Click here to switch to the map view.

The map label for this gene is mutH

Identifier: 126208581

GI number: 126208581

Start: 1286293

End: 1286973

Strand: Direct

Name: mutH

Synonym: APL_1109

Alternate gene names: 126208581

Gene position: 1286293-1286973 (Clockwise)

Preceding gene: 126208580

Following gene: 126208582

Centisome position: 56.55

GC content: 42.44

Gene sequence:

>681_bases
ATGCAACTTTCCACCTTTTCACATTCCGAAGACGAATTACTTAAAAAAGCGAACTGGCTTGCCGGTTTTACGCTGGGTGA
AATCGCACATCAATTAAATATTGATGTGCCTTTGGATTTGCGTCGTGATAAAGGTTGGGTCGGGCAATTAATCGAAACGG
CTTTAGGTGCAAAAGCCGGCAGCAAGCCCGAACAAGACTTTGCTCATCTAGGCATTGAACTGAAAACCATCCCTATCAAT
CATAAAGGTTTTCCGCTTGAAACCACTTTTGTCAGTTTAGCGCCGCTGACCCAAAATACCGGCATTACTTGGCAAACCTC
TCATGTTCGCCATAAATTACAAAAAGTGCTATGGATTCCGGTACAAGGAGAAAGACATATTCCGGTTGCCGAACGCCACA
TCGGTCAGCCGATTTTATGGGAGCCTTCATGTGAGCAAGAACAGCAGTTAAAAAATGACTGGGAAGAATTGATGGAATAC
ATTATTTTCGGACGTTTAAACGAAATTAATGCTACGCTCGGCGAAGTGCTGCAATTACGCCCTAAAGGCAGGAATAGGCG
ATCACTCACTGCAGCTGTTAATCAACAGGGTGAAAGGGTTCAATCGTTACCGTTAGGTTTTTATTTACGTAAACAATTTA
CCGCTGAAATTTTACAGAATTTTTTACGTTCTCCTCTTTAA

Upstream 100 bases:

>100_bases
GAATCGCCGTCGGTGTAATTCGCAATAACGCTTGGATGTAAATTCTCTACTGCGGGGAAAATGCGTGATAAGCGTTCCCC
TAAATCGTTATCATACGCTT

Downstream 100 bases:

>100_bases
TTTTTACATGACTCTCGCTATATTAGCGCCTTTTAAATTATAGGTAGTAACCTATTAAATTTTTCTCTGTTTAAAAGGAC
ATTTTATGTTTGATTGGATT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MQLSTFSHSEDELLKKANWLAGFTLGEIAHQLNIDVPLDLRRDKGWVGQLIETALGAKAGSKPEQDFAHLGIELKTIPIN
HKGFPLETTFVSLAPLTQNTGITWQTSHVRHKLQKVLWIPVQGERHIPVAERHIGQPILWEPSCEQEQQLKNDWEELMEY
IIFGRLNEINATLGEVLQLRPKGRNRRSLTAAVNQQGERVQSLPLGFYLRKQFTAEILQNFLRSPL

Sequences:

>Translated_226_residues
MQLSTFSHSEDELLKKANWLAGFTLGEIAHQLNIDVPLDLRRDKGWVGQLIETALGAKAGSKPEQDFAHLGIELKTIPIN
HKGFPLETTFVSLAPLTQNTGITWQTSHVRHKLQKVLWIPVQGERHIPVAERHIGQPILWEPSCEQEQQLKNDWEELMEY
IIFGRLNEINATLGEVLQLRPKGRNRRSLTAAVNQQGERVQSLPLGFYLRKQFTAEILQNFLRSPL
>Mature_226_residues
MQLSTFSHSEDELLKKANWLAGFTLGEIAHQLNIDVPLDLRRDKGWVGQLIETALGAKAGSKPEQDFAHLGIELKTIPIN
HKGFPLETTFVSLAPLTQNTGITWQTSHVRHKLQKVLWIPVQGERHIPVAERHIGQPILWEPSCEQEQQLKNDWEELMEY
IIFGRLNEINATLGEVLQLRPKGRNRRSLTAAVNQQGERVQSLPLGFYLRKQFTAEILQNFLRSPL

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family

Homologues:

Organism=Escherichia coli, GI1789196, Length=216, Percent_Identity=56.9444444444444, Blast_Score=266, Evalue=6e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTH_ACTP2 (A3N1B5)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053806.1
- ProteinModelPortal:   A3N1B5
- SMR:   A3N1B5
- STRING:   A3N1B5
- GeneID:   4849156
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1109
- eggNOG:   COG3066
- HOGENOM:   HBG296591
- OMA:   QDWEELM
- PhylomeDB:   A3N1B5
- ProtClustDB:   PRK05070
- BioCyc:   APLE416269:APL_1109-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00759
- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335
- Gene3D:   G3DSA:3.40.600.10
- SMART:   SM00927
- TIGRFAMs:   TIGR02248

Pfam domain/function: PF02976 MutH; SSF52980 Restrict_endonuc_II-like_core

EC number: NA

Molecular weight: Translated: 25793; Mature: 25793

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSTFSHSEDELLKKANWLAGFTLGEIAHQLNIDVPLDLRRDKGWVGQLIETALGAKAG
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SKPEQDFAHLGIELKTIPINHKGFPLETTFVSLAPLTQNTGITWQTSHVRHKLQKVLWIP
CCCHHHHHHCCEEEEEEECCCCCCCCHHHHEEEECCCCCCCCEEEHHHHHHHHHHHEEEE
VQGERHIPVAERHIGQPILWEPSCEQEQQLKNDWEELMEYIIFGRLNEINATLGEVLQLR
CCCCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
PKGRNRRSLTAAVNQQGERVQSLPLGFYLRKQFTAEILQNFLRSPL
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQLSTFSHSEDELLKKANWLAGFTLGEIAHQLNIDVPLDLRRDKGWVGQLIETALGAKAG
CCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SKPEQDFAHLGIELKTIPINHKGFPLETTFVSLAPLTQNTGITWQTSHVRHKLQKVLWIP
CCCHHHHHHCCEEEEEEECCCCCCCCHHHHEEEECCCCCCCCEEEHHHHHHHHHHHEEEE
VQGERHIPVAERHIGQPILWEPSCEQEQQLKNDWEELMEYIIFGRLNEINATLGEVLQLR
CCCCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
PKGRNRRSLTAAVNQQGERVQSLPLGFYLRKQFTAEILQNFLRSPL
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA