Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 126208709

GI number: 126208709

Start: 1430369

End: 1431739

Strand: Reverse

Name: gor [H]

Synonym: APL_1243

Alternate gene names: 126208709

Gene position: 1431739-1430369 (Counterclockwise)

Preceding gene: 126208711

Following gene: 126208702

Centisome position: 62.95

GC content: 45.66

Gene sequence:

>1371_bases
ATGACTAAACACTATGATTATCTAGCGATTGGCGGCGGTAGCGGCGGTATCGCCTCTATTAATCGAGCGGCAAGCTACGG
CAAAAAATGTGCGATTGTTGAAGCGAAGCATTTAGGCGGGACTTGCGTAAATGTCGGTTGTGTACCGAAGAAAGTAATGT
TCTACGGTGCGCATATCGCCGAAGCGATTAATAGCTATGCGCCGGATTACGGTTTCGACGTAACGGTGAATAATTTTGAT
TTCGTAAAATTAATTGAGAGTCGTGAAGCCTATATTTCTCGTATTCACACTTCATATAACAACGTATTAGCAAAAAATAA
CGTCGATGTATTAAACGGTTTCGCAAAATTTGTGGCCGCGAAAACGGTTGAAGTGACTTATGCGGACGGTAGCTCCGAGC
AAGTGACGGCGGATCATATTTTAATTGCGACCGGCGGTCGTCCGTCTATTCCGGCAATTAAAGGTGCGGAATACGGGATT
GATTCGGACGGTTTCTTCGCATTGCGCGAAGTGCCGAAACGTGTTGCGGTAGTCGGTGCCGGTTATATTGCGGTTGAAAT
TGCCGGCGTATTGAACAGCTTAGGTTCCGAAATGCATTTATTTGTACGCCAACACGCACCGTTACGTATGCAAGACCCGT
TAATTGTCGATACGTTGTTAGAAGTCTTGGCGCAAGACGGTATCACGCTACATACTCAAGCGATTCCGCAAGAAGTACGT
AAAAATGCCGACGGTTCGTTAGTATTAACCTTAGCGGACGGACGTGAAGCTACGGTTGATTGCTTAATTTGGGCAATCGG
TCGTGAACCGGCGTGCGATAAAATCAATCTTGATGCGGTAGGCGTAAAAACTAACGCGAAAGGTCAGATTATTGTCGATA
AATTCCAAAATACTAATGTACCGAATGTTTATGCGGTCGGCGATATTATCGAAGGCGGGATTGAATTAACACCGGTTGCG
GTAGCTGCAGGTCGTCGTTTATCCGAACGTTTGTTTAACAATAAACCGAACGAACATTTGGATTACAATTTAGTACCGAC
CGTTATCTTTAGCCATCCGCCGATCGGTACGGTCGGTTTAACCGAACCGCAAGCGATTGAACAATACGGTGCGGAGAATG
TAAAAGTCTATAAATCTTCGTTTACCGCGATGTACACCGCTGTGACTCAACATCGCCAGCCATGCCGTATGAAATTAGTG
TGTGTCGGTAAAGACGAAAAAGTAGTCGGTTTACACGGTATCGGTTTCGGTGTGGACGAAATGATTCAAGGCTTTGCGGT
AGCGATCAAAATGGGTGCAACCAAAGCCGATTTTGATAACACCGTAGCCATTCATCCGACCGGTTCGGAAGAGTTTGTAA
CAATGCGCTAA

Upstream 100 bases:

>100_bases
CTACTATGCCATTAAATCTATCACAATAATTTAATGCATTTTTACCAAAAGCGGTTAGAATTGAACCGCTTTTATTCTTT
ATTTATGTAGGAAAAGGATT

Downstream 100 bases:

>100_bases
GTGTGCGCTAGTCTGTAGGCTATATCATTTGAAAAGCGGATACTAAGGTATCCGTTTTTTATTTATACCAAAATAATTGT
TCGCCGGTGTTCCAAATTGT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTKHYDYLAIGGGSGGIASINRAASYGKKCAIVEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINSYAPDYGFDVTVNNFD
FVKLIESREAYISRIHTSYNNVLAKNNVDVLNGFAKFVAAKTVEVTYADGSSEQVTADHILIATGGRPSIPAIKGAEYGI
DSDGFFALREVPKRVAVVGAGYIAVEIAGVLNSLGSEMHLFVRQHAPLRMQDPLIVDTLLEVLAQDGITLHTQAIPQEVR
KNADGSLVLTLADGREATVDCLIWAIGREPACDKINLDAVGVKTNAKGQIIVDKFQNTNVPNVYAVGDIIEGGIELTPVA
VAAGRRLSERLFNNKPNEHLDYNLVPTVIFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCRMKLV
CVGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_456_residues
MTKHYDYLAIGGGSGGIASINRAASYGKKCAIVEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINSYAPDYGFDVTVNNFD
FVKLIESREAYISRIHTSYNNVLAKNNVDVLNGFAKFVAAKTVEVTYADGSSEQVTADHILIATGGRPSIPAIKGAEYGI
DSDGFFALREVPKRVAVVGAGYIAVEIAGVLNSLGSEMHLFVRQHAPLRMQDPLIVDTLLEVLAQDGITLHTQAIPQEVR
KNADGSLVLTLADGREATVDCLIWAIGREPACDKINLDAVGVKTNAKGQIIVDKFQNTNVPNVYAVGDIIEGGIELTPVA
VAAGRRLSERLFNNKPNEHLDYNLVPTVIFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCRMKLV
CVGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_455_residues
TKHYDYLAIGGGSGGIASINRAASYGKKCAIVEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINSYAPDYGFDVTVNNFDF
VKLIESREAYISRIHTSYNNVLAKNNVDVLNGFAKFVAAKTVEVTYADGSSEQVTADHILIATGGRPSIPAIKGAEYGID
SDGFFALREVPKRVAVVGAGYIAVEIAGVLNSLGSEMHLFVRQHAPLRMQDPLIVDTLLEVLAQDGITLHTQAIPQEVRK
NADGSLVLTLADGREATVDCLIWAIGREPACDKINLDAVGVKTNAKGQIIVDKFQNTNVPNVYAVGDIIEGGIELTPVAV
AAGRRLSERLFNNKPNEHLDYNLVPTVIFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCRMKLVC
VGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=53.5483870967742, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=39.873417721519, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI148277065, Length=458, Percent_Identity=36.6812227074236, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI33519430, Length=458, Percent_Identity=36.6812227074236, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI33519428, Length=458, Percent_Identity=36.6812227074236, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI33519426, Length=458, Percent_Identity=36.6812227074236, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI148277071, Length=458, Percent_Identity=36.6812227074236, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=37.3271889400922, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI291045268, Length=434, Percent_Identity=34.1013824884793, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=30.2832244008715, Blast_Score=186, Evalue=5e-47,
Organism=Escherichia coli, GI1789915, Length=456, Percent_Identity=75, Blast_Score=684, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=27.8396436525612, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=26.7543859649123, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=25.9911894273128, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=53.7280701754386, Blast_Score=428, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI71983429, Length=456, Percent_Identity=53.7280701754386, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=34.3220338983051, Blast_Score=274, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=32.7083333333333, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=30.718954248366, Blast_Score=188, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=51.931330472103, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=28.4501061571125, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=25, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=38.3474576271186, Blast_Score=281, Evalue=8e-76,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=38.5106382978723, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=38.5106382978723, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=38.5106382978723, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=31.6702819956616, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49026; Mature: 48894

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYLAIGGGSGGIASINRAASYGKKCAIVEAKHLGGTCVNVGCVPKKVMFYGAHIA
CCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEHHCCCEEEEECCCCHHHHHHHHHHH
EAINSYAPDYGFDVTVNNFDFVKLIESREAYISRIHTSYNNVLAKNNVDVLNGFAKFVAA
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHE
KTVEVTYADGSSEQVTADHILIATGGRPSIPAIKGAEYGIDSDGFFALREVPKRVAVVGA
EEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCHHEEEEEC
GYIAVEIAGVLNSLGSEMHLFVRQHAPLRMQDPLIVDTLLEVLAQDGITLHTQAIPQEVR
CHHEEHHHHHHHHCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHH
KNADGSLVLTLADGREATVDCLIWAIGREPACDKINLDAVGVKTNAKGQIIVDKFQNTNV
CCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCEECCEEEEEEECCCCCEEEEECCCCCC
PNVYAVGDIIEGGIELTPVAVAAGRRLSERLFNNKPNEHLDYNLVPTVIFSHPPIGTVGL
CEEEEEHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCC
TEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCRMKLVCVGKDEKVVGLHGIGFGVDE
CCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHH
MIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
HHHHEEEEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TKHYDYLAIGGGSGGIASINRAASYGKKCAIVEAKHLGGTCVNVGCVPKKVMFYGAHIA
CCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEHHCCCEEEEECCCCHHHHHHHHHHH
EAINSYAPDYGFDVTVNNFDFVKLIESREAYISRIHTSYNNVLAKNNVDVLNGFAKFVAA
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHE
KTVEVTYADGSSEQVTADHILIATGGRPSIPAIKGAEYGIDSDGFFALREVPKRVAVVGA
EEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCHHEEEEEC
GYIAVEIAGVLNSLGSEMHLFVRQHAPLRMQDPLIVDTLLEVLAQDGITLHTQAIPQEVR
CHHEEHHHHHHHHCCHHEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHH
KNADGSLVLTLADGREATVDCLIWAIGREPACDKINLDAVGVKTNAKGQIIVDKFQNTNV
CCCCCCEEEEEECCCCCEEEEEEEEECCCCCCCEECCEEEEEEECCCCCEEEEECCCCCC
PNVYAVGDIIEGGIELTPVAVAAGRRLSERLFNNKPNEHLDYNLVPTVIFSHPPIGTVGL
CEEEEEHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCC
TEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCRMKLVCVGKDEKVVGLHGIGFGVDE
CCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHH
MIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
HHHHEEEEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]