Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 126208716

GI number: 126208716

Start: 1436286

End: 1437362

Strand: Reverse

Name: fba [H]

Synonym: APL_1250

Alternate gene names: 126208716

Gene position: 1437362-1436286 (Counterclockwise)

Preceding gene: 126208717

Following gene: 126208715

Centisome position: 63.2

GC content: 44.01

Gene sequence:

>1077_bases
ATGGCATTATTAGACATCGTAAAACCGGGTGTAGTAACAGGCGATGACGTTCAAAAAGTATTCGCTTACGCTAAAGCAAA
CAACTTCGCTATCCCTGCGGTAAACTGCGTAGGTTCTGACTCTGTAAATGCGGTATTGGAAACGGCGGCACGCGTAAAAT
CACCTGTGATTATTCAGTTCTCTAACGGCGGTGCGCAATTCTACGCCGGTAAAGGTATTAAACCGACAAGCGGTATGCGT
GCGGATGTTTTAGGTGCGATTGCCGGTGCGAAACACGTTCATTCATTAGCGGAAGAATACGGTGTGCCGGTAATTCTTCA
TACCGACCACGCTGCGAAAAAATTACTGCCGTGGATTGACGGTTTGTTAGATGCGGGTGAAAAACATTTTGCGGAAACGG
GTAAACCGTTATTCTCTTCACACATGATTGATCTTTCGGAAGAACCGATTGAAGAAAATATGGCGATTTGTCGTGAGTAT
TTAGCGCGTATGGACAAAATGGGTATGACGCTTGAAATCGAAATCGGTATTACCGGCGGCGAAGAAGACGGTGTGGATAA
CTCTGATGTTGAAGAAGCGAAATTATATACTCAACCTGAAGACGTATTATACGTTTACGATCAATTAAATCCGGTAAGCC
CGCGTTTCACTGTTGCGGCGGCATTCGGTAACGTACACGGCGTTTATAAACCGGGTAACGTAAAATTAAAACCTTCTATT
TTAGGTGCGTCACAAGAGTTCGTTTCGAAAGAACGTAATCTTCCTGCGAAATCAATCGACTTCGTATTCCACGGCGGTTC
AGGCTCAAGCCGTGAAGAAATCCGTGAAGCAATCGGCTACGGTGCGATCAAAATGAACATCGATACCGATACGCAATGGG
CTTCTTGGGACGGTATTCTTCAATTCTACAAAGCGAACGAAGCATACTTACAAGGTCAATTAGGTAACCCTGAAGGTCCT
GACGCTCCAAATAAAAAATACTACGATCCGCGTGTTTGGTTACGTAAAATGGAAGAATCTATGTCTAAACGCTTAGAACA
ATCTTTCGAAGACTTAAACTGCGTGAACGTTTTATAA

Upstream 100 bases:

>100_bases
TTGATCTTGTGTAGGGGCGTATTGCATACGTCCTAAAACTCTCCATTAAGGGCGTATGTAATACGCCCCTACTGAATCAT
TTATTTAAAGGAAACTCAAA

Downstream 100 bases:

>100_bases
TTTCAGATTGTAAAAACTTTAGTAAAAAAGACCGCTTGTTAGCGGTCTTTTTCGTTGATAATTGTATAGGGATAACTGAT
AATGGTTTTTCCAAATATTC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MALLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKSPVIIQFSNGGAQFYAGKGIKPTSGMR
ADVLGAIAGAKHVHSLAEEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGKPLFSSHMIDLSEEPIEENMAICREY
LARMDKMGMTLEIEIGITGGEEDGVDNSDVEEAKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPSI
LGASQEFVSKERNLPAKSIDFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWDGILQFYKANEAYLQGQLGNPEGP
DAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVNVL

Sequences:

>Translated_358_residues
MALLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKSPVIIQFSNGGAQFYAGKGIKPTSGMR
ADVLGAIAGAKHVHSLAEEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGKPLFSSHMIDLSEEPIEENMAICREY
LARMDKMGMTLEIEIGITGGEEDGVDNSDVEEAKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPSI
LGASQEFVSKERNLPAKSIDFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWDGILQFYKANEAYLQGQLGNPEGP
DAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVNVL
>Mature_357_residues
ALLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKSPVIIQFSNGGAQFYAGKGIKPTSGMRA
DVLGAIAGAKHVHSLAEEYGVPVILHTDHAAKKLLPWIDGLLDAGEKHFAETGKPLFSSHMIDLSEEPIEENMAICREYL
ARMDKMGMTLEIEIGITGGEEDGVDNSDVEEAKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPSIL
GASQEFVSKERNLPAKSIDFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWDGILQFYKANEAYLQGQLGNPEGPD
APNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVNVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=356, Percent_Identity=71.6292134831461, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI87082041, Length=338, Percent_Identity=25.1479289940828, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788072, Length=274, Percent_Identity=28.1021897810219, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=352, Percent_Identity=49.7159090909091, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 39132; Mature: 39001

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00152 ATPASE_ALPHA_BETA ; PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKSPVIIQF
CCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEE
SNGGAQFYAGKGIKPTSGMRADVLGAIAGAKHVHSLAEEYGVPVILHTDHAAKKLLPWID
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLLDAGEKHFAETGKPLFSSHMIDLSEEPIEENMAICREYLARMDKMGMTLEIEIGITGG
HHHHCCHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
EEDGVDNSDVEEAKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPSI
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHHH
LGASQEFVSKERNLPAKSIDFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWDGIL
HCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
QFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVNVL
HHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure 
ALLDIVKPGVVTGDDVQKVFAYAKANNFAIPAVNCVGSDSVNAVLETAARVKSPVIIQF
CCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEE
SNGGAQFYAGKGIKPTSGMRADVLGAIAGAKHVHSLAEEYGVPVILHTDHAAKKLLPWID
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLLDAGEKHFAETGKPLFSSHMIDLSEEPIEENMAICREYLARMDKMGMTLEIEIGITGG
HHHHCCHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
EEDGVDNSDVEEAKLYTQPEDVLYVYDQLNPVSPRFTVAAAFGNVHGVYKPGNVKLKPSI
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCEECCCCEEECHHH
LGASQEFVSKERNLPAKSIDFVFHGGSGSSREEIREAIGYGAIKMNIDTDTQWASWDGIL
HCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
QFYKANEAYLQGQLGNPEGPDAPNKKYYDPRVWLRKMEESMSKRLEQSFEDLNCVNVL
HHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]