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The map label for this gene is fadJ [H]

Identifier: 126208364

GI number: 126208364

Start: 1027658

End: 1029775

Strand: Direct

Name: fadJ [H]

Synonym: APL_0888

Alternate gene names: 126208364

Gene position: 1027658-1029775 (Clockwise)

Preceding gene: 126208363

Following gene: 126208365

Centisome position: 45.18

GC content: 42.68

Gene sequence:

>2118_bases
ATGACAGAACAACCCATTCAGCAACCGATGTTTCAAGTCGAAGTAGATGAAAATCAGATTGCCATCATTCGCATTCACTC
TATTGATAATGATGAAAACTGGCTTCCCGAAAATTTTGCCGGCGAATTAAGAGAAGTTATCGGTACGCTGATTTATCGTC
AGGTACAAGGTGCGATTTTTATTTCGACACGGGCAAATCATTTTATTCAGGGCTTAAAACCGAGCCTTTTCAAAAACAAG
ACAAATGAGCAATTACTTGCTTTTTCCCAAGATGCACAAGCGATTATGCGAGAGTTAAATACGCTGAAAATGCCGATTGT
CGCCGCTATCGACGGGAATTGCTTTAGTGTCGGTCTGGAACTTTCCTTAGCTTGCGATTACCGTATCGCCAGTGATGAAT
CGCATACTTTCTTTGCGATGCCGCAAGTCCGTTCCGGCTTATTACCTTTTGCCGGCGGTACGCAACGTTTACCGCGTTTA
ATCGGTTTACGTTCCGCGCTACCGTTAATGTTATTCGGCGAAAAAATAACTGCCGAAACCGCCAAAGGATTGGGTTTGGT
TGATCGATTGGTGCCTAAAACTCGTCTTTTAACCGATGCTTATCAACTCTTACTAGAGAAGAAAATTCAAAAAGCCAATC
ATAAAAAACCGCTTACTTTCTTTAAAAAATGGCGTAAGCAGATCGAAGGTAATTCGTTCTTACGCGAAAAATTGCTTGAT
CGTACGGAAAATGCGATTTGGCTTAAAACGTTCGGTAATTACCCTGCGGTTGCCAAACTGATGGAACTGCTCAAAGAGCC
GCACTTTAAACAAGGGTTAATGCTCGAACAACAAGCCTTTGTCGAATTGTTTAATAGCGCAACCTCACAAGTATTAATCG
AATTAAAGAAAACCGAACGGGCAATGAAGGATAAATATCGTATTCGAGGTAATGTACGTGATGTCGCTCAAGTCAGTATT
TTAGGTTCGGGCTATATGGGCGCCGGTATTGCTTATTTAACCGCCAACAATGCTAAAGTACCGGTTCGCATAAAAGATAT
TCATCCGTCGGAAATTCGTAAAGCCTTACGTACCTGCTTTGAATTAATGCAAAAATCAACGGATAAAAATCAGCTTAATC
ACGGTGAAATGATCCAACGTATGAATCTGATTACCGGCGGAGAGCGATTAGTGGCGGCAAAATCAACCGATTTTGTGATT
GAAGCGGTGTATGAAGATCTCAAACTTAAACAACGGATGTTAGCCGAAAGTGAAAGCTACTATAGTGAACAGACCATTTT
TGCAACGAATACTTCAACCTTTGCGATTAAAGATATTGCGGCTTGTGCGATTCGTCCGGAAAACGTAATCGGGCTACATT
ATTTCAGCCCGGTTACCACGCAAAAAATGGTGGAAATCATACCGCATAGCGCAACCGGCGAACATACGATTGCGACGGCG
ATTCATTTTGCCATTCAACAAGGCAAAATCCCGTTGTTGGTTGCTGATAAGCAGGGCTTTTTTATTAATCGAGTTTTAAC
GCCGTTACTGCTTGAAGCGGTGCAATGTTTAATTGACGGCGAATCGATTGAATTTATCGATCGTTCGTTACAAGAATTCG
GCTTCAAATTAGGCCCGCTTGCCATGATCGACGAAATGGGGCTGGATGTATTGGTCAAATCGAACTCGGCTTTAGTCAGC
GAATTAGGCAGCCGTTTCAGTTTGCCTCAAGCGGTTGATTTATTGTTCCGAAATGAACGTAAAGGCTGTAAAAACAAACG
CGGTTTCTATATGTATGATCGCTTCGGAGAACGTTTACAGGAAGATAAAAGCATTTATCACGTGATGGAAACCATTGCCC
GTAACGATTTGGAATCCGAACAGATTGTCCGCCGTTGCCTGTTACGTATGCTCAACGAAGCGGCTTGGTGTTTACAGGAT
AAGATTATCGCCTCGACCGACGAAGGTAATGTCGCTTCCGTTCTCGCAATGGGCTTTCCGGAGTTTCGAGGCGGTATCTA
TGTCTATATCGAAAAAATCGGTGCAAAAGAAATCGTACGGCAATTACACTTACACACTAAACAATACGGTAAACGTTTCG
AACCTTGCGAATGGCTAATCCGACAAGCCGAACAATAA

Upstream 100 bases:

>100_bases
TGCGCTAAAACGTAAAGGCGGCGGTATTTCATTAGTCGCCTCCGGCGGTTTAGGCGGCTTAGGGGCGGCAATGGTATTAG
AAAGCGAATAAGGACAATCC

Downstream 100 bases:

>100_bases
GATACTTGACTAAAAAACCGGACTTTTACAATCGTCCGGTTTTTTATTAGAATCTAGCTATCGTTCCGCGCTTTCTTTAA
GGATTCTATAATGAAAAAAT

Product: putative fatty acid oxidation complex alpha subunit

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 705; Mature: 704

Protein sequence:

>705_residues
MTEQPIQQPMFQVEVDENQIAIIRIHSIDNDENWLPENFAGELREVIGTLIYRQVQGAIFISTRANHFIQGLKPSLFKNK
TNEQLLAFSQDAQAIMRELNTLKMPIVAAIDGNCFSVGLELSLACDYRIASDESHTFFAMPQVRSGLLPFAGGTQRLPRL
IGLRSALPLMLFGEKITAETAKGLGLVDRLVPKTRLLTDAYQLLLEKKIQKANHKKPLTFFKKWRKQIEGNSFLREKLLD
RTENAIWLKTFGNYPAVAKLMELLKEPHFKQGLMLEQQAFVELFNSATSQVLIELKKTERAMKDKYRIRGNVRDVAQVSI
LGSGYMGAGIAYLTANNAKVPVRIKDIHPSEIRKALRTCFELMQKSTDKNQLNHGEMIQRMNLITGGERLVAAKSTDFVI
EAVYEDLKLKQRMLAESESYYSEQTIFATNTSTFAIKDIAACAIRPENVIGLHYFSPVTTQKMVEIIPHSATGEHTIATA
IHFAIQQGKIPLLVADKQGFFINRVLTPLLLEAVQCLIDGESIEFIDRSLQEFGFKLGPLAMIDEMGLDVLVKSNSALVS
ELGSRFSLPQAVDLLFRNERKGCKNKRGFYMYDRFGERLQEDKSIYHVMETIARNDLESEQIVRRCLLRMLNEAAWCLQD
KIIASTDEGNVASVLAMGFPEFRGGIYVYIEKIGAKEIVRQLHLHTKQYGKRFEPCEWLIRQAEQ

Sequences:

>Translated_705_residues
MTEQPIQQPMFQVEVDENQIAIIRIHSIDNDENWLPENFAGELREVIGTLIYRQVQGAIFISTRANHFIQGLKPSLFKNK
TNEQLLAFSQDAQAIMRELNTLKMPIVAAIDGNCFSVGLELSLACDYRIASDESHTFFAMPQVRSGLLPFAGGTQRLPRL
IGLRSALPLMLFGEKITAETAKGLGLVDRLVPKTRLLTDAYQLLLEKKIQKANHKKPLTFFKKWRKQIEGNSFLREKLLD
RTENAIWLKTFGNYPAVAKLMELLKEPHFKQGLMLEQQAFVELFNSATSQVLIELKKTERAMKDKYRIRGNVRDVAQVSI
LGSGYMGAGIAYLTANNAKVPVRIKDIHPSEIRKALRTCFELMQKSTDKNQLNHGEMIQRMNLITGGERLVAAKSTDFVI
EAVYEDLKLKQRMLAESESYYSEQTIFATNTSTFAIKDIAACAIRPENVIGLHYFSPVTTQKMVEIIPHSATGEHTIATA
IHFAIQQGKIPLLVADKQGFFINRVLTPLLLEAVQCLIDGESIEFIDRSLQEFGFKLGPLAMIDEMGLDVLVKSNSALVS
ELGSRFSLPQAVDLLFRNERKGCKNKRGFYMYDRFGERLQEDKSIYHVMETIARNDLESEQIVRRCLLRMLNEAAWCLQD
KIIASTDEGNVASVLAMGFPEFRGGIYVYIEKIGAKEIVRQLHLHTKQYGKRFEPCEWLIRQAEQ
>Mature_704_residues
TEQPIQQPMFQVEVDENQIAIIRIHSIDNDENWLPENFAGELREVIGTLIYRQVQGAIFISTRANHFIQGLKPSLFKNKT
NEQLLAFSQDAQAIMRELNTLKMPIVAAIDGNCFSVGLELSLACDYRIASDESHTFFAMPQVRSGLLPFAGGTQRLPRLI
GLRSALPLMLFGEKITAETAKGLGLVDRLVPKTRLLTDAYQLLLEKKIQKANHKKPLTFFKKWRKQIEGNSFLREKLLDR
TENAIWLKTFGNYPAVAKLMELLKEPHFKQGLMLEQQAFVELFNSATSQVLIELKKTERAMKDKYRIRGNVRDVAQVSIL
GSGYMGAGIAYLTANNAKVPVRIKDIHPSEIRKALRTCFELMQKSTDKNQLNHGEMIQRMNLITGGERLVAAKSTDFVIE
AVYEDLKLKQRMLAESESYYSEQTIFATNTSTFAIKDIAACAIRPENVIGLHYFSPVTTQKMVEIIPHSATGEHTIATAI
HFAIQQGKIPLLVADKQGFFINRVLTPLLLEAVQCLIDGESIEFIDRSLQEFGFKLGPLAMIDEMGLDVLVKSNSALVSE
LGSRFSLPQAVDLLFRNERKGCKNKRGFYMYDRFGERLQEDKSIYHVMETIARNDLESEQIVRRCLLRMLNEAAWCLQDK
IIASTDEGNVASVLAMGFPEFRGGIYVYIEKIGAKEIVRQLHLHTKQYGKRFEPCEWLIRQAEQ

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=714, Percent_Identity=32.9131652661064, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI68989263, Length=646, Percent_Identity=29.8761609907121, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI261878539, Length=626, Percent_Identity=29.7124600638978, Blast_Score=229, Evalue=8e-60,
Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=30.9027777777778, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=29.1803278688525, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI194097323, Length=170, Percent_Identity=31.1764705882353, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI115430219, Length=209, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1788682, Length=699, Percent_Identity=38.7696709585122, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1790281, Length=657, Percent_Identity=30.1369863013699, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1787661, Length=292, Percent_Identity=31.8493150684932, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787659, Length=113, Percent_Identity=38.0530973451327, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI221142681, Length=116, Percent_Identity=31.8965517241379, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=733, Percent_Identity=32.7421555252388, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17508953, Length=733, Percent_Identity=32.7421555252388, Blast_Score=345, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17558304, Length=724, Percent_Identity=31.4917127071823, Blast_Score=335, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI25144276, Length=613, Percent_Identity=33.442088091354, Blast_Score=291, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71985930, Length=383, Percent_Identity=26.1096605744125, Blast_Score=136, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71985923, Length=363, Percent_Identity=25.6198347107438, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17553560, Length=295, Percent_Identity=31.1864406779661, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=28.4246575342466, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17563036, Length=298, Percent_Identity=29.5302013422819, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=161, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=196, Percent_Identity=29.5918367346939, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=113, Percent_Identity=34.5132743362832, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=102, Percent_Identity=39.2156862745098, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583077, Length=714, Percent_Identity=31.7927170868347, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24583079, Length=714, Percent_Identity=31.7927170868347, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI19921000, Length=714, Percent_Identity=31.7927170868347, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI20129971, Length=106, Percent_Identity=38.6792452830189, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653477, Length=106, Percent_Identity=38.6792452830189, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24653139, Length=148, Percent_Identity=33.1081081081081, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357171, Length=102, Percent_Identity=39.2156862745098, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 80006; Mature: 79875

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQPIQQPMFQVEVDENQIAIIRIHSIDNDENWLPENFAGELREVIGTLIYRQVQGAIF
CCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEE
ISTRANHFIQGLKPSLFKNKTNEQLLAFSQDAQAIMRELNTLKMPIVAAIDGNCFSVGLE
EEECHHHHHHCCCHHHHCCCCCCHHHEECHHHHHHHHHHHHHCCCEEEEECCCEEEEEEE
LSLACDYRIASDESHTFFAMPQVRSGLLPFAGGTQRLPRLIGLRSALPLMLFGEKITAET
EEEEEEEEEECCCCCEEEECHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHH
AKGLGLVDRLVPKTRLLTDAYQLLLEKKIQKANHKKPLTFFKKWRKQIEGNSFLREKLLD
HHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
RTENAIWLKTFGNYPAVAKLMELLKEPHFKQGLMLEQQAFVELFNSATSQVLIELKKTER
HCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKDKYRIRGNVRDVAQVSILGSGYMGAGIAYLTANNAKVPVRIKDIHPSEIRKALRTCF
HHHHHHHHCCCHHHHHHEEEECCCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHH
ELMQKSTDKNQLNHGEMIQRMNLITGGERLVAAKSTDFVIEAVYEDLKLKQRMLAESESY
HHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
YSEQTIFATNTSTFAIKDIAACAIRPENVIGLHYFSPVTTQKMVEIIPHSATGEHTIATA
HCCCEEEEECCCCEEHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHH
IHFAIQQGKIPLLVADKQGFFINRVLTPLLLEAVQCLIDGESIEFIDRSLQEFGFKLGPL
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCH
AMIDEMGLDVLVKSNSALVSELGSRFSLPQAVDLLFRNERKGCKNKRGFYMYDRFGERLQ
HHHHHCCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
EDKSIYHVMETIARNDLESEQIVRRCLLRMLNEAAWCLQDKIIASTDEGNVASVLAMGFP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCH
EFRGGIYVYIEKIGAKEIVRQLHLHTKQYGKRFEPCEWLIRQAEQ
HHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TEQPIQQPMFQVEVDENQIAIIRIHSIDNDENWLPENFAGELREVIGTLIYRQVQGAIF
CCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEE
ISTRANHFIQGLKPSLFKNKTNEQLLAFSQDAQAIMRELNTLKMPIVAAIDGNCFSVGLE
EEECHHHHHHCCCHHHHCCCCCCHHHEECHHHHHHHHHHHHHCCCEEEEECCCEEEEEEE
LSLACDYRIASDESHTFFAMPQVRSGLLPFAGGTQRLPRLIGLRSALPLMLFGEKITAET
EEEEEEEEEECCCCCEEEECHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHH
AKGLGLVDRLVPKTRLLTDAYQLLLEKKIQKANHKKPLTFFKKWRKQIEGNSFLREKLLD
HHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
RTENAIWLKTFGNYPAVAKLMELLKEPHFKQGLMLEQQAFVELFNSATSQVLIELKKTER
HCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKDKYRIRGNVRDVAQVSILGSGYMGAGIAYLTANNAKVPVRIKDIHPSEIRKALRTCF
HHHHHHHHCCCHHHHHHEEEECCCCCCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHH
ELMQKSTDKNQLNHGEMIQRMNLITGGERLVAAKSTDFVIEAVYEDLKLKQRMLAESESY
HHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
YSEQTIFATNTSTFAIKDIAACAIRPENVIGLHYFSPVTTQKMVEIIPHSATGEHTIATA
HCCCEEEEECCCCEEHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHH
IHFAIQQGKIPLLVADKQGFFINRVLTPLLLEAVQCLIDGESIEFIDRSLQEFGFKLGPL
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCH
AMIDEMGLDVLVKSNSALVSELGSRFSLPQAVDLLFRNERKGCKNKRGFYMYDRFGERLQ
HHHHHCCCEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHH
EDKSIYHVMETIARNDLESEQIVRRCLLRMLNEAAWCLQDKIIASTDEGNVASVLAMGFP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHCCH
EFRGGIYVYIEKIGAKEIVRQLHLHTKQYGKRFEPCEWLIRQAEQ
HHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA