Click here to switch to the map view.

The map label for this gene is gcp

Identifier: 126208590

GI number: 126208590

Start: 1295927

End: 1296970

Strand: Reverse

Name: gcp

Synonym: APL_1120

Alternate gene names: 126208590

Gene position: 1296970-1295927 (Counterclockwise)

Preceding gene: 126208591

Following gene: 126208589

Centisome position: 57.02

GC content: 48.66

Gene sequence:

>1044_bases
ATGCGAATTTTAGGTATTGAAACTTCCTGTGACGAAACGGGAGTGGCAATTTATGATGAAGAGAAAGGCTTGGTGGCAAA
CCAACTTTATAGCCAAATCGAAATGCATGCGGATTACGGCGGCGTCGTGCCGGAGTTGGCTTCACGTGATCATATCCGTA
AAACGTTACCGCTGATTCAAGAAGCGTTAAAAGAAGCGAATTTAACTGCAGCCGATATTGACGGTGTGGTTTATACCGCA
GGTCCGGGCTTAGTCGGAGCGTTATTAGTCGGCTCGACAATCGCCCGTTCGCTCGCCTATGCGTGGAACGTGCCCGCACT
CGGCGTACACCATATGGAAGGACATTTAATGGCGCCGATGTTGGAAGATAACCCGCCGGCGTTTCCGTTTGTGGCGTTAT
TGATTTCGGGCGGACATACCCAGCTTGTTAAAGTGGAGGGCGTAGGGCAGTATGAAATTTTAGGCGAATCGATTGACGAT
GCCGCCGGCGAAGCCTTTGATAAAACCGGCAAATTACTCGGATTGGATTATCCGGCGGGCGTGGCGGTTTCGCAGTTGGC
TGAGAAAGGTACGCCGAATCGTTTTGTATTTCCTCGTCCGATGACGGACAGACCGGGGCTGGATTTCAGCTTTTCCGGCT
TAAAGACCTTTGCCGCTAATACGATTAATGCCAATTTAGACGAGAACGGGCGGCTGGACGAACAAACTCGCTGTGATATT
GCTCACGCTTTCCAACAAGCGGTGGTGGACACGATTATCATCAAATGTAAGCGAGCTTTACAGCAAACCGGCTATAAACG
TCTTGTGATGGCGGGCGGTGTAAGTGCTAACAAGCAATTACGTACCGATTTGGCGGAGATGATGAAAAATTTAAAAGGCG
AGGTTTATTACCCTCGTCCGCAATTTTGTACCGATAACGGTGCAATGATTGCTTATACCGGGTTTTTACGCTTAAAAAAC
GGTGAAACCAGCGATTTAAGCATCAGCGTAAAACCTCGGTGGAATATGACCGAACTTCCTGATATTTCAACGACAGGCGG
TTAG

Upstream 100 bases:

>100_bases
CAATTCTAAGCAAGCGGTTGATTTTTATAAAAGTTTTGCAATTTTAGGGGCGTTATTTTTGAATAATGCCCCTTTCCCAT
TTCATAAATAAGACGAAAAT

Downstream 100 bases:

>100_bases
ATGTAAAAAATTTTGCTTTATTTTCTAAGGATGAAATCTTATGCAAAGTATGGAATTGCGCAACTATGTTATTAGTCTAA
AAAATAATTCACAACGTCGA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRILGIETSCDETGVAIYDEEKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQEALKEANLTAADIDGVVYTA
GPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLMAPMLEDNPPAFPFVALLISGGHTQLVKVEGVGQYEILGESIDD
AAGEAFDKTGKLLGLDYPAGVAVSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINANLDENGRLDEQTRCDI
AHAFQQAVVDTIIIKCKRALQQTGYKRLVMAGGVSANKQLRTDLAEMMKNLKGEVYYPRPQFCTDNGAMIAYTGFLRLKN
GETSDLSISVKPRWNMTELPDISTTGG

Sequences:

>Translated_347_residues
MRILGIETSCDETGVAIYDEEKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQEALKEANLTAADIDGVVYTA
GPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLMAPMLEDNPPAFPFVALLISGGHTQLVKVEGVGQYEILGESIDD
AAGEAFDKTGKLLGLDYPAGVAVSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINANLDENGRLDEQTRCDI
AHAFQQAVVDTIIIKCKRALQQTGYKRLVMAGGVSANKQLRTDLAEMMKNLKGEVYYPRPQFCTDNGAMIAYTGFLRLKN
GETSDLSISVKPRWNMTELPDISTTGG
>Mature_347_residues
MRILGIETSCDETGVAIYDEEKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQEALKEANLTAADIDGVVYTA
GPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLMAPMLEDNPPAFPFVALLISGGHTQLVKVEGVGQYEILGESIDD
AAGEAFDKTGKLLGLDYPAGVAVSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINANLDENGRLDEQTRCDI
AHAFQQAVVDTIIIKCKRALQQTGYKRLVMAGGVSANKQLRTDLAEMMKNLKGEVYYPRPQFCTDNGAMIAYTGFLRLKN
GETSDLSISVKPRWNMTELPDISTTGG

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=337, Percent_Identity=33.5311572700297, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI8923380, Length=340, Percent_Identity=31.7647058823529, Blast_Score=151, Evalue=8e-37,
Organism=Escherichia coli, GI1789445, Length=340, Percent_Identity=76.1764705882353, Blast_Score=554, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17557464, Length=357, Percent_Identity=30.812324929972, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71995670, Length=332, Percent_Identity=32.5301204819277, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320099, Length=371, Percent_Identity=34.7708894878706, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322891, Length=348, Percent_Identity=29.0229885057471, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20129063, Length=340, Percent_Identity=33.8235294117647, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI21357207, Length=331, Percent_Identity=30.5135951661631, Blast_Score=158, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_ACTP2 (A3N1C4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053815.1
- ProteinModelPortal:   A3N1C4
- SMR:   A3N1C4
- STRING:   A3N1C4
- MEROPS:   M22.001
- GeneID:   4848639
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1120
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   A3N1C4
- ProtClustDB:   PRK09604
- BioCyc:   APLE416269:APL_1120-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37518; Mature: 37518

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILGIETSCDETGVAIYDEEKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQ
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EALKEANLTAADIDGVVYTAGPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLMAPM
HHHHHCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEECCC
LEDNPPAFPFVALLISGGHTQLVKVEGVGQYEILGESIDDAAGEAFDKTGKLLGLDYPAG
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHCCCEEECCCCCC
VAVSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINANLDENGRLDEQTRCDI
HHHHHHHHCCCCCCEECCCCCCCCCCCCEECCCHHHHHHCCEECCCCCCCCCCHHHHHHH
AHAFQQAVVDTIIIKCKRALQQTGYKRLVMAGGVSANKQLRTDLAEMMKNLKGEVYYPRP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCC
QFCTDNGAMIAYTGFLRLKNGETSDLSISVKPRWNMTELPDISTTGG
CCCCCCCCEEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRILGIETSCDETGVAIYDEEKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQ
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EALKEANLTAADIDGVVYTAGPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLMAPM
HHHHHCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEECCC
LEDNPPAFPFVALLISGGHTQLVKVEGVGQYEILGESIDDAAGEAFDKTGKLLGLDYPAG
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHCCCEEECCCCCC
VAVSQLAEKGTPNRFVFPRPMTDRPGLDFSFSGLKTFAANTINANLDENGRLDEQTRCDI
HHHHHHHHCCCCCCEECCCCCCCCCCCCEECCCHHHHHHCCEECCCCCCCCCCHHHHHHH
AHAFQQAVVDTIIIKCKRALQQTGYKRLVMAGGVSANKQLRTDLAEMMKNLKGEVYYPRP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCC
QFCTDNGAMIAYTGFLRLKNGETSDLSISVKPRWNMTELPDISTTGG
CCCCCCCCEEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA