGCGGCCTACGATCAAGGCGCACACGTAACTTATATTGACCCG
ACTTCATCGCAAATCGGTCATAAAGAATCGATGAAGGACACCGCTCGCGTGTTGGGCAGAATGTACGATGCGATTGAATA
CCGCGGCTTTAAACAATCGGTGGTAAACGAATTGGCGGAATATGCGGGCGTGCCGGTATTCAACGGTTTAACCGATGAAT
TCCACCCGACCCAAATGTTAGCCGACGTTCTCACTATGATCGAAAATTGTGAAAAACCGTTAAGCCAAATCAGTTATGTT
TATATCGGTGACGCACGTAACAACGTAGGTAACTCATTACTGTTAATCGGTGCGAAATTAGGAATGGACGTTCGTATTTG
TGCGCCGAAAGCACTATTACCGGAAGACAGCCTTGTTGAAATGTGCCAAAAATTCGCAGCGGAAAGCGGTGCAAGAATTA
CCGTAACCGACGATATCGATACCGCAGTAAAAGGCGTAGATTTCGTACATACCGACGTTTGGGTATCGATGGGCGAACCG
CTTGAAACTTGGGGCGAACGTATCGATATGCTAATGCCGTATCAAGTTACGCCGGAACTCATGAAACGTACCGGTAATCC
GAAAGTGAAATTTATGCACTGCTTACCGGCATTCCATAACAGCGAAACGAAAATCGGTAAACAAGTTGCCGAAAAATATC
CGGCTCTGGCAAACGGTATCGAAGTAACCGAAGACGTTTTCGAATCGCCGGCAAACGTCGCTTTCGAACAAGCGGAAAAC
CGTATGCACACCATTAAAGCGGTCATGGTCGCAAGCTTAGCGTAA

Upstream 100 bases:

>100_bases
AATTCCACATTTTATATATCCACGATCTCGAATAAGTTGTTTCACTTATACAAGCGGTCAAATTTTTAAATCTTTTTACT
TATAAAACAGGAGCAATATC

Downstream 100 bases:

>100_bases
GAAGTAGAAAAAGGAACAAACATGAAAATCGTAGTAGCTTTAGGCGGTAACGCTTTATTAAAACGCGGTGAGCCGATGAC
CGCCCAAAACCAGTCGGCAA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAFNLKNRHLLSLVNHTEREIKFLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAHVTYIDP
TSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSVVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCEKPLSQISYV
YIGDARNNVGNSLLLIGAKLGMDVRICAPKALLPEDSLVEMCQKFAAESGARITVTDDIDTAVKGVDFVHTDVWVSMGEP
LETWGERIDMLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKIGKQVAEKYPALANGIEVTEDVFESPANVAFEQAEN
RMHTIKAVMVASLA

Sequences:

>Translated_334_residues
MAFNLKNRHLLSLVNHTEREIKFLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAHVTYIDP
TSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSVVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCEKPLSQISYV
YIGDARNNVGNSLLLIGAKLGMDVRICAPKALLPEDSLVEMCQKFAAESGARITVTDDIDTAVKGVDFVHTDVWVSMGEP
LETWGERIDMLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKIGKQVAEKYPALANGIEVTEDVFESPANVAFEQAEN
RMHTIKAVMVASLA
>Mature_333_residues
AFNLKNRHLLSLVNHTEREIKFLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAHVTYIDPT
SSQIGHKESMKDTARVLGRMYDAIEYRGFKQSVVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCEKPLSQISYVY
IGDARNNVGNSLLLIGAKLGMDVRICAPKALLPEDSLVEMCQKFAAESGARITVTDDIDTAVKGVDFVHTDVWVSMGEPL
ETWGERIDMLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKIGKQVAEKYPALANGIEVTEDVFESPANVAFEQAENR
MHTIKAVMVASLA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=330, Percent_Identity=38.4848484848485, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI18105007, Length=340, Percent_Identity=22.9411764705882, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=59.2705167173252, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1786469, Length=332, Percent_Identity=59.0361445783133, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI2367364, Length=341, Percent_Identity=26.6862170087977, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994908, Length=382, Percent_Identity=23.2984293193717, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322373, Length=330, Percent_Identity=31.5151515151515, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322331, Length=194, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24642586, Length=339, Percent_Identity=22.7138643067847, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 37339; Mature: 37208

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNLKNRHLLSLVNHTEREIKFLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCCC
RCAFEVAAYDQGAHVTYIDPTSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSVVNELAE
CEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YAGVPVFNGLTDEFHPTQMLADVLTMIENCEKPLSQISYVYIGDARNNVGNSLLLIGAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECC
GMDVRICAPKALLPEDSLVEMCQKFAAESGARITVTDDIDTAVKGVDFVHTDVWVSMGEP
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCHHEEHHHHHCCCCH
LETWGERIDMLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKIGKQVAEKYPALANGI
HHHHHHHHCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHCCC
EVTEDVFESPANVAFEQAENRMHTIKAVMVASLA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFNLKNRHLLSLVNHTEREIKFLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCCC
RCAFEVAAYDQGAHVTYIDPTSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSVVNELAE
CEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
YAGVPVFNGLTDEFHPTQMLADVLTMIENCEKPLSQISYVYIGDARNNVGNSLLLIGAKL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECC
GMDVRICAPKALLPEDSLVEMCQKFAAESGARITVTDDIDTAVKGVDFVHTDVWVSMGEP
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCHHEEHHHHHCCCCH
LETWGERIDMLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKIGKQVAEKYPALANGI
HHHHHHHHCCCCCCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHCCC
EVTEDVFESPANVAFEQAENRMHTIKAVMVASLA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]