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The map label for this gene is apxIIA [H]

Identifier: 126208432

GI number: 126208432

Start: 1095618

End: 1098488

Strand: Reverse

Name: apxIIA [H]

Synonym: APL_0956

Alternate gene names: 126208432

Gene position: 1098488-1095618 (Counterclockwise)

Preceding gene: 126208433

Following gene: 126208431

Centisome position: 48.3

GC content: 36.5

Gene sequence:

>2871_bases
ATGTCAAAAATCACTTTGTCATCATTAAAATCGTCCTTACAACAAGGATTGAAAAATGGGAAAAACAAGTTAAATCAAGC
AGGTACAACACTGAAGAATGGTTTAACTCAAACTGGTCATTCTCTACAGAATGGGGCTAAAAAATTAATCTTATATATTC
CTCAAGGCTATGATTCGGGTCAAGGAAATGGAGTTCAAGATTTAGTTAAAGCTGCTAATGATTTAGGTATTGAAGTATGG
CGAGAAGAACGCAGCAATTTGGACATTGCAAAAACTAGCTTTGATACAACTCAGAAAATTCTAGGTTTTACTGATAGAGG
AATTGTATTATTTGCACCTCAGCTAGATAATTTATTAAAGAAGAATCCTAAAATTGGCAATACATTAGGAAGTGCTTCTA
GCATCTCACAAAATATAGGTAAAGCCAATACTGTATTAGGTGGTATTCAATCTATTTTAGGATCTGTTTTATCTGGAGTA
AATCTGAATGAATTACTTCAAAATAAAGATCCTAATCAATTAGAACTTGCAAAAGCAGGGCTAGAACTGACTAATGAATT
AGTTGGTAATATTGCTAGCTCGGTGCAAACTGTAGATGCATTTGCAGAACAAATATCTAAACTAGGTTCACATTTACAGA
ATGTGAAAGGATTAGGAGGATTGAGTAATAAATTACAAAATCTACCAGATCTAGGAAAAGCAAGTTTAGGTTTGGACATT
ATCTCTGGTTTACTTTCTGGAGCATCTGCAGGTCTCATTTTAGCAGATAAAGAGGCTTCAACAGAAAAGAAAGCTGCCGC
AGGTGTAGAATTTGCTAACCAAATTATAGGTAATGTAACAAAAGCGGTCTCATCTTACATTCTTGCCCAACGAGTCGCTT
CAGGTTTGTCTTCAACTGGTCCTGTCGCTGCATTAATCGCATCTACAGTTGCACTAGCTGTTAGCCCTCTTTCATTCTTA
AATGTAGCTGATAAGTTTAAACAAGCTGATTTAATCAAATCATATTCTGAACGCTTCCAAAAATTAGGATATGATGGAGA
TCGTTTATTAGCTGATTTTCACCGTGAGACAGGAACTATTGATGCTTCTGTAACAACAATTAACACTGCTTTAGCAGCTA
TCTCCGGTGGAGTTGGAGCTGCAAGCGCGGGTTCTCTAGTCGGAGCTCCAGTTGCGTTACTCGTTGCTGGTGTTACGGGA
CTTATTACAACTATTCTAGAATATTCTAAACAAGCCATGTTTGAACATGTTGCAAATAAGGTTCATGACAGAATAGTTGA
ATGGGAGAAAAAACATAATAAAAACTATTTTGAGCAAGGTTATGATTCTCGTCATTTAGCTGATTTACAAGACAATATGA
AGTTTCTTATCAATTTAAATAAAGAACTTCAGGCTGAACGCGTAGTAGCTATTACCCAACAAAGATGGGATAACCAAATT
GGAGACCTAGCGGCAATTAGCCGTAGAACGGATAAAATTTCCAGTGGAAAAGCTTATGTGGATGCTTTTGAGGAGGGGCA
ACACCAGTCCTACGATTCATCCGTACAGCTAGATAACAAAAACGGTATTATTAATATTAGTAATACAAATAGAAAGACAC
AAAGTGTTTTATTCAGAACTCCATTACTAACTCCAGGTGAAGAGAATCGGGAACGTATTCAGGAAGGTAAAAATTCTTAT
ATTACAAAATTACATATACAAAGAGTTGACAGTTGGACTGTAACAGATGGTGATGCTAGCTCAAGCGTAGATTTCACTAA
TGTAGTACAACGAATCGCTGTGAAATTTGATGATGCAGGTAACATTATCGAATCTAAAGATACTAAAATTATCGCAAATT
TAGGTGCTGGTAACGATAATGTATTTGTTGGGTCAAGTACTACCGTTATTGATGGCGGGGACGGACATGATCGAGTTCAC
TACAGTAGAGGAGAATATGGCGCATTAGTTATTGATGCTACAGCCGAGACAGAAAAAGGCTCATATTCAGTAAAACGCTA
TGTCGGAGACAGTAAAGCATTACATGAAACAATTGCCACCCACCAAACAAATGTTGGTAATCGTGAAGAAAAAATTGAAT
ATCGTCGTGAAGATGATCGTTTTCATACTGGTTATACTGTGACGGACTCACTCAAATCAGTTGAAGAGATCATTGGTTCA
CAATTTAATGATATTTTCAAAGGAAGCCAATTTGATGATGTGTTCCATGGTGGTAATGGTGTAGACACTATTGATGGTAA
CGATGGTGACGATCATTTATTTGGTGGCGCAGGCGATGATGTTATCGATGGAGGAAACGGTAACAATTTCCTTGTTGGAG
GAACCGGTAATGATATTATCTCGGGAGGTAAAGATAATGATATATATGTCCATAAAACAGGCGATGGAAATGATTCTATT
ACAGACTCTGGCGGACAAGATACACTGGCATTTTCGGATGTAAATCTTAAAGACCTCACCTTTAAGAAAGTAGATTCTTC
TCTCGAAATCATTAATCAAAAAGGAGAAAAAGTTCGTATTGGGAATTGGTTCTTAGAAGATGATTTGGCTAGCACAGTTG
CTAACTATAAAGCTACGAATGACCGAAAAATTGAGGAAATTATTGGTAAAGGAGGAGAACGTATTACATCAGAACAAGTT
GATAAACTGATTAAGGAGGGTAACAATCAAATCTCTGCAGAAGCATTATCCAAAGTTGTGAATGATTACAATACGAGTAA
AGATAGACAGAACGTATCTAATAGCTTAGCAAAATTGATTTCTTCAGTCGGGAGCTTTACGTCTTCCTCAGACTTTAGGA
ATAATTTAGGAACATATGTTCCTTCATCAATAGATGTCTCGAATAATATTCAATTAGCTAGAGCCGCTTAA

Upstream 100 bases:

>100_bases
AAAAAGTAGCTGAAAAGACATTTCTTCAGTATGAGCAAGAGTTAATAACAGCTCTACAATAATATCTTTAAATGATCAAT
TATATAAAGGAGACTCTTTT

Downstream 100 bases:

>100_bases
TATTCAAATCATAGCAATCCTATGGTGTAAATTATAGGATTGTTATTTTTTTAAAGGAGAAGTTATGGAACCCAATAAAA
ATAAGGATCTTGGTTTAGCT

Product: RTX-II toxin determinant A

Products: NA

Alternate protein names: APPA; CLY-IIA; CYTC; Cytolysin II; HLY-IIA [H]

Number of amino acids: Translated: 956; Mature: 955

Protein sequence:

>956_residues
MSKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTGHSLQNGAKKLILYIPQGYDSGQGNGVQDLVKAANDLGIEVW
REERSNLDIAKTSFDTTQKILGFTDRGIVLFAPQLDNLLKKNPKIGNTLGSASSISQNIGKANTVLGGIQSILGSVLSGV
NLNELLQNKDPNQLELAKAGLELTNELVGNIASSVQTVDAFAEQISKLGSHLQNVKGLGGLSNKLQNLPDLGKASLGLDI
ISGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVTKAVSSYILAQRVASGLSSTGPVAALIASTVALAVSPLSFL
NVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTG
LITTILEYSKQAMFEHVANKVHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQAERVVAITQQRWDNQI
GDLAAISRRTDKISSGKAYVDAFEEGQHQSYDSSVQLDNKNGIINISNTNRKTQSVLFRTPLLTPGEENRERIQEGKNSY
ITKLHIQRVDSWTVTDGDASSSVDFTNVVQRIAVKFDDAGNIIESKDTKIIANLGAGNDNVFVGSSTTVIDGGDGHDRVH
YSRGEYGALVIDATAETEKGSYSVKRYVGDSKALHETIATHQTNVGNREEKIEYRREDDRFHTGYTVTDSLKSVEEIIGS
QFNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFGGAGDDVIDGGNGNNFLVGGTGNDIISGGKDNDIYVHKTGDGNDSI
TDSGGQDTLAFSDVNLKDLTFKKVDSSLEIINQKGEKVRIGNWFLEDDLASTVANYKATNDRKIEEIIGKGGERITSEQV
DKLIKEGNNQISAEALSKVVNDYNTSKDRQNVSNSLAKLISSVGSFTSSSDFRNNLGTYVPSSIDVSNNIQLARAA

Sequences:

>Translated_956_residues
MSKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTGHSLQNGAKKLILYIPQGYDSGQGNGVQDLVKAANDLGIEVW
REERSNLDIAKTSFDTTQKILGFTDRGIVLFAPQLDNLLKKNPKIGNTLGSASSISQNIGKANTVLGGIQSILGSVLSGV
NLNELLQNKDPNQLELAKAGLELTNELVGNIASSVQTVDAFAEQISKLGSHLQNVKGLGGLSNKLQNLPDLGKASLGLDI
ISGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVTKAVSSYILAQRVASGLSSTGPVAALIASTVALAVSPLSFL
NVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTG
LITTILEYSKQAMFEHVANKVHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQAERVVAITQQRWDNQI
GDLAAISRRTDKISSGKAYVDAFEEGQHQSYDSSVQLDNKNGIINISNTNRKTQSVLFRTPLLTPGEENRERIQEGKNSY
ITKLHIQRVDSWTVTDGDASSSVDFTNVVQRIAVKFDDAGNIIESKDTKIIANLGAGNDNVFVGSSTTVIDGGDGHDRVH
YSRGEYGALVIDATAETEKGSYSVKRYVGDSKALHETIATHQTNVGNREEKIEYRREDDRFHTGYTVTDSLKSVEEIIGS
QFNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFGGAGDDVIDGGNGNNFLVGGTGNDIISGGKDNDIYVHKTGDGNDSI
TDSGGQDTLAFSDVNLKDLTFKKVDSSLEIINQKGEKVRIGNWFLEDDLASTVANYKATNDRKIEEIIGKGGERITSEQV
DKLIKEGNNQISAEALSKVVNDYNTSKDRQNVSNSLAKLISSVGSFTSSSDFRNNLGTYVPSSIDVSNNIQLARAA
>Mature_955_residues
SKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTGHSLQNGAKKLILYIPQGYDSGQGNGVQDLVKAANDLGIEVWR
EERSNLDIAKTSFDTTQKILGFTDRGIVLFAPQLDNLLKKNPKIGNTLGSASSISQNIGKANTVLGGIQSILGSVLSGVN
LNELLQNKDPNQLELAKAGLELTNELVGNIASSVQTVDAFAEQISKLGSHLQNVKGLGGLSNKLQNLPDLGKASLGLDII
SGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVTKAVSSYILAQRVASGLSSTGPVAALIASTVALAVSPLSFLN
VADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGL
ITTILEYSKQAMFEHVANKVHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQAERVVAITQQRWDNQIG
DLAAISRRTDKISSGKAYVDAFEEGQHQSYDSSVQLDNKNGIINISNTNRKTQSVLFRTPLLTPGEENRERIQEGKNSYI
TKLHIQRVDSWTVTDGDASSSVDFTNVVQRIAVKFDDAGNIIESKDTKIIANLGAGNDNVFVGSSTTVIDGGDGHDRVHY
SRGEYGALVIDATAETEKGSYSVKRYVGDSKALHETIATHQTNVGNREEKIEYRREDDRFHTGYTVTDSLKSVEEIIGSQ
FNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFGGAGDDVIDGGNGNNFLVGGTGNDIISGGKDNDIYVHKTGDGNDSIT
DSGGQDTLAFSDVNLKDLTFKKVDSSLEIINQKGEKVRIGNWFLEDDLASTVANYKATNDRKIEEIIGKGGERITSEQVD
KLIKEGNNQISAEALSKVVNDYNTSKDRQNVSNSLAKLISSVGSFTSSSDFRNNLGTYVPSSIDVSNNIQLARAA

Specific function: One of the virulence factors of A.suis might be a secreted cytotoxin, possibly the extracellular hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001343
- InterPro:   IPR013550
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX; PF08339 RTX_C [H]

EC number: NA

Molecular weight: Translated: 102506; Mature: 102375

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTGHSLQNGAKKLILYIPQGYDSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHCCCEEEEEEEECCCCCC
QGNGVQDLVKAANDLGIEVWREERSNLDIAKTSFDTTQKILGFTDRGIVLFAPQLDNLLK
CCCCHHHHHHHHHHCCHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCEEEECCHHHHHHH
KNPKIGNTLGSASSISQNIGKANTVLGGIQSILGSVLSGVNLNELLQNKDPNQLELAKAG
CCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHH
LELTNELVGNIASSVQTVDAFAEQISKLGSHLQNVKGLGGLSNKLQNLPDLGKASLGLDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHH
ISGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVTKAVSSYILAQRVASGLSSTG
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PVAALIASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
DASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANK
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQAERVVAITQQRWDNQI
HHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCHH
GDLAAISRRTDKISSGKAYVDAFEEGQHQSYDSSVQLDNKNGIINISNTNRKTQSVLFRT
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHCC
PLLTPGEENRERIQEGKNSYITKLHIQRVDSWTVTDGDASSSVDFTNVVQRIAVKFDDAG
CCCCCCCHHHHHHHCCCCCCEEEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCC
NIIESKDTKIIANLGAGNDNVFVGSSTTVIDGGDGHDRVHYSRGEYGALVIDATAETEKG
CCCCCCCCEEEEEECCCCCCEEECCCEEEEECCCCCCCEEECCCCCCEEEEEECCCCCCC
SYSVKRYVGDSKALHETIATHQTNVGNREEKIEYRREDDRFHTGYTVTDSLKSVEEIIGS
CCHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHH
QFNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFGGAGDDVIDGGNGNNFLVGGTGNDII
HHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
SGGKDNDIYVHKTGDGNDSITDSGGQDTLAFSDVNLKDLTFKKVDSSLEIINQKGEKVRI
CCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEE
GNWFLEDDLASTVANYKATNDRKIEEIIGKGGERITSEQVDKLIKEGNNQISAEALSKVV
CCEEEHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
NDYNTSKDRQNVSNSLAKLISSVGSFTSSSDFRNNLGTYVPSSIDVSNNIQLARAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTGHSLQNGAKKLILYIPQGYDSG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHCCCEEEEEEEECCCCCC
QGNGVQDLVKAANDLGIEVWREERSNLDIAKTSFDTTQKILGFTDRGIVLFAPQLDNLLK
CCCCHHHHHHHHHHCCHHHHHHHHCCCCEECCCHHHHHHHHCCCCCCEEEECCHHHHHHH
KNPKIGNTLGSASSISQNIGKANTVLGGIQSILGSVLSGVNLNELLQNKDPNQLELAKAG
CCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHH
LELTNELVGNIASSVQTVDAFAEQISKLGSHLQNVKGLGGLSNKLQNLPDLGKASLGLDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHH
ISGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVTKAVSSYILAQRVASGLSSTG
HHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PVAALIASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
DASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANK
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQAERVVAITQQRWDNQI
HHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCHH
GDLAAISRRTDKISSGKAYVDAFEEGQHQSYDSSVQLDNKNGIINISNTNRKTQSVLFRT
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHCC
PLLTPGEENRERIQEGKNSYITKLHIQRVDSWTVTDGDASSSVDFTNVVQRIAVKFDDAG
CCCCCCCHHHHHHHCCCCCCEEEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHCCCCC
NIIESKDTKIIANLGAGNDNVFVGSSTTVIDGGDGHDRVHYSRGEYGALVIDATAETEKG
CCCCCCCCEEEEEECCCCCCEEECCCEEEEECCCCCCCEEECCCCCCEEEEEECCCCCCC
SYSVKRYVGDSKALHETIATHQTNVGNREEKIEYRREDDRFHTGYTVTDSLKSVEEIIGS
CCHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHH
QFNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFGGAGDDVIDGGNGNNFLVGGTGNDII
HHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
SGGKDNDIYVHKTGDGNDSITDSGGQDTLAFSDVNLKDLTFKKVDSSLEIINQKGEKVRI
CCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEE
GNWFLEDDLASTVANYKATNDRKIEEIIGKGGERITSEQVDKLIKEGNNQISAEALSKVV
CCEEEHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHH
NDYNTSKDRQNVSNSLAKLISSVGSFTSSSDFRNNLGTYVPSSIDVSNNIQLARAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1587585 [H]