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The map label for this gene is argH

Identifier: 126208647

GI number: 126208647

Start: 1356023

End: 1357399

Strand: Reverse

Name: argH

Synonym: APL_1179

Alternate gene names: 126208647

Gene position: 1357399-1356023 (Counterclockwise)

Preceding gene: 126208648

Following gene: 126208645

Centisome position: 59.68

GC content: 44.81

Gene sequence:

>1377_bases
ATGGCACTTTGGGGTGGACGTTTTAAACAAGAAGCTGATGCAAAATTTAAATTTTTCAATGACTCGTTACGTTTTGACTA
TCGTTTAGCATTACAAGACATTGACGGCTCAATCGGTTGGGCGAAAGCGATTACTTCGGTCGGTATTTTAACCGAGCAGG
AACACCAACAATTAGTGGTGGCGTTAAAAGAATTACGTGCGGAAATCGAGTCGAATATTGCGATTATTTTACGTGATGAT
GCGGAAGATATTCATAGCTGGGTAGAATCAAAACTGATCGAAAAAGTCGGCGATTTAGGTAAAAAACTCCACACCGGTCG
TAGCCGTAACGACCAAGTTGCGGTGGATATGAAAATGTGGTGTAAAGTGCAAGCGGTCGTATTGCAAGAGCGTATCCGTA
ACTTACAGCACAAACTGGTTGAAACTGCCGAAGCAAATCAAAATGCGGTGATGCCGGGTTATACCCATTTGCAACGTGCG
CAGCCGATTACTTTTGCACACTGGTGTATGGCGTATTACGAAATGTTAGAGCGTGATTTCAGCCGTTTAACCGATGCTTA
TAAACGTATGCACACTTGCCCGTTAGGTTCAGGCGCATTAGCCGGTACGGCTTATTCAATCGATCGTGATGCACTGGCAC
AGGATCTTGGTTTTGCAATCGGTACACGTAACAGTTTGGATTCGGTTTCGGATCGTGATCACGTGTTAGAACTGCTCTCA
ACCGCTTCGATCAGTATGGTGCATTTATCGCGTTTTGCCGAAGATTTGATTTTCTTCAATAGCGGTGAGTCGGCATTCTT
AGAATTATCGGATCGTGTTACTTCCGGTTCTTCATTAATGCCGCAAAAGAAAAATCCGGATGCGTGCGAGCTAATTCGTG
GTAAATCAGGCCGTGTTTTCGGGGCATTATCAGGTTTACTCACTACCTTAAAAGGTTTACCGCTCGCTTATAACAAAGAT
ATGCAAGAGGACAAAGAAGGCATCTTTGATGCGATGGAAACATGGCAGGCTTGCTTAGAGATTGGGGCGCTAGTGTTGGA
AGATATCAATGTGAACGTAGAACGTACCCGTGAAGCGGCACAGCAAGGTTATTCCAATGCGACCGAACTTGCCGATTATT
TAGTAGCGAAAGGTATTCCGTTCCGTGAAGCTCATCATATCGTGGGTGAAGCGGTGGTTTATGCGATCAGCAAACGTGAA
CCGTTGGAAGCGTTAAGCGTAGCGGAATTTAAACAGTTCCACCCGGTGATTGATGAAGACGTTTACCCGATTCTTTCGTT
AGAATCTTGTTTAGAAAAACGTAGTGCGAAAGGCGGGGTAAATCCGGAACGTGTCCGTGAAGCGATTGAAGCGGCTAAAG
TAAATTTAGGGGCTTAG

Upstream 100 bases:

>100_bases
AGATAATTATTGAATAATTCTGCATATTTATGCAAAATATCCCTATTCGGATGTACAGGACATCTTTTAAGAAGATTAAA
GAAGCGAAAAGGAACACAAT

Downstream 100 bases:

>100_bases
TTTTACCACGCACGGCAAGCCGTACGTGGTTACGATCAGCCTACGGCTGAGTGAGCCACTCTGTAGCTCTAGAACACTTT
GTGATGGTACTAGTCTTTGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MALWGGRFKQEADAKFKFFNDSLRFDYRLALQDIDGSIGWAKAITSVGILTEQEHQQLVVALKELRAEIESNIAIILRDD
AEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDMKMWCKVQAVVLQERIRNLQHKLVETAEANQNAVMPGYTHLQRA
QPITFAHWCMAYYEMLERDFSRLTDAYKRMHTCPLGSGALAGTAYSIDRDALAQDLGFAIGTRNSLDSVSDRDHVLELLS
TASISMVHLSRFAEDLIFFNSGESAFLELSDRVTSGSSLMPQKKNPDACELIRGKSGRVFGALSGLLTTLKGLPLAYNKD
MQEDKEGIFDAMETWQACLEIGALVLEDINVNVERTREAAQQGYSNATELADYLVAKGIPFREAHHIVGEAVVYAISKRE
PLEALSVAEFKQFHPVIDEDVYPILSLESCLEKRSAKGGVNPERVREAIEAAKVNLGA

Sequences:

>Translated_458_residues
MALWGGRFKQEADAKFKFFNDSLRFDYRLALQDIDGSIGWAKAITSVGILTEQEHQQLVVALKELRAEIESNIAIILRDD
AEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDMKMWCKVQAVVLQERIRNLQHKLVETAEANQNAVMPGYTHLQRA
QPITFAHWCMAYYEMLERDFSRLTDAYKRMHTCPLGSGALAGTAYSIDRDALAQDLGFAIGTRNSLDSVSDRDHVLELLS
TASISMVHLSRFAEDLIFFNSGESAFLELSDRVTSGSSLMPQKKNPDACELIRGKSGRVFGALSGLLTTLKGLPLAYNKD
MQEDKEGIFDAMETWQACLEIGALVLEDINVNVERTREAAQQGYSNATELADYLVAKGIPFREAHHIVGEAVVYAISKRE
PLEALSVAEFKQFHPVIDEDVYPILSLESCLEKRSAKGGVNPERVREAIEAAKVNLGA
>Mature_457_residues
ALWGGRFKQEADAKFKFFNDSLRFDYRLALQDIDGSIGWAKAITSVGILTEQEHQQLVVALKELRAEIESNIAIILRDDA
EDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDMKMWCKVQAVVLQERIRNLQHKLVETAEANQNAVMPGYTHLQRAQ
PITFAHWCMAYYEMLERDFSRLTDAYKRMHTCPLGSGALAGTAYSIDRDALAQDLGFAIGTRNSLDSVSDRDHVLELLST
ASISMVHLSRFAEDLIFFNSGESAFLELSDRVTSGSSLMPQKKNPDACELIRGKSGRVFGALSGLLTTLKGLPLAYNKDM
QEDKEGIFDAMETWQACLEIGALVLEDINVNVERTREAAQQGYSNATELADYLVAKGIPFREAHHIVGEAVVYAISKREP
LEALSVAEFKQFHPVIDEDVYPILSLESCLEKRSAKGGVNPERVREAIEAAKVNLGA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=456, Percent_Identity=42.5438596491228, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI68303542, Length=456, Percent_Identity=42.5438596491228, Blast_Score=358, Evalue=6e-99,
Organism=Homo sapiens, GI68303549, Length=456, Percent_Identity=40.3508771929825, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI68303547, Length=456, Percent_Identity=39.4736842105263, Blast_Score=318, Evalue=9e-87,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=70.8971553610503, Blast_Score=666, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=42.2657952069717, Blast_Score=369, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=40.0442477876106, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=40.0442477876106, Blast_Score=335, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_ACTP2 (A3N1I1)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053872.1
- ProteinModelPortal:   A3N1I1
- SMR:   A3N1I1
- STRING:   A3N1I1
- GeneID:   4849954
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1179
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   A3N1I1
- ProtClustDB:   PRK04833
- BioCyc:   APLE416269:APL_1179-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51037; Mature: 50905

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFKQEADAKFKFFNDSLRFDYRLALQDIDGSIGWAKAITSVGILTEQEHQQLVV
CCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHH
ALKELRAEIESNIAIILRDDAEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDMKMW
HHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHH
CKVQAVVLQERIRNLQHKLVETAEANQNAVMPGYTHLQRAQPITFAHWCMAYYEMLERDF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLTDAYKRMHTCPLGSGALAGTAYSIDRDALAQDLGFAIGTRNSLDSVSDRDHVLELLS
HHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TASISMVHLSRFAEDLIFFNSGESAFLELSDRVTSGSSLMPQKKNPDACELIRGKSGRVF
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHH
GALSGLLTTLKGLPLAYNKDMQEDKEGIFDAMETWQACLEIGALVLEDINVNVERTREAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QQGYSNATELADYLVAKGIPFREAHHIVGEAVVYAISKREPLEALSVAEFKQFHPVIDED
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
VYPILSLESCLEKRSAKGGVNPERVREAIEAAKVNLGA
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALWGGRFKQEADAKFKFFNDSLRFDYRLALQDIDGSIGWAKAITSVGILTEQEHQQLVV
CCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHH
ALKELRAEIESNIAIILRDDAEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDMKMW
HHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHH
CKVQAVVLQERIRNLQHKLVETAEANQNAVMPGYTHLQRAQPITFAHWCMAYYEMLERDF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLTDAYKRMHTCPLGSGALAGTAYSIDRDALAQDLGFAIGTRNSLDSVSDRDHVLELLS
HHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TASISMVHLSRFAEDLIFFNSGESAFLELSDRVTSGSSLMPQKKNPDACELIRGKSGRVF
HHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHH
GALSGLLTTLKGLPLAYNKDMQEDKEGIFDAMETWQACLEIGALVLEDINVNVERTREAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QQGYSNATELADYLVAKGIPFREAHHIVGEAVVYAISKREPLEALSVAEFKQFHPVIDED
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
VYPILSLESCLEKRSAKGGVNPERVREAIEAAKVNLGA
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA