Click here to switch to the map view.

The map label for this gene is ispA [H]

Identifier: 126208283

GI number: 126208283

Start: 929306

End: 930199

Strand: Direct

Name: ispA [H]

Synonym: APL_0807

Alternate gene names: 126208283

Gene position: 929306-930199 (Clockwise)

Preceding gene: 126208282

Following gene: 126208287

Centisome position: 40.86

GC content: 42.84

Gene sequence:

>894_bases
ATGAGCTATTCTCTCTCAACCGATCTTAGCGTTATACAACAGCGCATTAATGATTTCTTAAGTACCAAATTAAAAACCTA
TCCAGCTTATGATTCTGCGTTAATTGAAGCGATGTCTTACGCCGTATTACTAGGCGGGAAACGTGTTCGTCCGTTCTTAA
TTTATGCCACCGGCAGAATGCTCGACGTACCGTTTGAACAACTGGATCACAGTGCCGCCGCAATGGAAGCGATCCACGCT
TATTCATTGGTACACGATGATTTACCAGCAATGGACGATGACAAACTTCGCCGAGGTAAACCGACTTGCCATATCGCTTT
TGATGAAGCAACCGCCATTCTTGCCGGCGATGCGTTACAAAGTTTTGCCTTTGAACTGATTGCCCAAGACGAATCATTAA
CCGATTCGCAAAAAGTCCGCCAAATTCAATCGCTTGCCCAAGCTGCCGGTGCAAGAGGAATGTGTTTAGGGCAAAGCCTT
GATTTGCTCGCCGAAGATACAGCGGTCAATTTAGCCGAATTGGAATTAATTCATCGTAATAAAACCGGCGCATTAATTAT
TGCTTCCGTATTGATGGGCTTTAATTTATCCGCACATTCGCAAAATTTAGCAATAAAACAACCGCTTGAACGCTATGCGC
AAGCAATCGGATTAGCTTTCCAAGTGCAAGACGATATTTTAGATGTAATTGGCGAAACCGATAAAATCGGTAAAACCGTA
GGTTCGGATGAAAACTTGCATAAAAGCACTTATCCTAAACTGCTTGGTTTAGAAGGCGCACAGCAGAAAGCGCAGGACTT
ATACCAAACTGCATTAAATGCACTTGAGGAATTGCCGTTTGATACCACTGCGCTTAAAGAATTAGCGCATTTTATTGTCA
AACGTGAAAACTAA

Upstream 100 bases:

>100_bases
AACAAGGACAAGAACGCTTACAAAAAGCGGAACAACGCATTCAAATCTTACTCAATAAAAACGACCAAGCCGAACTTTCC
GATTACGAATAAAAATAACA

Downstream 100 bases:

>100_bases
TTTGCAAAAAATCGCGCGATTTTGACCTCTTACTTAAAGCATATAAAGGCGAGAATGACTCTCGCCTTTTTGTTTATTTA
CATTTACTTTTGAAAGGCAA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSYSLSTDLSVIQQRINDFLSTKLKTYPAYDSALIEAMSYAVLLGGKRVRPFLIYATGRMLDVPFEQLDHSAAAMEAIHA
YSLVHDDLPAMDDDKLRRGKPTCHIAFDEATAILAGDALQSFAFELIAQDESLTDSQKVRQIQSLAQAAGARGMCLGQSL
DLLAEDTAVNLAELELIHRNKTGALIIASVLMGFNLSAHSQNLAIKQPLERYAQAIGLAFQVQDDILDVIGETDKIGKTV
GSDENLHKSTYPKLLGLEGAQQKAQDLYQTALNALEELPFDTTALKELAHFIVKREN

Sequences:

>Translated_297_residues
MSYSLSTDLSVIQQRINDFLSTKLKTYPAYDSALIEAMSYAVLLGGKRVRPFLIYATGRMLDVPFEQLDHSAAAMEAIHA
YSLVHDDLPAMDDDKLRRGKPTCHIAFDEATAILAGDALQSFAFELIAQDESLTDSQKVRQIQSLAQAAGARGMCLGQSL
DLLAEDTAVNLAELELIHRNKTGALIIASVLMGFNLSAHSQNLAIKQPLERYAQAIGLAFQVQDDILDVIGETDKIGKTV
GSDENLHKSTYPKLLGLEGAQQKAQDLYQTALNALEELPFDTTALKELAHFIVKREN
>Mature_296_residues
SYSLSTDLSVIQQRINDFLSTKLKTYPAYDSALIEAMSYAVLLGGKRVRPFLIYATGRMLDVPFEQLDHSAAAMEAIHAY
SLVHDDLPAMDDDKLRRGKPTCHIAFDEATAILAGDALQSFAFELIAQDESLTDSQKVRQIQSLAQAAGARGMCLGQSLD
LLAEDTAVNLAELELIHRNKTGALIIASVLMGFNLSAHSQNLAIKQPLERYAQAIGLAFQVQDDILDVIGETDKIGKTVG
SDENLHKSTYPKLLGLEGAQQKAQDLYQTALNALEELPFDTTALKELAHFIVKREN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=294, Percent_Identity=52.0408163265306, Blast_Score=260, Evalue=9e-71,
Organism=Escherichia coli, GI1789578, Length=246, Percent_Identity=31.7073170731707, Blast_Score=86, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24651612, Length=253, Percent_Identity=26.4822134387352, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32551; Mature: 32420

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSLSTDLSVIQQRINDFLSTKLKTYPAYDSALIEAMSYAVLLGGKRVRPFLIYATGRM
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCE
LDVPFEQLDHSAAAMEAIHAYSLVHDDLPAMDDDKLRRGKPTCHIAFDEATAILAGDALQ
EECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHH
SFAFELIAQDESLTDSQKVRQIQSLAQAAGARGMCLGQSLDLLAEDTAVNLAELELIHRN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCHHHHHHHHHCC
KTGALIIASVLMGFNLSAHSQNLAIKQPLERYAQAIGLAFQVQDDILDVIGETDKIGKTV
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCHHHHHHC
GSDENLHKSTYPKLLGLEGAQQKAQDLYQTALNALEELPFDTTALKELAHFIVKREN
CCCCCCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYSLSTDLSVIQQRINDFLSTKLKTYPAYDSALIEAMSYAVLLGGKRVRPFLIYATGRM
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCE
LDVPFEQLDHSAAAMEAIHAYSLVHDDLPAMDDDKLRRGKPTCHIAFDEATAILAGDALQ
EECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHH
SFAFELIAQDESLTDSQKVRQIQSLAQAAGARGMCLGQSLDLLAEDTAVNLAELELIHRN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCHHHHHHHHHCC
KTGALIIASVLMGFNLSAHSQNLAIKQPLERYAQAIGLAFQVQDDILDVIGETDKIGKTV
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCHHHHHHC
GSDENLHKSTYPKLLGLEGAQQKAQDLYQTALNALEELPFDTTALKELAHFIVKREN
CCCCCCCHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]