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The map label for this gene is trpE [H]

Identifier: 126208631

GI number: 126208631

Start: 1340248

End: 1341798

Strand: Direct

Name: trpE [H]

Synonym: APL_1163

Alternate gene names: 126208631

Gene position: 1340248-1341798 (Clockwise)

Preceding gene: 126208626

Following gene: 126208632

Centisome position: 58.93

GC content: 42.94

Gene sequence:

>1551_bases
ATGAATCTCCATACTCAGCAAACACAGCTCCCCTATTATGAAGATACGACCGTCGCGTTTTATCATCTCTGTGATCATAA
ACCGCATACGCTATTATTGGATTCGGCGGAAATCCACAGTAAAAACAGCTTAAAAAGTTTATTGTTCGCTCAATCCGCAT
TACATATTTATTGCGACGCACAAACCGTAACTTTTGAGGCATTGACCGAAAACGGTAAAGCAATCTTACCTCATCTTCAA
ACTGCCCTTGCGCAATTATCTCCGGCACCAACTTGCAAAGTCTCAGCGGAATTTAACCGCTTGTCAGCAGCCTTCCCGCC
CATTGCCCAAAATTTGGATGAAGACAGCAAACTTAAAACTAGCACCGTGTTTGACGGTTTACGTTGTGTGAGCCGACTTT
TTGCCGATAAAGCGGAGCCGATCTATTTAGGCGGTTTATTTAGCTACGATTTGGTCGCTCATTTCATTCCGATGGACGGC
ATTCAATTACAAGATGACGGCTTAGGTTGCCACGATTACAGCTTCTATCTTGCCGAACAATTAGCAGTTATTGATCACCA
AAAACAAGAATCGGTACTGCATACTTTCTGTTTTGATGAAACCCAGCAAAACCGTTTACAGCAACAAGCGGTCGAATTTA
GCCAAATTCTTGCAAAATATCAGCCTTGCGAATTGCGTTTACCGATTCAAGCGGCAAGCAGTGAAGTGAAAACCAATATT
GAAGACGAAGCCTTTAAACAAATCGTTCAAAAGCTAAAACGTCATATTCATATCGGAGATGTATTCCAAATTGTACCTTC
ACGCCGTTTTAGTTTGCCTTGTCCGAATATTTTAGCGGCTTATCGCCAGCTTAAAATGAATAATCCAAGCCCGTATATGT
TCTTTATGCAAGGCGAAAACTTTACTTTATTCGGTGCATCACCCGAAAGTGCGCTGAAATATTCACAAGCTAATCGTCAA
TTAGAAATCTATCCGATTGCCGGCTCTCGTCCGCGTGGATTTGATGCTAATGGCAATATCGATCCGGAATTGGATTCACG
CTTAGAATTGGAATTACGTTTAGATCAAAAAGAATTGGCAGAACATTTAATGTTAGTCGATCTGGCTCGTAATGATGTCG
CACGAGTCTGCCAAGCCGGTACGCGTAAAGTGGTGGATCTGATGCAAATCGATCGCTATTCGCAAATTATGCACCTTGTT
TCTCGTGTGGTCGGCACATTGCGTAGCGATTTAGATGCGTTACACGCTTATCAGGCGTGTATGAATATGGGTACATTAAC
CGGTGCGCCAAAAATTAAAGCGATGCAATTAATTTACCAAGTAGAGCAACAAAAACGCCACAGTTACGGCGGTGCTGTCG
GTTACTTAACTTCGCACGGCGATTTAGATACCTGCATTGTGATTCGTTCTGCATTCGTACAAAACGGCATCGCTTACGTA
CAGGCAGGTTGCGGTGAAGTATTGGATTCGGATCCGCAATCGGAAGCGGATGAAACGCGTCACAAAGCGAAAGCCGTATT
AAAAGCAATCGCACAAGTTAATACCAAATAA

Upstream 100 bases:

>100_bases
TAGTTTTAGTCAAATCTTGCACATTTAAAAAATATACTTGACTTATTACATTTATACTAGTTTAATAGTACATAAATAAT
TTTAAACAAGGAATCGTGAA

Downstream 100 bases:

>100_bases
GGACGGATAAGCTATGGCACATATTCTTTTTGTTGATAATTTTGATTCGTTTACCTACAACCTTGTCGATCAATTTCGTG
AATTAGGTCATCAAGTGACG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MNLHTQQTQLPYYEDTTVAFYHLCDHKPHTLLLDSAEIHSKNSLKSLLFAQSALHIYCDAQTVTFEALTENGKAILPHLQ
TALAQLSPAPTCKVSAEFNRLSAAFPPIAQNLDEDSKLKTSTVFDGLRCVSRLFADKAEPIYLGGLFSYDLVAHFIPMDG
IQLQDDGLGCHDYSFYLAEQLAVIDHQKQESVLHTFCFDETQQNRLQQQAVEFSQILAKYQPCELRLPIQAASSEVKTNI
EDEAFKQIVQKLKRHIHIGDVFQIVPSRRFSLPCPNILAAYRQLKMNNPSPYMFFMQGENFTLFGASPESALKYSQANRQ
LEIYPIAGSRPRGFDANGNIDPELDSRLELELRLDQKELAEHLMLVDLARNDVARVCQAGTRKVVDLMQIDRYSQIMHLV
SRVVGTLRSDLDALHAYQACMNMGTLTGAPKIKAMQLIYQVEQQKRHSYGGAVGYLTSHGDLDTCIVIRSAFVQNGIAYV
QAGCGEVLDSDPQSEADETRHKAKAVLKAIAQVNTK

Sequences:

>Translated_516_residues
MNLHTQQTQLPYYEDTTVAFYHLCDHKPHTLLLDSAEIHSKNSLKSLLFAQSALHIYCDAQTVTFEALTENGKAILPHLQ
TALAQLSPAPTCKVSAEFNRLSAAFPPIAQNLDEDSKLKTSTVFDGLRCVSRLFADKAEPIYLGGLFSYDLVAHFIPMDG
IQLQDDGLGCHDYSFYLAEQLAVIDHQKQESVLHTFCFDETQQNRLQQQAVEFSQILAKYQPCELRLPIQAASSEVKTNI
EDEAFKQIVQKLKRHIHIGDVFQIVPSRRFSLPCPNILAAYRQLKMNNPSPYMFFMQGENFTLFGASPESALKYSQANRQ
LEIYPIAGSRPRGFDANGNIDPELDSRLELELRLDQKELAEHLMLVDLARNDVARVCQAGTRKVVDLMQIDRYSQIMHLV
SRVVGTLRSDLDALHAYQACMNMGTLTGAPKIKAMQLIYQVEQQKRHSYGGAVGYLTSHGDLDTCIVIRSAFVQNGIAYV
QAGCGEVLDSDPQSEADETRHKAKAVLKAIAQVNTK
>Mature_516_residues
MNLHTQQTQLPYYEDTTVAFYHLCDHKPHTLLLDSAEIHSKNSLKSLLFAQSALHIYCDAQTVTFEALTENGKAILPHLQ
TALAQLSPAPTCKVSAEFNRLSAAFPPIAQNLDEDSKLKTSTVFDGLRCVSRLFADKAEPIYLGGLFSYDLVAHFIPMDG
IQLQDDGLGCHDYSFYLAEQLAVIDHQKQESVLHTFCFDETQQNRLQQQAVEFSQILAKYQPCELRLPIQAASSEVKTNI
EDEAFKQIVQKLKRHIHIGDVFQIVPSRRFSLPCPNILAAYRQLKMNNPSPYMFFMQGENFTLFGASPESALKYSQANRQ
LEIYPIAGSRPRGFDANGNIDPELDSRLELELRLDQKELAEHLMLVDLARNDVARVCQAGTRKVVDLMQIDRYSQIMHLV
SRVVGTLRSDLDALHAYQACMNMGTLTGAPKIKAMQLIYQVEQQKRHSYGGAVGYLTSHGDLDTCIVIRSAFVQNGIAYV
QAGCGEVLDSDPQSEADETRHKAKAVLKAIAQVNTK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=509, Percent_Identity=55.2062868369352, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1788114, Length=413, Percent_Identity=29.7820823244552, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI87082077, Length=335, Percent_Identity=25.9701492537313, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=378, Percent_Identity=36.2433862433862, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6324361, Length=295, Percent_Identity=22.0338983050847, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57812; Mature: 57812

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLHTQQTQLPYYEDTTVAFYHLCDHKPHTLLLDSAEIHSKNSLKSLLFAQSALHIYCDA
CCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHCCHHHHHHHHHHHCCEEEEECC
QTVTFEALTENGKAILPHLQTALAQLSPAPTCKVSAEFNRLSAAFPPIAQNLDEDSKLKT
CEEEEHHHHCCCCEEHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHCCCCCCCHHH
STVFDGLRCVSRLFADKAEPIYLGGLFSYDLVAHFIPMDGIQLQDDGLGCHDYSFYLAEQ
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHH
LAVIDHQKQESVLHTFCFDETQQNRLQQQAVEFSQILAKYQPCELRLPIQAASSEVKTNI
HHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCHHHHCCC
EDEAFKQIVQKLKRHIHIGDVFQIVPSRRFSLPCPNILAAYRQLKMNNPSPYMFFMQGEN
CHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCC
FTLFGASPESALKYSQANRQLEIYPIAGSRPRGFDANGNIDPELDSRLELELRLDQKELA
EEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHH
EHLMLVDLARNDVARVCQAGTRKVVDLMQIDRYSQIMHLVSRVVGTLRSDLDALHAYQAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLTGAPKIKAMQLIYQVEQQKRHSYGGAVGYLTSHGDLDTCIVIRSAFVQNGIAYV
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHH
QAGCGEVLDSDPQSEADETRHKAKAVLKAIAQVNTK
HHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLHTQQTQLPYYEDTTVAFYHLCDHKPHTLLLDSAEIHSKNSLKSLLFAQSALHIYCDA
CCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHCCHHHHHHHHHHHCCEEEEECC
QTVTFEALTENGKAILPHLQTALAQLSPAPTCKVSAEFNRLSAAFPPIAQNLDEDSKLKT
CEEEEHHHHCCCCEEHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHCCCCCCCHHH
STVFDGLRCVSRLFADKAEPIYLGGLFSYDLVAHFIPMDGIQLQDDGLGCHDYSFYLAEQ
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHH
LAVIDHQKQESVLHTFCFDETQQNRLQQQAVEFSQILAKYQPCELRLPIQAASSEVKTNI
HHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHCCHHHHCCC
EDEAFKQIVQKLKRHIHIGDVFQIVPSRRFSLPCPNILAAYRQLKMNNPSPYMFFMQGEN
CHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCC
FTLFGASPESALKYSQANRQLEIYPIAGSRPRGFDANGNIDPELDSRLELELRLDQKELA
EEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHH
EHLMLVDLARNDVARVCQAGTRKVVDLMQIDRYSQIMHLVSRVVGTLRSDLDALHAYQAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLTGAPKIKAMQLIYQVEQQKRHSYGGAVGYLTSHGDLDTCIVIRSAFVQNGIAYV
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHH
QAGCGEVLDSDPQSEADETRHKAKAVLKAIAQVNTK
HHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]