Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 126208771

GI number: 126208771

Start: 1496719

End: 1498173

Strand: Reverse

Name: gnd [H]

Synonym: APL_1305

Alternate gene names: 126208771

Gene position: 1498173-1496719 (Counterclockwise)

Preceding gene: 126208772

Following gene: 126208769

Centisome position: 65.87

GC content: 43.51

Gene sequence:

>1455_bases
ATGTCAGTAAAAGGCGACATCGGCGTTATCGGTTTAGCGGTAATGGGCCAAAACTTAATTTTAAATATGAACGACAATGG
CTTTAAAGTAGTGGCGTATAACCGCACGACTTCAAAAGTGGATGAGTTCTTAGCAGGTGCGGCGAAAGGTACGAATATTA
TCGGTGCTTATTCGTTAGAAGACTTAGCAGCGAAATTAGAAAAACCGCGTAAAGTAATGTTAATGGTGCGTGCAGGCGAT
GTAGTGGATCAATTTATTGACGCATTACTACCGCATTTAGAAGAAGGTGACATCATTATTGACGGCGGTAACTCAAACTA
TCCGGATACTAACCGTCGTACCGCTGCATTAGCAGAAAAAGGTATTCGCTTTATCGGTACCGGTGTTTCAGGCGGTGAAG
AAGGTGCGCGTCACGGGCCTTCAATTATGCCGGGCGGTAACATTGAAGCGTGGGAACACGTTAAGCCGATTTTACAAGCG
ATTTCAGCGAAAACCGATAAAGGCGAGCCTTGCTGTGACTGGGTGGGCAAAGAAGGTGCGGGTCATTTCGTGAAAATGGT
TCACAACGGTATCGAATACGGCGATATGCAGTTAATTTGCGAAGCTTACCAATTCTTAAAAGACGGTTTAGGTTTAAGCT
ACGATGAAATGCAAGCGATTTTCCAAGAGTGGAAAAAAACTGAATTAGACAGCTACTTAATCGATATCACAACTGATATT
TTAGGTTATAAGGATACAGACGGCACACCGTTAGTAGAGAAAATCTTAGATACCGCAGGTCAAAAAGGTACAGGTAAATG
GACCGGTATCAATGCGTTAGATTTCGGTATTCCATTAACTTTAATCACTGAATCGGTATTCGCTCGTTGCGTATCTTCAT
TTAAAGATCAACGTGTAGCAGCTTCTAAATTATTTAACAAAACCATCATGCCGATTGAAGGCGATAAGAAAGTGTGGATT
GAAGCAGTTCGCAAAGCGTTACTTGCCTCAAAAATCATCTCTTATGCACAAGGCTTTATGTTAATTCGTGAAGCGTCAGA
AAACTTCGGTTGGGATATCAACTACGGTGCAACCGCATTGTTATGGCGTGAAGGCTGTATCATTCGTAGTCGTTTCTTAG
GTAATATCCGTGATGCGTATGAAGCGAATCCGGACTTAGTATTCTTAGGTTCAGACGATTACTTCAAAGGCATTTTAGAA
AACGCAATGGCAGACTGGCGTAAAGTGGTAGCGAAGTCTATCGAAGTGGGTATTCCTATGCCGTGTATGGCGTCAGCGAT
CACCTTCTTAGACGGTTATACTTCAGACCGTGTGCCGGCAAACTTACTGCAAGCACAGCGTGACTACTTCGGTGCGCACA
CTTATGAACGTACTGATAAACCACGCGGCGAGTTCTTCCACACTAACTGGACAGGTCGTGGCGGTAACACAGCTTCAACC
ACTTATGATGTGTAA

Upstream 100 bases:

>100_bases
TTTTCAGCTATGGAAAAATTAATTAAATAAGCGGTTAATTTTGCAAAAAATGTTACAAATTCGACCGCTTGTAACGAATC
AAAACCAACAGGAGAAAACA

Downstream 100 bases:

>100_bases
GATATTGCTGAACTAATTGCTTAGAGAAGCTTCTAAAAAGCGGGTAATTAATTTATTACCCGCTTTTTTTCAACTCAAAT
TAGGACTTCACTATGAAAAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSVKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDEFLAGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGD
VVDQFIDALLPHLEEGDIIIDGGNSNYPDTNRRTAALAEKGIRFIGTGVSGGEEGARHGPSIMPGGNIEAWEHVKPILQA
ISAKTDKGEPCCDWVGKEGAGHFVKMVHNGIEYGDMQLICEAYQFLKDGLGLSYDEMQAIFQEWKKTELDSYLIDITTDI
LGYKDTDGTPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAASKLFNKTIMPIEGDKKVWI
EAVRKALLASKIISYAQGFMLIREASENFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPDLVFLGSDDYFKGILE
NAMADWRKVVAKSIEVGIPMPCMASAITFLDGYTSDRVPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTAST
TYDV

Sequences:

>Translated_484_residues
MSVKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDEFLAGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGD
VVDQFIDALLPHLEEGDIIIDGGNSNYPDTNRRTAALAEKGIRFIGTGVSGGEEGARHGPSIMPGGNIEAWEHVKPILQA
ISAKTDKGEPCCDWVGKEGAGHFVKMVHNGIEYGDMQLICEAYQFLKDGLGLSYDEMQAIFQEWKKTELDSYLIDITTDI
LGYKDTDGTPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAASKLFNKTIMPIEGDKKVWI
EAVRKALLASKIISYAQGFMLIREASENFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPDLVFLGSDDYFKGILE
NAMADWRKVVAKSIEVGIPMPCMASAITFLDGYTSDRVPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTAST
TYDV
>Mature_483_residues
SVKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDEFLAGAAKGTNIIGAYSLEDLAAKLEKPRKVMLMVRAGDV
VDQFIDALLPHLEEGDIIIDGGNSNYPDTNRRTAALAEKGIRFIGTGVSGGEEGARHGPSIMPGGNIEAWEHVKPILQAI
SAKTDKGEPCCDWVGKEGAGHFVKMVHNGIEYGDMQLICEAYQFLKDGLGLSYDEMQAIFQEWKKTELDSYLIDITTDIL
GYKDTDGTPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVAASKLFNKTIMPIEGDKKVWIE
AVRKALLASKIISYAQGFMLIREASENFGWDINYGATALLWREGCIIRSRFLGNIRDAYEANPDLVFLGSDDYFKGILEN
AMADWRKVVAKSIEVGIPMPCMASAITFLDGYTSDRVPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTASTT
YDV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=481, Percent_Identity=62.7858627858628, Blast_Score=628, Evalue=1e-180,
Organism=Escherichia coli, GI1788341, Length=467, Percent_Identity=54.1755888650964, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=60.8695652173913, Blast_Score=617, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6321695, Length=486, Percent_Identity=58.8477366255144, Blast_Score=594, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=58.8114754098361, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24639279, Length=483, Percent_Identity=59.6273291925466, Blast_Score=568, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53183; Mature: 53052

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDEFLAGAAKGTNIIGAYSLE
CCCCCCCCCEEHEECCCCEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEECCHH
DLAAKLEKPRKVMLMVRAGDVVDQFIDALLPHLEEGDIIIDGGNSNYPDTNRRTAALAEK
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHC
GIRFIGTGVSGGEEGARHGPSIMPGGNIEAWEHVKPILQAISAKTDKGEPCCDWVGKEGA
CCEEEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
GHFVKMVHNGIEYGDMQLICEAYQFLKDGLGLSYDEMQAIFQEWKKTELDSYLIDITTDI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYKDTDGTPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVA
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ASKLFNKTIMPIEGDKKVWIEAVRKALLASKIISYAQGFMLIREASENFGWDINYGATAL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEE
LWREGCIIRSRFLGNIRDAYEANPDLVFLGSDDYFKGILENAMADWRKVVAKSIEVGIPM
EHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCMASAITFLDGYTSDRVPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTAST
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
TYDV
CCCC
>Mature Secondary Structure 
SVKGDIGVIGLAVMGQNLILNMNDNGFKVVAYNRTTSKVDEFLAGAAKGTNIIGAYSLE
CCCCCCCCEEHEECCCCEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEECCHH
DLAAKLEKPRKVMLMVRAGDVVDQFIDALLPHLEEGDIIIDGGNSNYPDTNRRTAALAEK
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHHHC
GIRFIGTGVSGGEEGARHGPSIMPGGNIEAWEHVKPILQAISAKTDKGEPCCDWVGKEGA
CCEEEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
GHFVKMVHNGIEYGDMQLICEAYQFLKDGLGLSYDEMQAIFQEWKKTELDSYLIDITTDI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGYKDTDGTPLVEKILDTAGQKGTGKWTGINALDFGIPLTLITESVFARCVSSFKDQRVA
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ASKLFNKTIMPIEGDKKVWIEAVRKALLASKIISYAQGFMLIREASENFGWDINYGATAL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEE
LWREGCIIRSRFLGNIRDAYEANPDLVFLGSDDYFKGILENAMADWRKVVAKSIEVGIPM
EHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PCMASAITFLDGYTSDRVPANLLQAQRDYFGAHTYERTDKPRGEFFHTNWTGRGGNTAST
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
TYDV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]