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The map label for this gene is lexA [H]

Identifier: 126208580

GI number: 126208580

Start: 1285601

End: 1286233

Strand: Direct

Name: lexA [H]

Synonym: APL_1108

Alternate gene names: 126208580

Gene position: 1285601-1286233 (Clockwise)

Preceding gene: 126208577

Following gene: 126208581

Centisome position: 56.52

GC content: 43.6

Gene sequence:

>633_bases
ATGTCACGTAAACACTTAACGGCTCGTCAGCAAGAAATTTTTGATTTTGTTAAACATCACATAGAAACCACCGGTATGCC
GCCGACCCGTGTTGAAATTGCAAGAGAAATCGGTTTTAAATCGCCGAATGCGGCAGAAGAACACTTAAAAGCATTGGCGC
GTAAAGGTTATATCGAAATGCTTTCCGGTACATCGCGCGGAATTCGTATTTTAGTCGATAACGAAGAAACTGCGGCAAAT
GACGATGGTTTACCGTTAATCGGCAAAGTGGCTGCCGGTACGCCGATTATGGCGATTGAACATGTGGAAAGTCATTATCC
GGTAAACGGCGCGATGTTTAATCCGAATGCCGACTATTTGCTCAAAGTAAACGGTAACTCCATGGAAAAAATCGGTATTT
TAGACGGTGACTTACTTGCGGTGCATAAAACCAATTTTGCCCGTAACGGCCAAGTCGTCGTCGCTCGCGTTGATGACGAA
GTGACCGTAAAACGCTTGGAGAAAAAAGGCGATCTTATTTATCTTCATCCTGAAAATGACGAGTTACAACCGATTATTGT
CGATCCTCGTATCGAATATATCGAAATTGAAGGAATCGCCGTCGGTGTAATTCGCAATAACGCTTGGATGTAA

Upstream 100 bases:

>100_bases
ACCATAAATTTGTGAGGATTTTCTGAATTTATCTAGTTACAAATAAAAAATTACTGTATATAATAACAAAAAATCTGTAT
ATAAAGACAGCGAGGAAAAA

Downstream 100 bases:

>100_bases
ATTCTCTACTGCGGGGAAAATGCGTGATAAGCGTTCCCCTAAATCGTTATCATACGCTTATGCAACTTTCCACCTTTTCA
CATTCCGAAGACGAATTACT

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSRKHLTARQQEIFDFVKHHIETTGMPPTRVEIAREIGFKSPNAAEEHLKALARKGYIEMLSGTSRGIRILVDNEETAAN
DDGLPLIGKVAAGTPIMAIEHVESHYPVNGAMFNPNADYLLKVNGNSMEKIGILDGDLLAVHKTNFARNGQVVVARVDDE
VTVKRLEKKGDLIYLHPENDELQPIIVDPRIEYIEIEGIAVGVIRNNAWM

Sequences:

>Translated_210_residues
MSRKHLTARQQEIFDFVKHHIETTGMPPTRVEIAREIGFKSPNAAEEHLKALARKGYIEMLSGTSRGIRILVDNEETAAN
DDGLPLIGKVAAGTPIMAIEHVESHYPVNGAMFNPNADYLLKVNGNSMEKIGILDGDLLAVHKTNFARNGQVVVARVDDE
VTVKRLEKKGDLIYLHPENDELQPIIVDPRIEYIEIEGIAVGVIRNNAWM
>Mature_209_residues
SRKHLTARQQEIFDFVKHHIETTGMPPTRVEIAREIGFKSPNAAEEHLKALARKGYIEMLSGTSRGIRILVDNEETAAND
DGLPLIGKVAAGTPIMAIEHVESHYPVNGAMFNPNADYLLKVNGNSMEKIGILDGDLLAVHKTNFARNGQVVVARVDDEV
TVKRLEKKGDLIYLHPENDELQPIIVDPRIEYIEIEGIAVGVIRNNAWM

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=207, Percent_Identity=64.2512077294686, Blast_Score=280, Evalue=3e-77,
Organism=Escherichia coli, GI1787431, Length=124, Percent_Identity=33.8709677419355, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23369; Mature: 23238

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKHLTARQQEIFDFVKHHIETTGMPPTRVEIAREIGFKSPNAAEEHLKALARKGYIEM
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
LSGTSRGIRILVDNEETAANDDGLPLIGKVAAGTPIMAIEHVESHYPVNGAMFNPNADYL
ECCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCEEEEEEHHCCCCCCCEEECCCCCEE
LKVNGNSMEKIGILDGDLLAVHKTNFARNGQVVVARVDDEVTVKRLEKKGDLIYLHPEND
EEECCCCEEEEEEECCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCCEEEECCCCC
ELQPIIVDPRIEYIEIEGIAVGVIRNNAWM
CCCEEEECCCEEEEEECCEEEEEEECCCCC
>Mature Secondary Structure 
SRKHLTARQQEIFDFVKHHIETTGMPPTRVEIAREIGFKSPNAAEEHLKALARKGYIEM
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
LSGTSRGIRILVDNEETAANDDGLPLIGKVAAGTPIMAIEHVESHYPVNGAMFNPNADYL
ECCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCEEEEEEHHCCCCCCCEEECCCCCEE
LKVNGNSMEKIGILDGDLLAVHKTNFARNGQVVVARVDDEVTVKRLEKKGDLIYLHPEND
EEECCCCEEEEEEECCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHCCCCEEEECCCCC
ELQPIIVDPRIEYIEIEGIAVGVIRNNAWM
CCCEEEECCCEEEEEECCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA