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The map label for this gene is ubiA

Identifier: 126208298

GI number: 126208298

Start: 950519

End: 951400

Strand: Reverse

Name: ubiA

Synonym: APL_0822

Alternate gene names: 126208298

Gene position: 951400-950519 (Counterclockwise)

Preceding gene: 126208299

Following gene: 126208297

Centisome position: 41.83

GC content: 43.31

Gene sequence:

>882_bases
ATGACAACTTTTTTTCAACAACATTTTTCTCGGAATAAATGGCTGGCGTATGCACAATTAATGCGCTTTGATAAGCCGAT
TGGAACTTTACTTTTGCTTCACCCGACATTATGGGCGTTATTTGCCGCCGCAGGCGGTATGCCGCCGTTGTCAGTGTTAG
TGATTTTCGTGTTAGGCGTAATCGTTATGCGTGCCGCCGGCTGTGTGATTAACGATTATGCCGATCGCCATATTGACGGT
GAAGTAAAACGTACCTCACAGCGCCCGCTTGCCACCGGGCGGGTGACGACGACGGAAGCAAAAATACTGTTCGTATTATT
GTTGTGTATCGCTTTTGTTTTGGACTTATTGCTTAACCGATATACTTTTTTACTGTCGTTTGTTGCGGTCGCGTTAGCGA
TTATTTATCCGTTTATGAAACGCTTTACCCATTTACCGCAAGTGGTATTAGGCATGGCGTTCGGTTGGGCGATCCCGATG
GCGTATGGTGCGGTAAGCGAATCGTTGCCGTTGGAGTGTTGGTTGTTATTTTTCGCCAATATTTTTTGGACGGTTGCTTA
TGATACGCAATATGCGATGGTTGATCGTGACGATGATCTGCGTATCGGGGTAAAATCCACTGCGATTTTGTTTGCGCAAT
ACGACAATAAAATTATCGCCTTATTGCAATTTATTACGTTAGTGCTATTAGTTATTTTCGGTTGGATAAGTCAATATCAT
TGGGGTTATTTTGTCGTGCTCGGCTTGAGCGCAAGTTTGTTTAGCCATCAATGTTGGCTGACCAAACAGCGAGTCAGAGA
GCAATGTTTTAAAGCGTTTTTGAATAATCACTATTTCGGTTTAGGTGTGTTTTTTGCGATTTTAGTCGGCATCTATGCTT
AA

Upstream 100 bases:

>100_bases
TTACCGAAGTGAATTATTTGTTTACAGATTTGCCGTTACCATTAGAATTACAGCAACGATTAGTTTCAACCAAAGTAGCA
GTACAAATCTGCGGTAATTA

Downstream 100 bases:

>100_bases
TGCAAAAAGAGTAAGCGGTTGAATTTTCTGAGATTTTTCCAAGAAAGTTAGCCGCTTTTTTATTTCCTAAGTTTACAAAT
TTTCCTGTGTTTTTAACCGC

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTTFFQQHFSRNKWLAYAQLMRFDKPIGTLLLLHPTLWALFAAAGGMPPLSVLVIFVLGVIVMRAAGCVINDYADRHIDG
EVKRTSQRPLATGRVTTTEAKILFVLLLCIAFVLDLLLNRYTFLLSFVAVALAIIYPFMKRFTHLPQVVLGMAFGWAIPM
AYGAVSESLPLECWLLFFANIFWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIIALLQFITLVLLVIFGWISQYH
WGYFVVLGLSASLFSHQCWLTKQRVREQCFKAFLNNHYFGLGVFFAILVGIYA

Sequences:

>Translated_293_residues
MTTFFQQHFSRNKWLAYAQLMRFDKPIGTLLLLHPTLWALFAAAGGMPPLSVLVIFVLGVIVMRAAGCVINDYADRHIDG
EVKRTSQRPLATGRVTTTEAKILFVLLLCIAFVLDLLLNRYTFLLSFVAVALAIIYPFMKRFTHLPQVVLGMAFGWAIPM
AYGAVSESLPLECWLLFFANIFWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIIALLQFITLVLLVIFGWISQYH
WGYFVVLGLSASLFSHQCWLTKQRVREQCFKAFLNNHYFGLGVFFAILVGIYA
>Mature_292_residues
TTFFQQHFSRNKWLAYAQLMRFDKPIGTLLLLHPTLWALFAAAGGMPPLSVLVIFVLGVIVMRAAGCVINDYADRHIDGE
VKRTSQRPLATGRVTTTEAKILFVLLLCIAFVLDLLLNRYTFLLSFVAVALAIIYPFMKRFTHLPQVVLGMAFGWAIPMA
YGAVSESLPLECWLLFFANIFWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIIALLQFITLVLLVIFGWISQYHW
GYFVVLGLSASLFSHQCWLTKQRVREQCFKAFLNNHYFGLGVFFAILVGIYA

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=277, Percent_Identity=36.8231046931408, Blast_Score=178, Evalue=6e-45,
Organism=Escherichia coli, GI1790473, Length=282, Percent_Identity=60.2836879432624, Blast_Score=334, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17553718, Length=279, Percent_Identity=36.9175627240143, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI32565247, Length=276, Percent_Identity=36.5942028985507, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17553720, Length=179, Percent_Identity=41.8994413407821, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32565245, Length=137, Percent_Identity=45.985401459854, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32565243, Length=136, Percent_Identity=45.5882352941176, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=292, Percent_Identity=31.5068493150685, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355567, Length=291, Percent_Identity=38.4879725085911, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_ACTP2 (A3N0I2)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053523.1
- STRING:   A3N0I2
- GeneID:   4850044
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0822
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- PhylomeDB:   A3N0I2
- ProtClustDB:   PRK12848
- BioCyc:   APLE416269:APL_0822-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33338; Mature: 33207

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d41e4a4)-; HASH(0x1d146754)-; HASH(0x1d610d08)-; HASH(0x1c9eba18)-; HASH(0x1c5bac40)-; HASH(0x1cf26664)-; HASH(0x1d2b0e5c)-; HASH(0x1c64bbc8)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFFQQHFSRNKWLAYAQLMRFDKPIGTLLLLHPTLWALFAAAGGMPPLSVLVIFVLGV
CCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IVMRAAGCVINDYADRHIDGEVKRTSQRPLATGRVTTTEAKILFVLLLCIAFVLDLLLNR
HHHHHCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YTFLLSFVAVALAIIYPFMKRFTHLPQVVLGMAFGWAIPMAYGAVSESLPLECWLLFFAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IFWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIIALLQFITLVLLVIFGWISQYH
HHHHHHCCCEEEEECCCCCCEEEEHHHEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHC
WGYFVVLGLSASLFSHQCWLTKQRVREQCFKAFLNNHYFGLGVFFAILVGIYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TTFFQQHFSRNKWLAYAQLMRFDKPIGTLLLLHPTLWALFAAAGGMPPLSVLVIFVLGV
CCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IVMRAAGCVINDYADRHIDGEVKRTSQRPLATGRVTTTEAKILFVLLLCIAFVLDLLLNR
HHHHHCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YTFLLSFVAVALAIIYPFMKRFTHLPQVVLGMAFGWAIPMAYGAVSESLPLECWLLFFAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IFWTVAYDTQYAMVDRDDDLRIGVKSTAILFAQYDNKIIALLQFITLVLLVIFGWISQYH
HHHHHHCCCEEEEECCCCCCEEEEHHHEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHC
WGYFVVLGLSASLFSHQCWLTKQRVREQCFKAFLNNHYFGLGVFFAILVGIYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA