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The map label for this gene is lpxL [H]

Identifier: 126208376

GI number: 126208376

Start: 1043459

End: 1044400

Strand: Reverse

Name: lpxL [H]

Synonym: APL_0900

Alternate gene names: 126208376

Gene position: 1044400-1043459 (Counterclockwise)

Preceding gene: 126208378

Following gene: 126208375

Centisome position: 45.92

GC content: 44.48

Gene sequence:

>942_bases
ATGACTGAGAATAAAAACATTCCGCCGTTTGAGTTACGCTTCTTGCACCCGAAATATTGGGGGCTTTGGCTGGGGCTGGG
GTTATTTAAATTAATTTTGTGCTTACCTTATCCGGTCCTGGTCGTATTAGGTAAGGGGATAGGTAAACTGTTTGCCAAAC
TTGGTTTCGGTAAACGTAGAATGCGTATTGCACGCCGGAATTTAGAACTCTGCTTTCCGGATTATTCCGCCGAACGGATT
CAAGCTATTTTAGCCAAAAATATCGAATCGGTCGGTATGGCGATTATTGAAACCGGTATGGCGTGGTTTTGGTCGGATAA
GCGTATTCTTAAATGGTCGAAAATCGAAGGGCTGGAACATCTTAAAAATCAGCCGCAAGGAGCGGGGATTTTATTAGTCG
GTGTGCATTTTCTCACGTTAGAAATGGGCGCACGCATTTTAGGGCTTCATCACCAAGGTGTGGGTGTTTATCGACCGAAT
GATAATCCGTTATTAGATTGGATTCAGTTTCGCGGCAGAGTACGCTCAAATAAGGCGATGCTCGATCGTAAAGACTTACG
CGGTATGATTCGCGCTTTAAAAGCGGGCGAGACGATTTGGTATGCGCCGGATCATGATTACGGACGTAAAAATAGCGTAT
TCGTGCCGTTTTTTGCCGTAAATGAAGCTTGTACTACGGCGGGGACGCGAATGTTATTACGTTCCGCACCGAATACGGTG
GTCGTGCCGTTCAGCCCGATTCGAAATGACGATTTTTCCGGATATACGGTAAAAGTCAGTCCGGCGGTTGATTTTAGTGA
ATGTAGTGATGAATTGGATACTGCAACCAAAATGAATAAAGTCGTTGAAACTGAAATTCTGAAAGAAGTCAGCCAATATA
TGTGGTTACATCGCCGGTTTAAAACACGCCCGCAAGAATCGGACAAGAGTTTATACGATTAA

Upstream 100 bases:

>100_bases
ATCAAGTCAAAAACCGAAGCAAAATTTAAAAATTTGATCTACTTAACACTTTTTTAGTGTTTTTGATTATAATCTATCCG
AAAAATTAGGATGGTAAAAA

Downstream 100 bases:

>100_bases
AATAAACCCGACATGAATTAATAGTGTCGGGTTTATTTTTTCTTTCCGTATTTTCTTTAATTTTTTAGTTGTTATTCGCA
AAAAATACTTGCATATTTAA

Product: lipid A biosynthesis lauroyl acyltransferase

Products: NA

Alternate protein names: Heat shock protein B [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTENKNIPPFELRFLHPKYWGLWLGLGLFKLILCLPYPVLVVLGKGIGKLFAKLGFGKRRMRIARRNLELCFPDYSAERI
QAILAKNIESVGMAIIETGMAWFWSDKRILKWSKIEGLEHLKNQPQGAGILLVGVHFLTLEMGARILGLHHQGVGVYRPN
DNPLLDWIQFRGRVRSNKAMLDRKDLRGMIRALKAGETIWYAPDHDYGRKNSVFVPFFAVNEACTTAGTRMLLRSAPNTV
VVPFSPIRNDDFSGYTVKVSPAVDFSECSDELDTATKMNKVVETEILKEVSQYMWLHRRFKTRPQESDKSLYD

Sequences:

>Translated_313_residues
MTENKNIPPFELRFLHPKYWGLWLGLGLFKLILCLPYPVLVVLGKGIGKLFAKLGFGKRRMRIARRNLELCFPDYSAERI
QAILAKNIESVGMAIIETGMAWFWSDKRILKWSKIEGLEHLKNQPQGAGILLVGVHFLTLEMGARILGLHHQGVGVYRPN
DNPLLDWIQFRGRVRSNKAMLDRKDLRGMIRALKAGETIWYAPDHDYGRKNSVFVPFFAVNEACTTAGTRMLLRSAPNTV
VVPFSPIRNDDFSGYTVKVSPAVDFSECSDELDTATKMNKVVETEILKEVSQYMWLHRRFKTRPQESDKSLYD
>Mature_312_residues
TENKNIPPFELRFLHPKYWGLWLGLGLFKLILCLPYPVLVVLGKGIGKLFAKLGFGKRRMRIARRNLELCFPDYSAERIQ
AILAKNIESVGMAIIETGMAWFWSDKRILKWSKIEGLEHLKNQPQGAGILLVGVHFLTLEMGARILGLHHQGVGVYRPND
NPLLDWIQFRGRVRSNKAMLDRKDLRGMIRALKAGETIWYAPDHDYGRKNSVFVPFFAVNEACTTAGTRMLLRSAPNTVV
VPFSPIRNDDFSGYTVKVSPAVDFSECSDELDTATKMNKVVETEILKEVSQYMWLHRRFKTRPQESDKSLYD

Specific function: Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA [H]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI1787292, Length=305, Percent_Identity=57.3770491803279, Blast_Score=353, Evalue=6e-99,
Organism=Escherichia coli, GI87082094, Length=304, Percent_Identity=50, Blast_Score=314, Evalue=5e-87,
Organism=Escherichia coli, GI1788161, Length=309, Percent_Identity=27.5080906148867, Blast_Score=114, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35816; Mature: 35685

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTENKNIPPFELRFLHPKYWGLWLGLGLFKLILCLPYPVLVVLGKGIGKLFAKLGFGKRR
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCHHH
MRIARRNLELCFPDYSAERIQAILAKNIESVGMAIIETGMAWFWSDKRILKWSKIEGLEH
HHHHHCCCEEECCCCCHHHHHHHHHHCHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHH
LKNQPQGAGILLVGVHFLTLEMGARILGLHHQGVGVYRPNDNPLLDWIQFRGRVRSNKAM
HHCCCCCCCEEEHHHHHHHHHHCCHHEEEEECCCEEECCCCCCHHHHHHHHCHHCCCHHH
LDRKDLRGMIRALKAGETIWYAPDHDYGRKNSVFVPFFAVNEACTTAGTRMLLRSAPNTV
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEE
VVPFSPIRNDDFSGYTVKVSPAVDFSECSDELDTATKMNKVVETEILKEVSQYMWLHRRF
EEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTRPQESDKSLYD
CCCCCCCCCCCCC
>Mature Secondary Structure 
TENKNIPPFELRFLHPKYWGLWLGLGLFKLILCLPYPVLVVLGKGIGKLFAKLGFGKRR
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCHHH
MRIARRNLELCFPDYSAERIQAILAKNIESVGMAIIETGMAWFWSDKRILKWSKIEGLEH
HHHHHCCCEEECCCCCHHHHHHHHHHCHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHH
LKNQPQGAGILLVGVHFLTLEMGARILGLHHQGVGVYRPNDNPLLDWIQFRGRVRSNKAM
HHCCCCCCCEEEHHHHHHHHHHCCHHEEEEECCCEEECCCCCCHHHHHHHHCHHCCCHHH
LDRKDLRGMIRALKAGETIWYAPDHDYGRKNSVFVPFFAVNEACTTAGTRMLLRSAPNTV
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEE
VVPFSPIRNDDFSGYTVKVSPAVDFSECSDELDTATKMNKVVETEILKEVSQYMWLHRRF
EEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTRPQESDKSLYD
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 7592970 [H]