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The map label for this gene is nrdA [H]

Identifier: 126208466

GI number: 126208466

Start: 1145469

End: 1147739

Strand: Direct

Name: nrdA [H]

Synonym: APL_0992

Alternate gene names: 126208466

Gene position: 1145469-1147739 (Clockwise)

Preceding gene: 126208465

Following gene: 126208467

Centisome position: 50.36

GC content: 43.99

Gene sequence:

>2271_bases
ATGCAAAAAACATTGATGGTAACCAAACGCAATGGTAAGCAAGAGCCGTTTGATTTGGATAAAATTCATCGCGTCATCAC
TTGGGCGGCCGAAGGTTTACATAATGTATCGGTATCACAAGTGGAACTGAGCGCACATATTCAGTTTTATCAAGGTATTC
GTACCGCCGATATTCACGAAACCATTATCAAAGCCGCCGCCGATTTAATCAGTACCGAAACGCCGGATTATCAATATCTT
GCCGCGCGTTTAGCCGTGTTCCATCTGCGTAAAAAAGCCTATGGAGACTTCACCCCACCTCATTTATTCACTCATATTAA
AAAGCTAGTGGCACTCGGTAAATACGATAAAGCGCTCTTAACCGACTATAATGAACAAGAATGGCAACTCATGAATGAAT
TTCTTGTACACAGCCGAGATATGGATTTCTCTTATGCGGCGGTCAAACAGCTCGAAGGAAAATATTTAGTCCAAAACCGA
GTGACCGGAGAGATCTATGAGTCGGCACAATTCTTATATCTTTTAGTATCGGCCTGTTTATTTTCTCAATATCCGAAAGC
CACTCGTTTAGATTATGTAAAACGCTTTTACGATGCGACTTCAACCTTCAAAATTTCATTGCCGACCCCGATTATGGCGG
GGGTAAGAACACCGACTCGTCAGTTTAGTTCTTGCGTATTGATCGAATGCGGCGATAGTTTGGATTCAATCAATGCCACT
TCCGCTGCAATTATTAAATACGTGTCGCAACGAGCGGGAATCGGCATTAACGCCGGTGCAATCCGAGCCTTGGGTAGCCC
GATTCGTCAAGGCGAAGCCTTCCACACCGGTTGCATTCCGTTCTATAAACATTTCCAAACGGCAGTGAAATCTTGCTCGC
AAGGCGGTGTACGTGGCGGTGCCGCAACGGTTTTCTACCCGCTATGGCACTTGGAAGCGGAAAGTTTATTGGTATTAAAA
AACAATCGAGGTGTAGAAGACAACCGCTGCCGTCATATGGACTACGGTGTACAGCTTAATAAGCTGATGTATCAACGCTT
AATTAAGGGTGGAGAGATCACTTTATTCAGCCCGTCTGATGTGCCCGGTCTGTATGAAGACTTTTTTGCCGATCAGGAAA
AATTTGAACAGCTTTATCTGCAATATGAACAAGACCCGAGCATTCGTAAACGTAGTGTGAAAGCAGTTGAATTGTTTTCA
TTGCTCATGCAAGAACGTGCCTCAACCGGTCGTATTTATATTCAGAATGTCGATCACTGCAATACGCACTCGCCGTTTAA
TCCGCAAGTCGCACCGATTAAACAATCCAATTTATGTTTAGAAATCGCATTGCCGACCAAACCGCTAAACGATATTAATG
ATGAAAACGGAGAAATTGCCCTCTGCACGCTTTCTGCGTTTAACTTAGGCACTTTGCAAAATTTAGATGAATTTGAACCG
CTTGCCGACTTAGTCGTACGCGCGCTAGATGCCTTATTAGATTATCAAGATTATCCGGTGAAAGCGGCAAAACACGCCGC
ATTAGCTCGCCGTTCGCTTGGCATCGGGGTAATCAACTACGCTTATTACTTAGCGAAAAACGGCGTGCGTTATTCGGACG
GTTCCGCCAATGCGCTTACGCACAGAACCTTTGAAGCGATGCAATATTATTTGCTGAAAGCCTCGCTCAATTTAGCCAAA
GAACAAGGTGCGTGTAAGTTATTCGATGAGACGAGCTATGCTCAAGGTATTCTGCCGATTGATAGCTATAAAAAAGAATT
GGATAACCTGACAACAGAACCGCTACATTATGATTGGGAAAATTTGCGCGCGGAGATTAAACAATTCGGCTTACGTAACT
CGACGTTAAGCTCATTAATGCCGTCAGAAACTTCCTCGCAAATTTCTAATGCAACCAACGGGATTGAGCCACCTCGTGGC
TACGTGAGTATCAAAGCCTCAAAAGACGGTATCTTAAAACAAGTTGTGCCGGAATATGAAAAGCTCCGTTCACAATACGA
GTTATTGTGGGATATCCCGGATATGAGCGGTTACTTACAGCTGGTCGGTATTATGCAGAAATTCATTGATCAGGCGATTT
CGGCAAATACCAATTATGACCCGCAAAAATTTGAAGACGGAAAAGTACCGATGAAACGCTTACTTGCCGATTTATTGACC
GCTTATAAATACGGACTAAAAACGCTCTATTACCAAAATACCAGAGACGGAGCGGAAGACGCCCAAGAGGACTTAAATGA
CGGTTGTGCCGGCGGTGCTTGCAAAATTTAG

Upstream 100 bases:

>100_bases
TCCGCTTGCACCTATTTCTACAAAACAATATCTTGTATATAAACATTTAAAAATCACAAGATATAGTGGTCAAATAATAA
GATAAAAGGAGACATATTTT

Downstream 100 bases:

>100_bases
TGTCTAGACCGAATGTAAATAACCACGGAATACACTAAAAACACAGAAATAATCGGAGAATTTTAACAGCCACAGCGTGG
CTCACTCAATCGAAGGCTGA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MQKTLMVTKRNGKQEPFDLDKIHRVITWAAEGLHNVSVSQVELSAHIQFYQGIRTADIHETIIKAAADLISTETPDYQYL
AARLAVFHLRKKAYGDFTPPHLFTHIKKLVALGKYDKALLTDYNEQEWQLMNEFLVHSRDMDFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVSACLFSQYPKATRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
SAAIIKYVSQRAGIGINAGAIRALGSPIRQGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATVFYPLWHLEAESLLVLK
NNRGVEDNRCRHMDYGVQLNKLMYQRLIKGGEITLFSPSDVPGLYEDFFADQEKFEQLYLQYEQDPSIRKRSVKAVELFS
LLMQERASTGRIYIQNVDHCNTHSPFNPQVAPIKQSNLCLEIALPTKPLNDINDENGEIALCTLSAFNLGTLQNLDEFEP
LADLVVRALDALLDYQDYPVKAAKHAALARRSLGIGVINYAYYLAKNGVRYSDGSANALTHRTFEAMQYYLLKASLNLAK
EQGACKLFDETSYAQGILPIDSYKKELDNLTTEPLHYDWENLRAEIKQFGLRNSTLSSLMPSETSSQISNATNGIEPPRG
YVSIKASKDGILKQVVPEYEKLRSQYELLWDIPDMSGYLQLVGIMQKFIDQAISANTNYDPQKFEDGKVPMKRLLADLLT
AYKYGLKTLYYQNTRDGAEDAQEDLNDGCAGGACKI

Sequences:

>Translated_756_residues
MQKTLMVTKRNGKQEPFDLDKIHRVITWAAEGLHNVSVSQVELSAHIQFYQGIRTADIHETIIKAAADLISTETPDYQYL
AARLAVFHLRKKAYGDFTPPHLFTHIKKLVALGKYDKALLTDYNEQEWQLMNEFLVHSRDMDFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVSACLFSQYPKATRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
SAAIIKYVSQRAGIGINAGAIRALGSPIRQGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATVFYPLWHLEAESLLVLK
NNRGVEDNRCRHMDYGVQLNKLMYQRLIKGGEITLFSPSDVPGLYEDFFADQEKFEQLYLQYEQDPSIRKRSVKAVELFS
LLMQERASTGRIYIQNVDHCNTHSPFNPQVAPIKQSNLCLEIALPTKPLNDINDENGEIALCTLSAFNLGTLQNLDEFEP
LADLVVRALDALLDYQDYPVKAAKHAALARRSLGIGVINYAYYLAKNGVRYSDGSANALTHRTFEAMQYYLLKASLNLAK
EQGACKLFDETSYAQGILPIDSYKKELDNLTTEPLHYDWENLRAEIKQFGLRNSTLSSLMPSETSSQISNATNGIEPPRG
YVSIKASKDGILKQVVPEYEKLRSQYELLWDIPDMSGYLQLVGIMQKFIDQAISANTNYDPQKFEDGKVPMKRLLADLLT
AYKYGLKTLYYQNTRDGAEDAQEDLNDGCAGGACKI
>Mature_756_residues
MQKTLMVTKRNGKQEPFDLDKIHRVITWAAEGLHNVSVSQVELSAHIQFYQGIRTADIHETIIKAAADLISTETPDYQYL
AARLAVFHLRKKAYGDFTPPHLFTHIKKLVALGKYDKALLTDYNEQEWQLMNEFLVHSRDMDFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVSACLFSQYPKATRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
SAAIIKYVSQRAGIGINAGAIRALGSPIRQGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATVFYPLWHLEAESLLVLK
NNRGVEDNRCRHMDYGVQLNKLMYQRLIKGGEITLFSPSDVPGLYEDFFADQEKFEQLYLQYEQDPSIRKRSVKAVELFS
LLMQERASTGRIYIQNVDHCNTHSPFNPQVAPIKQSNLCLEIALPTKPLNDINDENGEIALCTLSAFNLGTLQNLDEFEP
LADLVVRALDALLDYQDYPVKAAKHAALARRSLGIGVINYAYYLAKNGVRYSDGSANALTHRTFEAMQYYLLKASLNLAK
EQGACKLFDETSYAQGILPIDSYKKELDNLTTEPLHYDWENLRAEIKQFGLRNSTLSSLMPSETSSQISNATNGIEPPRG
YVSIKASKDGILKQVVPEYEKLRSQYELLWDIPDMSGYLQLVGIMQKFIDQAISANTNYDPQKFEDGKVPMKRLLADLLT
AYKYGLKTLYYQNTRDGAEDAQEDLNDGCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=798, Percent_Identity=28.6967418546366, Blast_Score=246, Evalue=6e-65,
Organism=Escherichia coli, GI2367133, Length=761, Percent_Identity=79.7634691195795, Blast_Score=1290, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=735, Percent_Identity=24.2176870748299, Blast_Score=150, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17555242, Length=649, Percent_Identity=28.8135593220339, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322123, Length=653, Percent_Identity=28.4839203675345, Blast_Score=240, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6320914, Length=653, Percent_Identity=27.718223583461, Blast_Score=230, Evalue=7e-61,
Organism=Drosophila melanogaster, GI17352481, Length=793, Percent_Identity=27.4905422446406, Blast_Score=249, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85075; Mature: 85075

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTLMVTKRNGKQEPFDLDKIHRVITWAAEGLHNVSVSQVELSAHIQFYQGIRTADIHE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
TIIKAAADLISTETPDYQYLAARLAVFHLRKKAYGDFTPPHLFTHIKKLVALGKYDKALL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHH
TDYNEQEWQLMNEFLVHSRDMDFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYLLVSACL
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSQYPKATRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCCCCCCHH
SAAIIKYVSQRAGIGINAGAIRALGSPIRQGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
AATVFYPLWHLEAESLLVLKNNRGVEDNRCRHMDYGVQLNKLMYQRLIKGGEITLFSPSD
CCEEEEHHHHCCCCCEEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYEDFFADQEKFEQLYLQYEQDPSIRKRSVKAVELFSLLMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFNPQVAPIKQSNLCLEIALPTKPLNDINDENGEIALCTLSAFNLGTLQNLDEFEP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHCCCHHHHH
LADLVVRALDALLDYQDYPVKAAKHAALARRSLGIGVINYAYYLAKNGVRYSDGSANALT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCCCCHHH
HRTFEAMQYYLLKASLNLAKEQGACKLFDETSYAQGILPIDSYKKELDNLTTEPLHYDWE
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCHHHHHHHHHCCCCCCCCCCHH
NLRAEIKQFGLRNSTLSSLMPSETSSQISNATNGIEPPRGYVSIKASKDGILKQVVPEYE
HHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
KLRSQYELLWDIPDMSGYLQLVGIMQKFIDQAISANTNYDPQKFEDGKVPMKRLLADLLT
HHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AYKYGLKTLYYQNTRDGAEDAQEDLNDGCAGGACKI
HHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQKTLMVTKRNGKQEPFDLDKIHRVITWAAEGLHNVSVSQVELSAHIQFYQGIRTADIHE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHH
TIIKAAADLISTETPDYQYLAARLAVFHLRKKAYGDFTPPHLFTHIKKLVALGKYDKALL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHH
TDYNEQEWQLMNEFLVHSRDMDFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYLLVSACL
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSQYPKATRLDYVKRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCCCCCCHH
SAAIIKYVSQRAGIGINAGAIRALGSPIRQGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
AATVFYPLWHLEAESLLVLKNNRGVEDNRCRHMDYGVQLNKLMYQRLIKGGEITLFSPSD
CCEEEEHHHHCCCCCEEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYEDFFADQEKFEQLYLQYEQDPSIRKRSVKAVELFSLLMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFNPQVAPIKQSNLCLEIALPTKPLNDINDENGEIALCTLSAFNLGTLQNLDEFEP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHCCCHHHHH
LADLVVRALDALLDYQDYPVKAAKHAALARRSLGIGVINYAYYLAKNGVRYSDGSANALT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCCCCHHH
HRTFEAMQYYLLKASLNLAKEQGACKLFDETSYAQGILPIDSYKKELDNLTTEPLHYDWE
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCHHHHHHHHHCCCCCCCCCCHH
NLRAEIKQFGLRNSTLSSLMPSETSSQISNATNGIEPPRGYVSIKASKDGILKQVVPEYE
HHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
KLRSQYELLWDIPDMSGYLQLVGIMQKFIDQAISANTNYDPQKFEDGKVPMKRLLADLLT
HHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AYKYGLKTLYYQNTRDGAEDAQEDLNDGCAGGACKI
HHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]