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The map label for this gene is pgi

Identifier: 126208607

GI number: 126208607

Start: 1313292

End: 1314932

Strand: Reverse

Name: pgi

Synonym: APL_1137

Alternate gene names: 126208607

Gene position: 1314932-1313292 (Counterclockwise)

Preceding gene: 126208608

Following gene: 126208599

Centisome position: 57.81

GC content: 41.19

Gene sequence:

>1641_bases
ATGCAAAATATTAACCCAACCCAAACTGCAGCTTGGTCCGCTTTAGAGCAGCATAAAGCGGATAATTTAAATATTCCTCA
GCTATTTGCCGAAGATGCTAATCGTTTTGACAAATATCACTTAAATTTTGAACAGCAAATTCTTGTCGATTTTTCTAAAA
ATGCGATTAATCAAAAGACATTAGAGCTATTGCGTCAGTTAGCGAATGAATGCGGTTTAGCTTCTGCAACCGAAGCGATG
TTCTCCGGTCAAAAAATCAATCGTACGGAGAATCGTGCGGTATTGCATACCGCATTACGTAATCGTTCTAATACGCCTGT
ACTTGTTGATGGCAAAGATGTGATGCCGGAAGTAAATGCAGTATTGGCTAAAATGAAAGATTTCTGTGAACGTATTATTT
CTGGAAGTTGGAAAGGTTATACCGGTAAAGCGATCACCGATGTGATCAATATCGGGATCGGCGGTTCGGATTTAGGTCCT
TATATGGTAACCGAAGCGTTACGCCCGTATAAAAATCACTTAAATATGCATTTCGTATCGAATGTAGACGGTACGCATAT
TGCGGAAGTGCTGAAAAAAGTAAATCCTGAAACGACATTAGTCTTAGTTGCATCAAAAACTTTTACTACCCAAGAAACGA
TGACCAATGCTTTAACTGCACGTGAGTGGTTATTAGCGGCGGTAAAAGACGAATCGGCAGTAGCGAAACACTTTGCGGCA
TTATCAACTAATGCGAAAGAAGTGGCAAAATTCGGGATTGATACGGCAAATATGTTCGAATTCTGGGATTGGGTAGGCGG
TCGTTATTCGTTATGGTCGGCAATCGGTCTTTCTATTGCGTTGTCATTAGGTTTTGAAAACTTTGAAGCATTGCTTTCTG
GCGCACATGCAATGGATAACCATTTCCGTACTGCACCGATTGAGAAAAATATCCCGACAACATTGGCGTTAATCGGTATC
TGGAACAGTAATTTCCTTGGTGCGGAAACCGAAGCGTTATTACCTTATGATCAATATTTACATCGCTTTGCTGCTTATTT
CCAACAAGGCAATATGGAATCAAACGGTAAATTCGTCGGTCGTGACGGTAGTCCGGTAACGCATCAAACCGGCCCGATTG
TATGGGGCGAGCCGGGCACTAACGGTCAGCACGCTTTCTATCAATTAATTCACCAAGGCACGAAGCTGATTCCTTGTGAT
TTTATCGCTCCGGCACAAACACATAATCCGGTCGGCGATCACCATGCAAAACTATTATCTAACTTCTTTGCACAAACAGA
AGCGCTTGCTTTTGGGAAATCGAAAGAAACCGTTGAAGCGGAATTTGTGGCGGCAGGTAAGAATTTAGCGGATGTTGCGG
AAATTGTGCCGTTTAAAGTATTTACCGGTAATAAACCGACAAACTCAATTTTAGTGCAAAAAATTACACCGTTCACTTTA
GGGGCGTTGATTGCAATGTATGAACATAAGATCTTCGTACAAGGGGTAATTTTCAATATCTACAGCTTTGACCAATGGGG
CGTAGAATTAGGTAAACAACTCGCAAATCGTATCTTACCTGAGTTACAAAATGCGGAGAAAATTAGCAGTCACGACAGTT
CGACTAACGGTTTAATTAATCAATTTAAAGCATGGCGTTAA

Upstream 100 bases:

>100_bases
CGAAAAACTTAATGAATTAGAAAAACGGTTGAATGATCTCGAATCTCGTCAATCTCAAGAGTAATTTATTTTAATTTTAA
TCAGCAAAAGGATAGTCCAA

Downstream 100 bases:

>100_bases
TCCGTCCGTAAGTATTTAATACCAAGCAATAGCGGTCATTTTTGCAATTTATTTTGTAAAAATGACCGCTATTTATTTTT
ACCGTACTTTTAATTTTTTG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MQNINPTQTAAWSALEQHKADNLNIPQLFAEDANRFDKYHLNFEQQILVDFSKNAINQKTLELLRQLANECGLASATEAM
FSGQKINRTENRAVLHTALRNRSNTPVLVDGKDVMPEVNAVLAKMKDFCERIISGSWKGYTGKAITDVINIGIGGSDLGP
YMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLVLVASKTFTTQETMTNALTAREWLLAAVKDESAVAKHFAA
LSTNAKEVAKFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFENFEALLSGAHAMDNHFRTAPIEKNIPTTLALIGI
WNSNFLGAETEALLPYDQYLHRFAAYFQQGNMESNGKFVGRDGSPVTHQTGPIVWGEPGTNGQHAFYQLIHQGTKLIPCD
FIAPAQTHNPVGDHHAKLLSNFFAQTEALAFGKSKETVEAEFVAAGKNLADVAEIVPFKVFTGNKPTNSILVQKITPFTL
GALIAMYEHKIFVQGVIFNIYSFDQWGVELGKQLANRILPELQNAEKISSHDSSTNGLINQFKAWR

Sequences:

>Translated_546_residues
MQNINPTQTAAWSALEQHKADNLNIPQLFAEDANRFDKYHLNFEQQILVDFSKNAINQKTLELLRQLANECGLASATEAM
FSGQKINRTENRAVLHTALRNRSNTPVLVDGKDVMPEVNAVLAKMKDFCERIISGSWKGYTGKAITDVINIGIGGSDLGP
YMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLVLVASKTFTTQETMTNALTAREWLLAAVKDESAVAKHFAA
LSTNAKEVAKFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFENFEALLSGAHAMDNHFRTAPIEKNIPTTLALIGI
WNSNFLGAETEALLPYDQYLHRFAAYFQQGNMESNGKFVGRDGSPVTHQTGPIVWGEPGTNGQHAFYQLIHQGTKLIPCD
FIAPAQTHNPVGDHHAKLLSNFFAQTEALAFGKSKETVEAEFVAAGKNLADVAEIVPFKVFTGNKPTNSILVQKITPFTL
GALIAMYEHKIFVQGVIFNIYSFDQWGVELGKQLANRILPELQNAEKISSHDSSTNGLINQFKAWR
>Mature_546_residues
MQNINPTQTAAWSALEQHKADNLNIPQLFAEDANRFDKYHLNFEQQILVDFSKNAINQKTLELLRQLANECGLASATEAM
FSGQKINRTENRAVLHTALRNRSNTPVLVDGKDVMPEVNAVLAKMKDFCERIISGSWKGYTGKAITDVINIGIGGSDLGP
YMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLVLVASKTFTTQETMTNALTAREWLLAAVKDESAVAKHFAA
LSTNAKEVAKFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFENFEALLSGAHAMDNHFRTAPIEKNIPTTLALIGI
WNSNFLGAETEALLPYDQYLHRFAAYFQQGNMESNGKFVGRDGSPVTHQTGPIVWGEPGTNGQHAFYQLIHQGTKLIPCD
FIAPAQTHNPVGDHHAKLLSNFFAQTEALAFGKSKETVEAEFVAAGKNLADVAEIVPFKVFTGNKPTNSILVQKITPFTL
GALIAMYEHKIFVQGVIFNIYSFDQWGVELGKQLANRILPELQNAEKISSHDSSTNGLINQFKAWR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=537, Percent_Identity=65.7355679702048, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=537, Percent_Identity=61.2662942271881, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=548, Percent_Identity=77.1897810218978, Blast_Score=900, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=541, Percent_Identity=64.1404805914972, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=64.1404805914972, Blast_Score=712, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=58.8342440801457, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=66.8488160291439, Blast_Score=748, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=66.8488160291439, Blast_Score=748, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=66.8488160291439, Blast_Score=748, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ACTP2 (A3N1E1)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053832.1
- ProteinModelPortal:   A3N1E1
- SMR:   A3N1E1
- STRING:   A3N1E1
- GeneID:   4849562
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1137
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   A3N1E1
- ProtClustDB:   PRK00179
- BioCyc:   APLE416269:APL_1137-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 60415; Mature: 60415

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 353-353 ACT_SITE 384-384 ACT_SITE 512-512

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNINPTQTAAWSALEQHKADNLNIPQLFAEDANRFDKYHLNFEQQILVDFSKNAINQKT
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCHHHHEEEHHHHHCCHHH
LELLRQLANECGLASATEAMFSGQKINRTENRAVLHTALRNRSNTPVLVDGKDVMPEVNA
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHH
VLAKMKDFCERIISGSWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHLNMHFVS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
NVDGTHIAEVLKKVNPETTLVLVASKTFTTQETMTNALTAREWLLAAVKDESAVAKHFAA
CCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LSTNAKEVAKFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFENFEALLSGAHAMDN
HCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
HFRTAPIEKNIPTTLALIGIWNSNFLGAETEALLPYDQYLHRFAAYFQQGNMESNGKFVG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCEEEC
RDGSPVTHQTGPIVWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAQTHNPVGDHHAKLLS
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHH
NFFAQTEALAFGKSKETVEAEFVAAGKNLADVAEIVPFKVFTGNKPTNSILVQKITPFTL
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCEEEECCCHHHH
GALIAMYEHKIFVQGVIFNIYSFDQWGVELGKQLANRILPELQNAEKISSHDSSTNGLIN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHH
QFKAWR
HHHCCC
>Mature Secondary Structure
MQNINPTQTAAWSALEQHKADNLNIPQLFAEDANRFDKYHLNFEQQILVDFSKNAINQKT
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCHHHHEEEHHHHHCCHHH
LELLRQLANECGLASATEAMFSGQKINRTENRAVLHTALRNRSNTPVLVDGKDVMPEVNA
HHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHH
VLAKMKDFCERIISGSWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHLNMHFVS
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEC
NVDGTHIAEVLKKVNPETTLVLVASKTFTTQETMTNALTAREWLLAAVKDESAVAKHFAA
CCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LSTNAKEVAKFGIDTANMFEFWDWVGGRYSLWSAIGLSIALSLGFENFEALLSGAHAMDN
HCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
HFRTAPIEKNIPTTLALIGIWNSNFLGAETEALLPYDQYLHRFAAYFQQGNMESNGKFVG
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCCCCEEEC
RDGSPVTHQTGPIVWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAQTHNPVGDHHAKLLS
CCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHH
NFFAQTEALAFGKSKETVEAEFVAAGKNLADVAEIVPFKVFTGNKPTNSILVQKITPFTL
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCEEEECCCCCCCCEEEECCCHHHH
GALIAMYEHKIFVQGVIFNIYSFDQWGVELGKQLANRILPELQNAEKISSHDSSTNGLIN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHH
QFKAWR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA