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The map label for this gene is gpmA

Identifier: 126208308

GI number: 126208308

Start: 966118

End: 966801

Strand: Direct

Name: gpmA

Synonym: APL_0832

Alternate gene names: 126208308

Gene position: 966118-966801 (Clockwise)

Preceding gene: 126208296

Following gene: 126208310

Centisome position: 42.48

GC content: 40.35

Gene sequence:

>684_bases
ATGGAATTAGTATTTATTCGTCACGGTTTCAGTGAATGGAATGCTAAAAACTTATTTACAGGCTGGCGTGATGTTAATTT
AACCGAACGTGGTATCGAAGAAGCGAAATCGGCAGGTCAAAAATTAAAAGCCGCCGGTTATGAATTCGATATCGCATTCA
CTTCGGTTTTAACTCGTGCAATTAAAACTTGTAATATCGTATTAGAAGAATCTAATCAATTATGGATTCCACAAGTGAAA
AACTGGCGTTTAAACGAGCGTCACTACGGTGCGTTACAAGGTTTAGACAAAAAAGCGACCGCCGAACAATACGGTGACGA
ACAAGTTCACATTTGGCGTCGCTCTTATGACATTTCTCCACCGGATTTAGATGCGGCGGATCCGAATTCTGCGCATAACG
ATCGTCGTTACGCACACTTACCGAAAGATGTCATTCCAAACGCGGAAAACCTCAAAATCACTTTAGAACGTGTTTTACCG
TTCTGGGAAGATCAAATCGCACCGGCGTTATTATCCGGCAAACGCGTACTGGTAACTGCACACGGTAACTCTCTTCGTGC
GTTAGCAAAACACATCATCGGTATTTCTGATGCTGAAATTATGGATTTTGAAATCCCTACCGGTCAGCCGTTAGTATTAA
AATTAGATGATAAATTAAACTTCGTAGAAAAATTCTATTTATAA

Upstream 100 bases:

>100_bases
CTCGCTTTTCTAAAAAGAAATCGGCTAACTATTTCAAAGTAAGTGGATTTTTGCTATAAATACACGGTTTTCAAATCAAC
TTAAATACATAGGAGGCTTT

Downstream 100 bases:

>100_bases
TTTAGTTTGTTCCTCAAACAAAAACGCTCGAAGCCAAAACTCCGAGCGTTTCTTTTTGCAAAAATTCAATAAAATTTAAC
CGCTTACCAAGCAAAAATTT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MELVFIRHGFSEWNAKNLFTGWRDVNLTERGIEEAKSAGQKLKAAGYEFDIAFTSVLTRAIKTCNIVLEESNQLWIPQVK
NWRLNERHYGALQGLDKKATAEQYGDEQVHIWRRSYDISPPDLDAADPNSAHNDRRYAHLPKDVIPNAENLKITLERVLP
FWEDQIAPALLSGKRVLVTAHGNSLRALAKHIIGISDAEIMDFEIPTGQPLVLKLDDKLNFVEKFYL

Sequences:

>Translated_227_residues
MELVFIRHGFSEWNAKNLFTGWRDVNLTERGIEEAKSAGQKLKAAGYEFDIAFTSVLTRAIKTCNIVLEESNQLWIPQVK
NWRLNERHYGALQGLDKKATAEQYGDEQVHIWRRSYDISPPDLDAADPNSAHNDRRYAHLPKDVIPNAENLKITLERVLP
FWEDQIAPALLSGKRVLVTAHGNSLRALAKHIIGISDAEIMDFEIPTGQPLVLKLDDKLNFVEKFYL
>Mature_227_residues
MELVFIRHGFSEWNAKNLFTGWRDVNLTERGIEEAKSAGQKLKAAGYEFDIAFTSVLTRAIKTCNIVLEESNQLWIPQVK
NWRLNERHYGALQGLDKKATAEQYGDEQVHIWRRSYDISPPDLDAADPNSAHNDRRYAHLPKDVIPNAENLKITLERVLP
FWEDQIAPALLSGKRVLVTAHGNSLRALAKHIIGISDAEIMDFEIPTGQPLVLKLDDKLNFVEKFYL

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=220, Percent_Identity=51.8181818181818, Blast_Score=246, Evalue=8e-66,
Organism=Homo sapiens, GI4505753, Length=220, Percent_Identity=53.1818181818182, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI4502445, Length=225, Percent_Identity=48.8888888888889, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI40353764, Length=225, Percent_Identity=48.8888888888889, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI71274132, Length=224, Percent_Identity=50.4464285714286, Blast_Score=227, Evalue=7e-60,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=54.0372670807453, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI1786970, Length=226, Percent_Identity=51.7699115044248, Blast_Score=254, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6322697, Length=225, Percent_Identity=51.5555555555556, Blast_Score=248, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324516, Length=276, Percent_Identity=31.8840579710145, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320183, Length=281, Percent_Identity=31.3167259786477, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324857, Length=108, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646216, Length=221, Percent_Identity=49.7737556561086, Blast_Score=223, Evalue=8e-59,
Organism=Drosophila melanogaster, GI85725270, Length=224, Percent_Identity=50.8928571428571, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI85725272, Length=224, Percent_Identity=50.8928571428571, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24650981, Length=224, Percent_Identity=50.8928571428571, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28571817, Length=219, Percent_Identity=38.8127853881278, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28571815, Length=219, Percent_Identity=38.8127853881278, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24648979, Length=219, Percent_Identity=38.8127853881278, Blast_Score=164, Evalue=4e-41,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_ACTP2 (A3N0J2)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053533.1
- ProteinModelPortal:   A3N0J2
- SMR:   A3N0J2
- STRING:   A3N0J2
- GeneID:   4848641
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0832
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   A3N0J2
- ProtClustDB:   PRK14118
- BioCyc:   APLE416269:APL_0832-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 25906; Mature: 25906

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 8-8 ACT_SITE 181-181

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVFIRHGFSEWNAKNLFTGWRDVNLTERGIEEAKSAGQKLKAAGYEFDIAFTSVLTRA
CEEEEEECCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHH
IKTCNIVLEESNQLWIPQVKNWRLNERHYGALQGLDKKATAEQYGDEQVHIWRRSYDISP
HHHHEEEEECCCCEECCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEEEEEECCCCC
PDLDAADPNSAHNDRRYAHLPKDVIPNAENLKITLERVLPFWEDQIAPALLSGKRVLVTA
CCCCCCCCCCCCCCCEEECCCHHHCCCCCCCEEEHHHHCCHHHHHHHHHHHCCCEEEEEE
HGNSLRALAKHIIGISDAEIMDFEIPTGQPLVLKLDDKLNFVEKFYL
CCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCHHHHHHHHCC
>Mature Secondary Structure
MELVFIRHGFSEWNAKNLFTGWRDVNLTERGIEEAKSAGQKLKAAGYEFDIAFTSVLTRA
CEEEEEECCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHH
IKTCNIVLEESNQLWIPQVKNWRLNERHYGALQGLDKKATAEQYGDEQVHIWRRSYDISP
HHHHEEEEECCCCEECCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEEEEEECCCCC
PDLDAADPNSAHNDRRYAHLPKDVIPNAENLKITLERVLPFWEDQIAPALLSGKRVLVTA
CCCCCCCCCCCCCCCEEECCCHHHCCCCCCCEEEHHHHCCHHHHHHHHHHHCCCEEEEEE
HGNSLRALAKHIIGISDAEIMDFEIPTGQPLVLKLDDKLNFVEKFYL
CCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA